MaxWell past webinars

Abstract

Genetic diseases of the human retina cause visual impairment to millions of people worldwide. The retina is a well characterized tissue at the back of the eye, and is a potential target for visual restoration therapies. The efficacy of these therapies can now be easily assessed using high-density microelectrode arrays (HD-MEA). In addition, HD­­-MEA technology can also be used to assess disease phenotypes, as well as other aspects of visual processing and development.

This webinar will include the following:

• Introduction to different analyses of retinal function using HD-MEAs
• Showcase of how HD-MEAs can contribute to visual restoration therapies
• Presentation of a case study involving FRMD7, a defective gene in human congenital nystagmus

Abstract

Recent developments in induced pluripotent stem cell (iPSC) technology have enabled easier access to human cells in vitro. With increasing availability of human iPSC-derived neurons, both healthy and disease cell lines, screening compounds for neurodegenerative diseases on human cells can potentially be performed in the earlier stages of drug discovery. To accelerate the functional characterization of iPSC-derived neurons and the effect of compounds, reproducible and relevant results are necessary.

In this webinar, the speakers will:

• Introduce high-resolution functional imaging of human iPSC-derived neurons
• Showcase how to extract functional features of hundreds of cells in a cell culture sample label-free
• Discuss electrophysiological parameters for characterizing the differences among several human neuronal cell lines