iPSC-derived Neurons

Study of iPSC-derived Neurons 

Webinar

Watch our iPSC webinar that introduces high-resolution functional imaging of human iPSC-derived neurons

What You Can Do

Evaluate Cell Function During Development
Track Cell Culture Activity Across Multiple Days and Obtain high-resolution activity maps of iPSC cultures using electrical activity

*Data from iPSC-derived Dopaminergic Neurons

MaxOne and MaxTwo enable recording of neuronal activity and label-free electrical imaging of whole samples. The extracellular action potential (EAP) activity map obtained provides information on:

• Location of spontaneously active cells
• EAP amplitude
• Spike rate

Characterize Network Connectivity and Synchrony
Analyze functional connectivity and synchrony of iPSC-derived neuronal cultures

MaxOne and MaxTwo allow long-term tracking of active neurons. Connectivity and synchrony can be extracted from:

• Network burst features (burst frequency, length, amplitude, etc.)
• Pairwise correlations in neuronal spike trains
• Response to selective electrical stimulation

Investigate Cell Maturity and Excitability
Study propagation of action potentials along axonal arbors of hundreds of iPSC-derived neurons simultaneously

MaxOne and MaxTwo capture the activity of neurons at high signal quality and unprecedented spatio-temporal resolution, allowing the detection of action potentials along axons.

• Observe axonal action potential propagation of single neurons across multiple days.
• Analyze axonal conduction velocity.
• Compare axonal action potential propagation between healthy and disease model cell lines.

Download Application Brochure