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bioRxiv
|
2025
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Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs

Kriti Chaplot, Lin Zhang, Julia Wessman, Miguel Rivera, Zhihui Wang, Fei Wang, Xin Duan, Pamela M. England, Iain C. Clark, Erik M. Ullian
Preprint
Disease Modeling
Functional Phenotyping
Organoids
MaxLab Live
MaxOne
Scientific Reports
|
2025
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Seeding Alzheimer’s disease-associated tau pathology in MAPT knock-in primary neurons causes early axonopathy and synaptic dysfunction

Rebecca L. Mueller, Benjamin Combs, Nicholas M. Kanaan
Journal Article
Disease Modeling
Neuronal Cell Cultures
MaxLab Live
MaxOne
Biomaterials
|
2025
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Development of an innervated human skin equivalent to model nociceptive circuitry in vitro

Daniele Bellantoni, Costantino Casale, Claudia Mazio, Francesco Urciuolo, Giorgia Imparato, Paolo Antonio Netti
Journal Article
Disease Modeling
Functional Phenotyping
Method Development
Pharmacology & Toxicology
Neuronal Cell Cultures
MaxLab Live
MaxOne
bioRxiv
|
2025
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Novel Gain of Function Mouse Model of KCNT1-Related Epilepsy

Sarah L. Olguin, Daniel Davis, Ammara Rehman, Sean W. Berg, Elizabeth Sahagun, Payton S. Oswalt, Mandar Patil, Paula D. M. Sullivan, Bing Zhang, Elizabeth C. Bryda, Roy Ben-Shalom, Jill L. Silverman
Preprint
Disease Modeling
Neuronal Cell Cultures
MaxLab Live
MaxTwo
bioRxiv
|
2025
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Distributional invariance and proportional scaling in axonal conduction

Laurie D. Cohen, Shimon Marom
Preprint
Functional Phenotyping
Neuronal Cell Cultures
MaxLab Live
MaxOne
bioRxiv
|
2025
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A toolbox for navigating and analyzing the spatiotemporal properties of retinal waves

Kaylee M. Yeager, Rishikesh K. Gupta, Elysia A. Gauthier, Alexander J. Fisch, Natalie A. Clark, Fernanda S. Orsi, Alexandre Tiriac
Preprint
Functional Phenotyping
Method Development
Retina
MaxOne
Frontiers in Neural Circuits
|
2025
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Emergent functions of noise-driven spontaneous activity: homeostatic maintenance of criticality and memory consolidation

Narumitsu Ikeda, Dai Akita, Hirokazu Takahashi
Journal Article
Biocomputing
Neuronal Cell Cultures
MaxOne
Applied Sciences
|
2025
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Neuroengineering Frontiers: A Selective Review of Neural Interfaces, Brain–Machine Interactions, and Artificial Intelligence in Neurodegenerative Diseases

Mutiyat Usman, Simachew Ashebir, Chioma Okey-Mbata, Yeoheung Yun, Seongtae Kim, Mutiyat Usman, Simachew Ashebir, Chioma Okey-Mbata, Yeoheung Yun, Seongtae Kim
Journal Article
Disease Modeling
Method Development
Biocomputing
Organoids
MaxLab Live
NeuroToxicology
|
2025
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Development of a network formation assay for developmental neurotoxicity hazard screening using 3D human iPSC derived BrainSpheres

SL Boyd, M. Mayil Vahanan, J. Monroe, JA Conley, KE Carstens, TJ Shafer
Journal Article
Functional Phenotyping
Method Development
Pharmacology & Toxicology
Organoids
MaxLab Live
MaxTwo
arXiv
|
2025
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Bridging integrated information theory and the free-energy principle in living neuronal networks

Teruki Mayama, Sota Shimizu, Yuki Takano, Dai Akita, Hirokazu Takahashi
Preprint
Neuronal Cell Cultures
MaxOne
Frontiers in Cellular Neuroscience
|
2025
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Microglia-containing neural organoids as brain microphysiological systems for long-term culture

Alex Rittenhouse, Caroline Krall, Jesse Plotkin, Lena Smirnova
Journal Article
Functional Phenotyping
Organoids
MaxLab Live
MaxTwo
Journal of Pharmaceutical Analysis
|
2025
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Brain organoids-on-chip for neural diseases modeling: History, challenges and trends

Hongyong Zhang, Nan Huang, Sumin Bian, Mohamad Sawan
Journal Article
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arXiv
|
2025
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Emergence of Deviance Detection in Cortical Cultures through Maturation, Criticality, and Early Experience

Zhuo Zhang, Amit Yaron, Dai Akita, Tomoyo Isoguchi Shiramatsu, Zenas C. Chao, Hirokazu Takahashi
Preprint
Neuronal Cell Cultures
MaxLab Live
MaxOne
Neurobiology of Disease
|
2025
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Human iPSC-derived glutamatergic neurons with pathogenic KCNQ2 variants display hyperactive bursting phenotypes

Maria Sundberg, Carole Shum, Erika M. Norabuena, Nina R. Makhortova, Cidi Chen, Lucy Yu, Emma V. Wightman, Kristina Kim, Sang Yeon Han, Jennifer Howe, Annapurna Poduri, Elizabeth D. Buttermore, Stephen W. Scherer, Mustafa Sahin
Journal Article
Disease Modeling
Neuronal Cell Cultures
MaxLab Live
MaxTwo
Translational Vision Science & Technology
|
2025
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Sustained Neurotrophic Factor Co-Treatment Enhances Donor and Host Retinal Ganglion Cell Survival in Mice

Jonathan R. Soucy, Julia Oswald, Emil Kriukov, Monichan Phay, John Masland, Christian Pernstich, Petr Baranov
Journal Article
Functional Phenotyping
Retina
MaxLab Live
MaxOne
Brain
|
2025
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A human striatal-midbrain assembloid model of alpha-synuclein propagation

Hoang-Dai Tran, Min-Kyoung Shin, Xin Yi Yeo, Sangyong Jung, Muhammad Junaid, Su Bin Lim, Jungmo Kim, Hyun Goo Woo, Charlotte R Denman, Run-Run Han
Journal Article
Disease Modeling
Organoids
MaxLab Live
MaxOne
bioRxiv
|
2025
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Incubator-Free Organoid Culture in a Sealed Recirculatory System

Yohei Rosen, Kivilcim Doganyigit, Santhosh Arul, Eliot Wachtel, Drew Ehrlich, Vaishnavi Venuturimilli, Matilda Mouzaya, Sophia Oriaku, Bi Ndiforchu, Gregory Kaurala, Sebastian Hernandez, Maryam Moarefian, Hunter Schweiger, Ariana Cisneros, Mojtaba Zeraatkar, Jinghui Geng, Mohammed A. Mostajo-Radji, Ethan Winkler, David Haussler, Mircea Teodorescu
Preprint
Functional Phenotyping
Method Development
Organoids
MaxOne
|
2025
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Beyond Structure: Next-Generation Electrophysiological Platforms for Functional Brain Organoids

Ji-Hyoung Cha, Keuntae Kim, Il-Joo Cho
Journal Article
Functional Phenotyping
Organoids
MaxOne
Lab on a Chip
|
2025
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Advances in large-scale electrophysiology with high-density microelectrode arrays

Manuel Schröter, Fernando Cardes, Cat-Vu H. Bui, Lorenzo Davide Dodi, Tobias Gänswein, Julian Bartram, Lorenca Sadiraj, Philipp Hornauer, Sreedhar Kumar, Maria Pascual-Garcia, Andreas Hierlemann
Journal Article
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bioRxiv
|
2025
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Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability

Sara Nolbrant, Jenelle L. Wallace, Jingwen W. Ding, Tianjia Zhu, Jess L. Sevetson, Janko Kajtez, Isabella A. Baldacci, Emily K. Corrigan, Kaylynn Hoglin, Reed McMullen, Megan S. Ostrowski, Matthew T. Schmitz, Arnar Breevoort, Dani Swope, Fengxia Wu, Bryan J. Pavlovic, Sofie R. Salama, Agnete Kirkeby, Hao Huang, Nathan K. Schaefer, Alex A. Pollen
Preprint
Functional Phenotyping
Organoids
MaxLab Live
MaxOne
Frontiers in Neural Circuits
|
2025
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Deviance detection and regularity sensitivity in dissociated neuronal cultures

Zhuo Zhang, Amit Yaron, Dai Akita, Tomoyo Isoguchi Shiramatsu, Zenas C. Chao, Hirokazu Takahashi
Journal Article
Functional Phenotyping
Pharmacology & Toxicology
Neuronal Cell Cultures
MaxOne
Communications Biology
|
2025
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Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory

Dowlette-Mary Alam El Din, Leah Moenkemoeller, Alon Loeffler, Forough Habibollahi, Jack Schenkman, Amitav Mitra, Tjitse van der Molen, Lixuan Ding, Jason Laird, Maren Schenke, Erik C. Johnson, Brett J. Kagan, Thomas Hartung, Lena Smirnova
Journal Article
Functional Phenotyping
Organoids
MaxLab Live
MaxTwo
Research Square
|
2025
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Epigenetic Reactivation of CDKL5 Rescues CDKL5 Deficiency Disorder

Kyle Fink, Julian Halmai, David Cameron, Casiana Gonzalez, Mandeep Singh, Anber Ansari, Viktoria Haghani, Emma Monsen, Alyssa Paynton-Cheney, Jennifer Waldo, Timothy Fenton, Roy Ben-Shalom, Jill Silverman
Preprint
Disease Modeling
Pharmacology & Toxicology
Organoids
MaxLab Live
MaxOne
Cyborg and Bionic Systems (Washington, D.C.)
|
2025
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Dynamic Network Plasticity and Sample Efficiency in Biological Neural Cultures: A Comparative Study with Deep Reinforcement Learning

Moein Khajehnejad, Forough Habibollahi, Alon Loeffler, Aswin Paul, Adeel Razi, Brett J. Kagan
Journal Article
Biocomputing
Neuronal Cell Cultures
MaxOne
Advanced Therapeutics
|
2025
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Topology and Mechanism of Broadband and Fast Multi‐Characteristic Opsin for Neuromodulation

Samarendra Mohanty, Pratyajit Mohapatra, Amir Singh, William Marks, Subrata Batabyal, Michael Carlson, Najam Sharif, Sanghoon Kim
Journal Article
Functional Phenotyping
Retina
MaxLab Live
MaxOne
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