Publications

Publications

 


Selected Publications

Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.


All Publications

Show all

2018

Automatic Spike Sorting Algorithm for High-Density Microelectrode Arrays

Diggelmann, Roland; Fiscella, Michele; Hierlemann, Andreas; Franke, Felix

Automatic Spike Sorting Algorithm for High-Density Microelectrode Arrays Journal Article

Journal of Neurophysiology, 120 (4), 2018.

Abstract | Links | BibTeX | Tags: MEA Technology

2017

A Multi-Functional Microelectrode Array Featuring 59760 Electrodes, 2048 Electrophysiology Channels, Stimulation, Impedance Measurement and Neurotransmitter Detection Channels

Dragas, Jelena; Viswam, Vijay; Shadmani, Amir; Chen, Yihui; Bounik, Raziyeh; Stettler, Alexander; Radivojevic, Milos; Geissler, Sydney; Obien, Marie Engelene J; Müller, Jan; Hierlemann, Andreas

A Multi-Functional Microelectrode Array Featuring 59760 Electrodes, 2048 Electrophysiology Channels, Stimulation, Impedance Measurement and Neurotransmitter Detection Channels Journal Article

IEEE journal of solid-state circuits, 52 (6), pp. 1576-1590, 2017, ISSN: 0018-9200.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology

2015

Revealing neuronal function through microelectrode array recordings

Obien, Marie Engelene J; Deligkaris, Kosmas; Bullmann, Torsten; Bakkum, Douglas J; Frey, Urs

Revealing neuronal function through microelectrode array recordings Journal Article

Frontiers in Neuroscience, 9 , pp. 423, 2015, ISSN: 1662453X.

Abstract | Links | BibTeX | Tags: MEA Technology, Review

2014

A 1024-channel CMOS microelectrode array with 26,400 electrodes for recording and stimulation of electrogenic cells in vitro

Ballini, Marco; Müller, Jan; Livi, Paolo; Chen, Yihui; Frey, Urs; Stettler, Alexander; Shadmani, Amir; Viswam, Vijay; Jones, Ian L; Jäckel, David; Radivojevic, Milos; Lewandowska, Marta K; Gong, Wei; Fiscella, Michele; Bakkum, Douglas J; Heer, Flavio; Hierlemann, Andreas

A 1024-channel CMOS microelectrode array with 26,400 electrodes for recording and stimulation of electrogenic cells in vitro Journal Article

IEEE Journal of Solid-State Circuits, 49 (11), pp. 2705-2719, 2014, ISSN: 00189200.

Abstract | Links | BibTeX | Tags: MaxOne, MEA Technology

2013

Sub-millisecond closed-loop feedback stimulation between arbitrary sets of individual neurons.

Müller, Jan; Bakkum, Douglas J; Hierlemann, Andreas

Sub-millisecond closed-loop feedback stimulation between arbitrary sets of individual neurons. Journal Article

Frontiers in Neural Circuits, 6 , pp. 121, 2013, ISSN: 1662-5110.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology, Neuronal Networks, Stimulation

2011

Growing cells atop microelectronic chips: Interfacing electrogenic cells in vitro with CMOS-based microelectrode arrays

Hierlemann, Andreas; Frey, Urs; Hafizovic, Sadik; Heer, Flavio

Growing cells atop microelectronic chips: Interfacing electrogenic cells in vitro with CMOS-based microelectrode arrays Journal Article

Proceedings of the IEEE, 99 (2), pp. 252-284, 2011, ISSN: 00189219.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology, Review

2010

Compact voltage and current stimulation buffer for high-density microelectrode arrays

Livi, Paolo; Heer, Flavio; Frey, Urs; Bakkum, Douglas J; Hierlemann, Andreas

Compact voltage and current stimulation buffer for high-density microelectrode arrays Journal Article

IEEE Transactions on Biomedical Circuits and Systems, 4 (6), pp. 372-378, 2010, ISSN: 19324545.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology, Stimulation

Switch-matrix-based high-density microelectrode array in CMOS technology

Frey, Urs; Sedivy, Jan; Heer, Flavio; Pedron, Rene; Ballini, Marco; Müller, Jan; Bakkum, Douglas J; Hafizovic, Sadik; Faraci, Francesca D; Greve, Frauke; Kirstein, Kay Uwe; Hierlemann, Andreas

Switch-matrix-based high-density microelectrode array in CMOS technology Journal Article

IEEE Journal of Solid-State Circuits, 45 (2), pp. 467-482, 2010, ISSN: 00189200.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology

2006

CMOS microelectrode array for bidirectional interaction with neuronal networks

Heer, Flavio; Hafizovic, Sadik; Franks, Wendy; Blau, Axel; Ziegler, Christiane; Hierlemann, Andreas

CMOS microelectrode array for bidirectional interaction with neuronal networks Journal Article

IEEE Journal of Solid-State Circuits, 41 (7), pp. 1620-1629, 2006, ISSN: 00189200.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology, Neuronal Networks, Stimulation

2005

Impedance characterization and modeling of electrodes for biomedical applications

Franks, Wendy; Schenker, Iwan; Schmutz, Patrik; Hierlemann, Andreas

Impedance characterization and modeling of electrodes for biomedical applications Journal Article

IEEE Transactions on Biomedical Engineering, 52 (7), pp. 1295-1302, 2005, ISSN: 00189294.

Abstract | Links | BibTeX | Tags: MEA Technology

2004

Cell-based CMOS sensor and actuator arrays

Jenkner, Martin; Tartagni, Marco; Hierlemann, Andreas; Thewes, Roland

Cell-based CMOS sensor and actuator arrays Journal Article

IEEE Journal of Solid-State Circuits, 39 (12), pp. 2431-2437, 2004, ISSN: 00189200.

Abstract | Links | BibTeX | Tags: MEA Technology, Review

CMOS microelectrode array for the monitoring of electrogenic cells

Heer, Flavio; Franks, Wendy; Blau, Axel; Taschini, S; Ziegler, Christiane; Hierlemann, Andreas; Baltes, Henry

CMOS microelectrode array for the monitoring of electrogenic cells Journal Article

Biosensors & Bioelectronics, 20 (2), pp. 358-366, 2004, ISSN: 0956-5663.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MEA Technology

 

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