Conference 2024 Presented Poster

Title

The Importance of High-Density Microelectrode Arrays for Recording Multi-Scale Extracellular Potential and Label-Free Characterization of Network Dynamics in iPSC-Derived Neurons

In this poster you can learn more about how:

• Higher spatial resolution improves neuronal culture characterization
• Small electrode size and spacing relate to higher sensitivity
• High density and small electrode size allow access to subcellular features

Abstract

iPSC-derived brain models are crucial for studying neurological disorders like epilepsy, Alzheimer’s, and Parkinson’s. Real-time, label-free measurements of electrical activity in iPSC-derived neurons reveal important insights into their functional states and neuronal networks. Microelectrode arrays (MEAs) measure electrophysiological activity, with electrode density and configuration influencing recording quality and reproducibility. In this poster, we show that electrode size plays a major role in electrophysiological data quality. Small electrodes on MaxWell Biosystems high-density-MEAs (HD-MEAs) ensure detection of even the smallest spikes and uniquely offer direct access to neurons (cellular level) and their axons (subcellular level). The AxonTracking Assay enables high-throughput characterization of disease models targeting axon initial segments, axonal branching, and axon conduction. Nevertheless, our HD-MEAs facilitate phenotypic screening, disease modeling, and expedites drug discovery using in vitro cellular models.

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