MaxOne

Solid-State Nanopores for Spatially Resolved Chemical Neuromodulation

November 28, 2024
Ouissame Mnie-Filali
Blog, MaxOne, Retina

A recent study from the project, published in Nano Letters, describes a planar neural interface that utilizes diffusion-driven neurotransmitter release through a solid-state nanopore array. To test its potential as a spatially resolved neural interface for stimulating neurons with glutamate, the scientists recorded rat retinal tissue on the MaxOne Single-Well HD-MEA. The results showed an increase in glutamate-evoked activity over time, with a clear-cut difference between cellslocated near the nanopores…

Read More

FGF8-mediated gene regulation affects regional identity in human cerebral organoids

November 26, 2024
Ouissame Mnie-Filali
Blog, MaxOne, Organoids, Publications

The roles of FGF signaling and its effector genes remain poorly characterized in human experimental models mimicking early fetal telencephalic development.

In this publication, scientists under the supervision of Dr Michele Studer used an optimized protocol for human iPSC-derived brain organoid generation to study how FGF8 signalling impacts neuronal development and differentiation. MaxOne Single-Well HD-MEA was used to characterize the electrical activity of these organoids…

Read More

First Human Brain Slices Study using Optogenetics and HD-MEA Published in Nature Neuroscience

November 18, 2024
Ouissame Mnie-Filali
Blog, Brain Slices, MaxOne, Press Release, Publications

Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices This paper demonstrated for the first time that optogenetic tools can be used to modulate network activity in human brain slices, bridging the long-lasting gap between human and animal studies. The MaxOne Single-Well High-Density Microelectrode (HD-MEA) System was used to record the spontaneous and light-evoked activity of human hippocampal slices. Andrews, J.P., Geng, J., Voitiuk, K. et al. Multimodal evaluation of network activity and optogenetic interventions in human…

Read More

Join the Conversation with Prof. Feng Guo

July 19, 2024
Patricia Valerio
Applications, Blog, MaxOne, Organoids, Publications

Interview Join the Conversation with Prof. Dr. Feng Guo Intelligent BioMedical Systems (IBMS) Lab, Indiana University Bloomington, USA Dr. Feng Guo presenting at the MxW Summit 2024, in Zurich “If you have one electrode covered by many neurons, you acquire average information, which is not enough for specific computing conditions. What we really aim is high resolution at a single-neuron level, something we can achieve with MaxOne HD-MEA.” Back in April, we had the pleasure of having Dr. Feng Guo…

Read More

New Therapeutic Target in the Fight Against ALS

February 14, 2024
Patricia Valerio
Blog, iPSC, MaxOne, Press Release, Publications

Scientists uncover a new protein in a pathway for neurotoxicity and cell death A new study published in Nature takes us one step forward in understanding the key mechanisms behind neurodegenerative diseases. With the urgent need for human cellular models to study such pathologies, scientists have developed a new 2D cell culture model with features mirroring those of human brains, with the support from MaxWell Biosystems’ high-density Microelectrode arrays (HD-MEAs). Delving deeper into the effects of the abnormal accumulation of TAR DNA-binding protein…

Read More
Contact Us






Albisriederstrasse 253
8047 Zurich, Switzerland
+41 44 244 24 24
Schedule a call
info@mxwbio.com
Subscribe to our Newsletter