Publication

Butylphthalide enhances neurorestoration following ischemic stroke by restructuring microvasculature through vimentin modulation

December 1, 2025
Compound Testing
Disease Modeling
MaxLab Live
MaxOne
MaxOne Chip
Neuronal Cell Cultures
Haiyan Xiao, Haochen Xie, Meng Qin, Chenwei Zuo, Ruimao Zheng, Shaochan Zhang, Shiyi Sun, Jingxue Ye, Min Wang, Yu Tian, Li Cao, Guibo Sun
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Abstract

Details

Ischemic stroke severely threatens human health. Rapid restoration of cerebral blood flow (CBF) in ischemic microvessels is significant as it enhances neurovascular function, prevents neuronal death, and minimises cerebrovascular injury. Although butylphthalide (NBP) is commonly used to treat ischemic stroke, its exact molecular target remains unclear.