Publications

Publications

 


Selected Publications

Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.


All Publications

Show all

2019

Accurate signal-source localization in brain slices by means of high-density microelectrode arrays

Obien, Marie Engelene J; Hierlemann, Andreas; Frey, Urs

Accurate signal-source localization in brain slices by means of high-density microelectrode arrays Journal Article

Scientific Reports, 9 (788), 2019.

Abstract | Links | BibTeX | Tags: Brain Slice

2017

Large-scale mapping of cortical synaptic projections with extracellular electrode arrays

Shein-Idelson, Mark; Pammer, Lorenz; Hemberger, Mike; Laurent, Gilles

Large-scale mapping of cortical synaptic projections with extracellular electrode arrays Journal Article

Nature Methods, 14 (9), pp. 882–889, 2017, ISSN: 1548-7091.

Abstract | Links | BibTeX | Tags: Brain Slice, MaxOne, Neuronal Networks

High-density Mapping of Brain Slices Using a Large Multi-functional High-density CMOS Microelectrode Array System

Viswam, Vijay; Bounik, Raziyeh; Shadmani, Amir; Dragas, Jelena; Obien, Marie Engelene J; Muller, Jan; Chen, Yihui; Hierlemann, Andreas

High-density Mapping of Brain Slices Using a Large Multi-functional High-density CMOS Microelectrode Array System Conference

19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS) Kaohsiung, Taiwan, 2017, ISSN: 2167-0021.

Abstract | Links | BibTeX | Tags: Brain Slice, ETH-CMOS-MEA, HD-MEA

2016

Multiple single-unit long-term tracking on organotypic hippocampal slices using high-density microelectrode arrays

Gong, Wei; Sencar, Jure; Bakkum, Douglas J; Jäckel, David; Obien, Marie Engelene J; Radivojevic, Milos; Hierlemann, Andreas

Multiple single-unit long-term tracking on organotypic hippocampal slices using high-density microelectrode arrays Journal Article

Frontiers in Neuroscience, 10 , pp. 1-16, 2016, ISSN: 1662453X.

Abstract | Links | BibTeX | Tags: Brain Slice, ETH-CMOS-MEA

2009

Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices

Frey, Urs; Egert, Ulrich; Heer, Flavio; Hafizovic, Sadik; Hierlemann, Andreas

Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices Journal Article

Biosensors and Bioelectronics, 24 (7), pp. 2191-2198, 2009, ISSN: 09565663.

Abstract | Links | BibTeX | Tags: Brain Slice, ETH-CMOS-MEA

 

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