MaxTwo

MaxTwo Multi-Well High-Density Microelectrode Arrays (HD-MEAs) represent a next-generation electrophysiology platform for higher-throughput applications. The system enables precise recording and stimulation of electrogenic cells across multiple wells, combining single-cell sensitivity with scalable experimental capacity. MaxTwo captures electrical activity from individual cells and complex networks with high precision, allowing scientists to detect even the smallest action potentials. This accelerates data collection and deepens insight into cellular function.

Scale-up your experiments

Discover the full potential of HD-MEAs at throughput: scalable, precise, and designed for automation.

Consistent high resolution in every well

Increase throughput without compromising data quality. Each well features 26,400 electrodes at a density of 3,265 electrodes/mm², maintaining single-cell and subcellular resolution across the entire plate.

Automation-tested platform

Engineered for compatibility with standard laboratory automation tools. MaxTwo is designed for seamless integration with liquid handlers, plate movers, and robotic systems, enabling plug-and-play operation for automated workflows.

Efficient large-scale data handling

Manage high volumes of recordings with ease. Batch processing and report generation streamline analysis across multiple wells and experiments, accelerating insight and decision-making.

Fully integrated perfusion system

Control experimental conditions across all wells with the first fully integrated perfusion system in a MEA multi-well platform. Maintain sample viability with minimal noise while recording from all wells in parallel.

Unlock the full potential of your sample

Confirm what you expected and reveal what was never visible before through high sensitivity, targeted stimulation, and novel phenotypic readouts.

High sensitivity for subtle signals

Trust every data point with MaxTwo’s low noise (in the microvolt range) and precise time resolution (in microseconds). Discover subtle phenotypes, even from the tiniest action potentials, that may otherwise go undetected.

Novel phenotypic readouts at scale

Track axons non-invasively, for the first time at throughput, across hundreds of neurons. MaxTwo enables long-term, label free recording and analysis to reveal functional phenotypes and developmental changes over time.

Targeted electrical stimulation

Access advanced stimulation capabilities to investigate functional connectivity and hidden network dynamics. Precise electrode targeting allows for reproducible stimulation of your sample.

Reproducibility and trust in every well

Guarantee unmatched reproducibility, meaningful results, and experimental stability, all supported by a high-quality, precision-engineered platform.

Always at the right spot

Ensure optimal recording and extract high-quality, relevant data from every well. Each MaxTwo well includes 26,400 high-resolution electrodes with a fine pitch, with flexible selection to precisely target the cells within the neuronal network.

Optimized protocols for consistency

Follow optimized and validated plating protocols for your applications, ensuring efficiency and reliable results.

Quality-assured multi-well plates

Rely on MaxTwo Well Plates manufactured to the highest standards and tested to ensure reliable performance, biocompatibility, and consistency across all wells.

Stable across multiple measurements

Temperature regulation and controlled CO₂ input maintain consistent culture conditions across sessions, ensuring reliable signal acquisition over multiple recordings. This supports reproducible results in longitudinal studies with repeated measurements.

Technical 

Specifications

One-button Interface
Open/close the cover
Turn on/off the system
Lock the well plate
System Status Indicator
LED
Dimension (L x W x H)
40x16x12 cm3
Well-Plate Compatibility
6- and 24-Well Plate
Temperature Control
Yes
CO2 control
Yes, via gas mixer

MaxTwo Well Plates

MaxTwo Well Plates enable high-resolution imaging of different types of cell electrical activities of multiple samples in parallel, from network to subcellular levels.

Plate
Specifications

Features
6-Well Plate
24-Well Plate
Well-Plate dimension (L x W x H)
127.8 x 85.8 x 16.1 mm3
127.8 x 85.8 x 16.1 mm3
Number of wells
6
24
Well (inner) diameter
29.0 mm
15.3 mm
Active sensing area
3.85 x 2.10 mm2
3.85 x 2.10 mm2
Total number of electrodes
6 x 26ʼ400
24 x 26ʼ400
Electrode density
3’265 electrodes/mm2
3’265 electrodes/mm2
Electrode center-to-center distance
17.5 µm
17.5 µm
Electrode size
12.0 x 8.8 µm2
11.5 x 11.5 µm2
Electrode material
Platinum Black
Platinum
Surface topography
<2.0 µm
<0.3 µm
Sampling rate
10.0 kHz/channel
10.0 kHz/channel
Number of recording channels
1ʼ020/well
1ʼ020/well
Typical noise per well
3.6 µVrms
3.8 µVrms
Electrical stimulation
Yes
No
Simultaneous recordings
All 6 wells in parallel
6 wells in parallel, row by row
Electronic ID
No
Yes
Sterilization treatment
No
EtO treatment according to EN ISO 11737-2

MaxTwo Accessories

MaxTwo
Perfusion System
Discover the groundbreaking MaxTwo Perfusion System, the first fully integrated multi-well MEA perfusion system on the market. The MaxTwo Perfusion System enables continuous, parallel perfusion across all wells, maintaining a stable environment for the sample throughout the entire experiment. With consistent medium flow, this system supports acute sample viability and high-quality recordings across every well.

MaxTwo Perfusion
System Features

Dimension (LxWxH)
63 x 39 x 25 cm3
Well plate compatibility
6-Well Plate
Perfusion rate
0.04 - 3.00 mL/min
Medium temperature
Room temperature - 60 °C
Medium volume
500 mL with bottle heater
100 mL - 10 L with in-line heater
Autoclavable components
Cartidges, tubings
Do you want to learn more?

Book a one-to-one call with one of our experts to discuss how MaxWell Biosystems HD-MEA platforms can empower your research!

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