Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays
October 15, 2020 | 5pm (CET), 8am (PST), 11am (EDT)
Co-hosted MaxWell Biosystems and FUJIFILM Cellular Dynamics Webinar
Marie Obien, Ph.D.
VP Marketing and Sales at MaxWell Biosystems
Simon Hilcove, Ph.D.
Assoc. Director Product Development at FUJIFILM Cellular Dynamics
Doctorate Student at ETH Zürich
Recent advances in the field of cellular reprogramming have opened a route to study the fundamental mechanisms underlying common neurological disorders. High-density microelectrode-arrays (HD-MEAs) provide unprecedented means to study neuronal physiology at different scales, ranging from network through single-neuron to subcellular features.
In this webinar, we will:
- Introduce how HD-MEAs was used to characterize and compare human induced-pluripotent-stem-cell (iPSC)-derived dopaminergic and motor neurons, including isogenic neuronal lines modeling Parkinson’s disease and amyotrophic lateral sclerosis in-vitro.
- Present the metrics used for phenotype characterization and drug testing.
- Demonstrate the ability to detect drug effects with HD-MEA.