Engineered Neural Networks for Disease Modeling and Drug Discovery

The webinar covered

• Micro- and nano-channel PDMS platforms enable directional neuronal network fabrication at single-neuron resolution.
• Integration with patient primary or iPSC-derived cells enables precise, personalized disease modeling.
• A biophysical modeling approach coupled with neuronal networks on a chip enables quantification of synaptic receptor alterations in isolated neuronal pairs.
• Application of information theory reveals increased feedback motifs and enhanced information transfer in glioblastoma-infiltrated neuronal networks.