Organoids

FGF8-mediated gene regulation affects regional identity in human cerebral organoids

November 26, 2024
Ouissame Mnie-Filali
Blog, MaxOne, Organoids, Publications

The roles of FGF signaling and its effector genes remain poorly characterized in human experimental models mimicking early fetal telencephalic development.

In this publication, scientists under the supervision of Dr Michele Studer used an optimized protocol for human iPSC-derived brain organoid generation to study how FGF8 signalling impacts neuronal development and differentiation. MaxOne Single-Well HD-MEA was used to characterize the electrical activity of these organoids…

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Join the Conversation with Prof. Feng Guo

July 19, 2024
Patricia Valerio
Applications, Blog, MaxOne, Organoids, Publications

Interview Join the Conversation with Prof. Dr. Feng Guo Intelligent BioMedical Systems (IBMS) Lab, Indiana University Bloomington, USA Dr. Feng Guo presenting at the MxW Summit 2024, in Zurich “If you have one electrode covered by many neurons, you acquire average information, which is not enough for specific computing conditions. What we really aim is high resolution at a single-neuron level, something we can achieve with MaxOne HD-MEA.” Back in April, we had the pleasure of having Dr. Feng Guo…

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Join the Conversation with Prof. Tarja Malm

November 2, 2023
Patricia Valerio
Blog, iPSC, Organoids, Technology

Interview Join the Conversation with Prof. Dr. Tarja Malm Malm Lab / Neuroinflammation Research Group, A.I. Virtanen Institute, University of Eastern Finland Back in May 2023, we had the pleasure of having Prof. Dr. Tarja Malm present at the 3rd In-Vitro 2D & 3D Neuronal Networks Summit, the MxW Summit 2023. Dr. Tarja captivated the audience with insights into modeling brain functions with microglia-containing organoids.Recently, we had the privilege to engage in an inspiring conversation with Dr. Tarja about her…

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MaxWell Monthly Must-Reads | World Organoid Research Day

March 22, 2023
Patricia Valerio
Blog, MaxWell Monthly Must-Reads, Organoids

  Today is World Organoid Research Day! Let’s celebrate the incredible advances being made in this fascinating and yet rapidly evolving field of research by raising awareness on the potential of organoids in advancing biomedical research, drug discovery, regenerative medicine, modeling complex diseases, personalized medicine, reducing animal testing, and advancing stem cell research. Grown from human stem cells, organoids are miniaturized three-dimensional structures that closely resemble the architecture and function of real human organs, providing a more complex and comprehensive…

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Join the Conversation with Prof. Kenneth S. Kosik and Dr. Tal Sharf

December 24, 2021
Marie Obien
Applications, Blog, Featured, MaxOne, Organoids, Publications

Interview and Featured Publication Join the Conversation with Prof. Kenneth Kosik and Dr. Tal Sharf Recently, Dr. Tal Sharf, Prof. Kenneth S. Kosik and colleagues released a pre-print on their novel work entitled, “Human brain organoid networks”, currently under revision. Aiming to explore the physiological behavior of neuronal circuits within organoids, this work demonstrates that human brain organoids have self-organized neuronal assemblies of sufficient size, cellular orientation, and functional connectivity to co-activate and generate field potentials from their collective transmembrane…

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