iPSC | MaxWell Biosystems

Join the Conversation with Prof. Tarja Malm

November 2, 2023

Interview Join the Conversation with Prof. Dr. Tarja Malm Malm Lab / Neuroinflammation Research Group, A.I. Virtanen Institute, University of Eastern Finland Back in May 2023, we had the pleasure of having Prof. Dr. Tarja Malm present at the 3rd In-Vitro 2D & 3D Neuronal Networks Summit, the MxW Summit 2023. Dr. Tarja captivated the audience with insights into modeling brain functions with microglia-containing organoids.Recently, we had the privilege to engage in an inspiring conversation with Dr. Tarja about her…

HD-MEAs play a role in the functional characterization of human iPSC-derived dopaminergic neurons

June 22, 2021

Diana Freire

Blog, iPSC, MaxOne, News, Publications

Maria Sundberg from the Boston Children’s Hospital, Harvard Medical School, and colleagues, recently reported in Nature Communications a study on the reciprocal copy number variations (CNVs) of 16p11.2 gene region, associated with a wide spectrum of neuropsychiatric and neurodevelopmental disorders. For the functional analysis of the developing iPSC-derived dopaminergic (DA) neuron network, complementary-metal-oxide-semiconductor (CMOS)-based high-density microelectrode arrays (HD-MEAs), MaxOne System by MaxWell Biosystems was extensively used. 16p.11.2 Reciprocal copy number variations (CNVs) in neuropsychiatric disorders 16p.11.2 CNVs have been implicated in…

Observing the activity of human-derived neurons in health and in disease

April 9, 2021

Marie Obien

Applications, Blog, Featured, iPSC, News, Publications

The combination of two technologies—induced pluripotent stem cells and high-density microelectrode arrays—offers an unprecedented platform to study human brain activity in detail outside the body. Back in 2006, Prof. Yamanaka and colleagues revealed a technique to reprogram adult skin cells into embryonic-like cells called induced pluripotent stem cells or iPSCs. This Nobel Prize winning technology enables access to human neurons derived from adult blood or skin cells in a high-throughput manner, thus opening up the possibilities to study neurological…

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