Wednesday, April 23, 2025 | 09:30 & 17:00 CEST
00:30 & 08:00 PDT | 03:30 & 11:00 EDT | 15:30 & 23:00 CST | 16:30 & 00:00 JST

Construction and Evaluation of Neural Organoid Networks and Circuits on High Density Microelectrode Arrays (HD-MEAs)
Inter-regional connections and networks are fundamental architectural motifs of the human brain, enabling the integration of neural circuits to generate complex functions. To investigate the mechanistic significance of such connections in neural circuit development, we propose in vitro models of inter-regional networks by constructing networks of multiple neural organoids on High-Density Microelectrode Arrays (HD-MEAs). HD-MEAs provide a powerful platform for recording and analyzing the spatiotemporal activity patterns of neural organoid networks, allowing us to examine functional connectivity in the inter-organoid networks.