Cardiomyocytes

MaxOne for Cardiomyocyte Studies  Cardiomyocyte Applications

MaxOne Cardiomyocyte

MaxOne offers fast and reliable sensing of beating cardiomyocytes, as well as long-term and label-free monitoring for applications in safety pharmacology.  Because of its high spatio-temporal resolution, it enables to:

  • electrically image the propagation of action potentials over entire culture of cardiomyocytes
  • assess effects of cardioactive drugs and compounds on cell viability and function of beating cardiomyocytes

What You Can Do

Detect electrical activity of cardiomyocytes

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Electrical Acivity of Cardiomyocyte

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MaxOne enables to image electrical wave propagation pattern along cardiomyocyte monolayers.

  • Locate the origine and the direction of the activity
  • Identify burst from selected electrodes

Detect electrical activity in differentiated cardiomyocytes

MaxOne enables to detect electrical activity in cardiomyocytes differentiated from embryoid bodies plated on the MEA

  • Reveal spontaneous beating activity
  • Record regular beating activity from one single electrode

Assess Effects of cardioactive drugs and compounds

MaxOne enables to extract electrophysiological properties such as amplitude, frequency, upstroke duration and propagation velocity.

  • Characterise wild-type neonatal rat cardiomyocytes culture with unprecedented details over days
  • Characterise responses of healthy cardiomyocytes to pharmacological manipulation during short-term and long-term application


Publications —

Cardiomyocytes Studies

High-resolution Functional Imaging of Cardiomyocytes Derived from Embryonic Stem Cell Spheroids

Obien, Marie Engelene J; Muller, Jan; Boos, Julia Alicia; Bounik, Raziyeh; Fiscella, Michele; Hierlemann, Andreas

High-resolution Functional Imaging of Cardiomyocytes Derived from Embryonic Stem Cell Spheroids Conference

International Society for Stem Cell Research (ISSCR) Boston, MA, USA, 2017.

Links | BibTeX

A synthetic mammalian electro-genetic transcription circuit

Weber, Wilfried; Luzi, Stefan; Karlsson, Maria; Sanchez-Bustamante, Carlota Diaz; Frey, Urs; Hierlemann, Andreas; Fussenegger, Martin

A synthetic mammalian electro-genetic transcription circuit Journal Article

Nucleic Acids Research, 37 (4), pp. 1-8, 2009, ISSN: 03051048.

Abstract | Links | BibTeX

Modulation of cardiomyocyte electrical properties using regulated bone morphogenetic protein-2 expression.

Sanchez-Bustamante, Carlota Diaz; Frey, Urs; Kelm, Jens M; Hierlemann, Andreas; Fussenegger, Martin

Modulation of cardiomyocyte electrical properties using regulated bone morphogenetic protein-2 expression. Journal Article

Tissue Engineering. Part A, 14 (12), pp. 1969-1988, 2008, ISSN: 1937-3341.

Abstract | Links | BibTeX

Perforated CMOS microchip platform for immobilization and activity monitoring of electrogenic cells

Greve, Frauke; Lichtenberg, Jan; Kirstein, Kay Uwe; Frey, Urs; Perriard, Jean Claude; Hierlemann, Andreas

Perforated CMOS microchip platform for immobilization and activity monitoring of electrogenic cells Journal Article

Journal of Micromechanics and Microengineering, 17 (3), pp. 462-471, 2007, ISSN: 0960-1317.

Abstract | Links | BibTeX

Single-chip microelectronic system to interface with living cells

Heer, Flavio; Hafizovic, Sadik; Ugniwenko, T; Frey, Urs; Franks, Wendy; Perriard, Evelyne; Perriard, Jean Claude; Blau, Axel; Ziegler, Christiane; Hierlemann, Andreas

Single-chip microelectronic system to interface with living cells Journal Article

Biosensors & Bioelectronics, 22 (11), pp. 2546-2553, 2006, ISSN: 0956-5663.

Abstract | Links | BibTeX

Patterned cell adhesion by self-assembled structures for use with a CMOS cell-based biosensor

Franks, Wendy; Tosatti, Samuele; Heer, Flavio; Seif, Philipp; Textor, Marcus; Hierlemann, Andreas

Patterned cell adhesion by self-assembled structures for use with a CMOS cell-based biosensor Journal Article

Biosensors & Bioelectronics, 22 (7), pp. 1426-1433, 2006, ISSN: 0956-5663.

Abstract | Links | BibTeX

Microfluidics/CMOS orthogonal capabilities for cell biology

Linder, Vincent; Koster, Sander; Franks, Wendy; Kraus, Tobias; Verpoorte, Elisabeth; Heer, Flavio; Hierlemann, Andreas; de Rooij, Nico F

Microfluidics/CMOS orthogonal capabilities for cell biology Journal Article

Biomedical Microdevices, 8 (2), pp. 159-166, 2006, ISSN: 1572-8781.

Abstract | Links | BibTeX

Characterization of a microfluidic dispensing system for localised stimulation of cellular networks

Kraus, Tobias; Verpoorte, Elisabeth; Linder, Vincent; Franks, Wendy; Hierlemann, Andreas; Heer, Flavio; Hafizovic, Sadik; Fujii, Teruo; de Rooij, Nico F; Koster, Sander

Characterization of a microfluidic dispensing system for localised stimulation of cellular networks Journal Article

Lab Chip, 6 (2), pp. 218-229, 2006.

Abstract | Links | BibTeX

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