Profiling and programming in vitro neuronal diversity at single-cell resolution

The webinar covered

• How combining transcription factors overexpression with developmental signaling modulation enables the generation of diverse human neuron types.
• Findings from a comprehensive screen of 480 patterning conditions using single-cell transcriptomics on 700,000 cells.
• Functional profiling of neurons using MaxWell Biosystems’ MaxTwo HD-MEA platform to capture activity, connectivity, and morphological diversity across different patterning conditions.
• The relationship between transcriptomic signatures and neuronal structure, revealing mechanisms of maturation and identity formation.