Neuronal
Cell Cultures

Every Cell has a Story to Tell.
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Neuronal cell cultures are powerful in vitro models for investigating development, connectivity, and dysfunction of the nervous system. But to truly understand how neurons behave, you need more than structure; you need their detailed function.

Our High-Density Microelectrode Array (HD-MEA) technology captures rich, reproducible functional data at subcellular, single-cell, and network levels, providing you with scalable workflows to reveal subtle phenotypes, track maturation, and confidently screen compounds with ease and precision.

Easily capture the full story of your neurons

Our Technology

Complete the picture of your neuronal activity

Get more meaningful data on how your neurons fire, connect, and mature, going beyond standard assays with rich functional readouts at subcellular, single-cell, and network levels.

Reveal hidden action potential insights

Acquire reliable action potentials, from tiniest to strongest, to reconstruct the subcellular axonal behavior of your cells. Uncover novel functional mechanisms and phenotypes others cannot see.

Sensitivity to subtle and unseen phenotypes

Biologically relevant changes aren’t always obvious. Detect nuanced functional differences other systems might miss, even in sparse, co-cultured or early-stage neuronal models, thanks to our high-resolution and low-noise signal acquisition.

Always at the right spot, never miss a neuron

Record high-quality signals with thousands of electrodes per well, precisely positioned beneath your cells of interest, and capture activity with unmatched resolution.

Reproducibility at the core

Neuronal cell cultures are biologically variable, but your recordings do not have to be. See functional differences that you can trust: engineered for long-term, stable experiments and consistent signal acquisition across sessions.

Functional characterization
of neuronal cultures

Perform high-resolution electrophysiological recordings across a wide range of neuronal cell cultures, comprising a diverse selection of cell types and modelling diseases, thanks to the MaxOne single-well and MaxTwo multi-well HD-MEAs. With high fidelity and reproducibility, you can characterize the populational network dynamics, whole sample as well as single cell activity, and even subcellularly axonal activity propagation.

Comprehensive characterization for a wide range of neuronal culture types

For every neuronal culture model, our HD-MEA Systems are designed to reveal their full functional profile.  A range of neuronal cultures are characterized at different levels, from activity across the whole sample at single-cell resolution, population network dynamics, to electrically reconstructed axonal branches, unique to users of our HD-MEA technology.

Reproducibility for your studies

Capture robust and reproducible phenotypes across healthy and disease conditions with our MaxTwo System. In the panel below, we showcase spontaneous network bursting features originating from FUJIFILM Cellular Dynamics, Inc. iPSC-derived control and ALS-associated mutant motor neuron cultures, co-cultured with iCell Astrocytes 2.0 (FCDI) and recorded on a MaxTwo 24-Well Plate.

Resources

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