Brain Slices

MaxOne for Brain Slice Studies  Brain Slice Studies

MaxOne Brain Slice Study

MaxOne enables researchers to perform label-free analysis of intact brain networks in vitro:

  • Acute brain slices
  • Organotypic brain slice cultures and organoids
  • Ex-vivo brain preparation (e.g., eye-brain from turtles)

What You Can Do

Capture Single Neuron and Network-Wide Field Potentials

MaxOne enables recording of neuronal activity across multiple scales at high spatio-temporal resolution.

Signals MaxOne Brain Slice

  • Both local field potentials and spikes from intact brain networks can be detected simultaneously.
  • Low noise signals facilitate the extraction of neuronal acti
    vity features from experiments.

Waves Brain Slice

  • Propagating field potentials across brain areas can be captured and analyzed.

Perform Large-Scale Mapping of Cells and Synaptic Projections

Extract and analyze the action potential spatial fields, axonal projections, and postsynaptic signals of every active neuron in the brain tissue. MaxOne can detect spiking neurons in brain slices and can elicit neuronal activity by electrical stimulation.

Cerebellar Brain Slice

  • A neuronal activity map can be extracted to identify areas of the brain slice with spiking neurons.
  • Spiking frequency

Spiking Turtle Brain Slice

  • Postsynaptic events can be revealed by spike-trigerred averaging as a slow +/- signal post-spike. (M. Shein-Idelson, et al., Nat. Methods, 2017)

MaxOne Tissue Holder

TIssue Holder Brain Slice

MaxOne Tissue Holder flattens the brain slice on the MEA for stable and reprocible experiments.
The tissue holder keeps the tissue pressed and fixed on the MEA throughout the experiment, in the presence of solution perfusion.

Learn More

Publications —

Brain Slices Applications

Accurate signal-source localization in brain slices by means of high-density microelectrode arrays

Obien, Marie Engelene J; Hierlemann, Andreas; Frey, Urs

Accurate signal-source localization in brain slices by means of high-density microelectrode arrays Journal Article

Scientific Reports, 9 (788), 2019.

Abstract | Links | BibTeX

Large-scale mapping of cortical synaptic projections with extracellular electrode arrays

Shein-Idelson, Mark; Pammer, Lorenz; Hemberger, Mike; Laurent, Gilles

Large-scale mapping of cortical synaptic projections with extracellular electrode arrays Journal Article

Nature Methods, 14 (9), pp. 882–889, 2017, ISSN: 1548-7091.

Abstract | Links | BibTeX

High-density Mapping of Brain Slices Using a Large Multi-functional High-density CMOS Microelectrode Array System

Viswam, Vijay; Bounik, Raziyeh; Shadmani, Amir; Dragas, Jelena; Obien, Marie Engelene J; Muller, Jan; Chen, Yihui; Hierlemann, Andreas

High-density Mapping of Brain Slices Using a Large Multi-functional High-density CMOS Microelectrode Array System Conference

19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS) Kaohsiung, Taiwan, 2017, ISSN: 2167-0021.

Abstract | Links | BibTeX

Multiple single-unit long-term tracking on organotypic hippocampal slices using high-density microelectrode arrays

Gong, Wei; Sencar, Jure; Bakkum, Douglas J; Jäckel, David; Obien, Marie Engelene J; Radivojevic, Milos; Hierlemann, Andreas

Multiple single-unit long-term tracking on organotypic hippocampal slices using high-density microelectrode arrays Journal Article

Frontiers in Neuroscience, 10 , pp. 1-16, 2016, ISSN: 1662453X.

Abstract | Links | BibTeX

Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices

Frey, Urs; Egert, Ulrich; Heer, Flavio; Hafizovic, Sadik; Hierlemann, Andreas

Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices Journal Article

Biosensors and Bioelectronics, 24 (7), pp. 2191-2198, 2009, ISSN: 09565663.

Abstract | Links | BibTeX

Contacts








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