Every Cell Counts.
MxW Bulletin | Edition No. 1 | 2021

Editor's Note

Hello Everyone! 

I'm super excited to share with you something new that we are organizing... Our very first User Meeting is happening this month! I will let you read Urs' interview below to learn more about this event, but I can assure you that the fully-packed program is a must-see and must-attend. :-) 

Here are the conten
ts of this newsletter: Enjoy reading and keep in touch. 

Special Invitation

In-Vitro 2D & 3D Neuronal Networks Summit

Dr. Urs Frey
CEO of MaxWell Biosystems

Hi Urs, what is the exciting news that you would like to share with our readers today?
Hello Everyone! We are excited to announce the first In-Vitro 2D & 3D Neuronal Networks Summit (MaxWell Biosystems User Meeting) that will be held on April 22-23, 2021! While we would have loved to meet you all in person, we are happy to make use of all the exciting options an interactive online event can offer. You can connect from anywhere around the world, directly from your office, your home, your lab or wherever you may be. We worked hard to present to you a comprehen-
sive program, featuring scientific exchange and lively interactions.

Could you tell us more about the event?
It will be a two-day event (Program): the first day is open to everybody and the second day is exclusive for MaxWell users.

We are thrilled and grateful to have many great international speakers. On the first day, open for all, we feature talks from Prof. Ken Kosik (UC Santa Barbara, USA), who will present their lab's latest organoid research (pre-print bioRxiv) and Prof. Andreas Hierlemann (ETH Zürich, Switzerland), who recently published a key paper on characterizing iPSC-derived neurons (Advanced Biology publication). Furthermore, in the first session, Dr. Kenta Shimba (University of Tokyo, Japan) will be sharing their recent work on characterizing axons and Prof. Nael Nadif Kasri (Radboud University, Netherlands) will share their research on using hiPSC to unveil mechanisms underlying neurodevelopment disorders. In the second session, Martina de Gennaro (IOB, Switzerland) will present their recently published work on retinal organdies. This will be followed by Ana Rita Gomes (University of Lisbon, Portugal) who will discuss how to use forebrain organoids to model the Rett syndrome. Then, Dr. Silvia Benito-Kwiecinski (MRC Laboratory of Molecular Biology, UK) will introduce her recent publication on how timing in early brain development sets humans apart from apes. We will host two panel discussions, one focusing on functional characterization of human iPSC-derived neurons and the other on current advancements in brain organoid / spheroid research and application. 

During the invite only event on the second day, our users will be able to discuss and share their experiences using our high-density microelectrode array (HD-MEA) technology. In addition to talks by Dr. Mojtaba Bandarabadi (University of Lausanne, Switzerland) and Dr. Pierre Yger (Institute de la Vision, France), as well as panel discussions, we will host “Tips & Tricks Sessions” that all our users will benefit from, including a session on cell culture techniques on HD-MEAs and another on the MaxLab Live Software. There will also be an Open Q&A session.

This sounds really exciting! Who should attend?
Everyone interested in neuroscience, stem cell biology, bio / neuroengineering or anyone curious to learn more about HD-MEAs (technology and applications)! It is also a good chance to get to know about us and our users. Whether you are an expert in microelectrode array technology and applications, a newcomer in the field, or just wondering what the technology can be used for, there will be something for you to learn. We want to bring scientists from all over the world together and foster scientific exchange and collaboration.
Thanks a lot, Urs, for telling us more about the MaxWell User Meeting. I am sure a lot of readers would like to register now. How to register?

The entire MaxWell Biosystems Team and I are very much looking forward to e-meeting you at the event! The sessions are spread across the day in the European timezone, so that as many people from around the world can attend, or at least a part of it, live, encouraging an interactive event.

You can register by clicking the button below.
Register today!


Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays

Credits: M. Oeggerli
Advanced Biology 
Silvia Ronchi and colleagues from Prof. Andreas Hierlemann's group at the Department of Biosystems Science and Engineering, ETH Zürich recently published an article in Advanced Biology and also featured on the from cover of the journal. In this paper, the authors describe how MaxOne was used to characterize healthy and diseased iPSC-derived dopaminergic and motor neurons, including isogenic neuronal lines modeling Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS). Read more about phenotype characterization and drug testing with HD-MEAs in our blog article. 
Blog post

We already hosted three MaxWell Webinars in 2021 featuring guest speakers!

In January, Dr. Pierre Yger from Institut de la Vision spoke about fast and accurate spike sorting for thousands of channels used for any extracellular recording (in vitro and in vivo). As a follow-up in March, Dr. Alessio Buccino, Postdoctoral Fellow at ETH Zürich talked about SpikeInterface, a unified framework for spike sorting. 

In February, Ms. Martina De Gennaro, Doctoral Researcher at Institute of Molecular and Clinical Ophthalmology Basel (IOB), presented the results they published in their recent Cell paper.

You can watch the replays anytime by clicking the button below. Let us know if there are any topics that you would like to see in one of our future webinars. 
Watch replays

MxW News

We're Growing! Announcing New MxW Team Members
We are very happy to welcome new members to the MxW team! 

Tech R&D: Our R&D team continues to grow with Dr. Xinyue Yuan (lower left), who joined the team in January as our new Circuit Designer / R&D Engineer and Naomi Cantos (lower right) who started in February as R&D Associate. Both are involved in developing our current products further and innovating the future ones.

Sales and Marketing: Saki Vezzoli (upper left) and Franka Butzbach (upper right) joined us for their intership in February as Inside Sales Associate and Scientific Sales Associate, respectively, to strengthen our sales team. Maria Kampardi (upper middle) started last March as a Digital Marketing Associate and will support us in growing our online presence.
SfN Connectome 2021
We presented and exhibited at the SfN Connectome 2021 from January 11 - 13. The MaxWell team introduced two scientific posters:
  1. Axontracking assay: automatic identification and functional characterization of axons;
  2. Label-free functional characterization of human brain organoids at single-cell resolution.
Moreover, we hosted a Social in which we featured an interactive presentation to discuss how you can discover your cells' story using HD-MEA technology.

Did you miss us at this conference? We would be happy to discuss our latest scientific discoveries with you. Just book a call with us today!
iFORUM 2021

We also had the chance to be invited to give a talk at the iFORUM organized by FUJIFILM Cellular Dynamics.
This digital meeting brought together speakers from academia, government, biotech, and pharma who presented cutting-edge research. The replays are available online.

Latest Publications using MxW Technology

iPSC-derived Neurons
S. Ronchi, A. P. Buccino, G. Prack, S. S. Kumar, M. Schröter, M. Fiscella, A. Hierlemann,
"Electrophysiological Phenotype Characterization of Human iPSC‐Derived Neuronal Cell Lines by Means of High‐Density Microelectrode Arrays", Advanced Biology. 2021 (DOI: 10.1002/adbi.202000223)
Brain Organoids
T. Sharf, T. can der Molen, E. Guzman, S. M. K. Glasauer, G. Luna, Z. Cheng, M. Audouard,K. G. Ranasinghe, K. Kudo, S.S. Nagarajan, K. R. Tovar, L.R. Petzold, P.K. Hansma, K. S. Kosik
"Intrinsic Network Activity in Human Brain Organoids", bioRxiv. 2021 (DOI: 
Connectivity Algorithms
T. Kim, P. Hornauer, C. Donner, A. Hierlemann, K. Borgwardt, M. Schröter, D. Roqueiro
"Comparison of connectivity inference algorithms for classification of neuronal cultures using graph kernels", ECMLPKDD PharmML. 2020 (DOI: 
Did we miss to highlight your work? We are doing our best to monitor all publications where our technology has been used, but we may occasionally not be aware or overlook some works. Please let us know by sending an email to info@mxwbio.com so that we can feature your research in our website and newsletters. Feel free to also let us know if you will present in any upcoming conferences or events so that we can also share it in our social media and other channels. Thank you!