論文

Publications

 


Selected Publications

Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.


All Publications

175 entries « 2 of 9 »
21. Silverman, Jill L; Fenton, Timothy; Haouchine, Olivia; Hallam, Elizabeth; Smith, Emily; Jackson, Kiya; Rahbarian, Darlene; Canales, Cesar; Adhikari, Anna; Nord, Alex; Ben-Shalom, Roy: Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1mutations. In: Research Square, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
22. Habibollahi, Forough; Kagan, Brett J; Burkitt, Anthony N; French, Chris: Critical dynamics arise during structured information presentation within embodied in vitro neuronal networks. In: Nature Communications, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
23. Radivojevic, Milos; Punga, Anna Rostedt: Functional imaging of conduction dynamics in cortical and spinal axons. In: eLife, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
24. Duru, Jens; Maurer, Benedikt; Doran, Ciara Giles; Jelitto, Robert; Küchler, Joël; Ihle, Stephan J; Ruff, Tobias; John, Robert; Genocchi, Barbara; Vörös, János: Investigation of the input-output relationship of engineered neural networks using high-density microelectrode arrays. In: Biosensors and Bioelectronics, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
25. Yamamoto, Hideaki; Hirano-Iwata, Ayumi; Sato, Shigeo: Microfluidic technologies for reconstituting neuronal network functions in vitro. In: JSAP Review, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
26. Zhao, Eric T; Hull, Jacob M; Hemed, Nofar Mintz; Ulusan, Hasan; Bartram, Julian; Zhang, Anqi; Wang, Pingyu; Pham, Albert; Silvia Ronchi, John Huguenard R; Hierlemann, Andreas; Melosh, Nicholas A: A CMOS-based highly scalable flexible neural electrode interface. In: Science Advances, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
27. Girardi, Gregory; Zumpano, Danielle; Goshi, Noah; Raybould, Helen; Seker, Erkin: Cultured Vagal Afferent Neurons as Sensors for Intestinal Effector Molecules. In: biosensors, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
28. Bartram, Julian; Franke, Felix; Kumar, Sreedhar Saseendran; Buccino, Alessio Paolo; Xue, Xiaohan; Gänswein, Tobias; Schröter, Manuel; Kim, Taehoon; Kasuba, Krishna Chaitanya; Hierlemann, Andreas: Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking. In: eLife, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
29. Duru, Jens; Maurer, Benedikt; Doran, Ciara Giles; Jelitto, Robert; Küchler, Joël; Ihle, Stephan J; Ruff, Tobias; John, Robert; Genocchi, Barbara; Vörös, János: Investigation of the input-output relationship of engineered neural networks using high-density microelectrode arrays. In: SSRN, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
30. Xu, He Jax; Yao, Yao; Yao, Fenyong; Chen, Jiehui; Li, Meishi; Yang, Xianfa; Li, Sheng; Lu, Fangru; Hu, Ping; He, Shuijin; Peng, Guangdun; Jing, Naihe: Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells. In: Cell Regeneration, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
31. Radivojevic, Milos; Punga, Anna Rostedt: Functional imaging of conduction dynamics in cortical and spinal axons. In: BioRxiv, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
32. Cai, Hongwei; Ao, Zheng; Tian, Chunhui; Wu, Zhuhao; Liu, Hongcheng; Tchieu, Jason; Gu, Mingxia; Mackie, Ken; and Guo, Feng: Brain Organoid Computing for Artificial Intelligence. In: bioRxiv, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
33. Lin, Waka; Shiomoto, Shusaku; Yamada, Saki; Watanabe, Hikaru; Kawashima, Yudai; Eguchi, Yuichi; Muramatsu, Koichi; Sekino, Yuko: Dendritic spine formation and synapse maturation in transcription factor-induced human iPSC-derived neurons. In: iScience, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
34. Qian, Junming; Guan, Xiaonan; Xie, Bing; Xu, Chuanyun; Niu, Jacqueline; Tang, Xin; Li, Charles H; Colecraft, Henry M; Jaenisch, Rudolf; Liu, Shawn X: Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons. In: Science Translational Medicine, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
35. Kim, Eunhee; Jeon, Sungwoong; Yang, Yoon-Sil; Jin, Chaewon; Kim, Jin-young; Oh, Yong- Seok; Rah, Jong-Cheol; and Choi, Hongsoo: A Neurospheroid-Based Microrobot for Targeted Neural Connections in a Hippocampal Slice. In: Advanced Materials, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
36. Kim, Taehoon; Chen, Dexiong; Hornauer, Philipp; Emmenegger, Vishalini; Bartram, Julian; Ronchi, Silvia; Hierlemann, Andreas; Schröter, Manuel; Roqueiro, Damian: Predicting in vitro single-neuron firing rates upon pharmacological perturbation using Graph Neural Networks. In: Frontiers in Neuroinformatics, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
37. Sato, Yuya; Yamamoto, Hideaki; Kato, Hideyuki; Tanii, Takashi; Sato, Shigeo; Hirano-Iwata, Ayumi: Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks. In: Frontiers in Neuroscience, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
38. Bartram, Julian; Franke, Felix; Kumar, Sreedhar Saseendran; Buccino, Alessio Paolo; Xue, Xiaohan; Gänswein, Tobias; Schröter, Manuel; Kim, Taehoon; Kasuba, Krishna Chaitanya; Hierlemann, Andreas: Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking. In: bioRxiv, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
39. Han, Xiaobo; Matsuda, Naoki; Ishibashi, Yuto; Odawara, Aoi; Takahashi, Sayuri; Tooi, Norie; Kinoshita, Koshi; Suzuki, Ikuro: A functional neuron maturation device provides convenient application on microelectrode array for neural network measurement. In: Biomaterials Research, 2022. (Type: Journal Article | Abstract | Links | BibTeX)
40. Lent, Jonas Van; Vendredy, Leen; Adriaenssens, Elias; Authier, Tatiana Da Silva; Asselbergh, Bob; Kaji, Marcus; Weckhuysen, Sarah; Bosch, Ludo Van Den; Baets, Jonathan; Timmerman, Vincent: Downregulation of PMP22 ameliorates myelin defects in iPSC-derived human organoid cultures of CMT1A. In: Brain, 2022. (Type: Journal Article | Abstract | Links | BibTeX)
175 entries « 2 of 9 »

175 entries « 2 of 4 »

2022

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking

Xue, Xiaohan; Buccino, Alessio Paolo; Kumar, Sreedhar Saseendran; Hierlemann, Andreas; Bartram, Julian

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking Journal Article

Journal of Neural Engineering, 2022.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, Activity Assay, HD-MEA, MaxOne, Network Assay, Primary Neuronal Cell Culture, Publication

Functional neuronal circuitry and oscillatory dynamics in human brain organoids

Sharf Tal; Molen, Tjitse; Glasauer Stella; Guzman Elmer; Buccino Alessio; Luna Gabriel; Cheng Zhuowei; Audouard Morgane; Ranasinghe Kamalini; Kudo Kiwamu; Nagarajan Srikantan; Tovar Kenneth; Petzold Linda; Hierlemann Andreas; Hansma Paul; ; Kosik, Kenneth;

Functional neuronal circuitry and oscillatory dynamics in human brain organoids Journal Article

Nature Communications, 2022.

Abstract | Links | BibTeX | タグ: MaxOne, Neuronal Networks, Organoids

Suppression without inhibition: how retinal computation contributes to saccadic suppression

Idrees, Saad; Baumann, Matthias-Philipp; Korympidou, Maria M; Schubert, Timm; Kling, Alexandra; Franke, Katrin; Hafed, Ziad M; Franke, Felix; Münch, Thomas A

Suppression without inhibition: how retinal computation contributes to saccadic suppression Journal Article

Communications Biology, 2022.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne, Retina

P97/VCP ATPase inhibitors can rescue p97 mutation-linked motor neuron degeneration

Wang, F; Li, S; Wang, T Y; Lopez, G A; Antoshechkin, I; Chou, T F

P97/VCP ATPase inhibitors can rescue p97 mutation-linked motor neuron degeneration Journal Article

Brain Communications, 2022.

Abstract | Links | BibTeX | タグ: MaxTwo

Functional imaging of brain organoids using high-density microelectrode arrays

Schröter Manuel; Wang, Congwei; Terrigno Marco; Hornauer Philipp; Huang Ziqiang; Jagasia Ravi; Hierlemann Andreas

Functional imaging of brain organoids using high-density microelectrode arrays Journal Article

MRS Bulletin, 2022.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne, MaxTwo, Organoids

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells

Xu, Jax H; Yao, Yao; Yao, Fenyong; Chen, Jiehui; Li, Meishi; Xianfa, ; Yang, ; Li, Sheng; Lu, Fangru; Hu, Ping; He, Shuijin; Peng, Guangdun; Jing, Naihe

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells Journal Article

BioRxiv, 2022.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, CMOS, HD-MEA, IPSC, MaxOne

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons

Sommer Daniel ; Rajkumar, Sandeep; Seidel Mira; Aly Amr; Ludolph Albert; Ho Ritchie; Boeckers Tobias; Catanese Alberto.

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons Journal Article

Frontiers in Molecular Neuroscience, 2022.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne, Neuronal Networks

Automated detection of extracellular action potentials from single neurons

Cheng, Zhuowei; Guzman, Elmer; van der Molen, Tjitse; Sharf, Tal; Hansma, Paul K; Kosik, Kenneth S; Petzold, Linda; Tovar, Kenneth R

Automated detection of extracellular action potentials from single neurons Journal Article

bioRxiv, 2022.

Abstract | Links | BibTeX | タグ: Action Potential, HD-MEA, MaxOne

A Biodegradable Magnetic Microrobot Based on Gelatin Methacrylate for Precise Delivery of Stem Cells with Mass Production Capability

Noh Seungmin ; Jeon, Sungwoong; Kim Eunhee; Oh Untaek; Park Danbi; Park Sun Hwa; Kim Sung Won; Pané Salvador; Nelson Bradley; Kim Jin-young; Choi Hongsoo;

A Biodegradable Magnetic Microrobot Based on Gelatin Methacrylate for Precise Delivery of Stem Cells with Mass Production Capability Journal Article

Small, 2022.

Abstract | Links | BibTeX | タグ: MaxOne

Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks

Sato Yuya; Yamamoto, Hideaki; Kato Hideyuki; Tanii Takashi; Sato Shigeo; Hirano-Iwata Ayumi

Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks Journal Article

2022.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne, Neuronal Networks

Recording Saltatory Conduction Along Sensory Axons Using a High-Density Microelectrode Array

Shimba Kenta; Asahina, Takahiro; Sakai Koji; Kotani Kiyoshi; Jimbo Yasuhiko

Recording Saltatory Conduction Along Sensory Axons Using a High-Density Microelectrode Array Journal Article

Frontiers in Neuroscience, 2022.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne, Neuronal cell culture

Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics 2 electrophysiological phenotype of the A53T mutation

Hornauer Philipp; Prack, Gustavo; Anastasi Nadia; Ronchi Silvia; Kim Taehoon; Donner Christian; Fiscella Michele; Borgwardt Karsten; Taylor Verdon; Jagasia Ravi; Roqueiro Damian; Hierlemann Andreas;

Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics 2 electrophysiological phenotype of the A53T mutation Journal Article

bioRxiv, 2022.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne, Neuronal cell culture

Design strategies for controlling neuron-connected robots using reinforcement learning

Sawada, Haruto; Wake, Naoki; Sasabuchi, Kazuhiro; Takamatsu, Jun; Takahashi, Hirokazu; Ikeuchi, Katsushi

Design strategies for controlling neuron-connected robots using reinforcement learning Journal Article

arXiv, 2022.

Abstract | Links | BibTeX | タグ: Machine Learning, MaxOne, Stimulation

Engineered Biological Neural Networks on High Density CMOS Microelectrode Arrays

Duru Jens; Küchler, Joël; Ihle Stephan Forró Csaba; Bernardi Aeneas; Girardin Sophie; Hengsteler Julian; Wheeler Stephen; János; Ruff Tobias; J ; Vörös

Engineered Biological Neural Networks on High Density CMOS Microelectrode Arrays Journal Article

2022.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne, Neuronal Networks

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking

Xue, Xiaohan ; Buccino, Alessio Paolo ; Kumar, Sreedhar Saseendran ; Hierlemann, Andreas ; Bartram, Julian

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking Journal Article

bioRxiv, 2022.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, Neuronal Networks

Loss of Neurodevelopmental Gene CASK Disrupts Neural Connectivity in Human Cortical Excitatory Neurons

McSweeney, Danny; Gabriel, Rafael; Jin, Kang; Pang, Zhiping P; Aronow, Bruce; Pak, ChangHui

Loss of Neurodevelopmental Gene CASK Disrupts Neural Connectivity in Human Cortical Excitatory Neurons Journal Article

BioRxiv, 2022.

Abstract | Links | BibTeX | タグ: IPSC, MaxOne, Neuronal Networks

Autism genes converge on asynchronous development of shared neuron classes

Paulsen, Bruna; Velasco, Silvia; Kedaigle, Amanda J; Pigoni, Martina; Quadrato, Giorgia; Deo, Anthony J; Adiconis, Xian; Uzquiano, Ana; Sartore, Rafaela; Yang, Sung Min; Simmons, Sean K; Symvoulidis, Panagiotis; Kim, Kwanho; Tsafou, Kalliopi; Podury, Archana; Abbate, Catherine; Tucewicz, Ashley; Smith, Samantha N; Albanese, Alexandre; Barrett, Lindy; Sanjana, Neville E; Shi, Xi; Chung, Kwanghun; Lage, Kasper; Boyden, Edward S; andJoshua Levin, Aviv Regev Z; Arlotta, Paola

Autism genes converge on asynchronous development of shared neuron classes Journal Article

Nature, 602 , pp. 268–273, 2022.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne, Organoids

2021

Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD

Hruska-Plochan, Marian; Betz, Katharina M; Ronchi, Silvia; Wiersma, Vera I; Maniecka, Zuzanna; Hock, Eva-Maria; Laferriere, Florent; Sahadevan, Sonu; Hoop, Vanessa; Delvendahl, Igor; Panatta, Martina; van der Bourg, Alexander; Bohaciakova, Dasa; Frontzek, Karl; Aguzzi, Adriano; Lashley, Tammaryn; Robinson, Mark D; Karayannis, Theofanis; Mueller, Martin; Hierlemann, Andreas; Polymenidou, Magdalini

Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD Journal Article

BioRxiv, 2021.

Abstract | Links | BibTeX | タグ: Inhibitory Neurons, MEA Technology, Neuronal Networks

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

Kagan, Brett J; Kitchen, Andy C; Tran, Nhi T; Parker, Bradyn J; Bhat, Anjali; Rollo, Ben; Razi, Adeel; Friston, Karl J

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world Journal Article

BioRxiv, 2021.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, In-Vitro, MaxOne

Unifying framework for information processing in stochastically driven dynamical systems

Kubota, Tomoyuki; Takahashi, Hirokazu; and Nakajima, Kohei

Unifying framework for information processing in stochastically driven dynamical systems Journal Article

Physical Review Research, 2021.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, HD-MEA, MaxOne, Primary Neuronal Cell Culture, Stimulation

Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1

Schenke, Maren; Prause, Hélène-Christine; Bergforth, Wiebke; Przykopanski, Adina

Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1 Journal Article

toxins, 2021.

Abstract | Links | BibTeX | タグ: MaxOne

16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro

Sundberg, Maria; Pinson, Hannah; Smith, Richard S; Winden, Kellen D; Venugopal, Pooja; Tai, Derek J C; Gusella, James F; Talkowski, Michael E; Walsh, Christopher A; Tegmark, Max; Sahin, Mustafa

16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro Journal Article

Nature Communications, 12 (2897 ), 2021.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, IPSC, MaxOne

Inhibitory neurons exhibit high controlling ability in the cortical microconnectome

Kajiwara Motoki; Nomura, Ritsuki; Goetze Felix; Kawabata Masanori; Isomura Yoshikazu; Akutsu Tatsuya; Shimono Masanori;

Inhibitory neurons exhibit high controlling ability in the cortical microconnectome Journal Article

PLOS Computational Biology, 2021.

Abstract | Links | BibTeX | タグ: Brain Slice, MaxOne

Extracellular Recording of Entire Neural Networks Using a Dual-Mode Microelectrode Array With 19,584 Electrodes and High SNR

Yuan, Xinyue; Hierlemann, Andreas; Frey, Urs

Extracellular Recording of Entire Neural Networks Using a Dual-Mode Microelectrode Array With 19,584 Electrodes and High SNR Journal Article

IEEE, 2021.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, MEA Technology

Microelectrode Arrays: Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays

Ronchi, Silvia; Buccino, Alessio Paolo; Prack, Gustavo; Kumar, Sreedhar Saseendran; Schröter, Manuel; Fiscella, Michele; Hierlemann, Andreas

Microelectrode Arrays: Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays Journal Article

Advanced Biology, 5 (3), 2021.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, IPSC

Intrinsic network activity in human brain organoids

Sharf, Tal; van der Molen, Tjitse; Guzman, Elmer; Glasauer, Stella M K; Luna, Gabriel; Cheng, Zhouwei; Audouard, Morgane; Ranasinghe, Kamalini G; Kudo, Kiwamu; Nagarajan, Srikantan S; Tovar, Kenneth R; Petzold, Linda R; Hansma, Paul K; Kosik, Kenneth S

Intrinsic network activity in human brain organoids Journal Article

BioRxiv, 2021.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, Neuronal Networks, Organoids

2020

Different contrast encoding in ON and OFF visual pathways

Idrees, Saad; Münch, Thomas A

Different contrast encoding in ON and OFF visual pathways Journal Article

BioRxiv, 2020.

Abstract | Links | BibTeX | タグ: MaxOne, Retina

Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons

Battaglia, Chiara R; Cursano, Silvia; Calzia, Enrico; Catanese, Alberto; Boeckers, Tobias M

Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons Journal Article

Cell Death & Disease, 2020.

Abstract | Links | BibTeX | タグ: MaxTwo

MAPSYNE: Miniaturized micropipette system combined with high-density microelectrode arrays for automated manipulation of neuronal networks in-vitro

Ricci, Chiara; Frey, Urs; Obien, Marie Engelene J

MAPSYNE: Miniaturized micropipette system combined with high-density microelectrode arrays for automated manipulation of neuronal networks in-vitro Journal Article

IEEE, 2020.

Abstract | Links | BibTeX | タグ: Activity Scan Assay, HD-MEA, MaxOne, MEA Technology

Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level

Yuan, Xinyue; Schröter, Manuel; Obien, Marie Engelene J; Fiscella, Michele; Gong, Wei; Kikuchi, Tetsuhiro; Odawara, Aoi; Noji, Shuhei; Suzuki, Ikuro; Takahashi, Jun; Hierlemann, Andreas; Frey, Urs

Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level Journal Article

Nature Communications, 11 (4854), 2020.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, MEA Technology

A magnetically actuated microrobot for targeted neural cell delivery and selective connection of neural networks

Kim, Eunhee; Jeon, Sungwoong; An, Hyun-Kyu; Mehrnoosh Kianpour, Seong-Woon Yu ; Kim, Jin-young; Rah, Jong-Cheol; Choi, Hongsoo

A magnetically actuated microrobot for targeted neural cell delivery and selective connection of neural networks Journal Article

Science Advances, 6 (39), 2020.

Abstract | Links | BibTeX | タグ: microrobot, Neuronal Networks

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution

Cowan, Cameron S; Renner, Magdalena; Gennaro, Martina De; Gross-Scherf, Brigitte; Goldblum, David; Hou, Yanyan; Munz, Martin; Rodrigues, Tiago M; Krol, Jacek; Szikra, Tamas; Cuttat, Rachel; Waldt, Annick; Papasaikas, Panagiotis; Diggelmann, Roland; Patino-Alvarez, Claudia P; Galliker, Patricia; Spirig, Stefan E; Pavlinic, Dinko; Gerber-Hollbach, Nadine; Schuierer, Sven; Srdanovic, Aldin; Balogh, Marton; Panero, Riccardo; Kusnyerik, Akos; Szabo, Arnold; Stadler, Michael B; Orgül, Selim; Picelli, Simone; Hasler, Pascal W; Hierlemann, Andreas; Scholl, Hendrik P N; Roma, Guglielmo; Nigsch, Florian; Roska, Botond

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution Journal Article

CellPress, 182 , pp. 1623–1640, 2020.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, Organoids

Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays

Ronchi, Silvia; Buccino, Alessio Paolo; Prack, Gustavo; Kumar, Sreedhar Saseendran; Schröter, Manuel; Fiscella, Michele; Hierlemann, Andreas

Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays Journal Article

BioRxiv, 2020.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, IPSC

Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability

Al-Absi, Abdel-Rahman; Qvist, Per; Okujeni, Samora; Khan, Ahmad Raza; Glerup, Simon; Sanchez, Connie; Nyengaard, Jens R

Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability Journal Article

Molecular Neurobiology, 2020.

Abstract | Links | BibTeX | タグ: MaxOne, Slices

Sleep as a default state of cortical and subcortical networks

Bandarabadi, Mojtaba; Vassalli, Anne; Tafti, Mehdi

Sleep as a default state of cortical and subcortical networks Journal Article

Current Opinion in Physiology, 15 , pp. 60-67, 2020.

Abstract | Links | BibTeX | タグ: Neuronal Networks, Review, Sleep

Neural Autopoiesis: Organizing Self-Boundaries by Stimulus Avoidance in Biological and Artificial Neural Networks

Masumori, Atsushi; Sinapayen, Lana; Maruyama, Norihiro; Mita, Takeshi; Bakkum, Douglas J; Frey, Urs; Takahashi, Hirokazu; Ikegami, Takashi

Neural Autopoiesis: Organizing Self-Boundaries by Stimulus Avoidance in Biological and Artificial Neural Networks Journal Article

Artificial Life, 26 (1), pp. 130-151, 2020, ISSN: 1064-5462.

Abstract | Links | BibTeX | タグ: Neuronal Networks

Perceptual saccadic suppression starts in the retina

Idrees, Saad; Baumann, Matthias P; Franke, Felix; Münch, Thomas A; Hafed, Ziad M

Perceptual saccadic suppression starts in the retina Journal Article

Nature Communications, 11 (1977), 2020.

Links | BibTeX | タグ: ETH-CMOS-MEA, MaxOne, Retina

Massively parallel microwire arrays integrated withCMOS chips for neural recording

Obaid, Abdulmalik; Hanna, Mina-Elrahb; Wu, Yu-Wei; Kollo, Mihaly; Racz, Romeo; Angle, Matthew R; Muller, Jan; Brackbill, Nora; Wray, William; Franke, Felix; Chichilnski, E J; Hierlemann, Andreas; Ding, Jun B; Schaefer, Andreas T; Melosh, Nicholas A

Massively parallel microwire arrays integrated withCMOS chips for neural recording Journal Article

Science Advances, 2020.

Abstract | Links | BibTeX | タグ: Electrodes, ETH-CMOS-MEA

Inhibitory neurons are a Central Controlling regulator in the effective cortical microconnectome

Kajiwara, Motoki; Nomura, Ritsuki; Goetze, Felix; Akutsu, Tatsuya; Shimono, Masanori

Inhibitory neurons are a Central Controlling regulator in the effective cortical microconnectome Journal Article

bioRxiv , 2020.

Abstract | Links | BibTeX | タグ: Inhibitory Neurons

2019

Evaluation of Conduction Properties of Sensory Axons with High-Density Microelectrode Array

Shimba, Kenta; Asahina, Takahiro; Sakai, Koji; JImbo, Yasuhiko; Kotani, Kiyoshi

Evaluation of Conduction Properties of Sensory Axons with High-Density Microelectrode Array Conference

2019.

Abstract | Links | BibTeX | タグ: HD-MEA

Echo State Property of Neuronal Cell Cultures

Kubota, Tomoyuki; Nakajima, Kohei; Takahashi, Hirokazu

Echo State Property of Neuronal Cell Cultures Book Chapter

11731 , Springer, 2019, ISBN: 978-3-030-30493-5.

Abstract | Links | BibTeX | タグ: Action Potential, MaxOne, Neuronal cell culture

Large-Scale Mapping of Axonal Arbors Using High-Density Microelectrode Arrays

Bullmann Torsten; Radivojevic, Milos; Huber Stefan Deligkaris Kosmas; Hierlemann Andreas; Frey Urs T:

Large-Scale Mapping of Axonal Arbors Using High-Density Microelectrode Arrays Journal Article

Frontiers in Cellular Neuroscience , 13 , 2019, ISSN: 1662-5102.

Abstract | Links | BibTeX | タグ: Axonal Arbors, HD-MEA

Large-Scale, High-Resolution Microelectrode Arrays for Interrogation of Neurons and Networks

Obien, Marie Engelene J; Frey, Urs

Large-Scale, High-Resolution Microelectrode Arrays for Interrogation of Neurons and Networks Book Chapter

Springer, 2019.

Abstract | Links | BibTeX | タグ: In-Vitro, Neuronal Networks

Classification of Inhibitory and Excitatory Neurons of Dissociated Cultures Based on Action Potential Waveforms on High-density CMOS Microelectrode Arrays

Mita, Takeshi; Bakkum, Douglas J; Frey, Urs; Hierlemann, Andreas; Kanzaki, Ryohei; Takahashi, Hirokazu

Classification of Inhibitory and Excitatory Neurons of Dissociated Cultures Based on Action Potential Waveforms on High-density CMOS Microelectrode Arrays Journal Article

IEEJ Transactions on Electronics, Information and Systems, 139 (5), pp. 615-624, 2019, ISSN: 1348-8155.

Abstract | Links | BibTeX | タグ: Action Potential, HD-MEA

Technologies to Study Action Potential Propagation With a Focus on HD-MEAs

Emmenegger, Vishalini; Obien, Marie Engelene J; Franke, Felix; Hierlemann, Andreas

Technologies to Study Action Potential Propagation With a Focus on HD-MEAs Journal Article

Frontiers in Cellular Neuroscience, 13 , pp. 1-11, 2019, ISSN: 1662-5102 .

Abstract | Links | BibTeX | タグ: Action Potential, HD-MEA

Optimal Electrode Size for Multi-Scale Extracellular-Potential Recording From Neuronal Assemblies

Viswam, Vijay; Obien, Marie Engelene J; Franke, Felix; Frey, Urs; Hierlemann, Andreas

Optimal Electrode Size for Multi-Scale Extracellular-Potential Recording From Neuronal Assemblies Journal Article

Frontiers in Neuroscience, 13 , 2019, ISSN: 1662-453X.

Abstract | Links | BibTeX | タグ: Neuronal Assemblies

Medullary Respiratory Circuit Is Reorganized by a Seasonally-Induced Program in Preparation for Hibernation

Russell, Thomas L; Zhang, Jichang; Okoniewksi, Michal; Franke, Felix; Bichet, Sandrine; Hierlemann, Andreas

Medullary Respiratory Circuit Is Reorganized by a Seasonally-Induced Program in Preparation for Hibernation Journal Article

Frontiers in Neuroscience , 13 , 2019, ISSN: 1662-453X.

Abstract | Links | BibTeX | タグ: Respiratory Circuit

Single-Cell Electrical Stimulation Using CMOS-Based High-Density Microelectrode Arrays

Ronchi, Silvia; Fiscella, Michele; Marchetti, Camilla; Viswam, Vijay; Muller, Jan; Frey, Urs; Hierlemann, Andreas

Single-Cell Electrical Stimulation Using CMOS-Based High-Density Microelectrode Arrays Journal Article

Frontiers in Neuroscience, 13 , 2019, ISSN: 1662-453X .

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA, Stimulation

Accurate signal-source localization in brain slices by means of high-density microelectrode arrays

Obien, Marie Engelene J; Hierlemann, Andreas; Frey, Urs

Accurate signal-source localization in brain slices by means of high-density microelectrode arrays Journal Article

Scientific Reports, 9 (788), 2019.

Abstract | Links | BibTeX | タグ: Brain Slice

Monolithic CMOS sensor platform featuring an array of 9’216 carbon-nanotube-sensor elements and low-noise, wide-bandwidth and wide-dynamic-range readout circuitry

Dudina, Alexandra; Seichepine, Florent; Chen, Yihui; and Stettler, Alexander; Hierlemann, Andreas; and Frey, Urs

Monolithic CMOS sensor platform featuring an array of 9’216 carbon-nanotube-sensor elements and low-noise, wide-bandwidth and wide-dynamic-range readout circuitry Journal Article

Sensors and Actuators B: Chemical, 279 , pp. 255-266, 2019.

Abstract | Links | BibTeX | タグ: ETH-CMOS-MEA

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