MaxWell Biosystems Newsletter
Every Cell Counts
MxW Bulletin | Edition No. 2 | 2022
Dear *|FNAME|*,

Yet another extraordinary year has passed! We are thankful for having the opportunity to travel again and to attend and host events, as the 2nd In-Vitro 2D & 3D Neuronal Networks Summit in Zurich, ISSCR in San Francisco, SfN in San Diego as well as the many other conferences! These events were great opportunities to connect with scientists around the world, celebrate science and also to showcase our key product highlight of the year, the AxonTracking Assay. This product allows users of our technology to resolve action potential propagation along tiny axons of many cells on the chip simultaneously.

After a year of scaling up the MxTeam, we are now excited for 2023, delivering to all of you great new features and products.

Here in our last newsletter for 2022, we are excited to share the following:

MxW Summit 2023 - SAVE THE DATE!

3rd In-Vitro 2D & 3D Neuronal Networks Summit
15 - 17 May 2023 | Zurich | In-Person

What to Expect:
  • Scientific Sessions
  • Live Showcases
  • Sessions Exclusive to Users
  • Poster Sessions
  • What’s New at MaxWell
  • Dinner & Networking
  • Social Activities
Registration Opens Wednesday 11 January 10:00 CEST
Learn More about MxW Summit 2023 | Click here

Add MxW Summit 2023 to calendar:

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Looking Back at our Recent Conferences

SfN 2022 & MxW Satellite Event  | San Diego, USA
SfN 2022 in San Diego was an inspiring conference with all the presentations and posters showcasing the latest innovations in neuroscience.

Our MxW Social Satellite Event allowed us to network, meet our customers, our partners & friends in-person after such a long time!

Japan MxW User Meeting  | University of Tokyo, Japan
In early December we hosted our Japan MxW User Meeting at the The University of Tokyo and it was wonderful to meet again in-person after three years.

We were delighted to see the great results that were shared, showcasing a wide range of applications of our technology. We hope to be back again in Japan soon!
Development & 3D Modeling of the Human Brain 2022  | Cold Spring Harbor Lab, USA
The meeting was filled with fascinating presentations, posters and lots of important networking! And it was a pleasure to see posters from our users showcasing our technology!

The MxW team was also thrilled to be hosting a demonstration live from Zurich, showcasing how to functionally characterize brain organoids long-term using HD-MEAs. It was a great way to round off the final conference of 2022!

Latest Publications

Below is a selection of the latest publications featuring MaxWell Biosystems technology:

CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons

Danny McSweeney, Rafael Gabriel, Kang Jin, Zhiping P. Pang, Bruce Aronow and ChangHui Pak

iScience, October 2022 (DOI:

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

Brett J.Kagan, Andy C. Kitchen, Nhi T. Tran,  Forough Habibollahi, Moein Khajehnejad, Bradyn J. Parker, Anjali Bhat, Ben Rollo, Adeel Razi and Karl J.Friston

Neuron, October 2022 (DOI:

Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays

Rouhollah Habibey, Johannes Striebel, Felix Schmieder, Jürgen Czarske and Volker Busskamp

Frontiers in Neuroscience, October 2022 2022 (DOI:

Tracking axon initial segment plasticity using high-density microelectrode arrays: A computational study

Sreedhar S. Kumar, Tobias Gänswein, Alessio P. Buccino, Xiaohan Xue, Julian Bartram, Vishalini Emmenegger and Andreas Hierlemann

Frontiers in Neuroinformatics, October 2022 (DOI:


Repeated and On-Demand Intracellular Recordings of Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells

Jihyun Lee, Tobias Gänswein, Hasan Ulusan, Vishalini Emmenegger, Ardan M. Saguner, Firat Duru and Andreas Hierlemann

ACS Sensors, September 2022 (DOI:

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking

Xiaohan Xue, Alessio Paolo Buccino, Sreedhar Saseendran Kumar, Andreas Hierlemann and Julian Bartram

Journal of Neural Engineering, August 2022 (DOI: )

Df(h22q11)/+ mouse model exhibits reduced binding levels of GABAA receptors and structural and functional dysregulation in the inhibitory and excitatory networks of hippocampus

Abdel-Rahman Al-Absi, Sakeerthi Kethees Thambiappa, Ahmad Raza Khan, Simon Glerup, Connie Sanchez, Anne M. Landau and Jens R. Nyengaard 

Molecular and Cellular Neuroscience, August 2022 (DOI:

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays

Alessio Paolo Buccino, Tanguy Damart, Julian Bartram, Darshan Mandge, Xiaohan Xue, Mickael Zbili, Tobias Gänswein, Aurélien Jaquier, Vishalini Emmenegger, Henry Markram, Andreas Hierlemann and Werner Van Geit

bioRxiv, August 2022 (DOI:
All Publications featuring MaxWell Biosystems | Access Here
Did we not highlight your work? We are doing our best to monitor all publications where our technology has been used, but we may occasionally not be aware or overlook some works. Please let us know by sending an email to so that we can feature your research in our website and newsletters. Feel free to also let us know if you will present in any upcoming conferences or events so that we can also share it in our social media and other channels. Thank you!

Application Note with & Charles River Laboratories

Developing next-generation in vitro phenotypic assays for Huntington’s disease by combining a precision reprogrammed hiPSC-derived disease model with high-density microelectrode arrays
This Application note resulted from a collaboration between MaxWell Biosystems, and Charles River Laboratories (CRL). In this study, CRL functionally characterised ioGlutamatergic Neurons HTT 50CAG/WT and ioGlutamatergic Neurons Huntington's disease model developed by using the MaxTwo HD-MEA system.

In this application note you can learn how using the MaxTwo HD-MEA system and MaxLab Live Software Assays, such as the AxonTracking Assay, CRL generated phenotypic data showing that's Huntington's disease model has delayed neuronal network formation, decreased axonal branching and decreased spontaneous activity compared to the isogenic control.
1 - Maturation analysis; 2 - Single-cell and network development analysis; 3 - Single-cell analysis
Application Note | Access Here

MxW Customer Testimonial with Jens Duru, ETH Zürich

Laboratory of Biosensors and Bioelectronics (LBB), ETH Zurich, Switzerland
Coordinated by Prof. Dr. Janos Vörös
Recently we visited Jens Duru at the LBB, ETH Zurich, Switzerland where we witnessed Jens in the lab using our MaxOne HD-MEA system along with our new MaxOne+ Chip. Jens is one of our first customers to try our new MaxOne+ Chip for PDMS applications which will be launched soon!
“The MaxOne Chip provides the same high electrode density as the previous MaxOne Chip. We appreciate most about the new chip that its surface is flat, which enables hassle-free adhesion of PDMS microstructures.”

Jens Duru and MaxOne HD-MEA system with MaxOne+ Chip at LBB, ETH Zurich, 2022
Jens Duru Testimonial | Access Here

MaxWell Webinar Replay

Back in October, we were very happy to bring live an engaging webinar with Daniel Sommer, from AG Catanese (Cell Biology of Neurodegenerative Diseases), hosted by Marie Obien on "Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons"
Did you miss it? Do not worry! You can still watch the replay.
Watch Webinar Replay | Click Here

AxonTracking Assay Competition

MaxWell Biosystems congratulates the winner, Dr. Maria Sundberg from Sahin lab at Boston Children's Hospital for winning the AxonTracking Assay Competition and a travel grant of 2 000 USD to attend SfN 2022.

It was a pleasure having Dr. Maria Sundberg joining us at the meeting and social events!
Axon tracking of human iPSC derived glutamatergic neurons
 Dr. Maria Sundberg, Sahin Lab at Boston Children's Hospital
Learn More about AxonTracking Assay | Click Here

MaxWell Biosystems featured in Ibidi Calendar 2023

Description | Human iPSC-derived glutamatergic neurons and astrocytes were plated as a co-culture in a drop on top of a protein-coated HD-MEA MaxOne Chip. Neuronal cells were stained against β III tubulin (red), astrocytes against S100β (green) and cell nuclei with DAPI (blue). The rectangular-shaped shadow indicates the electrode array area. Images were acquired using a confocal microscope Zeiss LSM 780 with a 5x objective.
Image by Elvira Guella and Silke Seyock, MaxWell Biosystems
Ibidi Calendar 2023 | Access Here*
*All information regarding Ibidi Photo contest can be accessed here.

Update to MaxWell Biosystems Management Team

Welcome to Kim Schwendener as Head of HR and Finance
"It was surprisingly smooth and easy for me to adapt into my new role at MaxWell and it always felt as if I have been working with the team for years. I truly believe the reason for this how welcoming and trustful the entire team is!"

Kim joined MaxWell Biosystems in July 2022 and is responsible for all HR and Finance related topics and is a member of the executive team. Kim brings in more than 17 years of experience in finance, accounting, and HR. She has a profound and comprehensive knowledge of accounting, auditing, management reporting, budgeting, process implementation, human resources, and mobility. Kim holds a BS in Primary Education from Berne University of Teacher Education and a CAS in Strategic Finance from HWZ Zurich.

News & Careers

We are Growing and still looking for new MaxWellers!

2022 was the year to scale up the MaxWell Team! We would like to welcome aboard all the new MaxWellers who join us in 2022 for dedicating all efforts to bringing the best tools for our customers to discover their cell's story! 

Would you like to join MaxWell Biosystems?

MaxWell Biosystems is expanding and we are looking for new colleagues to join us in innovating the future of electrophysiology for drug discovery and basic research.

  • R&D Engineer Intern (100%) (6 months)
  • Field Application Scientist (100%)
  • Internships

Are you motivated, innovative and committed to delivering first-rate performance? Have you ever wanted to work with cutting-edge technology involving both engineering and biology? Do you enjoy working in an international, multidisciplinary, and diverse team? Then we might have a position for you!

We have several open positions and are about to open several more. If you are interested, please check our Careers page or send your inquiry to

Join Us | Click Here
To learn more about how you can discover your cell's story using our HD-MEAs, schedule a short-intro call with us!
Thanks for catching up with us - if you want to find out the latest news and updates as they happen click the links below and follow us on Twitter and LinkedIn!