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STAR Protocols
|
2026
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Protocol for tailored in vitro neuronal networks on high-density microelectrode arrays with polydimethylsiloxane microstructures

Anna-Christina Haeb, Hideaki Yamamoto, Paul Roach, Daniel Merryweather, Yuya Sato, Daniel Tornero, Jordi Soriano
Journal Article
Method Development
Microphysiological Systems
Neuronal Cell Cultures
MaxLab Live
MaxOne
Brain Research
|
2026
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Elevated FKBP5 expression associates with epilepsy-related molecular changes and promotes neuronal hyperexcitability

Meng Cai, Shuyang Wang, Mingsu Liu, Bin Lai, Chen Chen, Jing Ding, Xin Wang
Journal Article
Disease Modeling
Neuronal Cell Cultures
MaxLab Live
MaxOne
Stem Cell Reviews and Reports
|
2026
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Human Myelin Spheres for in Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling

Karan Ahuja, Roya Ramezankhani, Xinyu Wang, Thibaut Burg, Giulia Amos, Katrien Neyrinck, Alessio Silva, Geethika Arekatla, Eleanor Eva Cassidy, Fatemeharefeh Nami, Joke Terryn, Keimpe Wierda, Katlijn Vints, Niels Vandamme, Suresh Poovathingal, Ivo Lambrichts, Johannes V. Swinnen, Ludo Van Den Bosch, Lies De Groef, Lieve Moons, Catherine Verfaillie, Johan Neyts, Dirk Jochmans, Yoke Chin Chai
Journal Article
Functional Phenotyping
Organoids
MaxLab Live
MaxTwo
bioRxiv
|
2026
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A fast and simple algorithm for accurate spike detection in HD-MEA recordings

Juan A. Zegers Delgado, Nathaniel Renegar, Kasun Pathirage, Timothy K. Horiuchi, Pamela A. Abshire, Ricardo C. Araneda
Preprint
Method Development
Neuronal Cell Cultures
MaxLab Live
MaxOne
bioRxiv
|
2026
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Capturing self-renewing multipotent neural crest stem cells from human pluripotent stem cells

Yayoi Toyooka, Nami Kawaraichi, Daisuke Kamiya, Teruyoshi Yamashita, Yusaku Komoike, Kimiko Fukuda, Teppei Akaboshi, Hirokazu Matsumoto, Makoto Ikeya
Preprint
Functional Phenotyping
MaxLab Live
MaxTwo
bioRxiv
|
2026
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A three-compartment microfluidic platform for investigating signal transmission in the human sensory pathway†

Blandine F. Clément, Trui Osselaer, Claire Zhang, Giacomo Paccagnan, Tobias Ruff, János Vörös
Preprint
Method Development
Microphysiological Systems
Organoids
MaxOne
Lab on a Chip
|
2026
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MyeliMAP: a microfluidic-multielectrode array hybrid platform to investigate oligodendrocyte function in human iPSC derived brain-like networks

Karan Ahuja, Blandine F. Clément, Giulia Amos, Joël Küchler, Keimpe Wierda, Yoke Chin Chai, Lieve Moons, Catherine Verfaillie
Journal Article
Microphysiological Systems
Neuronal Cell Cultures
MaxOne
Cells
|
2026
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Network Hypoactivity in ALG13-CDG: Disrupted Developmental Pathways and E/I Imbalance as Early Drivers of Neurological Features in CDG

Rameen Shah, Rohit Budhhraja, Silvia Radenkovic, Graeme Preston, Alexia Tyler King, Sahar Sabry, Charlotte Bleukx, Ibrahim Shammas, Lyndsay Young, Jisha Chandran, Seul Kee Byeon, Ronald Hrstka, Doughlas Y. Smith, Nathan P. Staff, Richard Drake, Steven A. Sloan, Akhilesh Pandey, Eva Morava, Tamas Kozicz
Journal Article
Disease Modeling
MaxLab Live
MaxTwo
Nature Neuroscience
|
2026
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Axonal Eif5a hypusination controls local translation and mitigates defects in FUS-ALS

Diana Piol, Bilal Khalil, Tessa Robberechts, Theo Killian, Maria Georgopoulou, Gabriele Partel, David Wouters, Nikolai Hecker, Paraskevi Tziortzouda, Yana Verresen, Nikky Corthout, Sam Kint, Katy Vandereyken, Philip Van Damme, Thierry Voet, Kristofer Davie, Suresh Poovathingal, Ludo Van Den Bosch, Stein Aerts, Alejandro Sifrim, Sandrine Da Cruz
Journal Article
Disease Modeling
Neuronal Cell Cultures
MaxLab Live
MaxTwo
Journal of Neurophysiology
|
2025
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Microscale maps of bursting dynamics across human hippocampal slices from epilepsy patients

Matthew A.T. Elliott, John P. Andrews, Tjitse van der Molen, Jinghui Geng, Alex Spaeth, Anna Toledo, Kateryna Voitiuk, Cordero Core, Thomas Gillespie, Ari Sinervo, David F. Parks, Ash Robbins, Daniel Solís, Edward F. Chang, Tomasz Jan Nowakowski, Mircea Teodorescu, David Haussler, Tal Sharf
Journal Article
Disease Modeling
Functional Phenotyping
Brain Slices
MaxLab Live
MaxOne
Journal of Advanced Research
|
2025
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Butylphthalide enhances neurorestoration following ischemic stroke by restructuring microvasculature through vimentin modulation

Haiyan Xiao, Haochen Xie, Meng Qin, Chenwei Zuo, Ruimao Zheng, Shaochan Zhang, Shiyi Sun, Jingxue Ye, Min Wang, Yu Tian, Li Cao, Guibo Sun
Journal Article
Disease Modeling
Neuronal Cell Cultures
MaxLab Live
MaxOne
Biophysical Journal
|
2025
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Dynamics of excitability in axonal trees

Laurie D. Cohen, Tamar Galateanu, Shimon Marom
Journal Article
Functional Phenotyping
MaxLab Live
MaxOne
Nature Neuroscience
|
2025
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Preconfigured neuronal firing sequences in human brain organoids

Tjitse van der Molen, Alex Spaeth, Mattia Chini, Sebastian Hernandez, Gregory A. Kaurala, Hunter E. Schweiger, Cole Duncan, Sawyer McKenna, Jinghui Geng, Max Lim, Julian Bartram, Tobias Gänswein, Aditya Dendukuri, Zongren Zhang, Jesus Gonzalez-Ferrer, Kiran Bhaskaran-Nair, Aidan L. Morson, Cole R. K. Harder, Linda R. Petzold, Dowlette-Mary Alam El Din, Jason Laird, Maren Schenke, Lena Smirnova, Bradley M. Colquitt, Mohammed A. Mostajo-Radji, Paul K. Hansma, Mircea Teodorescu, Andreas Hierlemann, Keith B. Hengen, Ileana L. Hanganu-Opatz, Kenneth S. Kosik, Tal Sharf
Journal Article
Functional Phenotyping
Neuronal Cell Cultures
Organoids
Brain Slices
MaxOne
MaxTwo
bioRxiv
|
2025
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Ephaptic-Axonal Interactions Shape Radial Biases During Neural Self-Organization

Daniel Rebbin, Casper Hesp, Dimitris Pinotsis, Michael Levin, Wesley Clawson
Preprint
Functional Phenotyping
Neuronal Cell Cultures
MaxLab Live
MaxTwo
bioRxiv
|
2025
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Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs

Kriti Chaplot, Lin Zhang, Julia Wessman, Miguel Rivera, Zhihui Wang, Fei Wang, Xin Duan, Pamela M. England, Iain C. Clark, Erik M. Ullian
Preprint
Disease Modeling
Functional Phenotyping
Organoids
MaxLab Live
MaxOne
Scientific Reports
|
2025
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Seeding Alzheimer’s disease-associated tau pathology in MAPT knock-in primary neurons causes early axonopathy and synaptic dysfunction

Rebecca L. Mueller, Benjamin Combs, Nicholas M. Kanaan
Journal Article
Disease Modeling
Neuronal Cell Cultures
MaxLab Live
MaxOne
Biomaterials
|
2025
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Development of an innervated human skin equivalent to model nociceptive circuitry in vitro

Daniele Bellantoni, Costantino Casale, Claudia Mazio, Francesco Urciuolo, Giorgia Imparato, Paolo Antonio Netti
Journal Article
Disease Modeling
Functional Phenotyping
Method Development
Pharmacology & Toxicology
Neuronal Cell Cultures
MaxLab Live
MaxOne
bioRxiv
|
2025
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Novel Gain of Function Mouse Model of KCNT1-Related Epilepsy

Sarah L. Olguin, Daniel Davis, Ammara Rehman, Sean W. Berg, Elizabeth Sahagun, Payton S. Oswalt, Mandar Patil, Paula D. M. Sullivan, Bing Zhang, Elizabeth C. Bryda, Roy Ben-Shalom, Jill L. Silverman
Preprint
Disease Modeling
Neuronal Cell Cultures
MaxLab Live
MaxTwo
bioRxiv
|
2025
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Distributional invariance and proportional scaling in axonal conduction

Laurie D. Cohen, Shimon Marom
Preprint
Functional Phenotyping
Neuronal Cell Cultures
MaxLab Live
MaxOne
bioRxiv
|
2025
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A toolbox for navigating and analyzing the spatiotemporal properties of retinal waves

Kaylee M. Yeager, Rishikesh K. Gupta, Elysia A. Gauthier, Alexander J. Fisch, Natalie A. Clark, Fernanda S. Orsi, Alexandre Tiriac
Preprint
Functional Phenotyping
Method Development
Retina
MaxOne
Frontiers in Neural Circuits
|
2025
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Emergent functions of noise-driven spontaneous activity: homeostatic maintenance of criticality and memory consolidation

Narumitsu Ikeda, Dai Akita, Hirokazu Takahashi
Journal Article
Neuronal Cell Cultures
MaxOne
NeuroToxicology
|
2025
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Development of a network formation assay for developmental neurotoxicity hazard screening using 3D human iPSC derived BrainSpheres

SL Boyd, M. Mayil Vahanan, J. Monroe, JA Conley, KE Carstens, TJ Shafer
Journal Article
Functional Phenotyping
Method Development
Pharmacology & Toxicology
Organoids
MaxLab Live
MaxTwo
arXiv
|
2025
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Bridging integrated information theory and the free-energy principle in living neuronal networks

Teruki Mayama, Sota Shimizu, Yuki Takano, Dai Akita, Hirokazu Takahashi
Preprint
Neuronal Cell Cultures
MaxOne
Frontiers in Cellular Neuroscience
|
2025
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Microglia-containing neural organoids as brain microphysiological systems for long-term culture

Alex Rittenhouse, Caroline Krall, Jesse Plotkin, Lena Smirnova
Journal Article
Functional Phenotyping
Organoids
MaxLab Live
MaxTwo
arXiv
|
2025
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Emergence of Deviance Detection in Cortical Cultures through Maturation, Criticality, and Early Experience

Zhuo Zhang, Amit Yaron, Dai Akita, Tomoyo Isoguchi Shiramatsu, Zenas C. Chao, Hirokazu Takahashi
Preprint
Neuronal Cell Cultures
MaxLab Live
MaxOne
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