論文

Publications

 


Selected Publications

Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.


All Publications

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21. Zorzi, Giulio; Obien, Marie Engelene J; Fiscella, Michele; Leary, Noelle; Hierlemann, Andreas: Automatic extraction of axonal arbor morphology applied to h-iPSC-derived neurons. 11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018. (Type: Conference | Abstract | Links | BibTeX)
22. Bounik, Raziyeh; Gusmaroli, Massimiliano; Viswam, Vijay; Modena, Mario M; Hierlemann, Andreas: COMSOL modeling of an integrated impedance sensor in a hanging-drop platform. 11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018. (Type: Conference | Abstract | Links | BibTeX)
23. Yuan, Xinyue; Hierlemann, Andreas; Frey, Urs: Dual-mode Microelectrode Array with 20k-electrodes and High SNR for High-Throughput Extracellular Recording and Stimulation. 11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018. (Type: Conference | Abstract | Links | BibTeX)
24. Bakkum Douglas J; Radivojevic, Milos; Obien Marie Engelene; Jaeckel David; Frey Urs; Takahashi Hirokazu; Hierlemann Andreas : The axon initial segment drives the neuron's extracellular action potential. In: bioRxiv, pp. 1-30, 2018. (Type: Journal Article | Abstract | Links | BibTeX)
25. Radivojevic, Milos; Franke, Felix; Altermatt, Michael; Müller, Jan; Hierlemann, Andreas; Bakkum, Douglas J: Tracking individual action potentials throughout mammalian axonal arbors. In: eLife, 6 , pp. 1-23, 2017, ISSN: 2050-084X. (Type: Journal Article | Abstract | Links | BibTeX)
26. Viswam, Vijay; Bounik, Raziyeh; Shadmani, Amir; Dragas, Jelena; Obien, Marie Engelene J; Muller, Jan; Chen, Yihui; Hierlemann, Andreas: High-density Mapping of Brain Slices Using a Large Multi-functional High-density CMOS Microelectrode Array System. 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS) Kaohsiung, Taiwan, 2017, ISSN: 2167-0021. (Type: Conference | Abstract | Links | BibTeX)
27. Bullmann Torsten; Radivojevic, Milos; Huber Stefan Deligkaris Kosmas; Hierlemann Andreas; Frey Urs T:: Network Analysis Of High-Density Microelectrode Recordings. In: bioRxiv , (139436), pp. 1-23, 2017. (Type: Journal Article | Abstract | Links | BibTeX)
28. Dragas, Jelena; Viswam, Vijay; Shadmani, Amir; Chen, Yihui; Bounik, Raziyeh; Stettler, Alexander; Radivojevic, Milos; Geissler, Sydney; Obien, Marie Engelene J; Müller, Jan; Hierlemann, Andreas: A Multi-Functional Microelectrode Array Featuring 59760 Electrodes, 2048 Electrophysiology Channels, Stimulation, Impedance Measurement and Neurotransmitter Detection Channels. In: IEEE journal of solid-state circuits, 52 (6), pp. 1576-1590, 2017, ISSN: 0018-9200. (Type: Journal Article | Abstract | Links | BibTeX)
29. Jäckel, David; Bakkum, Douglas J; Russell, Thomas L; Müller, Jan; Radivojevic, Milos; Frey, Urs; Franke, Felix; Hierlemann, Andreas: Combination of High-density Microelectrode Array and Patch Clamp Recordings to Enable Studies of Multisynaptic Integration. In: Scientific Reports, 7 (1), pp. 978, 2017, ISSN: 2045-2322. (Type: Journal Article | Abstract | Links | BibTeX)
30. Seichepine, Florent; Rothe, Jorg; Dudina, Alexandra; Hierlemann, Andreas; Frey, Urs: Dielectrophoresis‐Assisted Integration of 1024 Carbon Nanotube Sensors into a CMOS Microsystem. In: Advanced Materials, 29 (17), 2017. (Type: Journal Article | Abstract | Links | BibTeX)
31. Yada, Yuichiro; Mita, Takeshi; Sanada, Akihiro; Yano, Ryuichi; Kanzaki, Ryohei; Bakkum, Douglas J; Hierlemann, Andreas; Takahashi, Hirokazu: Development of neural population activity toward self-organized criticality. In: Neuroscience, 343 , pp. 55-65, 2016, ISSN: 0306-4522. (Type: Journal Article | Abstract | Links | BibTeX)
32. Gong, Wei; Sencar, Jure; Bakkum, Douglas J; Jäckel, David; Obien, Marie Engelene J; Radivojevic, Milos; Hierlemann, Andreas: Multiple single-unit long-term tracking on organotypic hippocampal slices using high-density microelectrode arrays. In: Frontiers in Neuroscience, 10 , pp. 1-16, 2016, ISSN: 1662453X. (Type: Journal Article | Abstract | Links | BibTeX)
33. Deligkaris, Kosmas; Bullmann, Torsten; Frey, Urs: Extracellularly Recorded Somatic and Neuritic Signal Shapes and Classification Algorithms for High-Density Microelectrode Array Electrophysiology. In: Frontiers in Neuroscience, 10 , pp. 421, 2016, ISSN: 1662-453X. (Type: Journal Article | Abstract | Links | BibTeX)
34. Radivojevic, Milos; Jäckel, David; Altermatt, Michael; Müller, Jan; Viswam, Vijay; Hierlemann, Andreas; Bakkum, Douglas J: Electrical Identification and Selective Microstimulation of Neuronal Compartments Based on Features of Extracellular Action Potentials. In: Scientific Reports, 6 (1), pp. 1-20, 2016, ISSN: 2045-2322. (Type: Journal Article | Abstract | Links | BibTeX)
35. Franke, Felix; Fiscella, Michele; Sevelev, Maksim; Roska, Botond; Hierlemann, Andreas; Azeredo da Silveira, Rava : Structures of Neural Correlation and How They Favor Coding. In: Neuron, 89 (2), pp. 409-422, 2016, ISSN: 10974199. (Type: Journal Article | Abstract | Links | BibTeX)
36. Yonehara, Keisuke; Fiscella, Michele; Drinnenberg, Antonia; Esposti, Federico; Trenholm, Stuart; Krol, Jacek; Franke, Felix; Scherf, Brigitte Gross; Kusnyerik, Akos; Müller, Jan; Szabo, Arnold; Jüttner, Josephine; Cordoba, Francisco; Reddy, Ashrithpal Police; Németh, János; Nagy, Zoltán Zsolt; Munier, Francis; Hierlemann, Andreas; Roska, Botond: Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity. In: Neuron, 89 (1), pp. 177-193, 2016, ISSN: 10974199. (Type: Journal Article | Abstract | Links | BibTeX)
37. Jones, Ian L; Russell, Thomas L; Farrow, Karl; Fiscella, Michele; Franke, Felix; Müller, Jan; Jäckel, David; Hierlemann, Andreas: A method for electrophysiological characterization of hamster retinal ganglion cells using a high-density CMOS microelectrode array. In: Frontiers in Neuroscience, 9 , pp. 360, 2015, ISSN: 1662453X. (Type: Journal Article | Abstract | Links | BibTeX)
38. Fiscella, Michele; Franke, Felix; Farrow, Karl; Müller, Jan; Roska, Botond; Azeredo da Silveira, Rava ; Hierlemann, Andreas: Visual coding with a population of direction-selective neurons. In: Journal of Neurophysiology, 114 (4), pp. 2485-2499, 2015, ISSN: 0022-3077. (Type: Journal Article | Abstract | Links | BibTeX)
39. Okawa, Satoru; Mita, Takeshi; Bakkum, Douglas J; Frey, Urs; Hierlemann, Andreas; Kanzaki, Ryohei; Takahashi, Hirokazu: Chronic Co-Variation of Neural Network Configuration and Activity in Mature Dissociated Cultures. In: Electronics and Communications in Japan, 98 (5), pp. 34-42, 2015, ISSN: 1942-9541. (Type: Journal Article | Abstract | Links | BibTeX)
40. Lewandowska, Marta K; Bakkum, Douglas J; Rompani, Santiago B; Hierlemann, Andreas: Recording large extracellular spikes in microchannels along many axonal sites from individual neurons. In: PLoS ONE, 10 (3), pp. 1-24, 2015, ISSN: 19326203. (Type: Journal Article | Abstract | Links | BibTeX)
59 entries « 2 of 3 »

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59 entries « 2 of 2 »

2008

Modulation of cardiomyocyte electrical properties using regulated bone morphogenetic protein-2 expression.

Sanchez-Bustamante, Carlota Diaz; Frey, Urs; Kelm, Jens M; Hierlemann, Andreas; Fussenegger, Martin

Modulation of cardiomyocyte electrical properties using regulated bone morphogenetic protein-2 expression. Journal Article

Tissue Engineering. Part A, 14 (12), pp. 1969-1988, 2008, ISSN: 1937-3341.

Abstract | Links | BibTeX | タグ: Cardiomyocytes, ETH-CMOS-MEA

2007

A CMOS-based microelectrode array for interaction with neuronal cultures

Hafizovic, Sadik; Heer, Flavio; Ugniwenko, T; Frey, Urs; Blau, Axel; Ziegler, Christiane; Hierlemann, Andreas

A CMOS-based microelectrode array for interaction with neuronal cultures Journal Article

Journal of Neuroscience Methods, 164 (1), pp. 93-106, 2007, ISSN: 0165-0270.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, Neuronal Networks

Perforated CMOS microchip platform for immobilization and activity monitoring of electrogenic cells

Greve, Frauke; Lichtenberg, Jan; Kirstein, Kay Uwe; Frey, Urs; Perriard, Jean Claude; Hierlemann, Andreas

Perforated CMOS microchip platform for immobilization and activity monitoring of electrogenic cells Journal Article

Journal of Micromechanics and Microengineering, 17 (3), pp. 462-471, 2007, ISSN: 0960-1317.

Abstract | Links | BibTeX | タグ: Cardiomyocytes, ETH-CMOS-MEA

2006

Single-chip microelectronic system to interface with living cells

Heer, Flavio; Hafizovic, Sadik; Ugniwenko, T; Frey, Urs; Franks, Wendy; Perriard, Evelyne; Perriard, Jean Claude; Blau, Axel; Ziegler, Christiane; Hierlemann, Andreas

Single-chip microelectronic system to interface with living cells Journal Article

Biosensors & Bioelectronics, 22 (11), pp. 2546-2553, 2006, ISSN: 0956-5663.

Abstract | Links | BibTeX | タグ: Cardiomyocytes, ETH-CMOS-MEA, Neuronal Networks

Patterned cell adhesion by self-assembled structures for use with a CMOS cell-based biosensor

Franks, Wendy; Tosatti, Samuele; Heer, Flavio; Seif, Philipp; Textor, Marcus; Hierlemann, Andreas

Patterned cell adhesion by self-assembled structures for use with a CMOS cell-based biosensor Journal Article

Biosensors & Bioelectronics, 22 (7), pp. 1426-1433, 2006, ISSN: 0956-5663.

Abstract | Links | BibTeX | タグ: Cardiomyocytes, ETH-CMOS-MEA

CMOS microelectrode array for bidirectional interaction with neuronal networks

Heer, Flavio; Hafizovic, Sadik; Franks, Wendy; Blau, Axel; Ziegler, Christiane; Hierlemann, Andreas

CMOS microelectrode array for bidirectional interaction with neuronal networks Journal Article

IEEE Journal of Solid-State Circuits, 41 (7), pp. 1620-1629, 2006, ISSN: 00189200.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, MEA Technology, Neuronal Networks, Stimulation

Microfluidics/CMOS orthogonal capabilities for cell biology

Linder, Vincent; Koster, Sander; Franks, Wendy; Kraus, Tobias; Verpoorte, Elisabeth; Heer, Flavio; Hierlemann, Andreas; de Rooij, Nico F

Microfluidics/CMOS orthogonal capabilities for cell biology Journal Article

Biomedical Microdevices, 8 (2), pp. 159-166, 2006, ISSN: 1572-8781.

Abstract | Links | BibTeX | タグ: Cardiomyocytes, ETH-CMOS-MEA

Characterization of a microfluidic dispensing system for localised stimulation of cellular networks

Kraus, Tobias; Verpoorte, Elisabeth; Linder, Vincent; Franks, Wendy; Hierlemann, Andreas; Heer, Flavio; Hafizovic, Sadik; Fujii, Teruo; de Rooij, Nico F; Koster, Sander

Characterization of a microfluidic dispensing system for localised stimulation of cellular networks Journal Article

Lab Chip, 6 (2), pp. 218-229, 2006.

Abstract | Links | BibTeX | タグ: Cardiomyocytes, ETH-CMOS-MEA

2004

CMOS microelectrode array for the monitoring of electrogenic cells

Heer, Flavio; Franks, Wendy; Blau, Axel; Taschini, S; Ziegler, Christiane; Hierlemann, Andreas; Baltes, Henry

CMOS microelectrode array for the monitoring of electrogenic cells Journal Article

Biosensors & Bioelectronics, 20 (2), pp. 358-366, 2004, ISSN: 0956-5663.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, MEA Technology

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