論文

Publications

 


Selected Publications

Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.


All Publications

Show all

1. Sundberg, Maria; Pinson, Hannah; Smith, Richard S; Winden, Kellen D; Venugopal, Pooja; Tai, Derek J C; Gusella, James F; Talkowski, Michael E; Walsh, Christopher A; Tegmark, Max; Sahin, Mustafa: 16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro. In: Nature Communications, 12 (2897 ), 2021. (Type: Journal Article | Abstract | Links | BibTeX)
2. Ronchi, Silvia; Buccino, Alessio Paolo; Prack, Gustavo; Kumar, Sreedhar Saseendran; Schröter, Manuel; Fiscella, Michele; Hierlemann, Andreas: Microelectrode Arrays: Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays. In: Advanced Biology, 5 (3), 2021. (Type: Journal Article | Abstract | Links | BibTeX)
3. Ronchi, Silvia; Buccino, Alessio Paolo; Prack, Gustavo; Kumar, Sreedhar Saseendran; Schröter, Manuel; Fiscella, Michele; Hierlemann, Andreas: Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays. In: BioRxiv, 2020. (Type: Journal Article | Abstract | Links | BibTeX)
4. Ronchi, Silvia; Buccino, Alessio Paolo; Prack, Gustavo; Kumar, Sreedhar Saseendran; Schröter, Manuel; Fiscella, Michele; Hierlemann, Andreas: Microelectrode Arrays: Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays. In: Advanced Biology, 5 (3), 2020. (Type: Journal Article | Abstract | Links | BibTeX)
5. Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas: Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelectrode array. Contribution 700.13 , Society for Neuroscience (SfN) Meeting San Diego, CA, USA, 2018. (Type: Conference | Abstract | Links | BibTeX)
6. Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas: Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays. 11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018. (Type: Conference | Abstract | Links | BibTeX)
7. Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas: Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays. W-2151 , International Society for Stem Cell Research (ISSCR) Annual Meeting Melbourne, Australia, 2018. (Type: Conference | Abstract | Links | BibTeX)

Show all

2021

16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro

Sundberg, Maria; Pinson, Hannah; Smith, Richard S; Winden, Kellen D; Venugopal, Pooja; Tai, Derek J C; Gusella, James F; Talkowski, Michael E; Walsh, Christopher A; Tegmark, Max; Sahin, Mustafa

16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro Journal Article

Nature Communications, 12 (2897 ), 2021.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, IPSC, MaxOne

Microelectrode Arrays: Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays

Ronchi, Silvia; Buccino, Alessio Paolo; Prack, Gustavo; Kumar, Sreedhar Saseendran; Schröter, Manuel; Fiscella, Michele; Hierlemann, Andreas

Microelectrode Arrays: Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays Journal Article

Advanced Biology, 5 (3), 2021.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, IPSC

2020

Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays

Ronchi, Silvia; Buccino, Alessio Paolo; Prack, Gustavo; Kumar, Sreedhar Saseendran; Schröter, Manuel; Fiscella, Michele; Hierlemann, Andreas

Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays Journal Article

BioRxiv, 2020.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, IPSC

Microelectrode Arrays: Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays

Ronchi, Silvia; Buccino, Alessio Paolo; Prack, Gustavo; Kumar, Sreedhar Saseendran; Schröter, Manuel; Fiscella, Michele; Hierlemann, Andreas

Microelectrode Arrays: Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays Journal Article

Advanced Biology, 5 (3), 2020.

Abstract | Links | BibTeX | タグ: HD-MEA, IPSC

2018

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelectrode array

Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelectrode array Conference

Contribution 700.13 , Society for Neuroscience (SfN) Meeting San Diego, CA, USA, 2018.

Abstract | Links | BibTeX | タグ: HD-MEA, IPSC

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays

Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX | タグ: HD-MEA, IPSC

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays

Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays Conference

W-2151 , International Society for Stem Cell Research (ISSCR) Annual Meeting Melbourne, Australia, 2018.

Abstract | Links | BibTeX | タグ: HD-MEA, IPSC

 

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