English
繁體中文
简体中文
日本語
MaxWell Monthly Must-Reads (February 2022)
Welcome to our MaxWell Monthly Must-Reads blog for February 2022. After last months edition about retinal organoids we have arrived at the second blog. We have picked another theme this month and selected five papers that we have read including publications using our MaxOne and MaxTwo system. In February, we have decided to focus on ALS research. The deliberating neurodegenerative disease that forced the “The Iron Horse” (-Lou Gehrig, one of the most decorated baseball legends) to retire is medically known…
MaxWell Monthly Must-Reads (January 2022)
Welcome to our MaxWell Monthly Must-Reads blog for 2022. A new year also means new publications to highlight and new topics to discover. This year as well, for our monthly must-reads, we will choose a theme per month and select five papers that we think are worth reading. Last year we covered a range of topics and in our first edition of 2022, we have decided to focus on Retinal Organoids. Human brain organoids assemble functionally integrated bilateral optic vesicles.…
Join the Conversation with Prof. Kenneth S. Kosik and Dr. Tal Sharf
Interview and Featured Publication Join the Conversation with Prof. Kenneth Kosik and Dr. Tal Sharf Recently, Dr. Tal Sharf, Prof. Kenneth S. Kosik and colleagues released a pre-print on their novel work entitled, “Human brain organoid networks”, currently under revision. Aiming to explore the physiological behavior of neuronal circuits within organoids, this work demonstrates that human brain organoids have self-organized neuronal assemblies of sufficient size, cellular orientation, and functional connectivity to co-activate and generate field potentials from their collective transmembrane…
HyVIS project
MaxWell Biosystems Becomes a Key Partner in a €3M EU-Financed Project “HyVIS”: Next Generation Prosthesis for Visual Restoration Hybrid Synapse for Vision (HyVIS) is a project funded by European Union Horizon 2020 FET-OPEN program 1, which aims to combine several technologies to achieve the groundbreaking restoration of synaptic light-mediated input in retinas with impaired photoreceptors, leading to treatments for diseases such as in retinitis pigmentosa and age-related macular degeneration (AMD). The key focus of HyVIS project is the development of an artificial light-sensitive prosthesis,…
MaxWell Monthly Must-Reads (September 2021)
It is time for a new edition of our monthly blog. In the August edition during the summer holidays, we highlighted the latest developments on CMOS-based MEA technology. For the September edition, we decided to focus on high-throughput screening. With these articles, we would like to prepare you for our upcoming webinar which will be a live demo of our multiwell MEA system, MaxTwo. You can still register for this live demonstration here. In this Monthly Must-Reads edition, we highlighted…
MaxWell Monthly Must-Reads (August 2021)
It is time for a new edition of our monthly blog. In the August edition during the summer holidays, we highlight the latest developments on CMOS-based MEA technology. CMOS-based MEAs are used for detailed investigations of neuronal electrical activity at network and single-cell levels and to evaluate the effect of drugs on neuronal physiological activity. Therefore, for this Monthly Must-Reads edition, we decided to highlight the article written by Yuan X et al., in which switch-matrix (SM) and active-pixel-sensors…
Look back: the first In-vitro 2D and 3D Neuronal Networks Summit (MaxWell Biosystems User Meeting)
On April 22nd and 23rd, we hosted the first In-vitro 2D and 3D neuronal Networks Summit (MaxWell Biosystems User Meeting) and were very excited about the tremendously successful outcome, with over 700 registrants from 49 countries! First Day: Scientific Talks and Discussions Open for All The first day of the meeting was open to everybody. We had very interesting talks from seven invited speakers, who spoke about their work involving iPSC-derived neurons, brain organoids, and also high-density microelectrode array (HD-MEA)…
HD-MEAs play a role in the functional characterization of human iPSC-derived dopaminergic neurons
Maria Sundberg from the Boston Children’s Hospital, Harvard Medical School, and colleagues, recently reported in Nature Communications a study on the reciprocal copy number variations (CNVs) of 16p11.2 gene region, associated with a wide spectrum of neuropsychiatric and neurodevelopmental disorders. For the functional analysis of the developing iPSC-derived dopaminergic (DA) neuron network, complementary-metal-oxide-semiconductor (CMOS)-based high-density microelectrode arrays (HD-MEAs), MaxOne System by MaxWell Biosystems was extensively used. 16p.11.2 Reciprocal copy number variations (CNVs) in neuropsychiatric disorders 16p.11.2 CNVs have been implicated in…
Observing the activity of human-derived neurons in health and in disease
The combination of two technologies—induced pluripotent stem cells and high-density microelectrode arrays—offers an unprecedented platform to study human brain activity in detail outside the body. Back in 2006, Prof. Yamanaka and colleagues revealed a technique to reprogram adult skin cells into embryonic-like cells called induced pluripotent stem cells or iPSCs. This Nobel Prize winning technology enables access to human neurons derived from adult blood or skin cells in a high-throughput manner, thus opening up the possibilities to study neurological…
MaxWell Monthly Must-Reads (March 2021)
It is already time for the last MaxWell Monthly Must-Reads edition of the first quarter of 2021. Last month we focused on the topic of Simulation of extracellular neuronal spiking activity. In this edition we will focus on 3D Neural-Interfaces, and as always we selected five papers that we think are worth reading. Enjoy! Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids. by Park, Y., Franz, C. K., Ryu, H., Luan, H., Cotton, K. Y., Kim, J. U.,…