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Revealing single-neuron and network-activity interaction by combining high-density microelectrode array and optogenetics
In a recent study published in Nature Communications, researchers described an experimental setup in which they combined MaxOne Single-Well HD-MEA recordings and optogenetic stimulation using a digital mirror device, achieving parallel stimulation and recording at single-neuron resolution. Applied to rat cortical neuronal cultures, the authors demonstrated that neurons adapt their responses to optical stimulation, while network bursts disrupt this adaptation. Moreover...
Dopamine-induced relaxation of spike synchrony diversifies burst patterns in cultured hippocampal networks
In this study, researchers investigated how dopamine-induced changes in network synchrony affect burst patterns in primary hippocampal cultures, using a comprehensive approach with electrophysiological recordings, pharmacological interventions, and computational analyses. The team used the MaxOne Single-Well HD-MEA System to examine the effects of dopamine on the spiking activity of cultured hippocampal neurons from a network-level perspective. Their findings reveal...
Solid-State Nanopores for Spatially Resolved Chemical Neuromodulation
A recent study from the project, published in Nano Letters, describes a planar neural interface that utilizes diffusion-driven neurotransmitter release through a solid-state nanopore array. To test its potential as a spatially resolved neural interface for stimulating neurons with glutamate, the scientists recorded rat retinal tissue on the MaxOne Single-Well HD-MEA. The results showed an increase in glutamate-evoked activity over time, with a clear-cut difference between cellslocated near the nanopores...
FGF8-mediated gene regulation affects regional identity in human cerebral organoids
The roles of FGF signaling and its effector genes remain poorly characterized in human experimental models mimicking early fetal telencephalic development.
In this publication, scientists under the supervision of Dr Michele Studer used an optimized protocol for human iPSC-derived brain organoid generation to study how FGF8 signalling impacts neuronal development and differentiation. MaxOne Single-Well HD-MEA was used to characterize the electrical activity of these organoids...
First Human Brain Slices Study using Optogenetics and HD-MEA Published in Nature Neuroscience
Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices This paper demonstrated for the first time that optogenetic tools can be used to modulate network activity in human brain slices, bridging the long-lasting gap between human and animal studies. The MaxOne Single-Well High-Density Microelectrode (HD-MEA) System was used to record the spontaneous and light-evoked activity of human hippocampal slices. Andrews, J.P., Geng, J., Voitiuk, K. et al. Multimodal evaluation of network activity and optogenetic interventions in human…
Join the Conversation with Prof. Feng Guo
Interview Join the Conversation with Prof. Dr. Feng Guo Intelligent BioMedical Systems (IBMS) Lab, Indiana University Bloomington, USA Dr. Feng Guo presenting at the MxW Summit 2024, in Zurich “If you have one electrode covered by many neurons, you acquire average information, which is not enough for specific computing conditions. What we really aim is high resolution at a single-neuron level, something we can achieve with MaxOne HD-MEA.” Back in April, we had the pleasure of having Dr. Feng Guo…
New Therapeutic Target in the Fight Against ALS
Scientists uncover a new protein in a pathway for neurotoxicity and cell death A new study published in Nature takes us one step forward in understanding the key mechanisms behind neurodegenerative diseases. With the urgent need for human cellular models to study such pathologies, scientists have developed a new 2D cell culture model with features mirroring those of human brains, with the support from MaxWell Biosystems’ high-density Microelectrode arrays (HD-MEAs). Delving deeper into the effects of the abnormal accumulation of TAR DNA-binding protein…
Join the Conversation with Prof. Tarja Malm
Interview Join the Conversation with Prof. Dr. Tarja Malm Malm Lab / Neuroinflammation Research Group, A.I. Virtanen Institute, University of Eastern Finland Back in May 2023, we had the pleasure of having Prof. Dr. Tarja Malm present at the 3rd In-Vitro 2D & 3D Neuronal Networks Summit, the MxW Summit 2023. Dr. Tarja captivated the audience with insights into modeling brain functions with microglia-containing organoids.Recently, we had the privilege to engage in an inspiring conversation with Dr. Tarja about her…
MaxWell Monthly Must-Reads | World Alzheimer’s Day
On this World Alzheimer’s Day, we are raising awareness on the ongoing research that seeks to unravel the mysteries behind Alzheimer’s disease. Join us in celebrating the incredible advances in this research field and outstanding scientific tools supporting discoveries on risk factors and underlying mechanisms, as well as potential treatments for Alzheimer’s. Alzheimer’s disease is a progressive neurodegenerative disorder characterized by a decline in cognitive function and memory. Symptoms can include memory loss, confusion, language impairment, and changes in behavior…
Interview with Brett Kagan – Cortical Labs
MxW Interview with Brett Kagan Cortical Labs, Melbourne, Australia Recently, we had the pleasure of having Dr. Brett Kagan from Cortical Labs visiting us here in the MaxWell Biosystems HQ in Zurich and hosting an exciting seminar on their recent work and progress. Dr. Brett Kagan’s latest work on “training neural networks to play Pong using HD-MEAs”, published in Neuron (Kagan et al, Neuron, 2022), became viral last year, and we had the opportunity to learn more about this study,…