MaxOne

MaxOne Single-Well High-Density Microelectrode Arrays (HD-MEA) represent the next-generation electrophysiology platform that empowers scientists to tackle a wide range of applications through its precise capture of electrical signatures from electrogenic cells while offering precise control via electrical stimulation.

The ultimate signal quality

Trust your data capturing even the smallest signals with exceptional clarity and reproducibility.

Single-cell and subcellular resolution

Capture cellular signals with unmatched spatial and temporal resolution. MaxOne features 26,400 high-density electrodes at 3,265 electrodes/mm2 with a 20 kHz sampling rate. The MaxOne enables detailed insights from individual cells down to axonal signal propagation, ensuring exceptional data quality for your research.

Signal fidelity

Detect even the smallest signals with exceptional precision and sensitivity. MaxOne delivers industry-leading low-noise performance to ensure accurate data capture, even from weak or rare events.

Signal integrity

Ensure consistent, high-quality recordings for longitudinal experiments. A soft, biocompatible PEDOT coating covers 44% of the electrode area, creating an optimized surface for reliable signal acquisition over time.

Reproducibility

Achieve consistent results across experiments. MaxOne supports in-incubator operation and features automatic chip identification, minimizing variability due to environment and streamlining workflows.

Precise stimulation with full flexibility

Interact with neurons accurately and flexibly at high resolution with full control. Design every experiment with customizable stimulation protocols and targeted precision.

Precise stimulation

Deliver electrical stimulation with subcellular resolution. MaxOne’s ultra-small 11.5 × 11.5 µm² electrodes at high-density enable highly selective activation near the target neuron for effective and reproducible responses.

Customizable stimulation

Maximize the full potential of MaxOne with fully customizable stimulation patterns, sequences, and timing, empowering precise control and advanced experimental designs.

Flexible control

Integrate your own workflows and feedback systems. The versatile Application Programming Interface (API) provides seamless integration with MaxOne, offering full control over stimulation and recording for the development of advanced feedback systems for neurocomputing applications.

Versatility

Adapt seamlessly to any experimental setup with a system built for flexibility and integration.

Compatibility with external devices

Connect MaxOne effortlessly with external devices, including microscopes, perfusion systems, and more to enhance experimental capabilities and expand research possibilities. The compact footprint of the MaxOne Recording Unit and available ports for synchronization allow for easy integration.

Accessibility to data and interfacing

Gain open access to raw data and direct interfacing capabilities (API), allowing you to retrieve data seamlessly and send commands for complete experimental control and customization.

Suitable for acute and longitudinal recordings

Integrate the MaxOne Recording Unit with a perfusion system for acute recordings of brain slices or retina explants, or place the MaxOne Recording Unit in a humidified incubator for stable, longitudinal recordings of cultured samples.

Broad compatibility with different biological models

Work confidently with a wide range of biological preparations, including neuronal cultures, brain organoids and assembloids, brain slices, retina explants, and more, supported by established protocols.

Technical 

Specifications

Components
Recording Unit
Hub
System Status Indicator
LED
Dimension (L x W x H)
Recording Unit: 150 x 95 x 25 mm3
Hub: 185 x 280 x 90 mm3
Incubator friendly
Yes, for the Recording Unit
Accessory compatibility
Perfusion System
Tissue Holder
DigiPins

MaxOne
Chips

MaxOne Chips enable high-resolution imaging of different types of cell electrical activities from network to subcellular levels.

Chip
Specifications

Features
MaxOne
MaxOne+
Ring diameter
Inner: 19 mm
Outer: 24 mm
Inner: 32 mm
Outer: 35 mm
Inner: 19 mm
Outer: 24 mm
Inner: 32 mm
Outer: 35 mm
Typical applications
Cultured samples
Acute samples
Cultured samples
Acute samples
Organ-on-a-Chip
Organ-on-a-Chip
Ring height
8 mm
8 mm
Active sensing area
3.85 x 2.10 mm2
3.85 x 2.10 mm2
Total number of electrodes
26’400
26’400
Electrode density
3’265 electrodes/mm2
3’265 electrodes/mm2
Electrode center-to-center distance
17.5 µm
17.5 µm
Electrode size
8.8 x 12.0 µm2
11.5 x 11.5 µm2
Electrode material
Platinum Black
PEDOT / Platinum
Surface topography
<2.0 µm
<0.6 µm / <0.3 µm
Sampling rate
20 kHz/channel
20 kHz/channel
Number of recording channels
1’020
1’020
Typical noise per chip
3.3 µVrms
2.2 µVrms
Electrical stimulation
Yes
Yes
Electronic ID
No
Yes
Sterilization Treatment
No
Yes
MaxOne Tissue Holder
A practical and reliable tool for stabilizing tissue samples during recording. The MaxOne Tissue Holder gently flattens the tissue onto the MaxOne HD-MEA sensor area and keeps it securely in place throughout the experiment. It integrates seamlessly with the MaxOne Perfusion System, with outlet tubes conveniently mounted on the MaxOne Recording Unit’s magnetic plate.
MaxOne Perfusion System
Designed for stable bench-top acute recordings, the MaxOne Perfusion System delivers continuous flow of fresh, heated, and oxygenated media throughout recordings. Equipped with an inflow port and an inline heater, it maintains ideal physiological conditions, while the outflow port ensures a consistent media level during the entire experiment.
MaxOne DigiPins
The Digital Input Extension Board (DigiPins) enables precise synchronization between the MaxOne and external hardware. It relays external digital signals to the MaxOne Recording Unit.
Do you want to learn more?

Book a one-to-one call with one of our experts to discuss how MaxWell Biosystems HD-MEA platforms can empower your research!

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