Publications

Publications

 


Selected Publications

Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.


All Publications

Show all

2019

Large-Scale Mapping of Axonal Arbors Using High-Density Microelectrode Arrays

Bullmann Torsten; Radivojevic, Milos; Huber Stefan Deligkaris Kosmas; Hierlemann Andreas; Frey Urs T:

Large-Scale Mapping of Axonal Arbors Using High-Density Microelectrode Arrays Journal Article

Frontiers in Cellular Neuroscience , 13 , 2019, ISSN: 1662-5102.

Abstract | Links | BibTeX | Tags: Axonal Arbors, HD-MEA

Classification of Inhibitory and Excitatory Neurons of Dissociated Cultures Based on Action Potential Waveforms on High-density CMOS Microelectrode Arrays

Mita, Takeshi; Bakkum, Douglas J; Frey, Urs; Hierlemann, Andreas; Kanzaki, Ryohei; Takahashi, Hirokazu

Classification of Inhibitory and Excitatory Neurons of Dissociated Cultures Based on Action Potential Waveforms on High-density CMOS Microelectrode Arrays Journal Article

IEEJ Transactions on Electronics, Information and Systems, 139 (5), pp. 615-624, 2019, ISSN: 1348-8155.

Abstract | Links | BibTeX | Tags: Action Potential, HD-MEA

Technologies to Study Action Potential Propagation With a Focus on HD-MEAs

Emmenegger, Vishalini; Obien, Marie Engelene J; Franke, Felix; Hierlemann, Andreas

Technologies to Study Action Potential Propagation With a Focus on HD-MEAs Journal Article

Frontiers in Cellular Neuroscience, 13 , pp. 1-11, 2019, ISSN: 1662-5102 .

Abstract | Links | BibTeX | Tags: Action Potential, HD-MEA

2018

Impedance Spectroscopy and Electrophysiological Imaging of Cells With a High-Density CMOS Microelectrode Array System

Viswam, Vijay; Bounik, Raziyeh; Shadmani, Amir; Dragas, Jelena; Urwyler, Cedar; Boos, Julia Alicia; Obien, Marie Engelene J; Muller, Jan; Chen, Yihui; Hierlemann, Andreas

Impedance Spectroscopy and Electrophysiological Imaging of Cells With a High-Density CMOS Microelectrode Array System Journal Article

IEEE Transactions on Biomedical Circuits and Systems, 12 (6), pp. 1356-1368, 2018, ISSN: 1932-4545.

Abstract | Links | BibTeX | Tags: HD-MEA

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelectrode array

Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelectrode array Conference

Contribution 700.13 , Society for Neuroscience (SfN) Meeting San Diego, CA, USA, 2018.

Abstract | Links | BibTeX | Tags: HD-MEA, IPSC

Mechanisms of homeostatic synaptic plasticity

Bartram, Julian; Schroter, Manuel; Ronchi, Silvia; Emmenegger, Vishalini; Muller, Jan; Hierlemann, Andreas

Mechanisms of homeostatic synaptic plasticity Conference

Contribution 037.11 , Society for Neuroscience (SfN) Meeting San Diego, CA, USA, 2018.

Abstract | Links | BibTeX | Tags: HD-MEA

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays

Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX | Tags: HD-MEA, IPSC

Electrical impedance tomography on high-density microelectrode arrays

Urwyler, Cedar; Bounik, Raziyeh; Viswam, Vijay; Hierlemann, Andreas

Electrical impedance tomography on high-density microelectrode arrays Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX | Tags: HD-MEA

Probing synaptic connectivity and function using high-density microelectrode arrays and whole-cell patch-clamp recordings

Bartram, Julian; Schroter, Manuel; Ronchi, Silvia; Emmenegger, Vishalini; Muller, Jan; Hierlemann, Andreas

Probing synaptic connectivity and function using high-density microelectrode arrays and whole-cell patch-clamp recordings Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX | Tags: HD-MEA

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays

Fiscella, Michele; Leary, Noelle; Ronchi, Silvia; Hierlemann, Andreas

Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays Conference

W-2151 , International Society for Stem Cell Research (ISSCR) Annual Meeting Melbourne, Australia, 2018.

Abstract | Links | BibTeX | Tags: HD-MEA, IPSC

2017

High-density Mapping of Brain Slices Using a Large Multi-functional High-density CMOS Microelectrode Array System

Viswam, Vijay; Bounik, Raziyeh; Shadmani, Amir; Dragas, Jelena; Obien, Marie Engelene J; Muller, Jan; Chen, Yihui; Hierlemann, Andreas

High-density Mapping of Brain Slices Using a Large Multi-functional High-density CMOS Microelectrode Array System Conference

19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS) Kaohsiung, Taiwan, 2017, ISSN: 2167-0021.

Abstract | Links | BibTeX | Tags: Brain Slice, ETH-CMOS-MEA, HD-MEA

High-resolution Functional Imaging of Cardiomyocytes Derived from Embryonic Stem Cell Spheroids

Obien, Marie Engelene J; Muller, Jan; Boos, Julia Alicia; Bounik, Raziyeh; Fiscella, Michele; Hierlemann, Andreas

High-resolution Functional Imaging of Cardiomyocytes Derived from Embryonic Stem Cell Spheroids Conference

International Society for Stem Cell Research (ISSCR) Boston, MA, USA, 2017.

Links | BibTeX | Tags: Cardiomyocytes, HD-MEA

High-resolution Microelectrode Array Platform for Biomarker Discovery and Novel Functional Assays in Human iPSC-derived Neurons

Fiscella, Michele; Muller, Jan; Hierlemann, Andreas

High-resolution Microelectrode Array Platform for Biomarker Discovery and Novel Functional Assays in Human iPSC-derived Neurons Conference

International Society for Stem Cell Research (ISSCR) Meeting Boston, MA, USA, 2017.

Links | BibTeX | Tags: HD-MEA

Technology Trends and Commercialization of High-density Microelectrode Arrays for Advanced In-vitro Electrophysiology

Frey, Urs; Obien, Marie Engelene J; Muller, Jan; Hierlemann, Andreas

Technology Trends and Commercialization of High-density Microelectrode Arrays for Advanced In-vitro Electrophysiology Conference

IEEE International Symposium on Circuits and Systems (ISCAS Baltimore, MD, USA, 2017, ISSN: 2379-447X.

Abstract | Links | BibTeX | Tags: HD-MEA, In-Vitro

 

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