Webinars

• How combining TF overexpression with developmental signaling modulation enables the generation of diverse human neuron types.
• Findings from a comprehensive screen of 480 patterning conditions using single-cell transcriptomics on 700,000 cells.
• Functional profiling of neurons using MaxWell Biosystems’ MaxTwo HD-MEA platform to capture activity, connectivity, and morphological diversity across different patterning conditions.
• The relationship between transcriptomic signatures and neuronal structure, revealing mechanisms of maturation and identity formation.

• How the combination of MaxTwo Multi-Well High-Density Multielectrode Arrays (HD-MEA) and FUJIFILM hiPSC-derived neurons has opened new frontiers in investigating neurodegenerative disease mechanisms.
• Comparisons between disease-modeling neuronal lines for Parkinson’s, ALS, and FTD, with healthy donor data highlighting functional differences and disease phenotypes.
• The use of cutting-edge HD-MEA assays under optimized experimental conditions to detect even subtle phenotypic variations and to characterize disease models with greater precision.

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• Micro- and nano-channel PDMS platforms enable directional neuronal network fabrication at single-neuron resolution.
• Integration with patient primary or iPSC-derived cells enables precise, personalized disease modeling.
• A biophysical modeling approach coupled with neuronal networks on a chip enables quantification of synaptic receptor alterations in isolated neuronal pairs.
• Application of information theory reveals increased feedback motifs and enhanced information transfer in glioblastoma-infiltrated neuronal networks

• Inter-regional connectivity being key for complex brain functions
• Neural organoid networks serving as in vitro models of inter-regional brain circuits
• HD-MEAs enabling detailed analysis of organoid network activity and functional connectivity

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