Webinar

Profiling and programming in vitro neuronal diversity at single-cell resolution

October 28, 2025
MaxTwo
Neuronal Cell Cultures
Disease Modeling
ETH Zurich HD-MEA
Method Development
Hsiu-Chuan Lin, Philipp Hornauer
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Abstract

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The webinar covered

  • How combining transcription factors overexpression with developmental signaling modulation enables the generation of diverse human neuron types.
  • Findings from a comprehensive screen of 480 patterning conditions using single-cell transcriptomics on 700,000 cells.
  • Functional profiling of neurons using MaxWell Biosystems’ MaxTwo HD-MEA platform to capture activity, connectivity, and morphological diversity across different patterning conditions.
  • The relationship between transcriptomic signatures and neuronal structure, revealing mechanisms of maturation and identity formation.