Publications

Publications

 


Selected Publications

Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.


All Publications

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52 entries « 1 of 2 »

2020

Perceptual saccadic suppression starts in the retina

Idrees, Saad; Baumann, Matthias P; Franke, Felix; Münch, Thomas A; Hafed, Ziad M

Perceptual saccadic suppression starts in the retina Journal Article

Nature Communications, 11 (1977), 2020.

Links | BibTeX | Tags: ETH-CMOS-MEA, MaxOne, Retina

Massively parallel microwire arrays integrated withCMOS chips for neural recording

Obaid, Abdulmalik; Hanna, Mina-Elrahb; Wu, Yu-Wei; Kollo, Mihaly; Racz, Romeo; Angle, Matthew R; Muller, Jan; Brackbill, Nora; Wray, William; Franke, Felix; Chichilnski, E J; Hierlemann, Andreas; Ding, Jun B; Schaefer, Andreas T; Melosh, Nicholas A

Massively parallel microwire arrays integrated withCMOS chips for neural recording Journal Article

Science Advances, 2020.

Abstract | Links | BibTeX | Tags: Electrodes, ETH-CMOS-MEA

2019

Single-Cell Electrical Stimulation Using CMOS-Based High-Density Microelectrode Arrays

Ronchi, Silvia; Fiscella, Michele; Marchetti, Camilla; Viswam, Vijay; Muller, Jan; Frey, Urs; Hierlemann, Andreas

Single-Cell Electrical Stimulation Using CMOS-Based High-Density Microelectrode Arrays Journal Article

Frontiers in Neuroscience, 13 , 2019, ISSN: 1662-453X .

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Stimulation

Monolithic CMOS sensor platform featuring an array of 9’216 carbon-nanotube-sensor elements and low-noise, wide-bandwidth and wide-dynamic-range readout circuitry

Dudina, Alexandra; Seichepine, Florent; Chen, Yihui; and Stettler, Alexander; Hierlemann, Andreas; and Frey, Urs

Monolithic CMOS sensor platform featuring an array of 9’216 carbon-nanotube-sensor elements and low-noise, wide-bandwidth and wide-dynamic-range readout circuitry Journal Article

Sensors and Actuators B: Chemical, 279 , pp. 255-266, 2019.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA

Stimulation and Artifact-suppression Techniques for in-vitro High-density Microelectrode Array Systems.

Shadmani, Amir; Viswam, Vijay; Chen, Yihui; Bounik, Raziyeh; Dragas, Jelena; Radivojevic, Milos; Geissler, Sydney; Sitnikov, Sergey; Muller, Jan; Hierlemann, Andreas

Stimulation and Artifact-suppression Techniques for in-vitro High-density Microelectrode Array Systems. Journal Article

IEEE Transactions on Biomedical Engineering, 2019.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA

2018

The Axon Initial Segment is the Dominant Contributor to the Neuron's Extracellular Electrical Potential Landscape

Bakkum, Douglas J; Obien, Marie Engelene J; Radivojevic, Milos; Jäckel, David; Frey, Urs; Takahashi, Hirokazu; Hierlemann, Andreas

The Axon Initial Segment is the Dominant Contributor to the Neuron's Extracellular Electrical Potential Landscape Journal Article

Advanced Biosystems, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA

Long-term high-density extracellular recordings enable studies of muscle cell physiology and pathology

Lewandowska, Marta K; Bogatikov, Evgenii; Hierlemann, Andreas; Punga, Anna Rostedt

Long-term high-density extracellular recordings enable studies of muscle cell physiology and pathology Conference

Contribution 700.13 , Society for Neuroscience (SfN) Meeting San Diego, CA, USA, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Physiology

Investigating the analog modulation of action-potential waveforms in axonal arbors of cortical neurons using whole-cell patch-clamp recordings and high-density microelectrode arrays

Emmenegger, Vishalini; Bartram, Julian; Sitnikov, Sergey; Hierlemann, Andreas

Investigating the analog modulation of action-potential waveforms in axonal arbors of cortical neurons using whole-cell patch-clamp recordings and high-density microelectrode arrays Conference

Contribution 203.05 , Society for Neuroscience (SfN) Meeting, San Diego, CA, USA, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA

Single-neuron sub-cellular-resolution electrical stimulation with high-density microelectrode arrays

Ronchi, Silvia; Fiscella, Michele; Marchetti, Camilla; Viswam, Vijay; Müller, Jan; Frey, Urs; Hierlemann, Andreas

Single-neuron sub-cellular-resolution electrical stimulation with high-density microelectrode arrays Conference

Contribution 174.05 , Society for Neuroscience (SfN) Meeting San Diego, CA, USA, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Stimulation

Dual-Mode Microelectrode Array Featuring 20k Electrodes and High SNR for Extracellular Recording of Neural Networks

Yuan, Xinyue; Emmenegger, Vishalini; Obien, Marie Engelene J; Hierlemann, Andreas; Frey, Urs

Dual-Mode Microelectrode Array Featuring 20k Electrodes and High SNR for Extracellular Recording of Neural Networks Conference

paper 6065 , IEEE Biomedical Circuits and Systems Conference (BioCAS) Cleveland, Ohio, USA, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA

Long-Term High-Density Extracellular Recordings Enable Studies of Muscle Cell Physiology

Lewandowska, Marta K; Bogatikov, Evgenii; Hierlemann, Andreas; Punga, Anna Rostedt

Long-Term High-Density Extracellular Recordings Enable Studies of Muscle Cell Physiology Journal Article

Frontiers in Physiology, 9 , 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Muscle

Single-cell electrical stimulation with CMOS-based high-density microelectrode arrays

Ronchi, Silvia; Fiscella, Michele; Muller, Jan; Viswam, Vijay; Frey, Urs; Hierlemann, Andreas

Single-cell electrical stimulation with CMOS-based high-density microelectrode arrays Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Stimulation

Comparison of axonal-conduction velocity in developing primary cells and human iPSC-derived neurons

Obien, Marie Engelene J; Zorzi, Giulio; Fiscella, Michele; Leary, Noelle; Hierlemann, Andreas

Comparison of axonal-conduction velocity in developing primary cells and human iPSC-derived neurons Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MaxOne

Automatic extraction of axonal arbor morphology applied to h-iPSC-derived neurons

Zorzi, Giulio; Obien, Marie Engelene J; Fiscella, Michele; Leary, Noelle; Hierlemann, Andreas

Automatic extraction of axonal arbor morphology applied to h-iPSC-derived neurons Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MaxOne

COMSOL modeling of an integrated impedance sensor in a hanging-drop platform

Bounik, Raziyeh; Gusmaroli, Massimiliano; Viswam, Vijay; Modena, Mario M; Hierlemann, Andreas

COMSOL modeling of an integrated impedance sensor in a hanging-drop platform Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Microtissue

Dual-mode Microelectrode Array with 20k-electrodes and High SNR for High-Throughput Extracellular Recording and Stimulation

Yuan, Xinyue; Hierlemann, Andreas; Frey, Urs

Dual-mode Microelectrode Array with 20k-electrodes and High SNR for High-Throughput Extracellular Recording and Stimulation Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Stimulation

The axon initial segment drives the neuron's extracellular action potential

Bakkum Douglas J; Radivojevic, Milos; Obien Marie Engelene; Jaeckel David; Frey Urs; Takahashi Hirokazu; Hierlemann Andreas

The axon initial segment drives the neuron's extracellular action potential Journal Article

bioRxiv, pp. 1-30, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA

2017

Tracking individual action potentials throughout mammalian axonal arbors

Radivojevic, Milos; Franke, Felix; Altermatt, Michael; Müller, Jan; Hierlemann, Andreas; Bakkum, Douglas J

Tracking individual action potentials throughout mammalian axonal arbors Journal Article

eLife, 6 , pp. 1-23, 2017, ISSN: 2050-084X.

Abstract | Links | BibTeX | Tags: Data Analysis, ETH-CMOS-MEA, Neuronal Networks, Stimulation

High-density Mapping of Brain Slices Using a Large Multi-functional High-density CMOS Microelectrode Array System

Viswam, Vijay; Bounik, Raziyeh; Shadmani, Amir; Dragas, Jelena; Obien, Marie Engelene J; Muller, Jan; Chen, Yihui; Hierlemann, Andreas

High-density Mapping of Brain Slices Using a Large Multi-functional High-density CMOS Microelectrode Array System Conference

19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS) Kaohsiung, Taiwan, 2017, ISSN: 2167-0021.

Abstract | Links | BibTeX | Tags: Brain Slice, ETH-CMOS-MEA, HD-MEA

Network Analysis Of High-Density Microelectrode Recordings

Bullmann Torsten; Radivojevic, Milos; Huber Stefan Deligkaris Kosmas; Hierlemann Andreas; Frey Urs T:

Network Analysis Of High-Density Microelectrode Recordings Journal Article

bioRxiv , (139436), pp. 1-23, 2017.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA

A Multi-Functional Microelectrode Array Featuring 59760 Electrodes, 2048 Electrophysiology Channels, Stimulation, Impedance Measurement and Neurotransmitter Detection Channels

Dragas, Jelena; Viswam, Vijay; Shadmani, Amir; Chen, Yihui; Bounik, Raziyeh; Stettler, Alexander; Radivojevic, Milos; Geissler, Sydney; Obien, Marie Engelene J; Müller, Jan; Hierlemann, Andreas

A Multi-Functional Microelectrode Array Featuring 59760 Electrodes, 2048 Electrophysiology Channels, Stimulation, Impedance Measurement and Neurotransmitter Detection Channels Journal Article

IEEE journal of solid-state circuits, 52 (6), pp. 1576-1590, 2017, ISSN: 0018-9200.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology

Combination of High-density Microelectrode Array and Patch Clamp Recordings to Enable Studies of Multisynaptic Integration

Jäckel, David; Bakkum, Douglas J; Russell, Thomas L; Müller, Jan; Radivojevic, Milos; Frey, Urs; Franke, Felix; Hierlemann, Andreas

Combination of High-density Microelectrode Array and Patch Clamp Recordings to Enable Studies of Multisynaptic Integration Journal Article

Scientific Reports, 7 (1), pp. 978, 2017, ISSN: 2045-2322.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Neuronal Networks

Dielectrophoresis‐Assisted Integration of 1024 Carbon Nanotube Sensors into a CMOS Microsystem

Seichepine, Florent; Rothe, Jorg; Dudina, Alexandra; Hierlemann, Andreas; Frey, Urs

Dielectrophoresis‐Assisted Integration of 1024 Carbon Nanotube Sensors into a CMOS Microsystem Journal Article

Advanced Materials, 29 (17), 2017.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA

2016

Development of neural population activity toward self-organized criticality

Yada, Yuichiro; Mita, Takeshi; Sanada, Akihiro; Yano, Ryuichi; Kanzaki, Ryohei; Bakkum, Douglas J; Hierlemann, Andreas; Takahashi, Hirokazu

Development of neural population activity toward self-organized criticality Journal Article

Neuroscience, 343 , pp. 55-65, 2016, ISSN: 0306-4522.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Neuronal Networks

Multiple single-unit long-term tracking on organotypic hippocampal slices using high-density microelectrode arrays

Gong, Wei; Sencar, Jure; Bakkum, Douglas J; Jäckel, David; Obien, Marie Engelene J; Radivojevic, Milos; Hierlemann, Andreas

Multiple single-unit long-term tracking on organotypic hippocampal slices using high-density microelectrode arrays Journal Article

Frontiers in Neuroscience, 10 , pp. 1-16, 2016, ISSN: 1662453X.

Abstract | Links | BibTeX | Tags: Brain Slice, ETH-CMOS-MEA

Extracellularly Recorded Somatic and Neuritic Signal Shapes and Classification Algorithms for High-Density Microelectrode Array Electrophysiology

Deligkaris, Kosmas; Bullmann, Torsten; Frey, Urs

Extracellularly Recorded Somatic and Neuritic Signal Shapes and Classification Algorithms for High-Density Microelectrode Array Electrophysiology Journal Article

Frontiers in Neuroscience, 10 , pp. 421, 2016, ISSN: 1662-453X.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Neuronal Networks

Electrical Identification and Selective Microstimulation of Neuronal Compartments Based on Features of Extracellular Action Potentials

Radivojevic, Milos; Jäckel, David; Altermatt, Michael; Müller, Jan; Viswam, Vijay; Hierlemann, Andreas; Bakkum, Douglas J

Electrical Identification and Selective Microstimulation of Neuronal Compartments Based on Features of Extracellular Action Potentials Journal Article

Scientific Reports, 6 (1), pp. 1-20, 2016, ISSN: 2045-2322.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Neuronal Networks, Stimulation

Structures of Neural Correlation and How They Favor Coding

Franke, Felix; Fiscella, Michele; Sevelev, Maksim; Roska, Botond; Hierlemann, Andreas; Azeredo da Silveira, Rava

Structures of Neural Correlation and How They Favor Coding Journal Article

Neuron, 89 (2), pp. 409-422, 2016, ISSN: 10974199.

Abstract | Links | BibTeX | Tags: Data Analysis, ETH-CMOS-MEA, Neuronal Networks, Retina

Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity

Yonehara, Keisuke; Fiscella, Michele; Drinnenberg, Antonia; Esposti, Federico; Trenholm, Stuart; Krol, Jacek; Franke, Felix; Scherf, Brigitte Gross; Kusnyerik, Akos; Müller, Jan; Szabo, Arnold; Jüttner, Josephine; Cordoba, Francisco; Reddy, Ashrithpal Police; Németh, János; Nagy, Zoltán Zsolt; Munier, Francis; Hierlemann, Andreas; Roska, Botond

Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity Journal Article

Neuron, 89 (1), pp. 177-193, 2016, ISSN: 10974199.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Retina

2015

A method for electrophysiological characterization of hamster retinal ganglion cells using a high-density CMOS microelectrode array

Jones, Ian L; Russell, Thomas L; Farrow, Karl; Fiscella, Michele; Franke, Felix; Müller, Jan; Jäckel, David; Hierlemann, Andreas

A method for electrophysiological characterization of hamster retinal ganglion cells using a high-density CMOS microelectrode array Journal Article

Frontiers in Neuroscience, 9 , pp. 360, 2015, ISSN: 1662453X.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Retina

Visual coding with a population of direction-selective neurons

Fiscella, Michele; Franke, Felix; Farrow, Karl; Müller, Jan; Roska, Botond; Azeredo da Silveira, Rava ; Hierlemann, Andreas

Visual coding with a population of direction-selective neurons Journal Article

Journal of Neurophysiology, 114 (4), pp. 2485-2499, 2015, ISSN: 0022-3077.

Abstract | Links | BibTeX | Tags: Data Analysis, ETH-CMOS-MEA, Retina

Chronic Co-Variation of Neural Network Configuration and Activity in Mature Dissociated Cultures

Okawa, Satoru; Mita, Takeshi; Bakkum, Douglas J; Frey, Urs; Hierlemann, Andreas; Kanzaki, Ryohei; Takahashi, Hirokazu

Chronic Co-Variation of Neural Network Configuration and Activity in Mature Dissociated Cultures Journal Article

Electronics and Communications in Japan, 98 (5), pp. 34-42, 2015, ISSN: 1942-9541.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Neuronal Networks

Recording large extracellular spikes in microchannels along many axonal sites from individual neurons

Lewandowska, Marta K; Bakkum, Douglas J; Rompani, Santiago B; Hierlemann, Andreas

Recording large extracellular spikes in microchannels along many axonal sites from individual neurons Journal Article

PLoS ONE, 10 (3), pp. 1-24, 2015, ISSN: 19326203.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Neuronal Networks

2014

Parameters for burst detection

Bakkum, Douglas J; Radivojevic, Milos; Frey, Urs; Franke, Felix; Hierlemann, Andreas; Takahashi, Hirokazu

Parameters for burst detection Journal Article

Frontiers in Computational Neuroscience, 7 , pp. 1-12, 2014, ISSN: 1662-5188.

Abstract | Links | BibTeX | Tags: Data Analysis, ETH-CMOS-MEA

2013

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Bakkum, Douglas J; Frey, Urs; Radivojevic, Milos; Russell, Thomas L; Müller, Jan; Fiscella, Michele; Takahashi, Hirokazu; Hierlemann, Andreas

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites Journal Article

Nature Communications, 4 , pp. 1-12, 2013, ISSN: 2041-1723.

Abstract | Links | BibTeX | Tags: Data Analysis, ETH-CMOS-MEA, Neuronal Networks

Sub-millisecond closed-loop feedback stimulation between arbitrary sets of individual neurons.

Müller, Jan; Bakkum, Douglas J; Hierlemann, Andreas

Sub-millisecond closed-loop feedback stimulation between arbitrary sets of individual neurons. Journal Article

Frontiers in Neural Circuits, 6 , pp. 121, 2013, ISSN: 1662-5110.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology, Neuronal Networks, Stimulation

2012

Recording from defined populations of retinal ganglion cells using a high-density CMOS-integrated microelectrode array with real-time switchable electrode selection

Fiscella, Michele; Farrow, Karl; Jones, Ian L; Jäckel, David; Müller, Jan; Frey, Urs; Bakkum, Douglas J; Hantz, Péter; Roska, Botond; Hierlemann, Andreas

Recording from defined populations of retinal ganglion cells using a high-density CMOS-integrated microelectrode array with real-time switchable electrode selection Journal Article

Journal of Neuroscience Methods, 211 (1), pp. 103-113, 2012, ISSN: 01650270.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Retina

Applicability of independent component analysis on high-density microelectrode array recordings

Jäckel, David; Frey, Urs; Fiscella, Michele; Franke, Felix; Hierlemann, Andreas

Applicability of independent component analysis on high-density microelectrode array recordings Journal Article

Journal of Neurophysiology, 108 (1), pp. 334-348, 2012, ISSN: 0022-3077.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Spike Sorting

2011

Growing cells atop microelectronic chips: Interfacing electrogenic cells in vitro with CMOS-based microelectrode arrays

Hierlemann, Andreas; Frey, Urs; Hafizovic, Sadik; Heer, Flavio

Growing cells atop microelectronic chips: Interfacing electrogenic cells in vitro with CMOS-based microelectrode arrays Journal Article

Proceedings of the IEEE, 99 (2), pp. 252-284, 2011, ISSN: 00189219.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology, Review

2010

Compact voltage and current stimulation buffer for high-density microelectrode arrays

Livi, Paolo; Heer, Flavio; Frey, Urs; Bakkum, Douglas J; Hierlemann, Andreas

Compact voltage and current stimulation buffer for high-density microelectrode arrays Journal Article

IEEE Transactions on Biomedical Circuits and Systems, 4 (6), pp. 372-378, 2010, ISSN: 19324545.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology, Stimulation

Switch-matrix-based high-density microelectrode array in CMOS technology

Frey, Urs; Sedivy, Jan; Heer, Flavio; Pedron, Rene; Ballini, Marco; Müller, Jan; Bakkum, Douglas J; Hafizovic, Sadik; Faraci, Francesca D; Greve, Frauke; Kirstein, Kay Uwe; Hierlemann, Andreas

Switch-matrix-based high-density microelectrode array in CMOS technology Journal Article

IEEE Journal of Solid-State Circuits, 45 (2), pp. 467-482, 2010, ISSN: 00189200.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology

2009

Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices

Frey, Urs; Egert, Ulrich; Heer, Flavio; Hafizovic, Sadik; Hierlemann, Andreas

Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices Journal Article

Biosensors and Bioelectronics, 24 (7), pp. 2191-2198, 2009, ISSN: 09565663.

Abstract | Links | BibTeX | Tags: Brain Slice, ETH-CMOS-MEA

A synthetic mammalian electro-genetic transcription circuit

Weber, Wilfried; Luzi, Stefan; Karlsson, Maria; Sanchez-Bustamante, Carlota Diaz; Frey, Urs; Hierlemann, Andreas; Fussenegger, Martin

A synthetic mammalian electro-genetic transcription circuit Journal Article

Nucleic Acids Research, 37 (4), pp. 1-8, 2009, ISSN: 03051048.

Abstract | Links | BibTeX | Tags: Cardiomyocytes, ETH-CMOS-MEA

2008

Modulation of cardiomyocyte electrical properties using regulated bone morphogenetic protein-2 expression.

Sanchez-Bustamante, Carlota Diaz; Frey, Urs; Kelm, Jens M; Hierlemann, Andreas; Fussenegger, Martin

Modulation of cardiomyocyte electrical properties using regulated bone morphogenetic protein-2 expression. Journal Article

Tissue Engineering. Part A, 14 (12), pp. 1969-1988, 2008, ISSN: 1937-3341.

Abstract | Links | BibTeX | Tags: Cardiomyocytes, ETH-CMOS-MEA

2007

A CMOS-based microelectrode array for interaction with neuronal cultures

Hafizovic, Sadik; Heer, Flavio; Ugniwenko, T; Frey, Urs; Blau, Axel; Ziegler, Christiane; Hierlemann, Andreas

A CMOS-based microelectrode array for interaction with neuronal cultures Journal Article

Journal of Neuroscience Methods, 164 (1), pp. 93-106, 2007, ISSN: 0165-0270.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Neuronal Networks

Perforated CMOS microchip platform for immobilization and activity monitoring of electrogenic cells

Greve, Frauke; Lichtenberg, Jan; Kirstein, Kay Uwe; Frey, Urs; Perriard, Jean Claude; Hierlemann, Andreas

Perforated CMOS microchip platform for immobilization and activity monitoring of electrogenic cells Journal Article

Journal of Micromechanics and Microengineering, 17 (3), pp. 462-471, 2007, ISSN: 0960-1317.

Abstract | Links | BibTeX | Tags: Cardiomyocytes, ETH-CMOS-MEA

2006

Single-chip microelectronic system to interface with living cells

Heer, Flavio; Hafizovic, Sadik; Ugniwenko, T; Frey, Urs; Franks, Wendy; Perriard, Evelyne; Perriard, Jean Claude; Blau, Axel; Ziegler, Christiane; Hierlemann, Andreas

Single-chip microelectronic system to interface with living cells Journal Article

Biosensors & Bioelectronics, 22 (11), pp. 2546-2553, 2006, ISSN: 0956-5663.

Abstract | Links | BibTeX | Tags: Cardiomyocytes, ETH-CMOS-MEA, Neuronal Networks

Patterned cell adhesion by self-assembled structures for use with a CMOS cell-based biosensor

Franks, Wendy; Tosatti, Samuele; Heer, Flavio; Seif, Philipp; Textor, Marcus; Hierlemann, Andreas

Patterned cell adhesion by self-assembled structures for use with a CMOS cell-based biosensor Journal Article

Biosensors & Bioelectronics, 22 (7), pp. 1426-1433, 2006, ISSN: 0956-5663.

Abstract | Links | BibTeX | Tags: Cardiomyocytes, ETH-CMOS-MEA

CMOS microelectrode array for bidirectional interaction with neuronal networks

Heer, Flavio; Hafizovic, Sadik; Franks, Wendy; Blau, Axel; Ziegler, Christiane; Hierlemann, Andreas

CMOS microelectrode array for bidirectional interaction with neuronal networks Journal Article

IEEE Journal of Solid-State Circuits, 41 (7), pp. 1620-1629, 2006, ISSN: 00189200.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology, Neuronal Networks, Stimulation

Microfluidics/CMOS orthogonal capabilities for cell biology

Linder, Vincent; Koster, Sander; Franks, Wendy; Kraus, Tobias; Verpoorte, Elisabeth; Heer, Flavio; Hierlemann, Andreas; de Rooij, Nico F

Microfluidics/CMOS orthogonal capabilities for cell biology Journal Article

Biomedical Microdevices, 8 (2), pp. 159-166, 2006, ISSN: 1572-8781.

Abstract | Links | BibTeX | Tags: Cardiomyocytes, ETH-CMOS-MEA

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