論文

Publications

 


Selected Publications

Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.


All Publications

Show all

1. Bandarabadi, Mojtaba; Vassalli, Anne; Tafti, Mehdi: Sleep as a default state of cortical and subcortical networks. In: Current Opinion in Physiology, 15 , pp. 60-67, 2020. (Type: Journal Article | Abstract | Links | BibTeX)
2. Obien, Marie Engelene J; Deligkaris, Kosmas; Bullmann, Torsten; Bakkum, Douglas J; Frey, Urs: Revealing neuronal function through microelectrode array recordings. In: Frontiers in Neuroscience, 9 , pp. 423, 2015, ISSN: 1662453X. (Type: Journal Article | Abstract | Links | BibTeX)
3. Franke, Felix; Jackel, David; Dragas, Jelena; Muller, Jan; Radivojevic, Milos; Bakkum, Douglas J; Hierlemann, Andreas: High-density microelectrode array recordings and real-time spike sorting for closed-loop experiments: an emerging technology to study neural plasticity. In: Frontiers in Neural Circuits, 6 , pp. 105, 2012, ISSN: 1662-5110. (Type: Journal Article | Abstract | Links | BibTeX)
4. Jones, Ian L; Livi, Paolo; Lewandowska, Marta K; Fiscella, Michele; Roscic, Branka; Hierlemann, Andreas: The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics. In: Analytical and Bioanalytical Chemistry, 399 (7), pp. 2313-2329, 2011, ISSN: 1618-2650. (Type: Journal Article | Abstract | Links | BibTeX)
5. Hierlemann, Andreas; Frey, Urs; Hafizovic, Sadik; Heer, Flavio: Growing cells atop microelectronic chips: Interfacing electrogenic cells in vitro with CMOS-based microelectrode arrays. In: Proceedings of the IEEE, 99 (2), pp. 252-284, 2011, ISSN: 00189219. (Type: Journal Article | Abstract | Links | BibTeX)
6. Jenkner, Martin; Tartagni, Marco; Hierlemann, Andreas; Thewes, Roland: Cell-based CMOS sensor and actuator arrays. In: IEEE Journal of Solid-State Circuits, 39 (12), pp. 2431-2437, 2004, ISSN: 00189200. (Type: Journal Article | Abstract | Links | BibTeX)

Show all

2020

Sleep as a default state of cortical and subcortical networks

Bandarabadi, Mojtaba; Vassalli, Anne; Tafti, Mehdi

Sleep as a default state of cortical and subcortical networks Journal Article

Current Opinion in Physiology, 15 , pp. 60-67, 2020.

Abstract | Links | BibTeX | タグ: Neuronal Networks, Review, Sleep

2015

Revealing neuronal function through microelectrode array recordings

Obien, Marie Engelene J; Deligkaris, Kosmas; Bullmann, Torsten; Bakkum, Douglas J; Frey, Urs

Revealing neuronal function through microelectrode array recordings Journal Article

Frontiers in Neuroscience, 9 , pp. 423, 2015, ISSN: 1662453X.

Abstract | Links | BibTeX | タグ: MEA Technology, Review

2012

High-density microelectrode array recordings and real-time spike sorting for closed-loop experiments: an emerging technology to study neural plasticity

Franke, Felix; Jackel, David; Dragas, Jelena; Muller, Jan; Radivojevic, Milos; Bakkum, Douglas J; Hierlemann, Andreas

High-density microelectrode array recordings and real-time spike sorting for closed-loop experiments: an emerging technology to study neural plasticity Journal Article

Frontiers in Neural Circuits, 6 , pp. 105, 2012, ISSN: 1662-5110.

Abstract | Links | BibTeX | タグ: Neuronal Networks, Review, Spike Sorting

2011

The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics

Jones, Ian L; Livi, Paolo; Lewandowska, Marta K; Fiscella, Michele; Roscic, Branka; Hierlemann, Andreas

The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics Journal Article

Analytical and Bioanalytical Chemistry, 399 (7), pp. 2313-2329, 2011, ISSN: 1618-2650.

Abstract | Links | BibTeX | タグ: Review

Growing cells atop microelectronic chips: Interfacing electrogenic cells in vitro with CMOS-based microelectrode arrays

Hierlemann, Andreas; Frey, Urs; Hafizovic, Sadik; Heer, Flavio

Growing cells atop microelectronic chips: Interfacing electrogenic cells in vitro with CMOS-based microelectrode arrays Journal Article

Proceedings of the IEEE, 99 (2), pp. 252-284, 2011, ISSN: 00189219.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, MEA Technology, Review

2004

Cell-based CMOS sensor and actuator arrays

Jenkner, Martin; Tartagni, Marco; Hierlemann, Andreas; Thewes, Roland

Cell-based CMOS sensor and actuator arrays Journal Article

IEEE Journal of Solid-State Circuits, 39 (12), pp. 2431-2437, 2004, ISSN: 00189200.

Abstract | Links | BibTeX | タグ: MEA Technology, Review

 

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