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Primary Cell Cultures on MaxOne MEA
Dissociated cell cultures can be plated, grown, and imaged on MaxOne MEAs. The figure shows an overlay of multiple confocal stack images: cell bodies and neurites are visible on the left side and the electrode array is focused on the right side.
What You Can Do
Single Cell Level Analysis
Isolate extracellular action potentials from individual cells easily.
Select electrodes with the best signals from each cell and improve your spike sorting.
Analyze subcellular features, such as full axonal arbors in single neurons.
Electrical signals tracked along neurites enable to investigate novel parameters, difficult to obtain with previous technologies.
High-resolution axonal action potential propagation tracking
Axonal branch signals tracking
Network Level Analysis
Record and/or stimulate every cell on the MEA.
MaxOne allows simultaneous recording from thousands of cells yields rich datasets for studying neuronal networks. Stimulation experiments can be designed with high flexibility to manipulate network dynamics.
Electrically image active cells on the MEA.
Localize active cells on the MEA during experiments. The optical image from fluorescence microscopy matches the electrical image obtained using MaxOne.
Study cells and networks across different spatial and temporal scales.
Action potentials and local field potentials can be simultaneously recorded by MaxOne over time scales of microseconds to months. The raster plot shows the dynamics of network activity using 1,024 active electrode sites.
