Neuronal Networks

Neuronal Networks

 

Primary Cell Cultures on MaxOne MEA

Dissociated cell cultures can be plated, grown, and imaged on MaxOne MEAs. The figure shows an overlay of multiple confocal stack images: cell bodies and neurites are visible on the left side and the electrode array is focused on the right side.

What You Can Do

Single Cell Level Analysis

Isolate extracellular action potentials from individual cells easily.

Select electrodes with the best signals from each cell and improve your spike sorting.

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Analyze subcellular features, such as full axonal arbors in single neurons.

Electrical signals tracked along neurites enable to investigate novel parameters, difficult to obtain with previous technologies.

High-resolution axonal action potential propagation tracking


The video shows the propagation of an AP through the axonal arbor of a single neuron. Electrical signals tracked along neurites enable to investigate novel parameters, difficult to obtain with previous technologies.
Axonal branch signals tracking
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The video shows the propagation of a stimulation-induced action potential through a branching segment of an axon. To reduce noise and better reveal the action potential, 300 trials have been averaged.

Network Level Analysis

Record and/or stimulate every cell on the MEA.

MaxOne allows simultaneous recording from thousands of cells yields rich datasets for studying neuronal networks. Stimulation experiments can be designed with high flexibility to manipulate network dynamics.

Neuronal Networks 4

Electrically image active cells on the MEA.

Localize active cells on the MEA during experiments. The optical image from fluorescence microscopy matches the electrical image obtained using MaxOne.

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Electrical image Neuronal Networks

Study cells and networks across different spatial and temporal scales.

Action potentials and local field potentials can be simultaneously recorded by MaxOne over time scales of microseconds to months. The raster plot shows the dynamics of network activity using 1,024 active electrode sites.

Raster plot Neuronal Networks

 

Contact Us

We would love to chat with you! Book a one-to-one call with one of our scientist to discuss how MaxWell Biosystems’ high-content electrophysiology solutions can bring new key insights to your project or request a quote.



Contacts










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8047 Zurich, Switzerland

+41 44 244 24 24

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info@mxwbio.com

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