MaxOne

HD-MEAs play a role in the functional characterization of human iPSC-derived dopaminergic neurons

Maria Sundberg from the Boston Children’s Hospital, Harvard Medical School, and colleagues, recently reported in Nature Communications a study on the reciprocal copy number variations (CNVs) of 16p11.2 gene region, associated with a wide spectrum of neuropsychiatric and neurodevelopmental disorders. For the functional analysis of the developing iPSC-derived dopaminergic (DA) neuron network, complementary-metal-oxide-semiconductor (CMOS)-based high-density microelectrode arrays (HD-MEAs), MaxOne System by MaxWell Biosystems was extensively used. 16p.11.2 Reciprocal copy number variations (CNVs) in neuropsychiatric disorders 16p.11.2 CNVs have been implicated in…

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Retina study utilizing HD-MEAs (MaxOne) selected as “Best of Neuron”

The paper by K. Yonehara*, M. Fiscella*, A. Drinnenberg*, et al. entitled “Congenital Nystagmus Gene FRMD7 is necessary for establishing a neuronal circuit asymmetry for direction selectivity” was chosen for the “Best of Neuron” selection 2015-2016. “Best of Neuron“ includes ground-breaking neuroscience research published in Neuron and is a collection of editors’ and readers’ favorites. MaxWell Biosystems HD-MEA core technology was used in this study, to characterize the disease phenotype discovered in the FRMD7 mutant retina. Mutation in the FRMD7 gene is linked to the…

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