Publications

New Therapeutic Target in the Fight Against ALS

February 14, 2024
Patricia Valerio
Blog, iPSC, MaxOne, Press Release, Publications

Scientists uncover a new protein in a pathway for neurotoxicity and cell death A new study published in Nature takes us one step forward in understanding the key mechanisms behind neurodegenerative diseases. With the urgent need for human cellular models to study such pathologies, scientists have developed a new 2D cell culture model with features mirroring those of human brains, with the support from MaxWell Biosystems’ high-density Microelectrode arrays (HD-MEAs). Delving deeper into the effects of the abnormal accumulation of TAR DNA-binding protein…

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Join the Conversation with Prof. Kenneth S. Kosik and Dr. Tal Sharf

December 24, 2021
Marie Obien
Applications, Blog, Featured, MaxOne, Organoids, Publications

Interview and Featured Publication Join the Conversation with Prof. Kenneth Kosik and Dr. Tal Sharf Recently, Dr. Tal Sharf, Prof. Kenneth S. Kosik and colleagues released a pre-print on their novel work entitled, “Human brain organoid networks”, currently under revision. Aiming to explore the physiological behavior of neuronal circuits within organoids, this work demonstrates that human brain organoids have self-organized neuronal assemblies of sufficient size, cellular orientation, and functional connectivity to co-activate and generate field potentials from their collective transmembrane…

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HD-MEAs play a role in the functional characterization of human iPSC-derived dopaminergic neurons

June 22, 2021
Diana Freire
Blog, iPSC, MaxOne, News, Publications

Maria Sundberg from the Boston Children’s Hospital, Harvard Medical School, and colleagues, recently reported in Nature Communications a study on the reciprocal copy number variations (CNVs) of 16p11.2 gene region, associated with a wide spectrum of neuropsychiatric and neurodevelopmental disorders. For the functional analysis of the developing iPSC-derived dopaminergic (DA) neuron network, complementary-metal-oxide-semiconductor (CMOS)-based high-density microelectrode arrays (HD-MEAs), MaxOne System by MaxWell Biosystems was extensively used. 16p.11.2 Reciprocal copy number variations (CNVs) in neuropsychiatric disorders 16p.11.2 CNVs have been implicated in…

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Observing the activity of human-derived neurons in health and in disease

April 9, 2021
Marie Obien
Applications, Blog, Featured, iPSC, News, Publications

The combination of two technologies—induced pluripotent stem cells and high-density microelectrode arrays—offers an unprecedented platform to study human brain activity in detail outside the body.    Back in 2006, Prof. Yamanaka and colleagues revealed a technique to reprogram adult skin cells into embryonic-like cells called induced pluripotent stem cells or iPSCs. This Nobel Prize winning technology enables access to human neurons derived from adult blood or skin cells in a high-throughput manner, thus opening up the possibilities to study neurological…

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Capture the activity of thousands of communicating neurons all at once

September 25, 2020
Marie Obien
Featured, News, Publications, Technology

Latest Neurochip published in Nature Communications Today, a new generation of high-density microelectrode array (HD-MEA) technology has been published in Nature Communications (link). This publication not only demonstrates the excellent performance of the chip, but also describes the large-scale extraction of neuronal metrics, such as axonal conduction velocity, and includes impressive showcases of applications with various neuronal preparations. The developed versatile platform for label-free, live-cell electrical imaging will further accelerate drug discovery and basic research in the field of neuroscience.…

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