MaxOne

Versatility to empower your research

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MaxOne Single-Well High-Density Microelectrode Arrays (HD-MEA) represent the next-generation electrophysiology platform that empowers scientists to tackle a wide range of applications through its precise capture of electrical signatures from electrogenic cells while offering precise control via electrical stimulation.

MaxOne 
key features

Our Technology

Achieve ultimate signal quality

Trust your data by capturing even the smallest signals with exceptional clarity, stability, and reproducibility.

High resolution

Capture cellular signals with unmatched spatial and temporal resolution, down to single-cell and even sub-cellular detail. MaxOne features 26,400 high-density electrodes at 3,265 electrodes/mm2 with a 20 kHz sampling rate. MaxOne enables detailed insights from individual cells down to axonal signal propagation, ensuring exceptional data quality for your research.

Signal fidelity

Detect even the smallest signals with exceptional precision and sensitivity. MaxOne delivers industry-leading low-noise performance to ensure accurate data capture, even from weak or rare events.

Signal integrity

Ensure consistent, high-quality recordings for longitudinal experiments. A soft, biocompatible PEDOT coating covers 44% of the electrode area, creating an optimized surface for reliable signal acquisition over time.

Reproducibility

Achieve consistent results across experiments. MaxOne supports in-incubator operation and features automatic chip identification, minimizing variability due to environment and streamlining workflows.

Stimulate precisely with full flexibility

Interact with cells accurately and flexibly at high resolution with full control. Design every experiment with customizable stimulation protocols and targeted precision.

Precise

Deliver electrical stimulation with subcellular resolution. MaxOne’s ultra-small 11.5 × 11.5 µm² electrodes at high-density enable highly selective activation near the target neuron for effective and reproducible responses.

Customizable

Maximize the full potential of MaxOne with fully customizable stimulation patterns, sequences, and timing, empowering precise control and advanced experimental designs.

Flexible

Integrate your own workflows and feedback systems. The versatile Application Programming Interface (API) provides seamless integration with MaxOne, offering full control over stimulation and recording for the development of advanced feedback systems for neurocomputing applications.

Unlock versatility for every experiment

Adapt seamlessly to any experimental setup with a system built for flexibility and integration.

Compatibility with external devices

Connect MaxOne effortlessly with external devices, including microscopes, perfusion systems, and more to enhance experimental capabilities and expand research possibilities. The compact footprint of the MaxOne Recording Unit and available ports for synchronization allow for easy integration.

Accessibility to data and interfacing

Gain open access to raw data and direct interfacing capabilities (API), allowing you to retrieve data seamlessly and send commands for complete experimental control and customization.

Suitable for acute and longitudinal recordings

Integrate the MaxOne Recording Unit with a perfusion system for acute recordings of your sample, or place the MaxOne Recording Unit in a humidified incubator for stable, longitudinal recordings of cultured samples.

Broad compatibility with different biological models

Work confidently with a wide range of biological preparations, including neuronal cultures, brain organoids and assembloids, brain slices, retina explants, and more, supported by established protocols.

Relevant
Applications 

Functional Phenotyping
Neurocomputing
Method Development
Microphysiological Systems

Relevant
Biological Models

Organoids
Neuronal Cell Cultures
Brain Slices
Others
Retina

Technical
Specifications

Components
Hub
Recording Unit
System Status Indicator
LED
Components
(LxWxH)
Recording Unit: 150 x 95 x 25 mm3
Hub: 185 x 280 x 90 mm3
Incubator Friendly
Yes, for the Recording Unit
Accessory Compatibility
Perfusion System
Tissue Holder
DigiPins

MaxOne Chips

Our MaxOne HD-MEA chips power every MaxOne system, capturing even the most subtle electrical signals down to sub-cellular resolution, labels free. Learn more in our Technology section.

All MaxOne chips feature a high density of small, sensitive electrodes, for top resolution and flexible recording and stimulation. The MaxOne+ takes performance further with new PEDOT electrodes, offering exceptional biocompatibility and up to 50% higher Signal-to-Noise Ratio (SNR) for even clearer, more precise recordings.

Both MaxOne and MaxOne+ come in two formats: PSM for cultured samples, and PLM for acute tissues, as well as integration with imaging, perfusion, and other tools.

Need help choosing? Check the spec table below or contact our experts.

Chip Specifications

Features
MaxOne
MaxOne+
Ring diameter
Inner: 19 mm
Outer: 24 mm
Inner: 32 mm
Outer: 35 mm
Inner: 19 mm
Outer: 24 mm
Inner: 32 mm
Outer: 35 mm
Ring diameter
Cultured Samples
Acute Samples
Cultured samples
Organ-on-a-Chip
Acute samples
Organ-on-a-Chip
Ring height

8 mm

8 mm

Active sensing area

3.85 x 2.10 mm2

3.85 x 2.10 mm2

Total number of electrodes

26’400

26’400

Electrode density

3’265 electrodes/mm2

3’265 electrodes/mm2

Electrode center-to-center distance

17.5 µm

17.5 µm

Electrode size

8.8 x 12.0 µm2

11.5 x 11.5 µm2

Electrode material

Platinum Black

PEDOT / Platinum

Surface topography

<2.0 µm

<0.6 µm / <0.3 µm

Sampling rate

20 kHz/channel

20 kHz/channel

Number of recording channels

1’020

1’020

Typical noise per chip

3.3 µVrms

2.2 µVrms

Electrical stimulation

Yes

Yes

Electronic ID

No

Yes

Sterilization Treatment

No

Yes

MaxOne Tissue Holder

A practical and reliable tool for stabilizing tissue samples during recording. The MaxOne Tissue Holder gently flattens the tissue onto the MaxOne HD-MEA sensor area and keeps it securely in place throughout the experiment. It integrates seamlessly with the MaxOne Perfusion System, with outlet tubes conveniently mounted on the MaxOne Recording Unit’s magnetic plate.

MaxOne Perfusion System

Designed for stable bench-top acute recordings, the MaxOne Perfusion System delivers continuous flow of fresh, heated, and oxygenated media throughout recordings. Equipped with an inflow port and an inline heater, it maintains ideal physiological conditions, while the outflow port ensures a consistent media level during the entire experiment.

MaxOne DigiPins

The Digital Input Extension Board (DigiPins) enables precise synchronization between the MaxOne and external hardware. It relays external digital signals to the MaxOne Recording Unit.

Product Documentation

MaxOne Guide

Optimize your experiments with the MaxOne User Guide: step-by-step setup, safety, maintenance, and troubleshooting for the MaxOne HD-MEA system.

Brochures

MaxOne Brochure

Explore MaxOne, a powerful high-density microelectrode array (HD-MEA) system for precise, multi-level electrophysiological recordings and stimulation of electrogenic cells.

Brochures

MaxOne+ Brochure

Experience MaxOne⁺, the next generation ready-to-use HD-MEA chip with enhanced cell adhesion, superior signal quality, and powerful stimulation for peak performance.

J. P. Andrews et al.

Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices

Nature Neuroscience
|
2024
H. Cai et al.

Brain organoid reservoir computing for artificial intelligence

Nature Electronics
|
2023
J. Duru et al.

Investigation of the input-output relationship of engineered neural networks using high-density microelectrode arrays

Biosensors and Bioelectronics
|
2023
D. McSweeney, R. Gabriel, K. Jin, Z. P. Pang, B. Aronow, and C. Pak

CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons

iScience
|
2022

Prof. Feng Guo

Intelligent BioMedical Systems (IBMS) Lab, Indiana University Bloomington, USA

“If you have one electrode covered by many neurons, you acquire average information, which is not enough for specific computing conditions. What we really aim is high resolution at a single-neuron level, something we can achieve with MaxOne HD-MEA. The MaxOne provides electrical stimulation through individual manipulation of those electrodes. This was critical for our work, so I think those are two features that are super important for our application.”

Dr. Kateryna Voitiuk

University of California, Santa Cruz, USA

“The high resolution was a significant factor that allowed us to see seizure propagation and shutdown at a cellular level within the human slice tissue. The HD-MEA combined many scales of measurement that unlocked a lot of key insights: we were able to analyze single-cell waveforms, network-level dynamics between neurons, and local field potential propagation at the same time. Combining all of these electrophysiology modalities with tissue histology was really breathtaking.”

Dr. Jens Duru

Laboratory of Biosensors and Bioelectronics, ETH Zürich, Switzerland

“The MaxOne+ Chip provides the same high electrode density as the MaxOne Chip. What we appreciate the most about the MaxOne+ Chip is that its surface is flat, which enables hassle-free adhesion of PDMS microstructures.”

Dr. Danny McSweeney

Pak Lab, University of Massachusetts Amherst, USA

“The recordings were very straightforward and easy to perform. From plugging the chip into the recording unit and running recordings, the process was user-friendly. We have very much enjoyed integrating the MaxWell system into our research, and it has produced some of our most visually striking data yet.”

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