Applications

Swift induction of human spinal lower motor neurons and robust ALS cell screening via single-cell imaging

April 16, 2025
Ouissame Mnie-Filali
Blog, iPSC, MaxOne, Publications

Swift induction of human spinal lower motor neurons and robust ALS cell screening via single-cell imaging Selena Setsu, Satoru Morimoto, Shiho Nakamura, Fumiko Ozawa, Kagistia Hana Utami, Ayumi Nishiyama, Naoki Suzuki, Masashi Aoki, Yukio Takeshita, Yukihide Tomari, Hideyuki Okano. Stem Cell Reports. 2025 Jan 14. https://doi.org/10.1016/j.stemcr.2024.11.007 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by motor neuron degeneration. While induced pluripotent stem cells (iPSCs) have emerged as a powerful tool for drug screening and studying ALS pathology, challenges…

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FGF8-mediated gene regulation affects regional identity in human cerebral organoids

November 26, 2024
Ouissame Mnie-Filali
Blog, MaxOne, Organoids, Publications

The roles of FGF signaling and its effector genes remain poorly characterized in human experimental models mimicking early fetal telencephalic development.

In this publication, scientists under the supervision of Dr Michele Studer used an optimized protocol for human iPSC-derived brain organoid generation to study how FGF8 signalling impacts neuronal development and differentiation. MaxOne Single-Well HD-MEA was used to characterize the electrical activity of these organoids…

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First Human Brain Slices Study using Optogenetics and HD-MEA Published in Nature Neuroscience

November 18, 2024
Ouissame Mnie-Filali
Blog, Brain Slices, MaxOne, Press Release, Publications

Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices This paper demonstrated for the first time that optogenetic tools can be used to modulate network activity in human brain slices, bridging the long-lasting gap between human and animal studies. The MaxOne Single-Well High-Density Microelectrode (HD-MEA) System was used to record the spontaneous and light-evoked activity of human hippocampal slices. Andrews, J.P., Geng, J., Voitiuk, K. et al. Multimodal evaluation of network activity and optogenetic interventions in human…

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Join the Conversation with Prof. Feng Guo

July 19, 2024
Patricia Valerio
Applications, Blog, MaxOne, Organoids, Publications

Interview Join the Conversation with Prof. Dr. Feng Guo Intelligent BioMedical Systems (IBMS) Lab, Indiana University Bloomington, USA Dr. Feng Guo presenting at the MxW Summit 2024, in Zurich “If you have one electrode covered by many neurons, you acquire average information, which is not enough for specific computing conditions. What we really aim is high resolution at a single-neuron level, something we can achieve with MaxOne HD-MEA.” Back in April, we had the pleasure of having Dr. Feng Guo…

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New Therapeutic Target in the Fight Against ALS

February 14, 2024
Patricia Valerio
Blog, iPSC, MaxOne, Press Release, Publications

Scientists uncover a new protein in a pathway for neurotoxicity and cell death A new study published in Nature takes us one step forward in understanding the key mechanisms behind neurodegenerative diseases. With the urgent need for human cellular models to study such pathologies, scientists have developed a new 2D cell culture model with features mirroring those of human brains, with the support from MaxWell Biosystems’ high-density Microelectrode arrays (HD-MEAs). Delving deeper into the effects of the abnormal accumulation of TAR DNA-binding protein…

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