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MaxWell Monthly Must-Reads (September 2021)
It is time for a new edition of our monthly blog. In the August edition during the summer holidays, we highlighted the latest developments on CMOS-based MEA technology. For the September edition, we decided to focus on high-throughput screening. With these articles, we would like to prepare you for our upcoming webinar which will be a live demo of our multiwell MEA system, MaxTwo. You can still register for this live demonstration here. In this Monthly Must-Reads edition, we highlighted…
MaxWell Monthly Must-Reads (August 2021)
It is time for a new edition of our monthly blog. In the August edition during the summer holidays, we highlight the latest developments on CMOS-based MEA technology. CMOS-based MEAs are used for detailed investigations of neuronal electrical activity at network and single-cell levels and to evaluate the effect of drugs on neuronal physiological activity. Therefore, for this Monthly Must-Reads edition, we decided to highlight the article written by Yuan X et al., in which switch-matrix (SM) and active-pixel-sensors…
Look back: the first In-vitro 2D and 3D Neuronal Networks Summit (MaxWell Biosystems User Meeting)
On April 22nd and 23rd, we hosted the first In-vitro 2D and 3D neuronal Networks Summit (MaxWell Biosystems User Meeting) and were very excited about the tremendously successful outcome, with over 700 registrants from 49 countries! First Day: Scientific Talks and Discussions Open for All The first day of the meeting was open to everybody. We had very interesting talks from seven invited speakers, who spoke about their work involving iPSC-derived neurons, brain organoids, and also high-density microelectrode array (HD-MEA)…
HD-MEAs play a role in the functional characterization of human iPSC-derived dopaminergic neurons
Maria Sundberg from the Boston Children’s Hospital, Harvard Medical School, and colleagues, recently reported in Nature Communications a study on the reciprocal copy number variations (CNVs) of 16p11.2 gene region, associated with a wide spectrum of neuropsychiatric and neurodevelopmental disorders. For the functional analysis of the developing iPSC-derived dopaminergic (DA) neuron network, complementary-metal-oxide-semiconductor (CMOS)-based high-density microelectrode arrays (HD-MEAs), MaxOne System by MaxWell Biosystems was extensively used. 16p.11.2 Reciprocal copy number variations (CNVs) in neuropsychiatric disorders 16p.11.2 CNVs have been implicated in…
Observing the activity of human-derived neurons in health and in disease
The combination of two technologies—induced pluripotent stem cells and high-density microelectrode arrays—offers an unprecedented platform to study human brain activity in detail outside the body. Back in 2006, Prof. Yamanaka and colleagues revealed a technique to reprogram adult skin cells into embryonic-like cells called induced pluripotent stem cells or iPSCs. This Nobel Prize winning technology enables access to human neurons derived from adult blood or skin cells in a high-throughput manner, thus opening up the possibilities to study neurological…