Publications

Publications

 


Selected Publications

Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.


All Publications

Show all

2019

Single-Cell Electrical Stimulation Using CMOS-Based High-Density Microelectrode Arrays

Ronchi, Silvia; Fiscella, Michele; Marchetti, Camilla; Viswam, Vijay; Muller, Jan; Frey, Urs; Hierlemann, Andreas

Single-Cell Electrical Stimulation Using CMOS-Based High-Density Microelectrode Arrays Journal Article

Frontiers in Neuroscience, 13 , 2019, ISSN: 1662-453X .

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Stimulation

2018

Single-neuron sub-cellular-resolution electrical stimulation with high-density microelectrode arrays

Ronchi, Silvia; Fiscella, Michele; Marchetti, Camilla; Viswam, Vijay; Müller, Jan; Frey, Urs; Hierlemann, Andreas

Single-neuron sub-cellular-resolution electrical stimulation with high-density microelectrode arrays Conference

Contribution 174.05 , Society for Neuroscience (SfN) Meeting San Diego, CA, USA, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Stimulation

Single-cell electrical stimulation with CMOS-based high-density microelectrode arrays

Ronchi, Silvia; Fiscella, Michele; Muller, Jan; Viswam, Vijay; Frey, Urs; Hierlemann, Andreas

Single-cell electrical stimulation with CMOS-based high-density microelectrode arrays Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Stimulation

Dual-mode Microelectrode Array with 20k-electrodes and High SNR for High-Throughput Extracellular Recording and Stimulation

Yuan, Xinyue; Hierlemann, Andreas; Frey, Urs

Dual-mode Microelectrode Array with 20k-electrodes and High SNR for High-Throughput Extracellular Recording and Stimulation Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Stimulation

2017

Tracking individual action potentials throughout mammalian axonal arbors

Radivojevic, Milos; Franke, Felix; Altermatt, Michael; Müller, Jan; Hierlemann, Andreas; Bakkum, Douglas J

Tracking individual action potentials throughout mammalian axonal arbors Journal Article

eLife, 6 , pp. 1-23, 2017, ISSN: 2050-084X.

Abstract | Links | BibTeX | Tags: Data Analysis, ETH-CMOS-MEA, Neuronal Networks, Stimulation

2016

Electrical Identification and Selective Microstimulation of Neuronal Compartments Based on Features of Extracellular Action Potentials

Radivojevic, Milos; Jäckel, David; Altermatt, Michael; Müller, Jan; Viswam, Vijay; Hierlemann, Andreas; Bakkum, Douglas J

Electrical Identification and Selective Microstimulation of Neuronal Compartments Based on Features of Extracellular Action Potentials Journal Article

Scientific Reports, 6 (1), pp. 1-20, 2016, ISSN: 2045-2322.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Neuronal Networks, Stimulation

2013

Sub-millisecond closed-loop feedback stimulation between arbitrary sets of individual neurons.

Müller, Jan; Bakkum, Douglas J; Hierlemann, Andreas

Sub-millisecond closed-loop feedback stimulation between arbitrary sets of individual neurons. Journal Article

Frontiers in Neural Circuits, 6 , pp. 121, 2013, ISSN: 1662-5110.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology, Neuronal Networks, Stimulation

2010

Compact voltage and current stimulation buffer for high-density microelectrode arrays

Livi, Paolo; Heer, Flavio; Frey, Urs; Bakkum, Douglas J; Hierlemann, Andreas

Compact voltage and current stimulation buffer for high-density microelectrode arrays Journal Article

IEEE Transactions on Biomedical Circuits and Systems, 4 (6), pp. 372-378, 2010, ISSN: 19324545.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology, Stimulation

2006

CMOS microelectrode array for bidirectional interaction with neuronal networks

Heer, Flavio; Hafizovic, Sadik; Franks, Wendy; Blau, Axel; Ziegler, Christiane; Hierlemann, Andreas

CMOS microelectrode array for bidirectional interaction with neuronal networks Journal Article

IEEE Journal of Solid-State Circuits, 41 (7), pp. 1620-1629, 2006, ISSN: 00189200.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology, Neuronal Networks, Stimulation

 

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