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Nature Neuroscience
|
2026
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Axonal Eif5a hypusination controls local translation and mitigates defects in FUS-ALS

Diana Piol, Bilal Khalil, Tessa Robberechts, Theo Killian, Maria Georgopoulou, Gabriele Partel, David Wouters, Nikolai Hecker, Paraskevi Tziortzouda, Yana Verresen, Nikky Corthout, Sam Kint, Katy Vandereyken, Philip Van Damme, Thierry Voet, Kristofer Davie, Suresh Poovathingal, Ludo Van Den Bosch, Stein Aerts, Alejandro Sifrim, Sandrine Da Cruz
Journal Article
Disease Modeling
Neuronal Cell Cultures
MaxLab Live
MaxTwo
Journal of Neurophysiology
|
2025
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Microscale maps of bursting dynamics across human hippocampal slices from epilepsy patients

Matthew A.T. Elliott, John P. Andrews, Tjitse van der Molen, Jinghui Geng, Alex Spaeth, Anna Toledo, Kateryna Voitiuk, Cordero Core, Thomas Gillespie, Ari Sinervo, David F. Parks, Ash Robbins, Daniel Solís, Edward F. Chang, Tomasz Jan Nowakowski, Mircea Teodorescu, David Haussler, Tal Sharf
Journal Article
Disease Modeling
Functional Phenotyping
Brain Slices
MaxLab Live
MaxOne
Journal of Advanced Research
|
2025
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Butylphthalide enhances neurorestoration following ischemic stroke by restructuring microvasculature through vimentin modulation

Haiyan Xiao, Haochen Xie, Meng Qin, Chenwei Zuo, Ruimao Zheng, Shaochan Zhang, Shiyi Sun, Jingxue Ye, Min Wang, Yu Tian, Li Cao, Guibo Sun
Journal Article
Disease Modeling
Neuronal Cell Cultures
MaxLab Live
MaxOne
Biophysical Journal
|
2025
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Dynamics of excitability in axonal trees

Laurie D. Cohen, Tamar Galateanu, Shimon Marom
Journal Article
Functional Phenotyping
MaxLab Live
MaxOne
Nature Neuroscience
|
2025
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Preconfigured neuronal firing sequences in human brain organoids

Tjitse van der Molen, Alex Spaeth, Mattia Chini, Sebastian Hernandez, Gregory A. Kaurala, Hunter E. Schweiger, Cole Duncan, Sawyer McKenna, Jinghui Geng, Max Lim, Julian Bartram, Tobias Gänswein, Aditya Dendukuri, Zongren Zhang, Jesus Gonzalez-Ferrer, Kiran Bhaskaran-Nair, Aidan L. Morson, Cole R. K. Harder, Linda R. Petzold, Dowlette-Mary Alam El Din, Jason Laird, Maren Schenke, Lena Smirnova, Bradley M. Colquitt, Mohammed A. Mostajo-Radji, Paul K. Hansma, Mircea Teodorescu, Andreas Hierlemann, Keith B. Hengen, Ileana L. Hanganu-Opatz, Kenneth S. Kosik, Tal Sharf
Journal Article
Functional Phenotyping
Neuronal Cell Cultures
Organoids
Brain Slices
MaxOne
MaxTwo
bioRxiv
|
2025
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MyeliMAP: Studying Oligodendrocyte Function in Brain Networks

Karan Ahuja, Blandine F. Clément, Giulia Amos, Joël Küchler, Keimpe Wierda, Yoke Chin Chai, Lieve Moons, Catherine Verfaillie
Preprint
Method Development
Microphysiological Systems
MaxOne
bioRxiv
|
2025
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Ephaptic-Axonal Interactions Shape Radial Biases During Neural Self-Organization

Daniel Rebbin, Casper Hesp, Dimitris Pinotsis, Michael Levin, Wesley Clawson
Preprint
Functional Phenotyping
Neuronal Cell Cultures
MaxLab Live
MaxTwo
bioRxiv
|
2025
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Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs

Kriti Chaplot, Lin Zhang, Julia Wessman, Miguel Rivera, Zhihui Wang, Fei Wang, Xin Duan, Pamela M. England, Iain C. Clark, Erik M. Ullian
Preprint
Disease Modeling
Functional Phenotyping
Organoids
MaxLab Live
MaxOne
Scientific Reports
|
2025
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Seeding Alzheimer’s disease-associated tau pathology in MAPT knock-in primary neurons causes early axonopathy and synaptic dysfunction

Rebecca L. Mueller, Benjamin Combs, Nicholas M. Kanaan
Journal Article
Disease Modeling
Neuronal Cell Cultures
MaxLab Live
MaxOne
Biomaterials
|
2025
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Development of an innervated human skin equivalent to model nociceptive circuitry in vitro

Daniele Bellantoni, Costantino Casale, Claudia Mazio, Francesco Urciuolo, Giorgia Imparato, Paolo Antonio Netti
Journal Article
Disease Modeling
Functional Phenotyping
Method Development
Pharmacology & Toxicology
Neuronal Cell Cultures
MaxLab Live
MaxOne
bioRxiv
|
2025
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A toolbox for navigating and analyzing the spatiotemporal properties of retinal waves

Kaylee M. Yeager, Rishikesh K. Gupta, Elysia A. Gauthier, Alexander J. Fisch, Natalie A. Clark, Fernanda S. Orsi, Alexandre Tiriac
Preprint
Functional Phenotyping
Method Development
Retina
MaxOne
Frontiers in Neural Circuits
|
2025
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Emergent functions of noise-driven spontaneous activity: homeostatic maintenance of criticality and memory consolidation

Narumitsu Ikeda, Dai Akita, Hirokazu Takahashi
Journal Article
Neurocomputing
Neuronal Cell Cultures
MaxOne
NeuroToxicology
|
2025
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Development of a network formation assay for developmental neurotoxicity hazard screening using 3D human iPSC derived BrainSpheres

SL Boyd, M. Mayil Vahanan, J. Monroe, JA Conley, KE Carstens, TJ Shafer
Journal Article
Functional Phenotyping
Method Development
Pharmacology & Toxicology
Organoids
MaxLab Live
MaxTwo
arXiv
|
2025
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Bridging integrated information theory and the free-energy principle in living neuronal networks

Teruki Mayama, Sota Shimizu, Yuki Takano, Dai Akita, Hirokazu Takahashi
Preprint
Neuronal Cell Cultures
MaxOne
Frontiers in Cellular Neuroscience
|
2025
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Microglia-containing neural organoids as brain microphysiological systems for long-term culture

Alex Rittenhouse, Caroline Krall, Jesse Plotkin, Lena Smirnova
Journal Article
Functional Phenotyping
Organoids
MaxLab Live
MaxTwo
Neurobiology of Disease
|
2025
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Human iPSC-derived glutamatergic neurons with pathogenic KCNQ2 variants display hyperactive bursting phenotypes

Maria Sundberg, Carole Shum, Erika M. Norabuena, Nina R. Makhortova, Cidi Chen, Lucy Yu, Emma V. Wightman, Kristina Kim, Sang Yeon Han, Jennifer Howe, Annapurna Poduri, Elizabeth D. Buttermore, Stephen W. Scherer, Mustafa Sahin
Journal Article
Disease Modeling
Neuronal Cell Cultures
MaxLab Live
MaxTwo
Translational Vision Science & Technology
|
2025
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Sustained Neurotrophic Factor Co-Treatment Enhances Donor and Host Retinal Ganglion Cell Survival in Mice

Jonathan R. Soucy, Julia Oswald, Emil Kriukov, Monichan Phay, John Masland, Christian Pernstich, Petr Baranov
Journal Article
Functional Phenotyping
Retina
MaxLab Live
MaxOne
Brain
|
2025
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A human striatal-midbrain assembloid model of alpha-synuclein propagation

Hoang-Dai Tran, Min-Kyoung Shin, Xin Yi Yeo, Sangyong Jung, Muhammad Junaid, Su Bin Lim, Jungmo Kim, Hyun Goo Woo, Charlotte R Denman, Run-Run Han
Journal Article
Disease Modeling
Organoids
MaxLab Live
MaxOne
Frontiers in Neural Circuits
|
2025
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Deviance detection and regularity sensitivity in dissociated neuronal cultures

Zhuo Zhang, Amit Yaron, Dai Akita, Tomoyo Isoguchi Shiramatsu, Zenas C. Chao, Hirokazu Takahashi
Journal Article
Functional Phenotyping
Pharmacology & Toxicology
Neuronal Cell Cultures
MaxOne
Communications Biology
|
2025
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Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory

Dowlette-Mary Alam El Din, Leah Moenkemoeller, Alon Loeffler, Forough Habibollahi, Jack Schenkman, Amitav Mitra, Tjitse van der Molen, Lixuan Ding, Jason Laird, Maren Schenke, Erik C. Johnson, Brett J. Kagan, Thomas Hartung, Lena Smirnova
Journal Article
Functional Phenotyping
MaxLab Live
MaxTwo
Research Square
|
2025
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Epigenetic Reactivation of CDKL5 Rescues CDKL5 Deficiency Disorder

Kyle Fink, Julian Halmai, David Cameron, Casiana Gonzalez, Mandeep Singh, Anber Ansari, Viktoria Haghani, Emma Monsen, Alyssa Paynton-Cheney, Jennifer Waldo, Timothy Fenton, Roy Ben-Shalom, Jill Silverman
Preprint
Disease Modeling
Pharmacology & Toxicology
Organoids
MaxLab Live
MaxOne
bioRxiv
|
2025
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Online supervised learning of temporal patterns in biological neural networks under feedback control

Yuki Sono, Hideaki Yamamoto, Yusei Nishi, Takuma Sumi, Yuya Sato, Ayumi Hirano-Iwata, Yuichi Katori, Shigeo Sato
Preprint
Microphysiological Systems
Neurocomputing
Neuronal Cell Cultures
MaxOne
Cyborg and Bionic Systems (Washington, D.C.)
|
2025
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Dynamic Network Plasticity and Sample Efficiency in Biological Neural Cultures: A Comparative Study with Deep Reinforcement Learning

Moein Khajehnejad, Forough Habibollahi, Alon Loeffler, Aswin Paul, Adeel Razi, Brett J. Kagan
Journal Article
Neurocomputing
Neuronal Cell Cultures
MaxOne
Advanced Therapeutics
|
2025
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Topology and Mechanism of Broadband and Fast Multi‐Characteristic Opsin for Neuromodulation

Samarendra Mohanty, Pratyajit Mohapatra, Amir Singh, William Marks, Subrata Batabyal, Michael Carlson, Najam Sharif, Sanghoon Kim
Journal Article
Functional Phenotyping
Retina
MaxLab Live
MaxOne
Biosensors and Bioelectronics
|
2025
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An in vitro platform for characterizing axonal electrophysiology of individual human iPSC-derived nociceptors

Blandine F. Clément, Lorenzo Petrella, Lea Wallimann, Jens Duru, Christina M. Tringides, János Vörös, Tobias Ruff
Journal Article
Functional Phenotyping
Method Development
Microphysiological Systems
Pharmacology & Toxicology
Organoids
MaxOne
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