Abstract
Details
- Higher spatial resolution: MaxOne HD-MEAs (3,265 electrodes/mm²) show which neurons are active without labeling. Low-density MEAs with 8 or 16 electrodes only capture the averaged activity of a few cells.
- Greater sensitivity: Small, low-noise electrodes detect even the smallest spikes. Larger electrodes average the signals, which lowers spike amplitudes and hides the details of network activity.
- Subcellular access: HD-MEAs record both soma and axonal signals. The AxonTracking Assay follows action potentials as they travel along axons in dense iPSC-derived cultures.
- More reliable compound testing: Lower variability between samples makes drug effects easier to see (shown with retigabine). With low-density MEAs, the differences between conditions get lost.
- Applications: Phenotypic screening, disease modeling and drug discovery with in vitro neuronal models.