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MaxWell Biosystems Launches Commercial Expansion: Strengthening Regional Presence in EMEA
Zurich, Switzerland – May 22, 2025 MaxWell Biosystems AG is advancing its global go-to-market strategy with the establishment of a dedicated EMEA regional team, expanding its presence and partnerships across Europe, the Middle East, and Africa. This move is part of the company’s global commercial evolution as demand continues to rise for its high-resolution electrophysiology platforms. The newly formed EMEA regional team unites sales, business development, account management, and customer success roles to accelerate adoption, strengthen collaborations, and better serve the evolving…
An Implantable Biohybrid Neural Interface Toward Synaptic Deep Brain Stimulation
Sensory nerve regrowth is often limited by the inhibitory nature of the extracellular matrix, which restricts axonal regeneration. Although cortical and deep brain stimulation offer potential therapeutic approaches, their effectiveness in sensory restoration is hindered by challenges in spatial resolution, cell specificity, and accessibility. In a recent study published in Advanced Functional Materials, researchers introduced an implantable biohybrid neural interface that integrates neural spheroids with a stretchable stimulation array and a microfluidic axon guidance system...
Swift induction of human spinal lower motor neurons and robust ALS cell screening via single-cell imaging
Swift induction of human spinal lower motor neurons and robust ALS cell screening via single-cell imaging Selena Setsu, Satoru Morimoto, Shiho Nakamura, Fumiko Ozawa, Kagistia Hana Utami, Ayumi Nishiyama, Naoki Suzuki, Masashi Aoki, Yukio Takeshita, Yukihide Tomari, Hideyuki Okano. Stem Cell Reports. 2025 Jan 14. https://doi.org/10.1016/j.stemcr.2024.11.007 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by motor neuron degeneration. While induced pluripotent stem cells (iPSCs) have emerged as a powerful tool for drug screening and studying ALS pathology, challenges…
Revealing single-neuron and network-activity interaction by combining high-density microelectrode array and optogenetics
In a recent study published in Nature Communications, researchers described an experimental setup in which they combined MaxOne Single-Well HD-MEA recordings and optogenetic stimulation using a digital mirror device, achieving parallel stimulation and recording at single-neuron resolution. Applied to rat cortical neuronal cultures, the authors demonstrated that neurons adapt their responses to optical stimulation, while network bursts disrupt this adaptation. Moreover...
Dopamine-induced relaxation of spike synchrony diversifies burst patterns in cultured hippocampal networks
In this study, researchers investigated how dopamine-induced changes in network synchrony affect burst patterns in primary hippocampal cultures, using a comprehensive approach with electrophysiological recordings, pharmacological interventions, and computational analyses. The team used the MaxOne Single-Well HD-MEA System to examine the effects of dopamine on the spiking activity of cultured hippocampal neurons from a network-level perspective. Their findings reveal...
Solid-State Nanopores for Spatially Resolved Chemical Neuromodulation
A recent study from the project, published in Nano Letters, describes a planar neural interface that utilizes diffusion-driven neurotransmitter release through a solid-state nanopore array. To test its potential as a spatially resolved neural interface for stimulating neurons with glutamate, the scientists recorded rat retinal tissue on the MaxOne Single-Well HD-MEA. The results showed an increase in glutamate-evoked activity over time, with a clear-cut difference between cellslocated near the nanopores...
FGF8-mediated gene regulation affects regional identity in human cerebral organoids
The roles of FGF signaling and its effector genes remain poorly characterized in human experimental models mimicking early fetal telencephalic development.
In this publication, scientists under the supervision of Dr Michele Studer used an optimized protocol for human iPSC-derived brain organoid generation to study how FGF8 signalling impacts neuronal development and differentiation. MaxOne Single-Well HD-MEA was used to characterize the electrical activity of these organoids...
First Human Brain Slices Study using Optogenetics and HD-MEA Published in Nature Neuroscience
Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices This paper demonstrated for the first time that optogenetic tools can be used to modulate network activity in human brain slices, bridging the long-lasting gap between human and animal studies. The MaxOne Single-Well High-Density Microelectrode (HD-MEA) System was used to record the spontaneous and light-evoked activity of human hippocampal slices. Andrews, J.P., Geng, J., Voitiuk, K. et al. Multimodal evaluation of network activity and optogenetic interventions in human…
Join the Conversation with Prof. Feng Guo
Interview Join the Conversation with Prof. Dr. Feng Guo Intelligent BioMedical Systems (IBMS) Lab, Indiana University Bloomington, USA Dr. Feng Guo presenting at the MxW Summit 2024, in Zurich “If you have one electrode covered by many neurons, you acquire average information, which is not enough for specific computing conditions. What we really aim is high resolution at a single-neuron level, something we can achieve with MaxOne HD-MEA.” Back in April, we had the pleasure of having Dr. Feng Guo…
New Therapeutic Target in the Fight Against ALS
Scientists uncover a new protein in a pathway for neurotoxicity and cell death A new study published in Nature takes us one step forward in understanding the key mechanisms behind neurodegenerative diseases. With the urgent need for human cellular models to study such pathologies, scientists have developed a new 2D cell culture model with features mirroring those of human brains, with the support from MaxWell Biosystems’ high-density Microelectrode arrays (HD-MEAs). Delving deeper into the effects of the abnormal accumulation of TAR DNA-binding protein…