Ouissame Mnie-Filali

Solid-State Nanopores for Spatially Resolved Chemical Neuromodulation

A recent study from the project, published in Nano Letters, describes a planar neural interface that utilizes diffusion-driven neurotransmitter release through a solid-state nanopore array. To test its potential as a spatially resolved neural interface for stimulating neurons with glutamate, the scientists recorded rat retinal tissue on the MaxOne Single-Well HD-MEA. The results showed an increase in glutamate-evoked activity over time, with a clear-cut difference between cellslocated near the nanopores…

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FGF8-mediated gene regulation affects regional identity in human cerebral organoids

The roles of FGF signaling and its effector genes remain poorly characterized in human experimental models mimicking early fetal telencephalic development.

In this publication, scientists under the supervision of Dr Michele Studer used an optimized protocol for human iPSC-derived brain organoid generation to study how FGF8 signalling impacts neuronal development and differentiation. MaxOne Single-Well HD-MEA was used to characterize the electrical activity of these organoids…

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First Human Brain Slices Study using Optogenetics and HD-MEA Published in Nature Neuroscience

Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices This paper demonstrated for the first time that optogenetic tools can be used to modulate network activity in human brain slices, bridging the long-lasting gap between human and animal studies. The MaxOne Single-Well High-Density Microelectrode (HD-MEA) System was used to record the spontaneous and light-evoked activity of human hippocampal slices. Andrews, J.P., Geng, J., Voitiuk, K. et al. Multimodal evaluation of network activity and optogenetic interventions in human…

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