論文

Publications

 


Selected Publications

Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.


All Publications

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41. Bounik, Raziyeh; Gusmaroli, Massimiliano; Viswam, Vijay; Modena, Mario M; Hierlemann, Andreas: COMSOL modeling of an integrated impedance sensor in a hanging-drop platform. 11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018. (Type: Conference | Abstract | Links | BibTeX)
42. Yuan, Xinyue; Hierlemann, Andreas; Frey, Urs: Dual-mode Microelectrode Array with 20k-electrodes and High SNR for High-Throughput Extracellular Recording and Stimulation. 11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018. (Type: Conference | Abstract | Links | BibTeX)
43. Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas: Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays. 11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018. (Type: Conference | Abstract | Links | BibTeX)
44. Urwyler, Cedar; Bounik, Raziyeh; Viswam, Vijay; Hierlemann, Andreas: Electrical impedance tomography on high-density microelectrode arrays. 11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018. (Type: Conference | Abstract | Links | BibTeX)
45. Schroter, Manuel; Girr, Monika; Boos, Julia Alicia; Renner, Magdalena; Gazorpak, Mahshid; Gong, Wei; Bartram, Julian; Muller, Jan; Hierlemann, Andreas: Mapping neuronal network dynamics in developing cerebral organoids. 11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018. (Type: Conference | Abstract | Links | BibTeX)
46. Bartram, Julian; Schroter, Manuel; Ronchi, Silvia; Emmenegger, Vishalini; Muller, Jan; Hierlemann, Andreas: Probing synaptic connectivity and function using high-density microelectrode arrays and whole-cell patch-clamp recordings. 11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018. (Type: Conference | Abstract | Links | BibTeX)
47.da Drinnenberg Antonia; Franke, Felix; Morikawa Rei Jüttner; Hillier Daniel; Hantz Peter; Hierlemann Andreas; Azeredo Silveira Rava; Roska Botond K;: How diverse retinal functions arise from feedback at the first visual synapse. In: Neuron, 99 (1), pp. 117-134, 2018. (Type: Journal Article | Abstract | Links | BibTeX)
48. Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas: Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays. W-2151 , International Society for Stem Cell Research (ISSCR) Annual Meeting Melbourne, Australia, 2018. (Type: Conference | Abstract | Links | BibTeX)
49. Bakkum Douglas J; Radivojevic, Milos; Obien Marie Engelene; Jaeckel David; Frey Urs; Takahashi Hirokazu; Hierlemann Andreas : The axon initial segment drives the neuron's extracellular action potential. In: bioRxiv, pp. 1-30, 2018. (Type: Journal Article | Abstract | Links | BibTeX)
50. Viswam, Vijay; Obien, Marie Engelene J; Frey, Urs; Franke, Felix; Hierlemann, Andreas: Acquisition of Bioelectrical Signals with Small Electrodes. 2017 IEEE Biomedical Circuits and Systems Conference (BioCAS) Turin, Italy, 2017. (Type: Conference | Abstract | Links | BibTeX)
51. Radivojevic, Milos; Franke, Felix; Altermatt, Michael; Müller, Jan; Hierlemann, Andreas; Bakkum, Douglas J: Tracking individual action potentials throughout mammalian axonal arbors. In: eLife, 6 , pp. 1-23, 2017, ISSN: 2050-084X. (Type: Journal Article | Abstract | Links | BibTeX)
52. Tajima Satohiro; Mita, Takeshi; Bakkum Douglas Takahashi Hirokazu; Toyoizumi Taro J;: Locally embedded presages of global network bursts. In: National Academy of Sciences, pp. 1-6, 2017, ISSN: 0027-8424. (Type: Journal Article | Abstract | Links | BibTeX)
53. Shein-Idelson, Mark; Pammer, Lorenz; Hemberger, Mike; Laurent, Gilles: Large-scale mapping of cortical synaptic projections with extracellular electrode arrays. In: Nature Methods, 14 (9), pp. 882–889, 2017, ISSN: 1548-7091. (Type: Journal Article | Abstract | Links | BibTeX)
54. Obien, Marie Engelene J; Zorzi, Giulio; Hierlemann, Andreas: Mapping neuron cluster development based on axonal action potential propagation. The 40th Annual Meeting of the Japan Neuroscience Society Chiba, Japan, 2017. (Type: Conference | BibTeX)
55. Diggelmann, Roland; Fiscella, Michele; Hierlemann, Andreas; Franke, Felix: Pre-whitening as a means to improve dimensionality reduction and simplify clustering in spike-sorters for multi-electrode recordings. 26th Annual Computational Neuroscience Meeting (CNS2017) Antwerp, Belgium , 2017. (Type: Conference | Abstract | Links | BibTeX)
56. Viswam, Vijay; Bounik, Raziyeh; Shadmani, Amir; Dragas, Jelena; Obien, Marie Engelene J; Muller, Jan; Chen, Yihui; Hierlemann, Andreas: High-density Mapping of Brain Slices Using a Large Multi-functional High-density CMOS Microelectrode Array System. 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS) Kaohsiung, Taiwan, 2017, ISSN: 2167-0021. (Type: Conference | Abstract | Links | BibTeX)
57. Obien, Marie Engelene J; Muller, Jan; Boos, Julia Alicia; Bounik, Raziyeh; Fiscella, Michele; Hierlemann, Andreas: High-resolution Functional Imaging of Cardiomyocytes Derived from Embryonic Stem Cell Spheroids. International Society for Stem Cell Research (ISSCR) Boston, MA, USA, 2017. (Type: Conference | Links | BibTeX)
58. Fiscella, Michele; Muller, Jan; Hierlemann, Andreas: High-resolution Microelectrode Array Platform for Biomarker Discovery and Novel Functional Assays in Human iPSC-derived Neurons. International Society for Stem Cell Research (ISSCR) Meeting Boston, MA, USA, 2017. (Type: Conference | Links | BibTeX)
59. Frey, Urs; Obien, Marie Engelene J; Muller, Jan; Hierlemann, Andreas: Technology Trends and Commercialization of High-density Microelectrode Arrays for Advanced In-vitro Electrophysiology. IEEE International Symposium on Circuits and Systems (ISCAS Baltimore, MD, USA, 2017, ISSN: 2379-447X. (Type: Conference | Abstract | Links | BibTeX)
60. Hillier, Daniel; Fiscella, Michele; Drinnenberg, Antonia; Trenholm, Stuart; Rompani, Santiago B; Raics, Zoltan; Katona, Gergely; Jüttner, Josephine; Hierlemann, Andreas; Rozsa, Balazs; Roska, Botond: Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex. In: Nature Neuroscience, 20 (7), pp. 960–968, 2017, ISSN: 1097-6256. (Type: Journal Article | Abstract | Links | BibTeX)
103 entries « 3 of 6 »

103 entries « 3 of 3 »

2005

Impedance characterization and modeling of electrodes for biomedical applications

Franks, Wendy; Schenker, Iwan; Schmutz, Patrik; Hierlemann, Andreas

Impedance characterization and modeling of electrodes for biomedical applications Journal Article

IEEE Transactions on Biomedical Engineering, 52 (7), pp. 1295-1302, 2005, ISSN: 00189294.

Abstract | Links | BibTeX | タグ: MEA Technology

2004

Cell-based CMOS sensor and actuator arrays

Jenkner, Martin; Tartagni, Marco; Hierlemann, Andreas; Thewes, Roland

Cell-based CMOS sensor and actuator arrays Journal Article

IEEE Journal of Solid-State Circuits, 39 (12), pp. 2431-2437, 2004, ISSN: 00189200.

Abstract | Links | BibTeX | タグ: MEA Technology, Review

CMOS microelectrode array for the monitoring of electrogenic cells

Heer, Flavio; Franks, Wendy; Blau, Axel; Taschini, S; Ziegler, Christiane; Hierlemann, Andreas; Baltes, Henry

CMOS microelectrode array for the monitoring of electrogenic cells Journal Article

Biosensors & Bioelectronics, 20 (2), pp. 358-366, 2004, ISSN: 0956-5663.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, MEA Technology

103 entries « 3 of 3 »

 

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