Publications

 Selected Publications


Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.


Journals


D. Hillier, M. Fiscella, A. Drinnenberg, S. Trenholm, S. B. Rompani, Z. Raics, G. Katona, J. Juettner, A. Hierlemann , B. Rozsa, and B. Roska, “Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex,” Nat. Neurosci., Advanced online publication, May 2017.
Online

D. Jäckel, D. Bakkum, T. Russell, J. Müller, M. Radivojevic, U. Frey, F. Franke, A. Hierlemann, “Combination of High-density Microelectrode Array and Patch Clamp Recordings to Enable Studies of Multisynaptic Integration,” Sci. Rep., vol. 7, no. 1, p. 978, 2017 (DOI: 10.1038/s41598-017-00981-4).
Online

W. Gong, J. Senčar, D.J. Bakkum, D. Jäckel, M. E. J. Obien, M. Radivojevic, and A. Hierlemann, “Multiple single-unit long-term tracking on organotypic hippocampal slices using high-density microelectrode arrays”, Front. Neurosci. 2016, 10:537 (DOI: 10.3389/fnins.2016.00537).
Online

M. Radivojevic, D. Jäckel, M. Altermatt, J. Müller, V. Viswam, A. Hierlemann, D. Bakkum, “Electrical identification and selective microstimulation of neuronal compartments based on features of extracellular action potentials”, Scientific Reports 2016, 6, 31332 (DOI:10.1038/srep31332).
Online

M. K. Lewandowska, M. Radivojević, D. Jäckel, J. Müller, and A. Hierlemann, “Cortical axons, isolated in channels, display activity-dependent signal modulation as a result of targeted stimulation,” Front. Neurosci., 10:83, 2016 (DOI: 10.3389/fnins.2016.00083).
Online

K. Yonehara, M. Fiscella, A. Drinnenberg, F. Esposti, S. Trenholm, J. Krol, F. Franke, B. Gross-Scherf, A. Kusnyerik, J. Müller, A. Szabo, J. Jüttner, F. Cordoba, A. P. Reddy, J. Németh, Z. Nagy, F. Munier, A. Hierlemann, B. Roska, “Congenital nystagmus gene FRMD7 is necessary for establishing a neuronal circuit asymmetry for direction selectivity,” Neuron, 89(1), pp. 177-193, 2016 (DOI: 10.1016/j.neuron.2015.11.032).
Online

F. Franke, M. Fiscella, M. Sevelev, B. Roska, A. Hierlemann, R. Azeredo da Silveira, “Structures of neural correlation and how they favor coding,” Neuron, 2016, 89(2), pp. 409-422 (DOI: 10.1016/j.neuron.2015.12.037).
Online

I. L. Jones, T. L. Russell, K. Farrow, M. Fiscella, F. Franke, J. Müller, D. Jäckel and A. Hierlemann, “A method for electrophysiological characterization of hamster retinal ganglion cells using a high-density CMOS microelectrode array,” Front. Neurosci., 2015, 9:360 (DOI: 10.3389/fnins.2015.00360).
Online

M. Fiscella, F. Franke, K. Farrow, J. Müller, B. Roska, R. Azeredo da Silveira, A. Hierlemann, “Visual Coding with a Population of Direction-Selective Neurons,” Journal of Neurophysiology, 2015 (DOI: 10.1152/jn.00919.2014).
Online

J. Krol, I. Krol, C. P. Patino Alvarez, M. Fiscella, A. Hierlemann, B. Roska, W. Filipowicz, “A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture,” Nature Communications, 2015, 6:7305 (DOI:10.1038/ncomms8305).
Online

J. Dragas, D. Jaeckel, A. Hierlemann, F. Franke, “Complexity Optimisation and High-Throughput Low-Latency Hardware Implementation of a Multi-Electrode Spike-Sorting Algorithm,” IEEE Trans. On Neural Systems and Rehabilitation Engineering, 2015, 23(2), pp. 149-158 (DOI: 10.1109/TNSRE.2014.2370510).
Online

M. K. Lewandowska, D. J. Bakkum, S. B. Rompani, A. Hierlemann, “Recording Large Extracellular Spikes in Microchannels along Many Axonal Sites from Individual Neurons,” PLoS ONE, 2015, 10(3): e0118514 (DOI: 10.1371/journal.pone.0118514).
Online

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.
Online

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.
Online

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.
Online

S. Okawa, T. Mita, D. Bakkum, U. Frey, A. Hierlemann, R. Kanzaki, and H. Takahashi, “Chronic Co-variation of Neural Network Configuration and Activity in Mature Dissociated Cultures,” IEEJ Trans. Electron. Inf. Syst., vol. 134, no. 3, pp. 338–344, 2014.
English translation of this article is published here:
S. Okawa, T. Mita, D. Bakkum, U. Frey, A. Hierlemann, R. Kanzaki, and H. Takahashi, “Chronic Co-variation of Neural Network Configuration and Activity in Mature Dissociated Cultures,” Electron. Commun. Japan, vol. 98, no. 5, pp. 34–42, 2015.
Online

D. J. Bakkum, M. Radivojevic, U. Frey, F. Franke, A. Hierlemann, and H. Takahashi, “Parameters for burst detection,” Front. Comput. Neurosci., vol. 7, no. 193, Jan 2014.
Online

Jan Müller, Douglas Bakkum and Andreas Hierlemann, “Sub-millisecond closed-loop feedback stimulation between arbitrary sets of individual neurons,” Frontiers in Neural Circuits, 2013, 6:121 (DOI: 10.3389/fncir.2012.00121). Online

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.
Online

M. Fiscella, K. Farrow, I. L. Jones, D. Jäckel, J. Müller, U. Frey, D. J. Bakkum, P. Hantz, B. Roska, and A. Hierlemann, “Recording from Defined Populations of Retinal Ganglion Cells Using a High-Density CMOS-Integrated Microelectrode Array with Real-Time Switchable Electrode Selection,” Journal of Neuroscience Methods, vol. 211, no. 1, pp. 103–113, Aug. 2012.
Online

D. Jäckel, U. Frey, M. Fiscella, F. Franke and A. Hierlemann, “Applicability of Independent Component Analysis on High-Density Microelectrode Array Recordings”, Journal of Neurophysiology, vol. 108, no. 1, pp. 334–348, Apr. 2012.
Online * Editor’s Choice *

A. Hierlemann, U. Frey, S. Hafizovic, F. Heer, “Growing Cells atop Microelectronic Chips: Interfacing Electrogenic Cells in Vitro with CMOS-based Microelectrode Arrays,” Proceedings of the IEEE, Vol. 99, No. 2, pp. 252-284, 2011.
Online

P. Livi, F. Heer, U. Frey, D. J. Bakkum, and A. Hierlemann, “Compact Voltage and Current Stimulation Buffer for High-Density Microelectrode Arrays,” Biomedical Circuits and Systems, IEEE Transactions on, vol. 4, no. 6, pp. 372-378, 2010.
Online

U. Frey, J. Sedivy, F. Heer, R. Pedron, M. Ballini, J. Mueller, D. Bakkum, S. Hafizovic, F. D. Faraci, F. Greve, K.-U. Kirstein, and A. Hierlemann, “Switch-matrix-based High-density Microelectrode Array in CMOS Technology,” IEEE Journal of Solid-State Circuits, vol. 45, no. 2, pp. 467–482, Feb. 2010.
Online

W. Weber, S. Luzi, M. Karlsson, C. Diaz Sanchez-Bustamante, U. Frey, A. Hierlemann, and M. Fussenegger, “A Synthetic Mammalian Electro-genetic Transcription Circuit,” Nucleic Acids Research, vol. 37, no. 4, pp. e33, 2009.
Online

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.
Online

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger, “Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.
Online

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