MaxWell Webinars

Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays
October 15, 2020  |  5pm (CET), 8am (PST), 11am (EDT)

Co-hosted MaxWell Biosystems and FUJIFILM Cellular Dynamics Webinar

Watch the replay

Speaker

Silvia Ronchi
Doctorate Student at ETH Zürich

Abstract:

Recent advances in the field of cellular reprogramming have opened a route to study the fundamental mechanisms underlying common neurological disorders. High-density microelectrode-arrays (HD-MEAs) provide unprecedented means to study neuronal physiology at different scales, ranging from network through single-neuron to subcellular features.

In this webinar, we will:

• Introduce how HD-MEAs was used to characterize and compare human induced-pluripotent-stem-cell (iPSC)-derived dopaminergic and motor neurons, including isogenic neuronal lines modeling Parkinson’s disease and amyotrophic lateral sclerosis in-vitro.
• Present the metrics used for phenotype characterization and drug testing.
• Demonstrate the ability to detect drug effects with HD-MEA.

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