論文

Publications

 


Selected Publications

Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.


All Publications

Show all

33 entries « 2 of 2 »
21. Mita, Takeshi; Bakkum, Douglas J; Frey, Urs; Hierlemann, Andreas; Kanzaki, Ryohei; Takahashi, Hirokazu: Classification of Inhibitory and Excitatory Neurons of Dissociated Cultures Based on Action Potential Waveforms on High-density CMOS Microelectrode Arrays. In: IEEJ Transactions on Electronics, Information and Systems, 139 (5), pp. 615-624, 2019, ISSN: 1348-8155. (Type: Journal Article | Abstract | Links | BibTeX)
22. Emmenegger, Vishalini; Obien, Marie Engelene J; Franke, Felix; Hierlemann, Andreas: Technologies to Study Action Potential Propagation With a Focus on HD-MEAs. In: Frontiers in Cellular Neuroscience, 13 , pp. 1-11, 2019, ISSN: 1662-5102 . (Type: Journal Article | Abstract | Links | BibTeX)
23. Viswam, Vijay; Bounik, Raziyeh; Shadmani, Amir; Dragas, Jelena; Urwyler, Cedar; Boos, Julia Alicia; Obien, Marie Engelene J; Muller, Jan; Chen, Yihui; Hierlemann, Andreas: Impedance Spectroscopy and Electrophysiological Imaging of Cells With a High-Density CMOS Microelectrode Array System. In: IEEE Transactions on Biomedical Circuits and Systems, 12 (6), pp. 1356-1368, 2018, ISSN: 1932-4545. (Type: Journal Article | Abstract | Links | BibTeX)
24. Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas: Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelectrode array. Contribution 700.13 , Society for Neuroscience (SfN) Meeting San Diego, CA, USA, 2018. (Type: Conference | Abstract | Links | BibTeX)
25. Bartram, Julian; Schroter, Manuel; Ronchi, Silvia; Emmenegger, Vishalini; Muller, Jan; Hierlemann, Andreas: Mechanisms of homeostatic synaptic plasticity. Contribution 037.11 , Society for Neuroscience (SfN) Meeting San Diego, CA, USA, 2018. (Type: Conference | Abstract | Links | BibTeX)
26. Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas: Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays. 11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018. (Type: Conference | Abstract | Links | BibTeX)
27. Urwyler, Cedar; Bounik, Raziyeh; Viswam, Vijay; Hierlemann, Andreas: Electrical impedance tomography on high-density microelectrode arrays. 11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018. (Type: Conference | Abstract | Links | BibTeX)
28. Bartram, Julian; Schroter, Manuel; Ronchi, Silvia; Emmenegger, Vishalini; Muller, Jan; Hierlemann, Andreas: Probing synaptic connectivity and function using high-density microelectrode arrays and whole-cell patch-clamp recordings. 11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018. (Type: Conference | Abstract | Links | BibTeX)
29. Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas: Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays. W-2151 , International Society for Stem Cell Research (ISSCR) Annual Meeting Melbourne, Australia, 2018. (Type: Conference | Abstract | Links | BibTeX)
30. Viswam, Vijay; Bounik, Raziyeh; Shadmani, Amir; Dragas, Jelena; Obien, Marie Engelene J; Muller, Jan; Chen, Yihui; Hierlemann, Andreas: High-density Mapping of Brain Slices Using a Large Multi-functional High-density CMOS Microelectrode Array System. 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS) Kaohsiung, Taiwan, 2017, ISSN: 2167-0021. (Type: Conference | Abstract | Links | BibTeX)
31. Obien, Marie Engelene J; Muller, Jan; Boos, Julia Alicia; Bounik, Raziyeh; Fiscella, Michele; Hierlemann, Andreas: High-resolution Functional Imaging of Cardiomyocytes Derived from Embryonic Stem Cell Spheroids. International Society for Stem Cell Research (ISSCR) Boston, MA, USA, 2017. (Type: Conference | Links | BibTeX)
32. Fiscella, Michele; Muller, Jan; Hierlemann, Andreas: High-resolution Microelectrode Array Platform for Biomarker Discovery and Novel Functional Assays in Human iPSC-derived Neurons. International Society for Stem Cell Research (ISSCR) Meeting Boston, MA, USA, 2017. (Type: Conference | Links | BibTeX)
33. Frey, Urs; Obien, Marie Engelene J; Muller, Jan; Hierlemann, Andreas: Technology Trends and Commercialization of High-density Microelectrode Arrays for Advanced In-vitro Electrophysiology. IEEE International Symposium on Circuits and Systems (ISCAS Baltimore, MD, USA, 2017, ISSN: 2379-447X. (Type: Conference | Abstract | Links | BibTeX)
33 entries « 2 of 2 »

Show all

Sorry, no publications matched your criteria.