Human iPSC-derived glutamatergic neurons with pathogenic KCNQ2 variants display hyperactive bursting phenotypes
Maria Sundberg, Carole Shum, Erika M. Norabuena, Nina R. Makhortova, Cidi Chen, Lucy Yu, Emma V. Wightman, Kristina Kim, Sang Yeon Han, Jennifer Howe, Annapurna Poduri, Elizabeth D. Buttermore, Stephen W. Scherer, Mustafa Sahin
Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability
Sara Nolbrant, Jenelle L. Wallace, Jingwen W. Ding, Tianjia Zhu, Jess L. Sevetson, Janko Kajtez, Isabella A. Baldacci, Emily K. Corrigan, Kaylynn Hoglin, Reed McMullen, Megan S. Ostrowski, Matthew T. Schmitz, Arnar Breevoort, Dani Swope, Fengxia Wu, Bryan J. Pavlovic, Sofie R. Salama, Agnete Kirkeby, Hao Huang, Nathan K. Schaefer, Alex A. Pollen
Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory
Dowlette-Mary Alam El Din, Leah Moenkemoeller, Alon Loeffler, Forough Habibollahi, Jack Schenkman, Amitav Mitra, Tjitse van der Molen, Lixuan Ding, Jason Laird, Maren Schenke, Erik C. Johnson, Brett J. Kagan, Thomas Hartung, Lena Smirnova
HydroMEA: A 3D Hydrogel Based Microfluidic Device to Study Electrophysiology for Myelinated Nerve-on-Chip
Blandine F. Clément, Cédric Pfister, Timothy Kurer, Céline Labouesse, Dhanajay V. Deshmukh, Julian Hengsteler, Julia Lehmann, Lorenza G. Paganella, Tobias Ruff, Vilius Dranseika, Sean Weaver, Lukas Sommer, Mark W. Tibbitt, János Vörös, Christina M. Tringides
Triple-Negative Breast Cancer Cells Activate Sensory Neurons via TRPV1 to Drive Nerve Outgrowth and Tumor Progression
Hanan Bloomer, Savannah R. Parker, Audrey L. Pierce, Wesley Clawson, Mallory M. Caron, Thomas Gerton, Ankit Pandey, Thanh T. Le, Tolulope Adewumi, Charlotte Kuperwasser, Michael Levin, Madeleine J. Oudin
KCNQ2 Loss-of-Function variants disrupt neuronal maturation via early hyperexcitability followed by maladaptive network remodeling
N. Dirkx, M. Kaji, E. De Vriendt, G. Carleo, F. Miceli, B. Asselbergh, P. Verstraelen, N. Zonnekein, L. Carotenuto, L. T. Dang, V. Sommers, E. Vlaemynck, L. Lagae, B. Ceulemans, P. De Jonghe, W. H. De Vos, M. Taglialatela, S. Weckhuysen
The fast-dissociating D2 antagonist antipsychotic JNJ-37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment
Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Rita Citraro, Giovambattista De Sarro, Nina Dirkx, Marcus Kaji, Sarah Weckhuysen, Jeanette Reinshagen, Vincenzo Barrese, Natascia Guida, Carmine Ostacolo, Francesco Miceli, Philip Gribbon, Maurizio Taglialatela
Distinct Synaptic Mechanisms Drive NRXN1 Variant-Mediated Pathogenesis in iPSC-Derived Neuronal Models of Autism and Schizophrenia
Jay English, Danny McSweeney, Jinghui Geng, Ethan Howell, Fumiko Ribbe, Matthew Hinderhofer, Lydia Proskauer, Rebecca Sebastian, Le Wang, Tal Sharf, Zhiping P. Pang, ChangHui Pak
Synchronization of visual perception within the human fovea
Annalisa Bucci, Marc Büttner, Niklas Domdei, Federica B. Rosselli, Matej Znidaric, Julian Bartram, Tobias Gänswein, Roland Diggelmann, Martina De Gennaro, Cameron S. Cowan, Wolf Harmening, Andreas Hierlemann, Botond Roska, Felix Franke
ALG13 loss-of-function alters glycosylation, impairs neuronal maturation, and drives network hypoactivity in a cortical organoid model of CDG
Rameen Shah, Rohit Budhraja, Silvia Radenkovic, Graeme Preston, Alexia Tyler King, Sahar Sabry, Charlotte Bleukx, Ibrahim Shammas, Lyndsay Young, Jisha Chandran, Seul Kee Byeon, Ronald Hrstka, Doughlas Y. Smith, Nathan P. Staff, Richard Drake, Steven A. Sloan, Akhilesh Pandey, Eva Morava, Tamas Kozicz
Homophilic wiring principles underpin neuronal network topology in vitro
Danyal Akarca, Alexander WE Dunn, Philipp J Hornauer, Silvia Ronchi, Michele Fiscella, Congwei Wang, Marco Terrigno, Ravi Jagasia, Petra E Vértes, Susanna B Mierau, Ole Paulsen, Stephen J Eglen, Andreas Hierlemann, Duncan E Astle, Manuel Schröter
A feedback-driven brain organoid platform enables automated maintenance and high-resolution neural activity monitoring
Kateryna Voitiuk, Spencer T. Seiler, Mirella Pessoa de Melo, Jinghui Geng, Tjitse van der Molen, Sebastian Hernandez, Hunter E. Schweiger, Jess L. Sevetson, David F. Parks, Ash Robbins, Sebastian Torres-Montoya, Drew Ehrlich, Matthew A. T. Elliott, Tal Sharf, David Haussler, Mohammed A. Mostajo-Radji, Sofie R. Salama, Mircea Teodorescu