Every Cell Counts
MxW Bulletin | Edition No. 1 | 2023

It's Spring Time here in Zurich and as the flowers are blooming outside, we are also bringing some exciting news to your inbox that may be of interest to you. With a focus on the achievements of our Users, we are highlighting testimonials, recent publications, new application note with NeuCyte, and an optimized brain organoid plating protocol in this newsletter. 

The team is already traveling all around the world, so mark your calendars and meet the MxW Team at the upcoming conferences. Last but not least, since January, we've hit the ground running and are finalizing all the details for the much-anticipated 3rd In Vitro 2D & 3D Neuronal Networks Summit. This year, the MxW Summit 2023 is happening in-person in Zurich on May 15-17. Make sure you do not miss it!

Read on below: 

Thank you for being part of the MaxWell Community. We hope you will enjoy this edition. Stay in touch!                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                

     Marie and the MaxWell Biosystems Team

MxW User Testimonials

We believe the best way to showcase the potential of our products is to hear directly from our users. Read the testimonials below to see how our HD-MEA systems are driving research.
Dr. Maria Sundberg
Sahin Lab, Boston Children’s Hospital/Harvard Medical School, USA

“With MaxLab Live Software we analyze the neuronal network firing rates, network bursting phenotypes, and perform axon tracking for analyses of the neuronal branches and their functionality at single cell level.”
Danny McSweeney
Pak Lab, University of Massachusetts Amherst, USA

“The built-in analysis module was the best part of the MaxLab Live Software. The ability to easily analyze data with the MaxLab Live Software was wonderful, with suggested defaults, multiple export runs in single files and further data wrangling and graphing.” 
MxW Testimonials | Read More
MxW Summit 2023 - Register to Join Us!

3rd In-Vitro 2D & 3D Neuronal Networks Summit
15 - 17 May 2023 | Zurich | In-Person
Important Dates: 
Friday, 14 April:  Abstract Submission Deadline - Short Talk Consideration 
Monday, 17 April: Student Travel Grant Application Deadline
Sunday, 30 April: Abstract Submission Deadline - Poster Session Only
Monday, 1 May: Last day of Registration 
Learn More about the Summit and Register

Introducing the MxW Brain Organoid Protocol

Exciting news! With the experiences we gained through valuable feedback from our Users, we have recently launched the Brain Organoid Plating Protocol, now available to download on our website. 

The new protocol describes a robust and detailed workflow for reliable plating of brain organoids on our MaxOne HD-MEA chips. 

Protocol | Download Now

MxW Monthly Must-Reads | World Organoid Research Day

This month we focused our blog on the advances in organoid research for World Organoid Research Day
On March 22nd we celebrated World Organoid Research Day and the incredible advances being made in this fascinating and yet rapidly evolving field of research by raising awareness on the potential of organoids in advancing biomedical research, drug discovery, regenerative medicine, modeling complex diseases, personalized medicine, reducing animal testing, and stem cell research.
Read More

New Application Note with NeuCyte

Long-term functional characterization of SynFire® iNs and astrocytes co-cultured on MaxTwo multi-well high-density microelectrode arrays

The application note is a collaboration between NeuCyte and MaxWell Biosystems highlighting the findings from SynFire iNs cultured on MaxTwo 6-Well Plates across multiple recording over time. 

Together, the assessment of SynFire iNs on the MaxTwo Multi-Well HD-MEA System is shown to be a valuable assay for phenotypic screening, disease modeling and drug discovery.

Application Note | Learn More

Latest Publications

Below is a selection of the latest publications featuring MaxWell Biosystems technology:
Functional imaging of conduction dynamics in cortical and spinal axons

Milos Radivojevic, Anna Rostedt Punga
BioRxiv, March 2023. (DOI: https://doi.org/10.1101/2023.02.28.530461)

Dendritic spine formation and synapse maturation in transcription factor-induced human iPSC- derived neurons

Waka Lin, Shusaku Shiomoto, Saki Yamada, Hikaru Watanabe, Yudai Kawashima, Yuichi Eguchi, Koichi Muramatsu and Yuko Sekino
iScience, February 2023 (DOI: https://doi.org/10.1016/j.isci.2023.106285)

Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking

Julian Bartram, Felix Franke,Sreedhar Saseendran Kumar, Alessio Paolo Buccino, Xiaohan Xue, Tobias Gänswein, Manuel Schröter, Taehoon Kim, Krishna Chaitanya Kasuba and Andreas Hierlemann
BioRxiv, February 2023. (DOI: https://doi.org/10.1101/2023.01.06.523018)

A Neurospheroid-Based Microrobot for Targeted Neural Connections in a Hippocampal Slice

Eunhee Kim, Sungwoong Jeon, Yoon-Sil Yang, Chaewon Jin, Jin-young Kim, Yong-Seok Oh, Jong-Cheol Rah and Hongsoo Choi
Advanced Materials, January 2023 (DOI: https://doi.org/10.1002/adma.202208747)

Predicting in vitro single-neuron firing rates upon pharmacological perturbation using Graph Neural Networks

Taehoon Kim, Dexiong Chen, Philipp Hornauer, Vishalini Emmenegger, Julian Bartram, Silvia Ronchi, Andreas Hierlemann, Manuel Schröter and Damian Roqueiro
Frontiers in Neuroinformatics, January 2023
(DOI: https://doi.org/10.3389/fninf.2022.1032538)
Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks

Yuya Sato, Hideaki Yamamoto, Hideyuki Kato, Takashi Tanii, Shigeo Sato and Ayumi Hirano-Iwata
Frontiers in Neuroscience, January 2023
(DOI: https://doi.org/10.3389/fnins.2022.943310)

A functional neuron maturation device provides convenient application on microelectrode array for neural network measurement

Xiaobo Han, Naoki Matsuda, Yuto Ishibashi, Aoi Odawara, Sayuri Takahashi, Norie Tooi, Koshi Kinoshita and Ikuro Suzuki
Biomaterials Research, December 2022 (DOI: https://doi.org/10.1021/acssensors.2c01678)

Downregulation of PMP22 ameliorates myelin defects in iPSC-derived human organoid cultures of CMT1A

Jonas Van Lent, Leen Vendredy, Elias Adriaenssens,  Tatiana Da Silva Authier,  Bob Asselbergh, Marcus Kaji, Sarah Weckhuysen, Ludo Van Den Bosch, Jonathan Baets and Vincent Timmerman
Brain, December 2022 (DOI: https://doi.org/10.1093/brain/awac475 )

Generation of Human Striatal-Midbrain Assembloids From Human Pluripotent Stem Cells to Model Alpha-Synuclein Propagation

Hoang-Dai Tran, Min-Kyoung Shin, Charlotte Denman, Run-Run Han, Bernd Kuhn, Gordon Arbuthnott and Junghyun Jo
Sneak Peek - Cell Press, December 2022
(DOI: http://dx.doi.org/10.2139/ssrn.4288935)

Homophilic wiring principles underpin neuronal network topology in vitro

Danyal Akarca, Alexander W. E. Dunn, Philipp J.Hornauer, Silvia Ronchi, Michele Fiscella, Congwei Wang, Marco Terrigno, Ravi Jagasia, Petra E. Vértes, Susanna B. Mierau, Ole Paulsen, Stephen J. Eglen, Andreas Hierlemann, Duncan E. Astle and Manuel Schröter
bioRxiv, December 2022 (DOI: https://doi.org/10.1101/2022.03.09.483605

Biological Neurons vs Deep Reinforcement Learning: Sample efficiency in a simulated game-world

Habibollahi Forough, Khajehnejad Moein, Amitesh Gaurav and Brett Joseph Kagan
November 2022 

All Publications featuring MaxWell Biosystems | Access Here
Did we not highlight your work? We are doing our best to monitor all publications where our technology has been used, but we may occasionally not be aware or overlook some works. Please let us know by sending an email to info@mxwbio.com so that we can feature your research in our website and newsletters. Feel free to also let us know if you will present in any upcoming conferences or events so that we can also share it in our social media and other channels. Thank you!

Upcoming Conferences | Meet MaxWell Biosystems

Meet with us and discover how our products and applications can take your research to the next level! Our HD-MEA solutions will be showcased at these upcoming events:

•  iPSZürich 2023 | Zurich | 14 April

•  BACELL 3D | Basel | 8 - 9 May

•  MxW Summit 2023 | Zurich | 15 - 17 May

•  ISSCR 2023 | Boston | 14 - 17 June

•  MPS World Summit | Berlin | 26 - 30 June

Annual MxSnow Day | March 2023

Engelberg - Titlis, Switzerland

We recently had our annual MxSnow Day at the beautiful Engelberg-Titlis.

The MxW team escaped the fog in Zurich and arrived to sunshine and snowy mountains at the top of Titlis!

We had an action packed day of skiing, snowboarding, snowshoe-hiking, visiting the glacier cave and enjoying the cliff walk suspension bridge followed by a lively Après Ski in Engelberg to end the super day!

Join the MaxWell Biosystems Team

Could you be our next MaxWeller? Take a look at our open positions:

Highighted Positions

Sales Operations Project Manager

•  Evaluate and drive our sales data management and analytics and improvements to our CRM database

•  Optimize our sales processes, establish automation tools, and provide pipeline reports
•  Identify and implement operational improvements in our sales process

Apply Now
Field Application Scientist 

•  Identify, approach and communicate with potential customers; perform product presentations and demos
•  Identify, advance, and close business opportunities and manage sales contracts and customer contacts
• Represent MxW at conferences and trade shows

Apply Now
R&D Application Engineer 
• Lead electrode optimization and functionalization R&D projects
•  Contribute to other R&D projects, such as device characterization, test setups, etc
•  Optimise and prepare products for manufacturability
•  R&D support for production team and t
echnical customer support
Scientific Communications Specialist
•  Write compelling messages, generate materials for internal stakeholders and global audience
• Content ideation, creation, dissemination and updates of all publications across media channels
• Proofread all external communications and publications

Apply Now

MaxWell Biosystems is expanding and we are looking for new colleagues to join us in innovating the future of electrophysiology for drug discovery and basic research.

We have several open positions and are about to open several more. If you are interested, please check our Careers page or send your inquiry to hr@mxwbio.com.
Join Us | Find Out More

Do you want to learn more about our HD-MEA Technology?

You can discover your cell's story using our HD-MEAs, schedule a short-intro call with us!
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