# mxwbio.com > MaxWell Biosystems AG provides solutions to advance basic neuroscience research and accelerate preclinical drug discovery. ## Home [MaxWell Biosystems | High Resolution MEA Technology](https://webflow.mxwbio.com): MaxWell Biosystems AG provides solutions to advance basic neuroscience research and accelerate preclinical drug discovery. ## Careers [Careers](https://webflow.mxwbio.com/careers): Explore career opportunities at MaxWell Biosystems. Join our international team advancing neuroscience and drug discovery with HD-MEA technology. ## Our story [Our Story](https://webflow.mxwbio.com/our-story): From ETH Zurich spin-off to global innovator. Discover how MaxWell Biosystems pioneered HD-MEA technology for neuroscience and drug discovery. ## Contact us [Contact Us](https://webflow.mxwbio.com/contact-us): Get expert support, schedule a consultation, or request information about MaxWell Biosystems HD-MEA platforms. Contact our team in Switzerland or the USA. ## Products [MaxTwo](https://webflow.mxwbio.com/products/maxtwo): MaxTwo Multi-Well High-Density Microelectrode Arrays (HD-MEAs) represent a next-generation electrophysiology platform for higher-throughput applications. [MaxOne Single-Well HD-MEA | MaxWell Biosystems](https://webflow.mxwbio.com/products/maxone): MaxOne Single-Well High-Density Microelectrode Arrays (HD-MEA) represent the next-generation electrophysiology platform that empowers users to tackle a wide range of applications through its precise capture of electrical signatures from electrogenic cells as well as means to manipulate them with electrical stimulation. [MaxLab Live](https://webflow.mxwbio.com/products/maxlab-live): MaxLab Live is the all-in-one software for recording, analyzing, and interacting with biological samples using MaxOne and MaxTwo systems. ## Our people [Our People](https://webflow.mxwbio.com/our-people): Meet the MaxWell Biosystems team. Our R&D, commercial, and operations experts are united by innovation, scientific integrity, and advancing human health. ## Events [Symposium - Vienna](https://webflow.mxwbio.com/events/mxw-events/symposium---vienna): A One-Day Event of Breakthrough Discovery and Meaningful Community Exchange [MxW Organized Events](https://webflow.mxwbio.com/events/mxw-events): Explore MaxWell-hosted symposia, summits, and gatherings celebrating HD-MEA science and innovation. Connect with experts and discover new research. [Webinars](https://webflow.mxwbio.com/events/webinars): Join our webinar series featuring scientists using HD-MEA technology. Explore case studies, panel discussions, and innovative research insights. [MEAsterpiece Art Contest](https://webflow.mxwbio.com/events/mxw-events/measterpiece-art-contest): Science is about creating, discovering, and being bold, and so is art. We are inviting you to explore the beauty of scientific innovation through your lens. Whether it is an image of your sample on our HD-MEA chip that stood out to you, a dynamic MaxLab Live short video, or a  MaxWell-inspired drawing, let your creativity shine using MaxWell Biosystems tools and technology. [2nd Microelectrode Arrays in Neuroscience Social](https://webflow.mxwbio.com/events/mxw-events/2nd-microelectrode-arrays-in-neuroscience-social): Are you an MEA enthusiast, or an enthusiast by proxy, planning to attend SfN 2025 or simply in San Diego on Tuesday, November 18th? Join us for the 2nd Microelectrode Arrays in Neuroscience Social! [Conferences](https://webflow.mxwbio.com/events/conferences): Meet MaxWell Biosystems at leading conferences worldwide. Discover HD-MEA technology for organoids, neuronal cultures, and disease modeling research. [Symposium - Kyoto](https://webflow.mxwbio.com/events/mxw-events/symposium---kyoto): Place website meta description here [HNS Models to Accelerate Clinical Translation](https://webflow.mxwbio.com/events/mxw-events/hns-australia-2026): 3-day Symposium (March 3–5, 2026) in Adelaide bringing neuroscientists together to advance human brain models: organoids, 2D/3D tissues, analytics & translation. [NeuMoS 2026](https://webflow.mxwbio.com/events/mxw-events/neumos-2026): Join Neuronal Models Symposium (NeuMoS) 2026: Organoids, NAMs, and Neural Circuit Assays for Disease and Drug Discovery in Zurich, Sept 16-18. Connect with leaders in neuroscience, disease modeling, and biocomputing. Register now! [MxW Workshop - Shanghai 2026](https://webflow.mxwbio.com/events/mxw-events/mxw-workshop-shanghai-2026): Join us in Shanghai for a one-day workshop on in vitro neuronal network electrophysiology. Connect with scientists and innovators. Register now. [MxW-Workshop Tokyo 2026](https://webflow.mxwbio.com/events/mxw-events/mxw-workshop-tokyo-2026): Join MaxWell Biosystems in Tokyo for a workshop on neural dynamics, neuro-computation, and disease signatures. Connect with researchers in neuroscience. [MxW Workshop - Antwerp 2026](https://webflow.mxwbio.com/events/mxw-events/mxw-workshop-antwerp-2026): Join experts in Antwerp for scientific talks, practical workshop, and breakthroughs in neuroengineering and 2D/3D modeling. Network with the MxW community. [MxW Connect - London 2026](https://webflow.mxwbio.com/events/mxw-events/mxw-connect-london-2026): Join us in London for a one-day scientific event on advances in human in vitro models for neurodevelopment and neurodegeneration. Register now! [MaxWell Biosystems 10-Year Open House](https://webflow.mxwbio.com/events/mxw-events/mxw-10-year-open-house): Join MaxWell Biosystems’ 10-Year Open House in Zurich on 18 September 2026 to celebrate a decade of high-density MEA innovation, community, and collaboration. [Gladstone Seminar 2026](https://webflow.mxwbio.com/events/mxw-events/gladstone-seminar-2026): Register to the presentation "Advancing Functional Characterization of In-Vitro Models with Next-Generation Electrophysiology" [MxW Connect - San Diego 2026](https://webflow.mxwbio.com/events/mxw-events/mxw-connect-san-diego-2026): Join MaxWell Biosystems in San Diego for scientific talks and networking on high-content electrophysiology, disease modeling, and translational innovation. [MxW Connect - San Francisco 2026](https://webflow.mxwbio.com/events/mxw-events/mxw-connect-san-francisco-2026): MaxWell Biosystems event in San Francisco on organoids, biocomputing, and high-content electrophysiology, with talks and networking. ## Privacy policy [Privacy Policy](https://webflow.mxwbio.com/privacy-policy): Learn how MaxWell Biosystems collects, uses, and protects your personal data. Review our privacy practices, your rights, and how to control your information. ## Terms and conditions [Terms and Conditions](https://webflow.mxwbio.com/terms-and-conditions): Review the standard terms and conditions for purchases from MaxWell Biosystems AG, including quotations, delivery, payment, warranty, and liability terms. ## Search [Search Results](https://webflow.mxwbio.com/search): ## Our technology [Our Technology](https://webflow.mxwbio.com/our-technology): MaxWell Biosystems’ High-Density Microelectrode Array Technology ## Community voice [Community Voice](https://webflow.mxwbio.com/community-voice): Hear from HD-MEA users: interviews, research perspectives, and science-led insights on neuroscience, disease modeling, and neurocomputing. [Functional Phenotyping of Neurodevelopmental Disease Models on MaxOne HD-MEA](https://webflow.mxwbio.com/community-voice/danny-mc-sweeney): Interview with Danny McSweeney (Pak Lab, UMass Amherst) on using MaxOne HD-MEA and MaxLab Live to profile CASK loss-of-function in human induced cortical excitatory neurons, revealing altered firing, bursting, and network synchrony. [Modeling Pain-Related Nociceptive Networks with HD-MEA and Microfluidics](https://webflow.mxwbio.com/community-voice/dr-blandine-clement): Interview with Dr. Blandine Clement on using MaxOne HD-MEA and microfluidics to study nociceptive networks and peripheral pain mechanisms. [Brain Organoid Reservoir Computing on MaxOne HD-MEA](https://webflow.mxwbio.com/community-voice/feng-guo): Interview with Prof. Dr. Feng Guo (Indiana University Bloomington) on Brainoware: brain organoids + MaxOne HD-MEA for reservoir computing and AI. [Modeling Neurodevelopmental Disorders with Human iPSC Networks on HD-MEA](https://webflow.mxwbio.com/community-voice/dr-maria-sundberg): Interview with Dr. Maria Sundberg (Boston Children’s Hospital/Harvard Medical School) on modeling 16p11.2 deletion disorders using human iPSC-derived neuronal networks and High-Density CMOS MEA recordings with MaxTwo and MaxLab Live. [Training Living Neural Networks to Play Pong on MaxOne HD-MEA](https://webflow.mxwbio.com/community-voice/dr-brett-kagan): Interview with Dr. Brett Kagan (Cortical Labs) on DishBrain, training neural cultures to play Pong using MaxWell Biosystems' MaxOne HD-MEA, leveraging configurable electrode control and real-time API workflows for future biocomputing applications. [Engineering Human iPSC Neural Circuits with Microfluidics and HD-MEA](https://webflow.mxwbio.com/community-voice/rouhollah-habibey): User testimonial with Dr. Rouhollah Habibey (University of Bonn) on using MaxOne HD-MEA to monitor iPSC neuron network development, activity maps, and morphology over time. [Engineering iPSC Brain-Organoid Networks on MaxOne HD-MEA](https://webflow.mxwbio.com/community-voice/yoshiho-ikeuchi): Interview with Prof. Dr. Yoshiho Ikeuchi (University of Tokyo) on inter-regional organoid neural networks, MaxOne HD-MEA/MaxOne+ chips, and long-term, high-resolution electrophysiology to study circuit development. ## Blog news [Blog & News](https://webflow.mxwbio.com/blog-news): Stay up to date with MaxWell Biosystems! Explore blogs, featured science stories, publications, product launches, and company updates. ## Collaborations [Collaborations](https://webflow.mxwbio.com/collaborations): Partner with MaxWell Biosystems on projects advancing HD-MEA technology for drug discovery, organoid research, and precision medicine. ## About us [About us](https://webflow.mxwbio.com/about-us): MaxWell Biosystems is a global technology leader in high-content electrophysiology, advancing neuroscience and drug discovery research. ## Automation solutions [Automation Solutions](https://webflow.mxwbio.com/automation-solutions): MaxTwo integrates seamlessly into automated lab workflows. Scale functional electrophysiology with automation-ready HD-MEA technology. ## Knowledge hub [Knowledge Hub](https://webflow.mxwbio.com/knowledge-hub): Browse product docs, protocols, videos, posters, brochures, and app notes for MaxWell Biosystems HD-MEA platforms—all in one place. ## Training login [Training Login](https://webflow.mxwbio.com/training-login): Access the MaxWell Training Library for HD-MEA platforms. Login to explore tutorials, guides, and resources for MaxOne, MaxTwo, and MaxLab Live. ## Publications [Publications](https://webflow.mxwbio.com/publications): Discover peer-reviewed papers and publications from scientists using our HD-MEA platforms. ## Training sign up [Training Sign-Up](https://webflow.mxwbio.com/training-sign-up): Request access to the MaxWell Training Library. Submit your information and our support team will review your request to provide training resources. ## Campaigns [Focus on Neurocomputing](https://webflow.mxwbio.com/campaigns/neurocomputing-focus): Explore neurocomputing research with HD-MEA technology. Discover publications, protocols, and expert insights on biocomputing and in vitro neural networks. [Focus on Neuro-Disease Modeling](https://webflow.mxwbio.com/campaigns/neuro-disease-modeling-focus): Explore robust, reproducible functional phenotypes for in vitro neurological disease modeling using HD-MEA technology from MaxWell Biosystems. ## Applications [Brain Slices](https://webflow.mxwbio.com/applications/brain-slices): Study brain slices with HD-MEA technology. Record neuronal activity and network dynamics at high resolution for neuroscience research, disease modeling, and drug discovery. [Cardio and others](https://webflow.mxwbio.com/applications/cardio-and-others): Explore diverse HD-MEA applications across electrogenic cell and tissue models. Capture functional activity at high resolution for research, phenotyping, and drug discovery. [Disease Modeling](https://webflow.mxwbio.com/applications/disease-modeling): Advance disease modeling with high-resolution electrophysiology. Reveal functional phenotypes and treatment responses in cellular and tissue models with HD-MEAs. [Method Development](https://webflow.mxwbio.com/applications/method-development): Advance method development with flexible HD-MEA technology. Create custom workflows, integrate multimodal techniques, and develop novel analysis pipelines. [Functional Phenotyping](https://webflow.mxwbio.com/applications/functional-phenotyping): Quantify neuronal function with high-resolution electrophysiology. Uncover functional phenotypes, maturation, connectivity, and disease-related activity patterns with HD-MEAs. [Microphysiological Systems](https://webflow.mxwbio.com/applications/microphysiological-systems): Analyze microphysiological systems with HD-MEA technology. Capture functional activity in advanced tissue models for drug discovery, safety assessment, and translational research. [Neuronal Cell Cultures](https://webflow.mxwbio.com/applications/neuronal-cell-cultures): Analyze neuronal cell cultures with HD-MEA technology. Capture functional activity from subcellular to network levels for phenotyping, disease modeling, and drug discovery.‍ [Organoids](https://webflow.mxwbio.com/applications/organoids): Analyze organoids with high-resolution electrophysiology. Capture functional activity and network behavior for disease modeling, phenotyping, and drug discovery. [Pharmacology & Toxicology](https://webflow.mxwbio.com/applications/pharmacology-toxicology): Accelerate pharmacology and toxicology studies with HD-MEA technology. Quantify drug efficacy, safety, and dose-response effects through high-resolution functional readouts. [Retina](https://webflow.mxwbio.com/applications/retina): Study retinal function with HD-MEA technology. Record light-evoked responses and neural activity at high resolution for vision research, disease modeling, and drug discovery. [Biocomputing](https://webflow.mxwbio.com/applications/biocomputing): Advance biocomputing with HD-MEA technology. Record, stimulate, and train living neuronal networks to study learning, adaptation, and biological information processing. ## Open position [Computational Neuroscientist / Electrophysiology Data Analysis Engineer](https://webflow.mxwbio.com/open-position/computational-neuroscientist-electrophysiology-data-analysis-engineer): Join MaxWell Biosystems as Computational Neuroscientist / Electrophysiology Data Analysis Engineer in Zurich, Switzerland. [Digital Marketing and Event Specialist](https://webflow.mxwbio.com/open-position/digital-marketing-and-event-specialist): Join MaxWell Biosystems as Digital Marketing and Event Specialist in Zurich, Switzerland. [Field Application Scientist – China Focus](https://webflow.mxwbio.com/open-position/field-application-scientist-china-focus): Join MaxWell Biosystems as Field Application Scientist – China Focus in Zurich, Switzerland. ## Webinar [Advancing neurocomputing with engineered neuronal networks and high-content electrophysiology](https://webflow.mxwbio.com/webinar/advancing-neurocomputing-with-engineered-neuronal-networks-and-high-content-electrophysiology): Explore how engineered neuronal networks on HD-MEAs are advancing neurocomputing — from microfluidic connectivity design to closed-loop reservoir computing with living neural tissue. [ALS Disease Modeling with iPSC-Derived Neurons and HD-MEA Phenotyping](https://webflow.mxwbio.com/webinar/als-disease-modeling-with-ipsc-derived-neurons-and-hd-mea-phenotyping): Explore HD-MEA phenotyping of ALS patient iPSC-derived neurons with TARDBP mutations—single-cell and network-level functional changes, including hyperactivity and altered dynamics, to inform targeted treatment development. [Driving innovation in human neural models of development and disease](https://webflow.mxwbio.com/webinar/driving-innovation-in-human-neural-models-of-development-and-disease): Nature and MaxWell Biosystems webcast on human neural models of development and disease, featuring Sandrine Da Cruz and Barbara Treutlein on neuronal function, vulnerability and in vitro model innovation. [Human Retinal Signal Timing and Neural Computation](https://webflow.mxwbio.com/webinar/maxwell-webinar-with-annalisa-bucci): Explore how the human retina achieves precise visual timing. HD-MEA measurements of action potential propagation across thousands of retinal ganglion cells, integrated with modeling, imaging, and psychophysics to reveal neural computation mechanisms. [MaxLab Live Training Webinar with Dr. Silvia Ronchi](https://webflow.mxwbio.com/webinar/maxlab-live-training-webinar-with-dr-silvia-ronchi): MaxLab Live Training Webinar with Dr. Silvia Ronchi on MaxLab Live: HD-MEA recording, visualization, and data analysis workflows. Training resources for MaxWell users. [Human Epilepsy Network Dynamics and Optogenetic Neuromodulation](https://webflow.mxwbio.com/webinar/human-epilepsy-network-dynamics-and-optogenetic-neuromodulation): Discover how HD-MEA recordings and AAV-mediated optogenetics enable multimodal evaluation of network activity in human hippocampal slicesquantifying epileptiform dynamics and testing inhibition strategies in human brain tissue [Brain Organoid Network Models and Functional Connectivity](https://webflow.mxwbio.com/webinar/maxwell-webinar-with-dr-yoshiho-ikeuchi-and-dr-tomoya-duenki): Multi-organoid brain networks on HD-MEAs to model inter-regional circuits, capture spatiotemporal activity, and analyze functional connectivity in vitro. [Scalable Human Neuron Differentiation and Functional Profiling](https://webflow.mxwbio.com/webinar/maxwell-webinar-with-hsiu-chuan): Explore a scalable framework to generate diverse human neuron subtypes—480 patterning conditions and 700,000 single cells mapped by transcriptomics, plus MaxTwo HD-MEA functional profiling of activity, connectivity, and morphology. [Engineered Neural Networks for Disease Modeling and Drug Discovery](https://webflow.mxwbio.com/webinar/maxwell-webinar-with-prof-dr-janos-voros-and-dr-vaiva-vasiliauskaite): Discover how HD-MEA platforms and microstructured PDMS/nanochannels enable single-cell control of human iPSC neural networks for disease modeling, synaptic transmission studies, and glioblastoma circuit disruption. [Monogenic Epilepsy Disease Modeling and Drug Screening in iPSC Neurons](https://webflow.mxwbio.com/webinar/monogenic-epilepsy-disease-modeling-and-drug-screening-in-ipsc-neurons): Explore how HD-MEA phenotyping of human iPSC-derived neuronal networks reveals KCNQ2 loss- and gain-of-function signatures across development—and supports targeted drug screening for KCNQ2-related epileptic encephalopathies. [Neurodegenerative Disease Modeling with Human iPSC-Derived Neurons](https://webflow.mxwbio.com/webinar/maxwell-webinar-with-fujifilm-cellular-dynamics): Discover how MaxTwo multi-well HD-MEA assays and FUJIFILM hiPSC-derived neurons enable precise neurodegenerative disease phenotyping—case studies in Parkinson’s, ALS, and FTD, with optimized conditions to detect subtle functional differences. [Neural Engineering for Restoring Vision](https://webflow.mxwbio.com/webinar/neural-engineering-for-restoring-vision): Neural Engineering for Restoring Vision: HD-MEAs for evaluating retinal implants and decoding large-scale retinal activity for visual reconstruction. [Neurocomputing with brain organoids: closed-loop learning and network dynamics](https://webflow.mxwbio.com/webinar/neurocomputing-with-brain-organoids-closed-loop-learning-and-network-dynamics): Explore neurocomputing with brain organoids: closed-loop HD-MEA interfaces, functional phenotyping, and network dynamics linking organoid biology to adaptive computation on MaxOne. [Organoid-Based Models of Brain Development and Glioblastoma](https://webflow.mxwbio.com/webinar/organoid-based-models-of-brain-development-and-glioblastoma): Explore how human iPSC-derived brain organoids enable modeling of normal and pathological brain development—FGF8-driven neocortical identity, glioblastoma invasion, and HD-MEA approaches to measure maturation and network activity. ## Conference [2026 Grodins Research Symposium](https://webflow.mxwbio.com/conference/2026-grodins-research-symposium): [36th International Symposium on ALS/MND](https://webflow.mxwbio.com/conference/36th-international-symposium-on-als-mnd): [5th ALS Drug Development Summit 2026​](https://webflow.mxwbio.com/conference/5th-als-drug-development-summit-2026): [ASN 2026](https://webflow.mxwbio.com/conference/asn-2026): [6th RNA Metabolism in Neurological Disease Conference](https://webflow.mxwbio.com/conference/6th-rna-metabolism-in-neurological-disease-conference): [AD/PD 2026](https://webflow.mxwbio.com/conference/ad-pd-2026): [Alzheimer’s Research UK](https://webflow.mxwbio.com/conference/alzheimers-research-uk): [BaCell 3D 2026](https://webflow.mxwbio.com/conference/bacell-3d-2026): [Cortical Evolution 2026](https://webflow.mxwbio.com/conference/cortical-evolution-2026): [Cell Symposia: Gene and cell-based therapies: Progress in clinical translation](https://webflow.mxwbio.com/conference/cell-symposia-2025): [Cajal Challenge Accepted](https://webflow.mxwbio.com/conference/cajal-challenge-accepted): [EMBO | EMBL Symposium - Organoids: modelling organ development and disease in 3D](https://webflow.mxwbio.com/conference/embo-organoids-2025): We are joining the EMBO | EMBL Organoids Symposium! You can find us at our booth, join the conversation at our posters and talks, or take part in our interactive workshop to learn how HD-MEA technology supports organoid research and discovery. [CSHL Assembloids & Complex Cell-Cell Interactions across Tissues & Organs](https://webflow.mxwbio.com/conference/cshl-assembloids-2025): MaxWell Biosystems' workshop at CSHL Assembloids 2025 [FENS Forum 2026](https://webflow.mxwbio.com/conference/fens-forum-2026): Discover MaxWell Biosystems at FENS Forum 2026 and learn how next-generation HD-MEA technology brings high-resolution, label-free functional insights to neuroscience research. [BETx 2026](https://webflow.mxwbio.com/conference/betx-2026): [ISSCR - Accelerating PSC-Derived Cell Therapies: Starting with the End in Mind](https://webflow.mxwbio.com/conference/isscr-boston-2025): We are excited to be at ISSCR in Boston! Visit our booth, explore our latest posters, and join our Innovation Showcase. [GRC: Frontotemporal Dementia and Related Rare Dementias](https://webflow.mxwbio.com/conference/grc-frontotemporal-dementia-and-related-rare-dementias): [MPS 2026](https://webflow.mxwbio.com/conference/mps-2026): [iPSZürich 2026](https://webflow.mxwbio.com/conference/ipszurich): [iPSCs: Progress, Opportunities, and Challenges](https://webflow.mxwbio.com/conference/ipscs-progress-opportunities-and-challenges): [Latest Advances in Stem Cell-Based DM & Drug Screening](https://webflow.mxwbio.com/conference/latest-advances-in-stem-cell-based-dm-drug-screening): [ISSCR 2026](https://webflow.mxwbio.com/conference/isscr-2026): [Neuro Winter Summit](https://webflow.mxwbio.com/conference/neuro-winter-summit): [MPS: Membrane Physiology Symposium](https://webflow.mxwbio.com/conference/mps-membrane-physiology-symposium): [Neuroscience 2025 (SfN)](https://webflow.mxwbio.com/conference/neuroscience-2025): We are excited to be at Neuroscience 2025 (SfN) in San Diego! Visit our booth, explore our latest posters, and join our satellite event. Don’t miss the chance to apply for our SfN Travel Grant. [Neuroscience (SfN) 2026](https://webflow.mxwbio.com/conference/neuroscience-sfn-2026): Meet MaxWell Biosystems at Neuroscience 2026 and discover next-generation HD-MEA technology for neuroscience, with high-resolution, label-free functional insights from network to subcellular scale. [Nordic Organoids and MPS Symposium](https://webflow.mxwbio.com/conference/nordic-organoids-and-mps-symposium): [OrganoidNL Symposium 2026](https://webflow.mxwbio.com/conference/organoidnl-symposium-2026): Visit our poster to learn how next-generation HD-MEA technology supports non-invasive, label-free functional imaging of organoids, from network activity to subcellular resolution. [Oxford Glymphatic & Brain Clearance Symposium](https://webflow.mxwbio.com/conference/oxford-glymphatic-brain-clearance-symposium): [SMART Symposium on Cutting-Edge Research of Neuroscience](https://webflow.mxwbio.com/conference/smart-symposium-on-cutting-edge-research-of-neuroscience): [SMART ALS Symposium 2025](https://webflow.mxwbio.com/conference/smart-als-2025): [Organoid 4D: Development, Disease, Diversity and Discovery](https://webflow.mxwbio.com/conference/organoid-4d-development-disease-diversity-and-discovery): [Pain Mechanisms and Therapeutics Conference](https://webflow.mxwbio.com/conference/pain-mechanisms-and-therapeutics-conference): [Stem Cells in Neuroscience](https://webflow.mxwbio.com/conference/stem-cells-in-neuroscience): [SY-Stem](https://webflow.mxwbio.com/conference/sy-stem): [SOT 65th Annual Meeting and ToxExpo](https://webflow.mxwbio.com/conference/sot-65th-annual-meeting-and-toxexpo): [2nd Worldwide Sodium Channel Conference 2026](https://webflow.mxwbio.com/conference/wscc26): ## Author [Dr. Ambra Villani | MaxWell Biosystems](https://webflow.mxwbio.com/author/ambra-villani): Explore insights and contributions from Dr. Ambra Villani, Scientific Communications Specialist at MaxWell Biosystems. Discover their work in HD-MEA technology. [Dr. Anastasiia Tourbier | MaxWell Biosystems](https://webflow.mxwbio.com/author/anastasiia-tourbier): Explore insights and contributions from Dr. Anastasiia Tourbier, Senior Sales Manager at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/andrea-bevacqua): Explore insights and contributions from , Logistics and Production Specialist at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/any-rodrigues): Explore insights and contributions from , Account Management Intern at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/cajsa-thulin): Explore insights and contributions from , Process Engineer Intern at MaxWell Biosystems. Discover their work in HD-MEA technology. [Dr. Carlos Sanchez Priego | MaxWell Biosystems](https://webflow.mxwbio.com/author/carlos-sanchez-priego): Explore insights and contributions from Dr. Carlos Sanchez Priego, Field Application Scientist at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/carole-anne-vollette): Explore insights and contributions from , Field/Technical Application Scientist at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/cheyenne-diem): Explore insights and contributions from , Associate Data Scientist at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/dario-lenherr): Explore insights and contributions from , Production Manager Consumables & Process Engineer at MaxWell Biosystems. Discover their work in HD-MEA technology. [Dr. David Jäckel | MaxWell Biosystems](https://webflow.mxwbio.com/author/david-jckel): Explore insights and contributions from Dr. David Jäckel, Senior Product Manager at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/elvira-guella): Explore insights and contributions from , Account Manager at MaxWell Biosystems. Discover their work in HD-MEA technology. [Dr. Elisa Toscano | MaxWell Biosystems](https://webflow.mxwbio.com/author/elisa-toscano): Explore insights and contributions from Dr. Elisa Toscano, Field Application Scientist at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/endri-rama): Explore insights and contributions from , Senior R&D Engineer at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/ferran-esquius-cano): Explore insights and contributions from , Marketing & Lead Generation Coordinator at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/fabian-graf): Explore insights and contributions from , Account Manager at MaxWell Biosystems. Discover their work in HD-MEA technology. [Dr. Filippo Galluzzi | MaxWell Biosystems](https://webflow.mxwbio.com/author/filippo-galluzzi): Explore insights and contributions from Dr. Filippo Galluzzi, Application Scientist at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/ermanno-fiscella): Explore insights and contributions from , Senior Logistics Manager at MaxWell Biosystems. Discover their work in HD-MEA technology. [Dr. Francesca Puppo | MaxWell Biosystems](https://webflow.mxwbio.com/author/francesca-puppo): Explore insights and contributions from Dr. Francesca Puppo, Field Application Scientist at MaxWell Biosystems. Discover their work in HD-MEA technology. [Dr. Fraser McCready | MaxWell Biosystems](https://webflow.mxwbio.com/author/fraser-mccready): Explore insights and contributions from Dr. Fraser McCready, Field Application Scientist at MaxWell Biosystems. Discover their work in HD-MEA technology. [Francesco Modena | MaxWell Biosystems](https://webflow.mxwbio.com/author/francesco-modena): Explore insights and contributions from Francesco Modena, Data Scientist at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/giacomo-sulpizio): Explore insights and contributions from , Technical Application Specialist at MaxWell Biosystems. Discover their work in HD-MEA technology. 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[| MaxWell Biosystems](https://webflow.mxwbio.com/author/peter-kaplan): Explore insights and contributions from , IT Administrator and Software Engineer at MaxWell Biosystems. Discover their work in HD-MEA technology. [Dr. Praveena Manogaran | MaxWell Biosystems](https://webflow.mxwbio.com/author/praveena-manogaran): Explore insights and contributions from Dr. Praveena Manogaran, Head of Applications at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/sakura-blaser): Explore insights and contributions from , Executive Assistant to the CCO at MaxWell Biosystems. Discover their work in HD-MEA technology. [Robert Jelitto | MaxWell Biosystems](https://webflow.mxwbio.com/author/robert-jelitto): Explore insights and contributions from Robert Jelitto, Digital Platforms Specialist & Application Engineer at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/silke-seyock): Explore insights and contributions from , Application Scientist at MaxWell Biosystems. Discover their work in HD-MEA technology. [Dr. Silvia Oldani | MaxWell Biosystems](https://webflow.mxwbio.com/author/silvia-oldani): Explore insights and contributions from Dr. Silvia Oldani, Head of NAM at MaxWell Biosystems. Discover their work in HD-MEA technology. [Dr. Silvia Ronchi | MaxWell Biosystems](https://webflow.mxwbio.com/author/silvia-ronchi): Explore insights and contributions from Dr. Silvia Ronchi, Senior Product Manager, MaxTwo at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/simon-sennhauser): Explore insights and contributions from , Associate Application Scientist at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/simona-saporito): Explore insights and contributions from , R&D Engineer Intern at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/susanna-knig): Explore insights and contributions from , HR & Administrative Assistant at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/thevadarsan-kanthaiah): Explore insights and contributions from , R&D Engineer Intern at MaxWell Biosystems. Discover their work in HD-MEA technology. [Dr. Tom Dufor | MaxWell Biosystems](https://webflow.mxwbio.com/author/tom-dufor): Explore insights and contributions from Dr. Tom Dufor, Field Application Scientist at MaxWell Biosystems. Discover their work in HD-MEA technology. [Dr. Urs Frey | MaxWell Biosystems](https://webflow.mxwbio.com/author/urs-frey): Explore insights and contributions from Dr. Urs Frey, CEO at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/vijay-viswam): Explore insights and contributions from , R&D Project Manager at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/vasia-theodoropoulou): Explore insights and contributions from , Digital Marketing Specialist at MaxWell Biosystems. Discover their work in HD-MEA technology. [Dr. Xiaohan Xue | MaxWell Biosystems](https://webflow.mxwbio.com/author/xiaohan-xue): Explore insights and contributions from Dr. Xiaohan Xue, Head of APAC at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/xinyue-yuan): Explore insights and contributions from , Circuit Designer / R&D Engineer at MaxWell Biosystems. Discover their work in HD-MEA technology. [Dr. Zhuoliang (Ed) Li | MaxWell Biosystems](https://webflow.mxwbio.com/author/zhuoliang-ed-li): Explore insights and contributions from Dr. Zhuoliang (Ed) Li, Product Manager, MaxOne at MaxWell Biosystems. Discover their work in HD-MEA technology. [| MaxWell Biosystems](https://webflow.mxwbio.com/author/yasmine-laimeche): Explore insights and contributions from , Application Scientist Intern at MaxWell Biosystems. Discover their work in HD-MEA technology. ## Travel grant [Travel Grant for NeuMoS 2026](https://webflow.mxwbio.com/travel-grant/neumos-2026): Apply for the NeuMoS 2026 Travel Grant and receive up to €2,000 in travel support. Early-career researchers presenting at NeuMoS 2026 are invited to apply. [Travel Grant for SfN 2025](https://webflow.mxwbio.com/travel-grant/travel-grant-for-sfn-2025): Are you a young researcher sharing your work with the scientific community at the SfN 2025? At MaxWell Biosystems, we would love to support you. Apply now for a chance to get up to 2'000 CHF of your transportation and accommodation costs reimbursed; plus, showcase your findings to our user community! ## Updates [Beyond Neurodegeneration: Functional Signatures of Parkinson’s Disease with HD-MEAs](https://webflow.mxwbio.com/updates/beyond-neurodegeneration-functional-signatures-of-parkinsons-disease-with-hd-meas): Explore how HD-MEAs and software-based functional metrics capture Parkinson’s disease phenotypes across neuronal excitability, network dynamics, and axonal signaling. [Closed-loop training of organoids to balance a Cartpole (Inverted Pendulum)](https://webflow.mxwbio.com/updates/closed-loop-training-of-organoids-to-balance-a-cartpole-inverted-pendulum): Robbins et al. (UCSC) trained cortical organoids to balance a cartpole using closed-loop HD-MEA stimulation on MaxOne, revealing glutamate-dependent learning. [MaxWell Biosystems Launches Commercial Expansion: Strengthening Regional Presence in EMEA](https://webflow.mxwbio.com/updates/commercial-expansion): MaxWell Biosystems AG is advancing its global go-to-market strategy with the establishment of a dedicated EMEA regional team, expanding its presence and partnerships across Europe, the Middle East, and Africa. [Getting Started with Closed-Loop Experiments on HD-MEAs](https://webflow.mxwbio.com/updates/getting-started-with-closed-loop-experiments-on-hd-meas): Learn the basics of closed-loop experiments on HD-MEAs with MaxLab Live. A practical tutorial on real-time stimulation, recording, and feedback. [How Can Human Neural Models Better Support Development and Disease Research?](https://webflow.mxwbio.com/updates/how-can-human-neural-models-better-support-development-and-disease-research): Explore expert answers on human neural models, neurodegenerative disease, spatial transcriptomics, axonal vulnerability, and neuronal function. [Mapping Neuronal Diversity: Functional Validation of Induced Neurons with HD-MEAs and DeePhys](https://webflow.mxwbio.com/updates/mapping-neuronal-diversity-functional-validation-of-induced-neurons-with-hd-meas-and-deephys): Induced neurons can be molecularly diverse, but are they functionally distinct too? Learn how Lin et al. combine MaxTwo HD-MEA recordings and DeePhys analysis to validate iN subtypes with high-resolution electrophysiological phenotyping. [How Can Engineered Neuronal Networks Advance Neurocomputing?](https://webflow.mxwbio.com/updates/how-can-engineered-neuronal-networks-advance-neurocomputing): Explore expert answers on engineered neuronal networks, reservoir computing, biological computing challenges, artificial intelligence, and neurocomputing. [MaxLab Live 26.1: Advanced Analysis for High-Content Electrophysiology](https://webflow.mxwbio.com/updates/maxlab-live-26-1-advanced-analysis-for-high-content-electrophysiology): Discover what’s new in MaxLab Live 26.1, with novel neuronal and cardiac analysis readouts, parameter-free burst detection, and tailored metric exports for scalable high-content HD-MEA electrophysiology. [Spot the Differences in Developing Brain Circuits: How Organoids Replay Innate ‘Backbone’ Burst Motifs](https://webflow.mxwbio.com/updates/spot-the-differences-in-developing-brain-circuits-how-organoids-replay-innate-backbone-burst-motifs): Discover how HD-MEA recordings reveal recurring backbone burst motifs in developing brain organoids and neonatal slices, exposing structured neural activity not seen in 2D cultures. [New Therapeutic Target in the Fight Against ALS](https://webflow.mxwbio.com/updates/new-therapeutic-target-in-the-fight-against-als): Nature reports a new human iPSC-derived neuronal network model for ALS/FTLD that reveals NPTX2 as a key contributor to TDP-43 toxicity. Learn how MaxWell Biosystems’ MaxOne HD-MEAs enabled high-resolution functional profiling and supported identifying a potential therapeutic target. [Why Flexibility Matters in HD-MEA Recordings](https://webflow.mxwbio.com/updates/why-flexibility-matters-in-hd-mea-recordings): Learn how Switch Matrix HD-MEA technology enables high-resolution, low-noise electrophysiology with flexible electrode selection for recording and stimulation. ## Resources [Acute Brain Organoid Plating Protocol with Liquid Holder](https://webflow.mxwbio.com/resources/acute-brain-organoid-plating-protocol-liquid-holder): Acquire functional HD-MEA recordings from your brain organoids in no time with this unique and easy-to-use protocol. [Multimodal Mapping of Electrical and Mechanical Latency of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Layers](https://webflow.mxwbio.com/resources/acs-24-multimodal-mapping-electrical): [Cells on IC Chip](https://webflow.mxwbio.com/resources/acs-26-cells-ic-chip): [Dielectrophoresis-Assisted Integration of 1024 Carbon Nanotube Sensors into a CMOS Microsystem](https://webflow.mxwbio.com/resources/advanced-17-dielectrophoresis-assisted-integration-carbon): [Repeated and On-Demand Intracellular Recordings of Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells](https://webflow.mxwbio.com/resources/acs-22-repeated-on-demand-intracellular): [A Neurospheroid-Based Microrobot for Targeted Neural Connections in a Hippocampal Slice](https://webflow.mxwbio.com/resources/advanced-23-neurospheroid-based-microrobot-targeted): [The Axon Initial Segment is the Dominant Contributor to the Neuron's Extracellular Electrical Potential Landscape](https://webflow.mxwbio.com/resources/advanced-18-axon-initial-segment): [Electrophysiological Phenotype Characterization of Human iPSC‐Derived Neuronal Cell Lines by Means of High‐Density Microelectrode Arrays](https://webflow.mxwbio.com/resources/advanced-21-electrophysiological-phenotype-characterization): [Direct-Print 3D Electrodes for Large-Scale, High-Density, and Customizable Neural Interfaces](https://webflow.mxwbio.com/resources/advanced-24-direct-print-3d-electrodes): [Using Human-Induced Pluripotent Stem Cell Derived Neurons on Microelectrode Arrays to Model Neurological Disease: A Review](https://webflow.mxwbio.com/resources/advanced-23-using-human-induced-pluripotent): [Insulative Compression of Neuronal Tissues on Microelectrode Arrays by Perfluorodecalin Enhances Electrophysiological Measurements](https://webflow.mxwbio.com/resources/advanced-25-insulative-compression-neuronal): [Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation](https://webflow.mxwbio.com/resources/advanced-26-engineering-neuronal-network): [An Implantable Biohybrid Neural Interface Toward Synaptic Deep Brain Stimulation](https://webflow.mxwbio.com/resources/advanced-25-implantable-biohybrid-neural): [In Vitro to In Vivo: Bidirectional and High-Precision Generation of In Vitro and In Vivo Neuronal Spike Data](https://webflow.mxwbio.com/resources/algorithms-26-vitro-vivo-bidirectional): [Recapitulation of Perturbed Striatal Gene Expression Dynamics of Donor’s Brains With Ventral Forebrain Organoids Derived From the Same Individuals With Schizophrenia](https://webflow.mxwbio.com/resources/american-23-recapitulation-perturbed-striatal): [Behavior of neural networks in culture suggest that sporadic and genetic forms of Alzheimer's disease may not be equivalent](https://webflow.mxwbio.com/resources/alzheimers-26-behavior-neural-networks): [Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair](https://webflow.mxwbio.com/resources/advanced-26-astrocyte-enrichment-3d): [The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics](https://webflow.mxwbio.com/resources/analytical-10-potential-microelectrode-arrays): [API Documentation](https://webflow.mxwbio.com/resources/api-documentation): Learn how to use the MaxLab Live API, opening the door to custom, programmable, and integrated experimentation with MaxWell Biosystems' high-density microelectrode array (HD-MEA) systems. [Topology and Mechanism of Broadband and Fast Multi‐Characteristic Opsin for Neuromodulation](https://webflow.mxwbio.com/resources/advanced-25-topology-mechanism-broadband): [Application Note with CRL and bit.bio](https://webflow.mxwbio.com/resources/application-note-crl-bitbio): Developing next-generation in-vitro phenotypic assays for Huntington's disease by combining precision reprogrammed hiPSC-derived disease models with high-density microelectrode arrays. [Application of a high-density microelectrode array assay using a 3D human iPSC-derived brain microphysiological system model for in vitro neurotoxicity screening of environmental compounds](https://webflow.mxwbio.com/resources/archives-25-application-high-density-microelectrode): [Neuroengineering Frontiers: A Selective Review of Neural Interfaces, Brain–Machine Interactions, and Artificial Intelligence in Neurodegenerative Diseases](https://webflow.mxwbio.com/resources/applied-25-neuroengineering-frontiers-selective): [SpikeCanvas: An IoT-based control plane for event-triggered workflow orchestration of high-density neurophysiology data](https://webflow.mxwbio.com/resources/array-26-spikecanvas-iot-based-control): [Active Inference and Intentional Behaviour](https://webflow.mxwbio.com/resources/arxiv-23-active-inference-intentional): [Bridging integrated information theory and the free-energy principle in living neuronal networks](https://webflow.mxwbio.com/resources/arxiv-25-bridging-integrated-information): [Starting a Synthetic Biological Intelligence Lab from Scratch](https://webflow.mxwbio.com/resources/arxiv-24-starting-synthetic-biological): [Multielectrode Arrays for Functional Phenotyping of Neurons from Induced Pluripotent Stem Cell Models of Neurodevelopmental Disorders](https://webflow.mxwbio.com/resources/biology-22-multielectrode-arrays-functional): [AxonTracking Assay Brochure](https://webflow.mxwbio.com/resources/axontracking-assay-brochure): Explore axonal insights with the AxonTracking Assay: high-resolution, label-free HD-MEA recordings for automated, long-term tracking using MaxOne and MaxTwo. [Encoding Tactile Stimuli for Organoid Intelligence in Braille Recognition](https://webflow.mxwbio.com/resources/arxiv-25-encoding-tactile-stimuli): [Design strategies for controlling neuron-connected robots using reinforcement learning](https://webflow.mxwbio.com/resources/arxiv-22-design-strategies-controlling): [Emergence of Deviance Detection in Cortical Cultures through Maturation, Criticality, and Early Experience](https://webflow.mxwbio.com/resources/arxiv-25-emergence-deviance-detection): [A Computational Perspective on NeuroAI and Synthetic Biological Intelligence](https://webflow.mxwbio.com/resources/arxiv-25-computational-perspective-neuroai): [Spatially defined axonal guidance in neural organoids with micropatterned microfluidic channels](https://webflow.mxwbio.com/resources/bioengineering-26-spatially-defined-axonal): [Stress-free cell aggregation by using the CEPT cocktail enhances embryoid body and organoid fitness](https://webflow.mxwbio.com/resources/biofabrication-23-stress-free-cell-aggregation): [Neural Autopoiesis: Organizing Self-Boundaries by Stimulus Avoidance in Biological and Artificial Neural Networks](https://webflow.mxwbio.com/resources/arxiv-20-neural-autopoiesis-organizing): [Biological Neurons Compete with Deep Reinforcement Learning in Sample Efficiency in a Simulated Gameworld](https://webflow.mxwbio.com/resources/arxiv-24-biological-neurons-compete): [A biocompatible multi-electrode cell for the study of neurons using capillary microscopy](https://webflow.mxwbio.com/resources/biomedical-25-biocompatible-multi-electrode-cell): [Development of an innervated human skin equivalent to model nociceptive circuitry in vitro](https://webflow.mxwbio.com/resources/biomaterials-25-development-innervated-human): [Microfluidics/CMOS orthogonal capabilities for cell biology](https://webflow.mxwbio.com/resources/biomedical-06-microfluidicscmos-orthogonal-capabilities): [Biomimetic Visual Information Spatiotemporal Encoding Method for In Vitro Biological Neural Networks](https://webflow.mxwbio.com/resources/biomimetics-25-biomimetic-visual-information): [Dynamics of excitability in axonal trees](https://webflow.mxwbio.com/resources/biophysical-25-dynamics-excitability-axonal): [A functional neuron maturation device provides convenient application on microelectrode array for neural network measurement](https://webflow.mxwbio.com/resources/biomaterials-22-functional-neuron-maturation): [Distributional invariance and proportional scaling in axonal conduction](https://webflow.mxwbio.com/resources/biophysics-25-distributional-invariance-proportional): [Inhibitory neurons are a Central Controlling regulator in the effective cortical microconnectome](https://webflow.mxwbio.com/resources/biorxiv-20-inhibitory-neurons-central): [Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics electrophysiological phenotype of the A53T mutation](https://webflow.mxwbio.com/resources/biorxiv-22-downregulating-synuclein-ipsc-derived): [Automated detection of extracellular action potentials from single neurons](https://webflow.mxwbio.com/resources/biorxiv-22-automated-detection-extracellular): [A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays](https://webflow.mxwbio.com/resources/biorxiv-22-multi-modal-fitting-approach): [Different contrast encoding in ON and OFF visual pathways](https://webflow.mxwbio.com/resources/biorxiv-20-different-contrast-encoding): [Network analysis of high-density microelectrode recordings](https://webflow.mxwbio.com/resources/biorxiv-17-network-analysis-high-density): [OpenMEA: Open-Source Microelectrode Array Platform for Bioelectronic Interfacing](https://webflow.mxwbio.com/resources/biorxiv-22-openmea-open-source-microelectrode): [Human neuron subtype programming through combinatorial patterning with scRNA-seq readouts](https://webflow.mxwbio.com/resources/biorxiv-23-human-neuron-subtype): [Potentiating NaV1.1 in Dravet syndrome patient iPSC-derived GABAergic neurons increases neuronal firing frequency and decreases network synchrony](https://webflow.mxwbio.com/resources/biorxiv-23-potentiating-nav11-dravet): [Protosequences in human cortical organoids model intrinsic states in the developing cortex](https://webflow.mxwbio.com/resources/biorxiv-23-protosequences-human-cortical): [Dopamine-induced Relaxation of Connectivity Diversifies Burst Patterns in Cultured Hippocampal Networks](https://webflow.mxwbio.com/resources/biorxiv-24-dopamine-induced-relaxation-connectivity): [Multiscale Cloud-Based Pipeline for Neuronal Electrophysiology Analysis and Visualization](https://webflow.mxwbio.com/resources/biorxiv-24-multiscale-cloud-based-pipeline): [RT-Sort: an action potential propagation-based algorithm for real time spike detection and sorting with millisecond latencies](https://webflow.mxwbio.com/resources/biorxiv-24-rt-sort-action-potential): [Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing](https://webflow.mxwbio.com/resources/biorxiv-24-characterizing-targeting-glioblastoma): [Distinct Synaptic Mechanisms Drive NRXN1 Variant-Mediated Pathogenesis in iPSC-Derived Neuronal Models of Autism and Schizophrenia](https://webflow.mxwbio.com/resources/biorxiv-25-distinct-synaptic-mechanisms): [HIPPIE: A Multimodal Deep Learning Model for Electrophysiological Classification of Neurons](https://webflow.mxwbio.com/resources/biorxiv-25-hippie-multimodal-deep): [Altered Protein Phosphorylation in a Novel Midbrain Organoid Model for Bipolar Disorder](https://webflow.mxwbio.com/resources/biorxiv-25-altered-protein-phosphorylation): [APP overexpression delays synaptic development and alters neuronal network properties](https://webflow.mxwbio.com/resources/biorxiv-25-app-overexpression-delays): [Chronic social defeat causes dysregulation of systemic glucose metabolism via the cerebellar fastigial nucleus](https://webflow.mxwbio.com/resources/biorxiv-25-chronic-social-defeat): [Sustained neurotrophic factor cotreatment enhances donor and host retinal ganglion cell survival in mice](https://webflow.mxwbio.com/resources/biorxiv-24-sustained-neurotrophic-factor): [Engineered biological neural networks as basic logic operators](https://webflow.mxwbio.com/resources/biorxiv-25-engineered-biological-neural): [Ephaptic-Axonal Interactions Shape Radial Biases During Neural Self-Organization](https://webflow.mxwbio.com/resources/biorxiv-25-ephaptic-axonal-interactions-shape): [ALG13 loss-of-function alters glycosylation, impairs neuronal maturation, and drives network hypoactivity in a cortical organoid model of CDG](https://webflow.mxwbio.com/resources/biorxiv-25-alg13-loss-of-function-alters): [HydroMEA: A 3D Hydrogel Based Microfluidic Device to Study Electrophysiology for Myelinated Nerve-on-Chip](https://webflow.mxwbio.com/resources/biorxiv-25-hydromea-3d-hydrogel): [Induction and long-term maintenance of hindbrain-like neural stem cells in xeno- and basic fibroblast growth factor-free conditions](https://webflow.mxwbio.com/resources/biorxiv-25-induction-long-term-maintenance): [Incubator-Free Organoid Culture in a Sealed Recirculatory System](https://webflow.mxwbio.com/resources/biorxiv-25-incubator-free-organoid-culture): [Modeling Organoid Population Electrophysiology Dynamics](https://webflow.mxwbio.com/resources/biorxiv-25-modeling-organoid-population): [MAIS: an in-vitro sandbox enables adaptive neuromodulation via scalable neural interfaces](https://webflow.mxwbio.com/resources/biorxiv-25-mais-in-vitro-sandbox): [Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability](https://webflow.mxwbio.com/resources/biorxiv-25-interspecies-organoids-reveal): [Excess prenatal folic acid supplementation alters cortical gene expression networks and electrophysiology](https://webflow.mxwbio.com/resources/biorxiv-25-excess-prenatal-folic): [Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs](https://webflow.mxwbio.com/resources/biorxiv-25-rapid-generation-ventral): [Novel Gain of Function Mouse Model of KCNT1-Related Epilepsy](https://webflow.mxwbio.com/resources/biorxiv-25-novel-gain-function): [Repetitive stimulation modifies network characteristics of neural organoid circuits](https://webflow.mxwbio.com/resources/biorxiv-25-repetitive-stimulation-modifies): [Recreating coronary vascularization and sympathetic innervation of myocardium on a human pluripotent stem cell-derived heart organoid](https://webflow.mxwbio.com/resources/biorxiv-25-recreating-coronary-vascularization): [KCNQ2 Loss-of-Function variants disrupt neuronal maturation via early hyperexcitability followed by maladaptive network remodeling](https://webflow.mxwbio.com/resources/biorxiv-25-kcnq2-loss-of-function-variants): [A toolbox for navigating and analyzing the spatiotemporal properties of retinal waves](https://webflow.mxwbio.com/resources/biorxiv-25-toolbox-navigating-analyzing): [Self-organization of high-dimensional geometry of neural activity in culture](https://webflow.mxwbio.com/resources/biorxiv-25-self-organization-high-dimensional-geometry): [In vitro 2 In vivo : Bidirectional and High-Precision Generation of In Vitro and In Vivo Neuronal Spike Data](https://webflow.mxwbio.com/resources/biorxiv-25-vitro-vivo): [LTP-patterned electromagnetic stimulation induces NMDA receptor-dependent synaptic plasticity in cortical networks](https://webflow.mxwbio.com/resources/biorxiv-26-ltp-patterned-electromagnetic-stimulation): [Triple-Negative Breast Cancer Cells Activate Sensory Neurons via TRPV1 to Drive Nerve Outgrowth and Tumor Progression](https://webflow.mxwbio.com/resources/biorxiv-25-triple-negative-breast-cancer): [Neuronal Population Effects of Ketamine on Human Brain Organoids](https://webflow.mxwbio.com/resources/biorxiv-26-neuronal-population-effects): [A water compartment cell culture lid enables stable longitudinal recording of neuronal networks in vitro](https://webflow.mxwbio.com/resources/biorxiv-26-water-compartment-cell): [Stimulation modulates cell assemblies linked with gene networks in the human temporal cortex ex vivo](https://webflow.mxwbio.com/resources/biorxiv-25-stimulation-modulates-cell): [Microelectrode Arrays Technology for Brain-on-a-Chip Applications](https://webflow.mxwbio.com/resources/biosensors-26-microelectrode-arrays-technology): [A three-compartment microfluidic platform for investigating signal transmission in the human sensory pathway†](https://webflow.mxwbio.com/resources/biorxiv-26-three-compartment-microfluidic-platform): [Capturing self-renewing multipotent neural crest stem cells from human pluripotent stem cells](https://webflow.mxwbio.com/resources/biorxiv-26-capturing-self-renewing-multipotent): [Single-chip microelectronic system to interface with living cells](https://webflow.mxwbio.com/resources/biosensors-07-single-chip-microelectronic-system): [Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices](https://webflow.mxwbio.com/resources/biosensors-09-microelectronic-system-high-resolution): [Patterned cell adhesion by self-assembled structures for use with a CMOS cell-based biosensor](https://webflow.mxwbio.com/resources/biosensors-07-patterned-cell-adhesion): [Investigation of the input-output relationship of engineered neural networks using high-density microelectrode arrays](https://webflow.mxwbio.com/resources/biosensors-23-investigation-input-output-relationship): [Evaluation of Conduction Properties of Sensory Axons with High-Density Microelectrode Array](https://webflow.mxwbio.com/resources/bmeicon-20-evaluation-conduction-properties): [Measuring and Inducing the Plasticity of Single-Neuron Scale at Multiple Points](https://webflow.mxwbio.com/resources/bmeicon-23-measuring-inducing-plasticity): [Downregulation of PMP22 ameliorates myelin defects in iPSC-derived human organoid cultures of CMT1A](https://webflow.mxwbio.com/resources/brain-22-downregulation-pmp22-ameliorates): [CMOS microelectrode array for the monitoring of electrogenic cells](https://webflow.mxwbio.com/resources/biosensors-04-cmos-microelectrode-array): [Breathe-Easy Foil MaxTwo 6-Well Plate Video Instruction](https://webflow.mxwbio.com/resources/breathe-easy-foil-maxtwo-6-well-plate-video-instruction): See how easy it is to apply the Breathe-Easy® sealing membranes on our MaxTwo Multiwell Plates, minimizing evaporation and ensuring optimal conditions for your sample. [Cultured Vagal Afferent Neurons as Sensors for Intestinal Effector Molecules](https://webflow.mxwbio.com/resources/biosensors-23-cultured-vagal-afferent): [Closed-loop neurostimulation via expression of magnetogenetics-sensitive protein in inhibitory neurons leads to reduction of seizure activity in a rat model of epilepsy](https://webflow.mxwbio.com/resources/brain-23-closed-loop-neurostimulation-via): [Activity- and Spatial-dependent Variations in Axonal Conduction Recorded from Microtunnel Electrodes](https://webflow.mxwbio.com/resources/bmeicon-23-activity-spatial-dependent-variations): [Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells](https://webflow.mxwbio.com/resources/cell-23-generation-functional-posterior): [An in vitro platform for characterizing axonal electrophysiology of individual human iPSC-derived nociceptors](https://webflow.mxwbio.com/resources/biosensors-25-in-vitro-platform): [Fully defined NGN2 neuron protocol reveals diverse signatures of neuronal maturation](https://webflow.mxwbio.com/resources/cell-24-fully-defined-ngn2): [A human striatal-midbrain assembloid model of alpha-synuclein propagation](https://webflow.mxwbio.com/resources/brain-25-human-striatal-midbrain-assembloid): [P97/VCP ATPase inhibitors can rescue p97 mutation-linked motor neuron degeneration](https://webflow.mxwbio.com/resources/brain-22-p97vcp-atpase-inhibitors): [Elevated FKBP5 expression associates with epilepsy-related molecular changes and promotes neuronal hyperexcitability](https://webflow.mxwbio.com/resources/brain-26-elevated-fkbp5-expression): [Brain Organoid Supplementary Guide](https://webflow.mxwbio.com/resources/brain-organoid-supplementary-guide): Discover helpful tips for optimizing your organoid and spheroid cultures and their recordings on the MaxOne and MaxTwo systems. [Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution](https://webflow.mxwbio.com/resources/cell-20-cell-types-human): [Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons](https://webflow.mxwbio.com/resources/cell-20-corticotropin-releasing-hormone-crh): [Cerebral Cortical-Like Organoid Model of PPP2R5D Induced Genetic Intellectual Disability Displays Variant-Specific Disease Severity Phenotype](https://webflow.mxwbio.com/resources/cell-26-cerebral-cortical-like-organoid): [The fast-dissociating D2 antagonist antipsychotic JNJ-37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment](https://webflow.mxwbio.com/resources/british-25-fast-dissociating-d2-antagonist): [Cryopreservation of brain organoids - a tool for on-demand organoid banking](https://webflow.mxwbio.com/resources/cell-26-cryopreservation-brain-organoids): [Goal-directed learning in cortical organoids](https://webflow.mxwbio.com/resources/cell-26-goal-directed-learning-cortical): [Wnt activation and dual SMAD inhibition for induction and maintenance of hindbrain-like neural stem cell from hiPSCs](https://webflow.mxwbio.com/resources/cell-26-wnt-activation-dual): [Kv7.2 loss-of-function causes early hyperexcitability and network remodelling](https://webflow.mxwbio.com/resources/brain-26-kv72-loss-of-function-causes): [Closed-loop reservoir computing with engineered neuronal networks on HD-MEAs](https://webflow.mxwbio.com/resources/closed-loop-reservoir-computing-with-engineered-neuronal-networks-on-hd-meas): This webinar explores how engineered neuronal networks can be used to investigate cortical computation and advance biological computing. It highlights how network architecture shapes neuronal dynamics and how closed-loop HD-MEA interfacing enables living networks to generate temporal patterns and function as computational reservoirs. [Overexpression of Toxic Poly(Glycine-Alanine) Aggregates in Primary Neuronal Cultures Induces Time-Dependent Autophagic and Synaptic Alterations but Subtle Activity Impairments](https://webflow.mxwbio.com/resources/cells-24-overexpression-toxic-polyglycine-alanine): [Suppression without inhibition: how retinal computation contributes to saccadic suppression](https://webflow.mxwbio.com/resources/communications-22-suppression-without-inhibition): [Network Hypoactivity in ALG13-CDG: Disrupted Developmental Pathways and E/I Imbalance as Early Drivers of Neurological Features in CDG](https://webflow.mxwbio.com/resources/cells-26-network-hypoactivity-alg13-cdg): [Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory](https://webflow.mxwbio.com/resources/communications-25-human-neural-organoid): [Mutual generation in neuronal activity across the brain via deep neural approach, and its network interpretation](https://webflow.mxwbio.com/resources/communications-23-mutual-generation-neuronal): [Drug treatment alters performance in a neural microphysiological system of information processing](https://webflow.mxwbio.com/resources/communications-25-drug-treatment-alters): [Construction and Evaluation of Neural Organoid Networks and Circuits on High Density Microelectrode Arrays (HD-MEAs)](https://webflow.mxwbio.com/resources/construction-and-evaluation-of-neural-organoid-networks-and-circuits-on-high-density-microelectrode-arrays-hd-meas): Learn how inter-regional connectivity underlies complex brain functions and how neural organoid networks can model these circuits in vitro. The talk highlights how HD-MEAs enable detailed analysis of organoid network activity and functional connectivity. [Dynamic Network Plasticity and Sample Efficiency in Biological Neural Cultures: A Comparative Study with Deep Reinforcement Learning](https://webflow.mxwbio.com/resources/cyborg-25-dynamic-network-plasticity): [Sleep as a default state of cortical and subcortical networks](https://webflow.mxwbio.com/resources/current-20-sleep-default-state): [Driving innovation in human neural models of development and disease](https://webflow.mxwbio.com/resources/driving-innovation-in-human-neural-models-of-development-and-disease): Explore the latest advances in human neural models for studying brain development and neurodegenerative disease. In this Nature co-organized webinar, researchers from ETH Zürich and VIB-KU Leuven discuss spatial transcriptomics, ALS research, stem cell–derived neuronal systems, and next-generation approaches for functional phenotyping and disease modeling. [A Robust Pipeline for the Multi‐Stage Accelerated Differentiation of Functional 3D Cortical Organoids from Human Pluripotent Stem Cells](https://webflow.mxwbio.com/resources/current-23-robust-pipeline-multistage): [Dot Plating MaxOne Chip Video Instruction](https://webflow.mxwbio.com/resources/dot-plating-maxone-chip-video-instruction): Just a single tiny drop is all it takes to get the best out of your iPSC-derived neuronal cultures or primary cell cultures on MaxOne Chips. [Dot Plating MaxTwo 6-Well Plate Video Instruction](https://webflow.mxwbio.com/resources/dot-plating-maxtwo-6-well-plate-video-instruction): Just a single tiny drop to get the best from your iPSC-derived neuronal cultures or primary cell cultures on MaxTwo Multiwell Plates. [Chronic Co-Variation of Neural Network Configuration and Activity in Mature Dissociated Cultures](https://webflow.mxwbio.com/resources/electronics-15-chronic-co-variation-neural): [Tracking individual action potentials throughout mammalian axonal arbors](https://webflow.mxwbio.com/resources/elife-17-tracking-individual-action): [Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking](https://webflow.mxwbio.com/resources/elife-23-parallel-reconstruction-excitatory): [Functional imaging of conduction dynamics in cortical and spinal axons](https://webflow.mxwbio.com/resources/elife-23-functional-imaging-conduction): [Electrical Stimulation Guide](https://webflow.mxwbio.com/resources/electrical-stimulation-guide): This guide outlines the principles of electrical stimulation and provides recommendations for safe and effective use with MaxWell Biosystems’ products. [FGF8-mediated gene regulation affects regional identity in human cerebral organoids](https://webflow.mxwbio.com/resources/elife-24-fgf8-mediated-gene-regulation): [Elixirgen Scientific - MxW Application Note](https://webflow.mxwbio.com/resources/elixirgen-scientific-mxw-application-note): Long-term Characterization of Quick-NeuronTMExciatory - Human iPSC-derived Neurons with High-Density Microelectrode Arrays [Neurons on Microelectrode Arrays and In Vitro Electrophysiological Data Analysis](https://webflow.mxwbio.com/resources/emerging-25-neurons-microelectrode-arrays): [Homophilic wiring principles underpin neuronal network topology in vitro](https://webflow.mxwbio.com/resources/elife-25-homophilic-wiring-principles): [Exchangeable Pin Connectors Instructions](https://webflow.mxwbio.com/resources/exchangeable-pin-connectors-instructions): This protocol describes how to exchange the Exchangeable Pin Connectors of the MaxOne Recording Unit [Internet-Connected Cortical Organoids for Project-Based Stem Cell and Neuroscience Education](https://webflow.mxwbio.com/resources/eneuro-23-internet-connected-cortical-organoids): [FCDI Application Note Dataset](https://webflow.mxwbio.com/resources/fcdi-application-note-dataset): Compare healthy and diseased neuronal models: track development, uncover activity differences, and enable advanced spike-based analysis. [Fully integrated 128-electrode CMOS chip for bidirectional interaction with electrogenic cells](https://webflow.mxwbio.com/resources/eurosensors-05-fully-integrated-128-electrode): [Whole-Brain Evaluation of Cortical Microconnectomes](https://webflow.mxwbio.com/resources/eneuro-23-whole-brain-evaluation-cortical): [Human cerebral organoids reveal PFOA-induced axonal injury as a conserved mechanism of neurodevelopmental disruption](https://webflow.mxwbio.com/resources/environment-26-human-cerebral-organoids): [High-density microelectrode array recordings and real-time spike sorting for closed-loop experiments: an emerging technology to study neural plasticity](https://webflow.mxwbio.com/resources/frontiers-12-high-density-microelectrode-array): [Parameters for burst detection](https://webflow.mxwbio.com/resources/frontiers-14-parameters-burst-detection): [From Self-Organization to Learning: Mouse Forebrain Organoids as Models of Network Assembly and Goal-Directed Adaptation](https://webflow.mxwbio.com/resources/from-self-organization-to-learning-mouse-forebrain-organoids-as-models-of-network-assembly-and-goal-directed-adaptation): This webinar explores how brain organoids can be used as adaptive biological networks for neurocomputing. It covers how organoid circuits self-organize into distinct network architectures and how closed-loop HD-MEA interfacing enables goal-directed learning—linking network dynamics, functional phenotyping, and real-time feedback-driven training. [Revealing neuronal function through microelectrode array recordings](https://webflow.mxwbio.com/resources/frontiers-15-revealing-neuronal-function): [A method for electrophysiological characterization of hamster retinal ganglion cells using a high-density CMOS microelectrode array](https://webflow.mxwbio.com/resources/frontiers-15-method-electrophysiological-characterization): [Sub-millisecond closed-loop feedback stimulation between arbitrary sets of individual neurons](https://webflow.mxwbio.com/resources/frontiers-13-sub-millisecond-closed-loop-feedback): [Extracellularly Recorded Somatic and Neuritic Signal Shapes and Classification Algorithms for High-Density Microelectrode Array Electrophysiology](https://webflow.mxwbio.com/resources/frontiers-16-extracellularly-recorded-somatic): [Long-Term High-Density Extracellular Recordings Enable Studies of Muscle Cell Physiology](https://webflow.mxwbio.com/resources/frontiers-18-long-term-high-density-extracellular): [Optimal Electrode Size for Multi-Scale Extracellular-Potential Recording From Neuronal Assemblies](https://webflow.mxwbio.com/resources/frontiers-19-optimal-electrode-size): [Multiple Single-Unit Long-Term Tracking on Organotypic Hippocampal Slices Using High-Density Microelectrode Arrays](https://webflow.mxwbio.com/resources/frontiers-16-multiple-single-unit-long-term): [Technologies to Study Action Potential Propagation With a Focus on HD-MEAs](https://webflow.mxwbio.com/resources/frontiers-19-technologies-study-action): [Single-Cell Electrical Stimulation Using CMOS-Based High-Density Microelectrode Arrays](https://webflow.mxwbio.com/resources/frontiers-19-single-cell-electrical-stimulation): [Medullary Respiratory Circuit Is Reorganized by a Seasonally-Induced Program in Preparation for Hibernation](https://webflow.mxwbio.com/resources/frontiers-19-medullary-respiratory-circuit): [Aging-dependent altered transcriptional programs underlie activity impairments in human C9orf72-mutant motor neurons](https://webflow.mxwbio.com/resources/frontiers-22-aging-dependent-altered-transcriptional): [Cortical Axons, Isolated in Channels, Display Activity-Dependent Signal Modulation as a Result of Targeted Stimulation](https://webflow.mxwbio.com/resources/frontiers-16-cortical-axons-isolated): [Large-Scale Mapping of Axonal Arbors Using High-Density Microelectrode Arrays](https://webflow.mxwbio.com/resources/frontiers-19-large-scale-mapping-axonal): [Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays](https://webflow.mxwbio.com/resources/frontiers-22-long-term-morphological-functional): [Predicting in vitro single-neuron firing rates upon pharmacological perturbation using Graph Neural Networks](https://webflow.mxwbio.com/resources/frontiers-23-predicting-vitro-single-neuron): [To brain or not to brain organoids](https://webflow.mxwbio.com/resources/frontiers-23-brain-not-brain): [Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks](https://webflow.mxwbio.com/resources/frontiers-23-microfluidic-cell-engineering): [Recording Saltatory Conduction Along Sensory Axons Using a High-Density Microelectrode Array](https://webflow.mxwbio.com/resources/frontiers-22-recording-saltatory-conduction): [CardioMEA: comprehensive data analysis platform for studying cardiac diseases and drug responses](https://webflow.mxwbio.com/resources/frontiers-24-cardiomea-comprehensive-data): [Brain organoids engineered to give rise to glia and neural networks after 90 days in culture exhibit human-specific proteoforms](https://webflow.mxwbio.com/resources/frontiers-24-brain-organoids-engineered): [Engineered Biological Neural Networks on High Density CMOS Microelectrode Arrays](https://webflow.mxwbio.com/resources/frontiers-22-engineered-biological-neural): [Tracking axon initial segment plasticity using high-density microelectrode arrays: A computational study](https://webflow.mxwbio.com/resources/frontiers-22-tracking-axon-initial): [Chronic silencing of Drd1a-Cre+ neurons impairs dopaminergic-driven cortical activation](https://webflow.mxwbio.com/resources/frontiers-25-chronic-silencing-drd1a-cre): [Microglia-containing neural organoids as brain microphysiological systems for long-term culture](https://webflow.mxwbio.com/resources/frontiers-25-microglia-containing-neural-organoids): [Sensory-spinal neuron co-culture platform enables analysis of sensory-driven spinal activation](https://webflow.mxwbio.com/resources/frontiers-25-sensory-spinal-neuron-co-culture): [Emergent functions of noise-driven spontaneous activity: homeostatic maintenance of criticality and memory consolidation](https://webflow.mxwbio.com/resources/frontiers-25-emergent-functions-noise-driven): [Cell-based CMOS sensor and actuator arrays](https://webflow.mxwbio.com/resources/ieee-04-cell-based-cmos-sensor): [Echo State Property of Neuronal Cell Cultures](https://webflow.mxwbio.com/resources/icann-19-echo-state-property): [A modular and flexible open source cell incubator system for mobile and stationary use](https://webflow.mxwbio.com/resources/hardwarex-24-modular-flexible-open): [Deviance detection and regularity sensitivity in dissociated neuronal cultures](https://webflow.mxwbio.com/resources/frontiers-25-deviance-detection-regularity): [CMOS Microelectrode Array for Bidirectional Interaction With Neuronal Networks](https://webflow.mxwbio.com/resources/ieee-06-cmos-microelectrode-array): [Impedance characterization and modeling of electrodes for biomedical applications](https://webflow.mxwbio.com/resources/ieee-05-impedance-characterization-modeling): [DHDDS-related juvenile parkinsonism is caused by impaired lipid metabolism, glycosylation, and mitochondrial dysfunction, which can be rescued by NAD⁺ treatment](https://webflow.mxwbio.com/resources/genetic-26-dhdds-related-juvenile-parkinsonism): [11'000 Electrode-, 126 channel-CMOS microelectrode array for electrogenic cells](https://webflow.mxwbio.com/resources/ieee-07-11000-electrode-channel-cmos): [Harnessing the potential of human induced pluripotent stem cells, functional assays and machine learning for neurodevelopmental disorders](https://webflow.mxwbio.com/resources/frontiers-25-harnessing-potential-human): [Compact Voltage and Current Stimulation Buffer for High-Density Microelectrode Arrays](https://webflow.mxwbio.com/resources/ieee-10-compact-voltage-current): [Switch-Matrix-Based High-Density Microelectrode Array in CMOS Technology](https://webflow.mxwbio.com/resources/ieee-10-switch-matrix-based-high-density-microelectrode): [A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro](https://webflow.mxwbio.com/resources/ieee-14-1024-channel-cmos-microelectrode): [22.8 Multi-functional microelectrode array system featuring 59,760 electrodes, 2048 electrophysiology channels, impedance and neurotransmitter measurement units](https://webflow.mxwbio.com/resources/ieee-16-multi-functional-microelectrode-array): [Complexity Optimization and High-Throughput Low-Latency Hardware Implementation of a Multi-Electrode Spike-Sorting Algorithm](https://webflow.mxwbio.com/resources/ieee-14-complexity-optimization-high-throughput): [Acquisition of bioelectrical signals with small electrodes](https://webflow.mxwbio.com/resources/ieee-17-acquisition-bioelectrical-signals): [Impedance Spectroscopy and Electrophysiological Imaging of Cells With a High-Density CMOS Microelectrode Array System](https://webflow.mxwbio.com/resources/ieee-18-impedance-spectroscopy-electrophysiological): [Dual-mode Microelectrode Array Featuring 20k Electrodes and High SNR for Extracellular Recording of Neural Networks](https://webflow.mxwbio.com/resources/ieee-18-dual-mode-microelectrode-array): [MAPSYNE: Miniaturized micropipette system combined with high-density microelectrode arrays for automated manipulation of neuronal networks in-vitro](https://webflow.mxwbio.com/resources/ieee-20-mapsyne-miniaturized-micropipette): [Stimulation and Artifact-Suppression Techniques for In Vitro High-Density Microelectrode Array Systems](https://webflow.mxwbio.com/resources/ieee-19-stimulation-artifact-suppression-techniques): [Development of a Hypersensitivity Evaluation Method for Cultured Sensory Neurons Using Electrical Activity Recording](https://webflow.mxwbio.com/resources/ieee-23-development-hypersensitivity-evaluation): [Multi-Functional HD-MEA Platform for High-Resolution Impedance Imaging and Electrophysiological Recordings of Brain Slices](https://webflow.mxwbio.com/resources/ieee-23-multi-functional-hd-mea-platform): [In Vitro Multi-Functional Microelectrode Array Featuring 59 760 Electrodes, 2048 Electrophysiology Channels, Stimulation, Impedance Measurement, and Neurotransmitter Detection Channels](https://webflow.mxwbio.com/resources/ieee-17-vitro-multi-functional-microelectrode): [Extracellular Recording of Entire Neural Networks Using a Dual-Mode Microelectrode Array With 19 584 Electrodes and High SNR](https://webflow.mxwbio.com/resources/ieee-21-extracellular-recording-entire): [Neural Activity and Information Processing Capacity of Neuronal Culture](https://webflow.mxwbio.com/resources/ieee-23-neural-activity-information): [Classification of Inhibitory and Excitatory Neurons of Dissociated Cultures Based on Action Potential Waveforms on High-density CMOS Microelectrode Arrays](https://webflow.mxwbio.com/resources/ieej-19-classification-inhibitory-excitatory): [Installing Decompression Library to load MaxLab Live Recordings](https://webflow.mxwbio.com/resources/installing-decompression-library-load-maxlab-live-recordings): This guide explains how to install the decompression library required to read MaxLab Live recordings with external tools. [iPSC-Derived Neurons Poster](https://webflow.mxwbio.com/resources/ipsc-derived-neurons-poster): Label-Free Functional Characterization of Human iPSC-Derived Neurons at Subcellular Resolution [iPSC FTD Disease Poster](https://webflow.mxwbio.com/resources/ipsc-ftd-disease-poster): High-Density Microelectrode Arrays for Modeling, Phenotyping, and Screening in a Human Model of Frontotemporal Dementia [Depth recording capabilities of planar high-density microelectrode arrays](https://webflow.mxwbio.com/resources/international-09-depth-recording-capabilities): [A feedback-driven brain organoid platform enables automated maintenance and high-resolution neural activity monitoring](https://webflow.mxwbio.com/resources/internet-25-feedback-driven-brain-organoid): [Integra Application Note Dataset](https://webflow.mxwbio.com/resources/integra-application-note-dataset): Use this dataset to validate neuronal function with human iPSC-derived cultures: assess baseline activity, pharmacological responses, and recovery dynamics. [CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons](https://webflow.mxwbio.com/resources/iscience-22-cask-loss-function): [Beyond Structure: Next-Generation Electrophysiological Platforms for Functional Brain Organoids](https://webflow.mxwbio.com/resources/international-25-beyond-structure-next-generation): [Dendritic spine formation and synapse maturation in transcription factor-induced human iPSC-derived neurons](https://webflow.mxwbio.com/resources/iscience-23-dendritic-spine-formation): [An integrated in vitro platform and biophysical modeling approach for studying synaptic transmission in isolated neuronal pairs](https://webflow.mxwbio.com/resources/iscience-26-integrated-vitro-platform): [Modeling embryonic heart vascular plexus development and sympathetic innervation on a human heart organoid](https://webflow.mxwbio.com/resources/iscience-26-modeling-embryonic-heart): [Unperturbed Dye-based Imaging of Spontaneous Synchronized Calcium Activity in iPSC-derived Neuronal Cultures](https://webflow.mxwbio.com/resources/iscience-26-unperturbed-dye-based-imaging): [Applicability of independent component analysis on high-density microelectrode array recordings](https://webflow.mxwbio.com/resources/journal-12-applicability-independent-component): [A perforated CMOS microchip for immobilization and activity monitoring of electrogenic cells](https://webflow.mxwbio.com/resources/journal-07-perforated-cmos-microchip): [Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking](https://webflow.mxwbio.com/resources/journal-22-inferring-monosynaptic-connections): [A CMOS-based microelectrode array for interaction with neuronal cultures](https://webflow.mxwbio.com/resources/journal-07-cmos-based-microelectrode-array): [Automatic spike sorting for high-density microelectrode arrays](https://webflow.mxwbio.com/resources/journal-18-automatic-spike-sorting): [Visual coding with a population of direction-selective neurons](https://webflow.mxwbio.com/resources/journal-15-visual-coding-population): [Recording from defined populations of retinal ganglion cells using a high-density CMOS-integrated microelectrode array with real-time switchable electrode selection](https://webflow.mxwbio.com/resources/journal-12-recording-defined-populations): [Butylphthalide enhances neurorestoration following ischemic stroke by restructuring microvasculature through vimentin modulation](https://webflow.mxwbio.com/resources/journal-25-butylphthalide-enhances-neurorestoration): [Regulation of Dendrite and Dendritic Spine Formation by TCF20](https://webflow.mxwbio.com/resources/journal-25-regulation-dendrite-dendritic): [Identification of secondary microglial formation centers in the human fetal brain](https://webflow.mxwbio.com/resources/journal-26-identification-secondary-microglial): [Microfluidic technologies for reconstituting neuronal network functions in vitro](https://webflow.mxwbio.com/resources/jsap-23-microfluidic-technologies-reconstituting): [A fast and simple algorithm for accurate spike detection in HD-MEA recordings](https://webflow.mxwbio.com/resources/journal-26-fast-simple-algorithm): [High-density Multielectrode Array Recordings of Retinal Waves Using An Electrophysiology Platform](https://webflow.mxwbio.com/resources/journal-25-high-density-multielectrode-array): [Microscale maps of bursting dynamics across human hippocampal slices from epilepsy patients](https://webflow.mxwbio.com/resources/journal-25-microscale-maps-bursting): [Brain organoids-on-chip for neural diseases modeling: History, challenges and trends](https://webflow.mxwbio.com/resources/journal-25-brain-organoids-on-chip-neural): [High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels](https://webflow.mxwbio.com/resources/lab-15-high-resolution-cmos-mea): [Driving electrochemical reactions at the microscale using CMOS microelectrode arrays](https://webflow.mxwbio.com/resources/lab-23-driving-electrochemical-reactions): [Advances in large-scale electrophysiology with high-density microelectrode arrays](https://webflow.mxwbio.com/resources/lab-25-advances-large-scale-electrophysiology): [LD-HD-MEA Poster](https://webflow.mxwbio.com/resources/ld-hd-mea-poster): The Importance Of High-Density Microelectrode Arrays For Recording Multi-Scale Extracellular Potential And Label-Free Characterization Of Network Dynamics in iPSC-Derived Neurons [MyeliMAP: a microfluidic-multielectrode array hybrid platform to investigate oligodendrocyte function in human iPSC derived brain-like networks](https://webflow.mxwbio.com/resources/lab-26-myelimap-microfluidic-multielectrode-array): [Characterization of a microfluidic dispensing system for localised stimulation of cellular networks](https://webflow.mxwbio.com/resources/lab-06-characterization-microfluidic-dispensing): [Seamless integration of CMOS microsensors into open microfluidic systems](https://webflow.mxwbio.com/resources/lab-25-seamless-integration-cmos): [MaxOne Acute Brain Slice Protocol](https://webflow.mxwbio.com/resources/maxone-acute-brain-slice-protocol): Capture high-density electrophysiology recordings from acute brain slices with the MaxOne Tissue Holder and Perfusion System for stable, reproducible results. [MaxLab Live Manual](https://webflow.mxwbio.com/resources/maxlab-live-manual): This manual provides a complete guide to using MaxLab Live software, from setup and data acquisition to analysis and multiplate workflows. [MaxOne Acute Brain Slice Protocol - Cerebellum](https://webflow.mxwbio.com/resources/maxone-acute-brain-slice-protocol-cerebellum): Capture high-density electrophysiology recordings from acute cerebellar brain slices with the MaxOne Tissue Holder and Perfusion System for stable, reproducible results. [MaxLab Live API Module Overview](https://webflow.mxwbio.com/resources/maxlab-live-api-module-overview): Unlock MaxLab Live’s API module: real-time data access, custom workflows, external integrations, and advanced stimulation control for enhanced experimental capabilities. [MaxOne+ and MaxOne Handling, Cleaning, and Storage Recommendations](https://webflow.mxwbio.com/resources/maxone-maxone-handling-cleaning-storage-recommendations): Guide for cell culture with MaxOne & MaxOne+Chips. [Brain Slice Application Brochure](https://webflow.mxwbio.com/resources/maxone-brain-slice-studies): [MaxOne Brochure](https://webflow.mxwbio.com/resources/maxone-brochure): Explore MaxOne, a powerful high-density microelectrode array (HD-MEA) system for precise, multi-level electrophysiological recordings and stimulation of electrogenic cells. [MaxOne Chip Holder](https://webflow.mxwbio.com/resources/maxone-chip-holder): Instructions for proper handling of the MaxOne chip holder during experiments [MaxOne Guide](https://webflow.mxwbio.com/resources/maxone-guide): Optimize your experiments with the MaxOne User Guide: step-by-step setup, safety, maintenance, and troubleshooting for the MaxOne HD-MEA system. [Cardiomyocyte Application Brochure](https://webflow.mxwbio.com/resources/maxone-cardiomyocytes): [MaxOne+ and MaxOne Cardiomyocytes Plating Protocol](https://webflow.mxwbio.com/resources/maxone-cardiomyocyte-plating-protocol): This document describes the protocol to plate and maintain cardiomyocytes using MaxOne. [MaxOne Digital Input Extension Board Instructions](https://webflow.mxwbio.com/resources/maxone-digital-inputextension-board-instructions): User guide for setting up the Digital Input Extension Board (DigiPins) to synchronize external events with MaxOne recordings using Python scripts. [MaxOne+ and MaxOne Neuronal Cell Plating Protocol](https://webflow.mxwbio.com/resources/maxone-maxone-neuronal-cell-plating-protocol): Follow this easy-to-use neuronal cell plating protocol for MaxOne,ensuring optimal cell growth and attachment with clear step-by-step instructions. [MaxTwo Brochure](https://webflow.mxwbio.com/resources/maxtwo-brochure): Unlock the potential of MaxTwo, a multiwell HD-MEA system offering unmatched resolution, high throughput, and exceptional sensitivity to maximize cell functional assays. [MaxOne Organoid Plating Video Instruction](https://webflow.mxwbio.com/resources/maxone-organoid-plating-video-instruction): Plating organoids on MaxOne Chips has never been so easy, thanks to our detailed step-by-step instructions, with practical tips at key stages. [Neuronal Cell Cultures Application Brochure](https://webflow.mxwbio.com/resources/maxone-neuronal-cell-cultures-application-brochure): [MaxOne Decontamination Recommendations](https://webflow.mxwbio.com/resources/maxone-decontamination-recommendations): This document describes the decontamination steps to follow before returning the MaxOne system. [MaxOne+ Brochure](https://webflow.mxwbio.com/resources/maxone-plus-brochure): Experience MaxOne⁺, the next generation ready-to-use HD-MEA chip with enhanced cell adhesion, superior signal quality, and powerful stimulation for peak performance. [MaxOne Tissue Holder And Perfusion System Instructions](https://webflow.mxwbio.com/resources/maxone-tissue-holder-perfusion-system-instructions): Instructions for setting up, handling and maintaining the MaxOne Tissue Holder and Perfusion System for reliable acute tissue recording on the MaxOne System. [MaxTwo Brain Organoid Plating Protocol](https://webflow.mxwbio.com/resources/maxtwo-brain-organoid-plating-protocol): Use this Brain Organoid Plating Protocol for MaxTwo to achieve high-throughput, longitudinal electrophysiology recordings of your neural organoids. [MaxOne+ and MaxOne Brain Organoid Plating Protocol](https://webflow.mxwbio.com/resources/maxone-maxone-brain-organoid-plating-protocol): Use this brain organoid plating protocol for MaxOne+& MaxOne to achieve optimal attachment and enable longitudinal electrophysiology recordings of your neural organoids. [MaxTwo Brain Organoid Plating Protocol Video Instructions](https://webflow.mxwbio.com/resources/maxtwo-brain-organoid-plating-protocol-video-instructions): Plating organoids on MaxTwo Multiwell Plates has never been so easy, thanks to our detailed step-by-step instructions, with practical tips at key stages. [MaxTwo Cardiomyocytes Plating Protocol](https://webflow.mxwbio.com/resources/maxtwo-cardiomyocytes-plating-protocol): This document describes the protocol to plate and maintain cardiomyocytes using MaxTwo 6 and 24-Well plates. [MaxTwo Decontamination Protocol](https://webflow.mxwbio.com/resources/maxtwo-decontamination-protocol): This document describes decontamination steps for the MaxTwo system. [Retina Application Brochure](https://webflow.mxwbio.com/resources/maxone-retinal-studies): [MaxTwo Guide](https://webflow.mxwbio.com/resources/maxtwo-guide): Optimize your experiments with the MaxTwo User Guide: step-by-step setup, safety, plate handling, maintenance, and troubleshooting for the MaxTwo HD-MEA system. [MaxTwo Perfusion System Brochure](https://webflow.mxwbio.com/resources/maxtwo-perfusion-system-brochure): Introducing the first fully integrated multiwell MEA perfusion system, MaxTwo Perfusion system ensures continuous medium flow and high-resolution data for advanced cell research. [Flexible and stretchable bioelectronics for organoids](https://webflow.mxwbio.com/resources/med-x-25-flexible-stretchable-bioelectronics): [MaxTwo Wellplate Handling](https://webflow.mxwbio.com/resources/maxtwo-wellplate-handling): Guidelines for handling MaxTwo well plates. [O-GlcNAcase dosage variants are associated with neuronal deficits and intellectual disability](https://webflow.mxwbio.com/resources/medrxiv-26-o-glcnacase-dosage-variants): [Microelectrode arrays cultured with in vitro neural networks for motion control tasks: encoding and decoding progress and advances](https://webflow.mxwbio.com/resources/microsystems-25-microelectrode-arrays-cultured): [MaxTwo Perfusion System Quick Guide](https://webflow.mxwbio.com/resources/maxtwo-perfusion-system-quick-guide): This quick guide explains how to set up the MaxTwo Perfusion System. [Modelling Normal and Pathological Brain Development and Function Using Human Organoid Systems](https://webflow.mxwbio.com/resources/modelling-normal-and-pathological-brain-development-and-function-using-human-organoid-systems): Explore how human iPSC-derived brain organoids can model normal and pathological brain development—from FGF8-driven neocortical identity to glioblastoma invasion. This edited webinar replay also covers practical guidance on using HD-MEAs to capture spontaneous activity in cerebral organoids, with troubleshooting tips to improve maturation and network-function readouts. [MaxTwo Neuronal Cell Plating Protocol](https://webflow.mxwbio.com/resources/maxtwo-neuronal-cell-plating-protocol): Maximize efficiency with this scalable protocol for high-throughput neuronal cell plating, ensuring best cell attachment and electrophysiology recordings. [Midbrain Organoids Poster](https://webflow.mxwbio.com/resources/midbrain-organoids-poster): Longitudinal profiling of midbrain organoid maturation, pharmacological response, and axon dysfunction–relevant functional readout [Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na+ channel dynamics in human neurons](https://webflow.mxwbio.com/resources/molecular-26-loss-schizophrenia-risk): [Spinal Cord Organoids from Human Amniotic Fluid iPSC Recapitulate the Diversity of Cell Phenotypes During Fetal Neural Tube Morphogenesis](https://webflow.mxwbio.com/resources/molecular-25-spinal-cord-organoids): [Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability](https://webflow.mxwbio.com/resources/molecular-20-layers-iiiii-prefrontal): [Social regression stems from a latent phase of GABAergic dysfunction and sensory breakdown in a model of synaptopathy](https://webflow.mxwbio.com/resources/molecular-26-social-regression-stems): [Df (h22q11)/+ mouse model exhibits reduced binding levels of GABAA receptors and structural and functional dysregulation in the inhibitory and excitatory networks of hippocampus](https://webflow.mxwbio.com/resources/molecular-22-df-h22q11-mouse): [Functional imaging of brain organoids using high-density microelectrode arrays](https://webflow.mxwbio.com/resources/mrs-22-functional-imaging-brain): [MxW - ACROBiosystems Application Note](https://webflow.mxwbio.com/resources/mxw-acrobiosystems-application-note): Acute recordings of spinal cord organoids generated via a commercially available kit from ACROBiosystems, performed on MaxTwo 6-Well Plate with Liquid Holder. [MxW - bit.bio Application Protocol](https://webflow.mxwbio.com/resources/mxw-bitbio-application-protocol): Co-culturing ioMotor Neurons and rat cortical astrocytes for HD-MEA [MxW - NeuCyte Application Note](https://webflow.mxwbio.com/resources/mxw-neucyte-application-note): Long-term functional characterization of SynFire®iNs and astrocytes co-cultured on MaxTwo multi-well high-density microelectrode arrays [MxW - Neucyte Application Protocol](https://webflow.mxwbio.com/resources/mxw-neucyte-application-protocol): SynFire®iN plating protocol and chemical long-term potentiation on MaxWell Biosystems Multi-Well High-Density Microelectrode Array (HD-MEA) [Solid-State Nanopores for Spatially Resolved Chemical Neuromodulation](https://webflow.mxwbio.com/resources/nano-24-solid-state-nanopores-spatially): [MxW - Elixirgen Application Protocol](https://webflow.mxwbio.com/resources/mxw-elixirgen-application-protocol): Culturing Human iPSC-derived Mixed Neurons on Multielectrode Arrays: MaxTwo Multiwell MEA [Polystyrene nanoplastics modulate neurite length in a size-specific manner](https://webflow.mxwbio.com/resources/nanoimpact-26-polystyrene-nanoplastics-modulate): [MxW - FCDI Application Note](https://webflow.mxwbio.com/resources/mxw-fcdi-application-note): Longitudinal Functional Profiling of HumaniPSC-derived Frontotemporal Dementia Neuronson HD-MEAs [Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites](https://webflow.mxwbio.com/resources/nature-13-tracking-axonal-action): [Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level](https://webflow.mxwbio.com/resources/nature-20-versatile-live-cell-activity): [16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro](https://webflow.mxwbio.com/resources/nature-21-16p112-deletion-associated): [A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture](https://webflow.mxwbio.com/resources/nature-15-network-comprising-short): [MxW - Integra Application Note](https://webflow.mxwbio.com/resources/mxw-integra-application-note): Semi-automated high-throughput electrophysiology of human iPSC-derived glutamatergic neuron–astrocyte co-cultures on MaxTwo 24-Well Plates, using the VIAFLO 96 for parallel media handling and TTX compound administration. [Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex](https://webflow.mxwbio.com/resources/nature-17-causal-evidence-retina-dependent): [Functional neuronal circuitry and oscillatory dynamics in human brain organoids](https://webflow.mxwbio.com/resources/nature-22-functional-neuronal-circuitry): [Engineering brain-on-a-chip platforms](https://webflow.mxwbio.com/resources/nature-24-engineering-brain-on-a-chip-platforms): [A 4096 channel event-based multielectrode array with asynchronous outputs compatible with neuromorphic processors](https://webflow.mxwbio.com/resources/nature-24-channel-event-based-multielectrode): [Large-scale mapping of cortical synaptic projections with extracellular electrode arrays](https://webflow.mxwbio.com/resources/nature-17-large-scale-mapping-cortical): [Perceptual saccadic suppression starts in the retina](https://webflow.mxwbio.com/resources/nature-20-perceptual-saccadic-suppression): [BiœmuS: A new tool for neurological disorders studies through real-time emulation and hybridization using biomimetic Spiking Neural Network](https://webflow.mxwbio.com/resources/nature-24-bimus-new-tool): [A high-density 1,024-channel probe for brain-wide recordings in non-human primates](https://webflow.mxwbio.com/resources/nature-24-high-density-1024-channel-probe): [Autism genes converge on asynchronous development of shared neuron classes](https://webflow.mxwbio.com/resources/nature-22-autism-genes-converge): [Brain organoid reservoir computing for artificial intelligence](https://webflow.mxwbio.com/resources/nature-23-brain-organoid-reservoir): [Critical dynamics arise during structured information presentation within embodied in vitro neuronal networks](https://webflow.mxwbio.com/resources/nature-23-critical-dynamics-arise): [Mechanical stimulation and electrophysiological monitoring at subcellular resolution reveals differential mechanosensation of neurons within networks](https://webflow.mxwbio.com/resources/nature-24-mechanical-stimulation-electrophysiological): [A model of human neural networks reveals NPTX2 pathology in ALS and FTLD](https://webflow.mxwbio.com/resources/nature-24-model-human-neural): [Axonal Eif5a hypusination controls local translation and mitigates defects in FUS-ALS](https://webflow.mxwbio.com/resources/nature-26-axonal-eif5a-hypusination): [Preconfigured neuronal firing sequences in human brain organoids](https://webflow.mxwbio.com/resources/nature-25-preconfigured-neuronal-firing): [Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices](https://webflow.mxwbio.com/resources/nature-24-multimodal-evaluation-network): [Revealing single-neuron and network-activity interaction by combining high-density microelectrode array and optogenetics](https://webflow.mxwbio.com/resources/nature-24-revealing-single-neuron-network-activity): [Defective ventral neurogenesis due to midfetal Chd8 mutation drives autistic-like behavior in mice](https://webflow.mxwbio.com/resources/nature-26-defective-ventral-neurogenesis): [Synchronization of visual perception within the human fovea](https://webflow.mxwbio.com/resources/nature-25-synchronization-visual-perception): [Dopamine-induced relaxation of spike synchrony diversifies burst patterns in cultured hippocampal networks](https://webflow.mxwbio.com/resources/neural-24-dopamine-induced-relaxation-spike): [A Multimodal Fitting Approach to Construct Single-Neuron Models with Patch Clamp and High-Density Microelectrode Arrays](https://webflow.mxwbio.com/resources/neural-24-multimodal-fitting-approach): [Neural Organoids Poster](https://webflow.mxwbio.com/resources/neural-organoids-poster): Next Generation Electrophysiology for Functional Characterization of Human Neural Organoids and Assembloids [Targeting PGE2 mediated senescent neuron improves tumour therapy](https://webflow.mxwbio.com/resources/neuro-oncology-25-targeting-pge2-mediated): [Human iPSC-derived glutamatergic neurons with pathogenic KCNQ2 variants display hyperactive bursting phenotypes](https://webflow.mxwbio.com/resources/neurobiology-25-human-ipsc-derived-glutamatergic): [Biological Neurons vs Deep Reinforcement Learning: Sample efficiency in a simulated game-world](https://webflow.mxwbio.com/resources/neurips-22-biological-neurons-vs): [Structures of Neural Correlation and How They Favor Coding](https://webflow.mxwbio.com/resources/neuron-16-structures-neural-correlation): [Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity](https://webflow.mxwbio.com/resources/neuron-16-congenital-nystagmus-gene): [How Diverse Retinal Functions Arise from Feedback at the First Visual Synapse](https://webflow.mxwbio.com/resources/neuron-18-how-diverse-retinal): [SpikeLab: Agentic tools for spike data analysis](https://webflow.mxwbio.com/resources/neuroscience-26-spikelab-agentic-tools): [In vitro neurons learn and exhibit sentience when embodied in a simulated game-world](https://webflow.mxwbio.com/resources/neuron-22-vitro-neurons-learn): [Development of neural population activity toward self-organized criticality](https://webflow.mxwbio.com/resources/neuroscience-17-development-neural-population): [Analgesic effect of Botulinum toxin in neuropathic pain is sodium channel independent](https://webflow.mxwbio.com/resources/neuropharmacology-24-analgesic-effect-botulinum): [Spontaneous Dynamics Predict the Effects of Targeted Intervention in Hippocampal Neuronal Cultures](https://webflow.mxwbio.com/resources/neuroscience-25-spontaneous-dynamics-predict): [Functional Cell-Type Identification in Neuronal Networks Using High-Density Microelectrode Arrays](https://webflow.mxwbio.com/resources/neuroscience-26-functional-cell-type-identification): [Modeling interregional propagation of α-synuclein in human striatal–midbrain assembloids](https://webflow.mxwbio.com/resources/neuroscience-26-modeling-interregional-propagation): [Reinforcement learning for closed-loop optimisation of spatiotemporal stimulation in patterned neuronal networks](https://webflow.mxwbio.com/resources/neuroscience-26-reinforcement-learning-closed-loop): [Organoids Application Brochure](https://webflow.mxwbio.com/resources/organoids-application-brochure): [Nikon Application Note](https://webflow.mxwbio.com/resources/nikon-application-note): Episcopic brightfield imaging of neuronal cells on high-densitymicroelectrode arrays enables prediction of cell region through AI learning [Unifying framework for information processing in stochastically driven dynamical systems](https://webflow.mxwbio.com/resources/physical-21-unifying-framework-information): [PDMS Application Guide](https://webflow.mxwbio.com/resources/pdms-application-guide): Find important guidelines on PDMS applications and learn how to culture and record from engineered neuronal networks on MaxWell Biosystems' HD-MEA platforms. [Inhibitory neurons exhibit high controlling ability in the cortical microconnectome](https://webflow.mxwbio.com/resources/plos-21-inhibitory-neurons-exhibit): [Inhibitory neurons exhibit high controlling ability in the cortical microconnectome](https://webflow.mxwbio.com/resources/plos-21-inhibitory-neurons-exhibit-f67cb): [Ensemble learning and ground-truth validation of synaptic connectivity inferred from spike trains](https://webflow.mxwbio.com/resources/plos-24-ensemble-learning-ground-truth): [Fragile polyQ assemblies cause Golgipathy in Huntington’s disease](https://webflow.mxwbio.com/resources/pathology-24-fragile-polyq-assemblies): [Development of a network formation assay for developmental neurotoxicity hazard screening using 3D human iPSC derived BrainSpheres](https://webflow.mxwbio.com/resources/neurotoxicology-25-development-network-formation): [A synthetic mammalian electro-genetic transcription circuit](https://webflow.mxwbio.com/resources/nucleic-09-synthetic-mammalian-electro-genetic): [Theoretical analysis of neuronal network’s response under different stimulus](https://webflow.mxwbio.com/resources/plos-24-theoretical-analysis-neuronal): [RT-Sort: An action potential propagation-based algorithm for real time spike detection and sorting with millisecond latencies](https://webflow.mxwbio.com/resources/plos-24-rt-sort-action-potential): [Recording Large Extracellular Spikes in Microchannels along Many Axonal Sites from Individual Neurons](https://webflow.mxwbio.com/resources/plos-15-recording-large-extracellular): [Growing Cells Atop Microelectronic Chips: Interfacing Electrogenic Cells In Vitro With CMOS-Based Microelectrode Arrays](https://webflow.mxwbio.com/resources/proceedings-10-growing-cells-atop): [Online supervised learning of temporal patterns in biological neural networks under feedback control](https://webflow.mxwbio.com/resources/proceedings-26-online-supervised-learning): [Profiling and programming in vitro neuronal diversity at single-cell resolution](https://webflow.mxwbio.com/resources/profiling-and-programming-in-vitro-neuronal-diversity-at-single-cell-resolution): This webinar presents how combining transcription factor overexpression with developmental signaling modulation enables the generation of diverse human neuron types. It highlights large-scale single-cell transcriptomics and functional profiling approaches used to link neuronal identity with activity, connectivity, and maturation. [Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1mutations](https://webflow.mxwbio.com/resources/research-23-hyperexcitability-translational-phenotypes): [Locally embedded presages of global network bursts](https://webflow.mxwbio.com/resources/proceedings-17-locally-embedded-presages): [The potential of in vitro neuronal networks cultured on Micro Electrode Arrays for biomedical research.](https://webflow.mxwbio.com/resources/progress-23-potential-vitro-neuronal): [Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice](https://webflow.mxwbio.com/resources/plos-25-isoflurane-activates-type): [Epigenetic Reactivation of CDKL5 Rescues CDKL5 Deficiency Disorder](https://webflow.mxwbio.com/resources/research-25-epigenetic-reactivation-cdkl5): [Revolutionizing Neurodegenerative Research: Case Studies and Innovations for HD-MEA assays with Human iPSC-derived Neurons](https://webflow.mxwbio.com/resources/revolutionizing-neurodegenerative-research-case-studies-and-innovations-for-hd-mea-assays-with-human-ipsc-derived-neurons): Learn how combining MaxTwo Multi-Well High-Density MEA technology with FUJIFILM hiPSC-derived neurons enables advanced investigation of neurodegenerative disease mechanisms, including comparative analyses of Parkinson’s, ALS, and FTD models versus healthy controls. The talk also highlights how optimized HD-MEA assays detect subtle functional phenotypes to precisely characterize disease models. [A magnetically actuated microrobot for targeted neural cell delivery and selective connection of neural networks](https://webflow.mxwbio.com/resources/science-20-magnetically-actuated-microrobot): [Massively parallel microwire arrays integrated with CMOS chips for neural recording](https://webflow.mxwbio.com/resources/science-20-massively-parallel-microwire): [Prefrontal synaptic regulation of homeostatic sleep pressure revealed through synaptic chemogenetics](https://webflow.mxwbio.com/resources/science-24-prefrontal-synaptic-regulation): [A CMOS-based highly scalable flexible neural electrode interface](https://webflow.mxwbio.com/resources/science-23-cmos-based-highly-scalable): [Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons](https://webflow.mxwbio.com/resources/science-23-multiplex-epigenome-editing): [Combination of High-density Microelectrode Array and Patch Clamp Recordings to Enable Studies of Multisynaptic Integration](https://webflow.mxwbio.com/resources/scientific-17-combination-high-density-microelectrode): [Electrical Identification and Selective Microstimulation of Neuronal Compartments Based on Features of Extracellular Action Potentials](https://webflow.mxwbio.com/resources/scientific-16-electrical-identification-selective): [Tellurium nanowire retinal nanoprosthesis improves vision in models of blindness](https://webflow.mxwbio.com/resources/science-25-tellurium-nanowire-retinal): [Human neuron subtype programming via single-cell transcriptome-coupled patterning screens](https://webflow.mxwbio.com/resources/science-25-human-neuron-subtype): [Accurate signal-source localization in brain slices by means of high-density microelectrode arrays](https://webflow.mxwbio.com/resources/scientific-19-accurate-signal-source-localization): [Seeding Alzheimer’s disease-associated tau pathology in MAPT knock-in primary neurons causes early axonopathy and synaptic dysfunction](https://webflow.mxwbio.com/resources/scientific-25-seeding-alzheimers-disease-associated): [Statistics Tutorial for MaxLab Live Exported Metrics](https://webflow.mxwbio.com/resources/statistics-tutorial-maxlab-live-exported-metrics): This document provides a detailed guide for analysing exported metrics from MaxLab Live using GraphPad. [Sliced Brain Organoid Protocol](https://webflow.mxwbio.com/resources/sliced-brain-organoid-protocol): This protocol describes the preparation, slicing, and recovery of human brain organoid sections optimized for high-density electrophysiological recordings on MaxWell Biosystems platforms [A Biodegradable Magnetic Microrobot Based on Gelatin Methacrylate for Precise Delivery of Stem Cells with Mass Production Capability](https://webflow.mxwbio.com/resources/small-22-biodegradable-magnetic-microrobot): [Spike Sorting MaxLab Live Recordings and Phenotyping with SpikeInterface and DeePhys](https://webflow.mxwbio.com/resources/spike-sorting-maxlab-live-recordings-phenotyping-spikeinterface-deephys): This guide explains how to process MaxLab Live recordings to extract single-neuron activity using SpikeInterface for spike sorting and DeePhys for downstream functional analysis. [Swift induction of human spinal lower motor neurons and robust ALS cell screening via single-cell imaging](https://webflow.mxwbio.com/resources/stem-25-swift-induction-human): [Establishing mouse forebrain organoids as models of intrinsic cortical network assembly](https://webflow.mxwbio.com/resources/stem-26-establishing-mouse-forebrain): [Monolithic CMOS sensor platform featuring an array of 9’216 carbon-nanotube-sensor elements and low-noise, wide-bandwidth and wide-dynamic-range readout circuitry](https://webflow.mxwbio.com/resources/sensors-19-monolithic-cmos-sensor): [Protocol for the enhanced analysis of electrophysiological data from high-density multi-electrode arrays with nicespike and spikeNburst](https://webflow.mxwbio.com/resources/star-25-protocol-enhanced-analysis): [Generation of Human Striatal-Midbrain Assembloids From Human Pluripotent Stem Cells to Model Alpha-Synuclein Propagation](https://webflow.mxwbio.com/resources/ssrn-22-generation-human-striatal-midbrain): [DeePhys: A machine learning–assisted platform for electrophysiological phenotyping of human neuronal networks](https://webflow.mxwbio.com/resources/stem-24-deephys-machine-learningassisted): [Engineered Neural Networks for Disease Modeling and Drug Discovery](https://webflow.mxwbio.com/resources/single-cell-level-control-of-neural-networks-on-hd-meas-for-fundamental-neuroscience-and-disease-modeling): Learn how micro- and nano-channel PDMS platforms enable directional neuronal network fabrication at single-neuron resolution and support personalized disease modeling using patient-derived cells. The talk also demonstrates how biophysical modeling and information-theoretic analysis of neuronal networks on a chip reveal synaptic receptor alterations and altered information flow in glioblastoma-infiltrated networks. [Measuring Neuronal Network Activity Using Human Induced Neuronal Cells](https://webflow.mxwbio.com/resources/stem-23-measuring-neuronal-network): [Protocol for tailored in vitro neuronal networks on high-density microelectrode arrays with polydimethylsiloxane microstructures](https://webflow.mxwbio.com/resources/star-26-protocol-tailored-vitro): [Forskolin-driven conversion of human somatic cells into induced neurons through regulation of the cAMP-CREB1-JNK signaling](https://webflow.mxwbio.com/resources/theranostics-24-forskolin-driven-conversion-human): [Human Myelin Spheres for in Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling](https://webflow.mxwbio.com/resources/stem-26-human-myelin-spheres): [Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression](https://webflow.mxwbio.com/resources/tissue-08-modulation-cardiomyocyte-electrical): [Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1](https://webflow.mxwbio.com/resources/toxins-21-human-relevant-sensitivity-ipsc-derived): [Retinal organoids with X-linked retinoschisis RS1 (E72K) mutation exhibit a photoreceptor developmental delay and are rescued by gene augmentation therapy](https://webflow.mxwbio.com/resources/stem-24-retinal-organoids-x-linked): [Perforated CMOS microchip platform for immobilization and activity monitoring of electrogenic cells](https://webflow.mxwbio.com/resources/transducers-05-perforated-cmos-microchip): [CMOS monolithic microelectrode array for stimulation and recording of natural neural networks](https://webflow.mxwbio.com/resources/transducers-03-cmos-monolithic-microelectrode): [High-density mapping of brain slices using a large multi-functional high-density CMOS microelectrode array system](https://webflow.mxwbio.com/resources/transducers-17-high-density-mapping-brain): [Sustained Neurotrophic Factor Co-Treatment Enhances Donor and Host Retinal Ganglion Cell Survival in Mice](https://webflow.mxwbio.com/resources/translational-25-sustained-neurotrophic-factor): [Whole Area Plating MaxOne Chip Video Instruction](https://webflow.mxwbio.com/resources/whole-area-plating-maxone-chip-video-instruction): Just a small drop is all it takes to get the most out of your iPSC-derived neuronal cultures or primary cell cultures on MaxOne Chips. [An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour](https://webflow.mxwbio.com/resources/translational-25-orexin-sensitive-subpopulation-layer): [Large-Scale, High-Resolution Microelectrode Arrays for Interrogation of Neurons and Networks](https://webflow.mxwbio.com/resources/vitro-19-large-scale-high-resolution-microelectrode): [Reducing education inequalities through cloud-enabled live-cell biotechnology](https://webflow.mxwbio.com/resources/trends-24-reducing-education-inequalities): [Whole Area Plating MaxTwo 6-Well Plate Video Instructions](https://webflow.mxwbio.com/resources/whole-area-plating-maxtwo-6-well-plate-video-instructions): Just a small drop to get the best from your iPSC-derived neuronal cultures or primary cell cultures on MaxTwo Multiwell Plates. ## Newsletter [Latest in Disease Modeling, Neurocomputing, Global Events and More](https://webflow.mxwbio.com/newsletter/latest-in-disease-modeling-neurocomputing-global-events-and-more): Explore MaxWell Biosystems resources for HD-MEA research, including human in vitro disease models, closed-loop neurocomputing workflows, MaxLab Live cardiac analysis, automation tools, webinars, events, and recent publications. [A short 2025 Recap, Publications and Happy Holidays!](https://webflow.mxwbio.com/newsletter/mxw-bulletin-2025-3): Explore MaxWell Biosystems’ 2025 recap, featuring product launches, community highlights, collaborative projects, publications, and holiday wishes. [Automation, practical guides and upcoming events](https://webflow.mxwbio.com/newsletter/mxw-bulletin-2026-1): Discover MaxWell Biosystems’ 2026 focus on automation, practical guides, reproducible workflows, and upcoming events in disease modeling and neurocomputing.