Isogenic forebrain organoids uncover early neurodevelopmental alterations and imbalances in neuronal function leading to hyperexcitation in Gaucher disease
James A. Crowe, Zuzana Matusova, Aline S. Girard, Amélie Rajon, David Colameo, Leal Oburoglu, Oskar G. Zetterdahl, Joachim Björklund, Claudia Puigsallosas Pastor, Svenja Krupp, Ulf Ellervik, Alessio Cremonesi, Daniel Tornero, David Penton Ribas, Henrik Ahlenius, Lukas Valihrach, Isaac Canals
A high-density microelectrode array integrated microfluidic platform for quantitative investigation of functional connectivity in interconnected human dopaminergic neurospheroids
Chiara Ausilio, Annachiara Scalzone, Valentina Mollo, Paolo Antonio Netti
In vitro programming and pseudounipolarization of human iPSC-derived sensory neurons
Pascal Röderer, Ana Catarina Costa, Martha Lürkens, Fiona Maria Roll, Franziska Buck, Luzia Heidrich, Jasmin Aicher, Anika Neureiter, Omar Mossad, Holger Trucks-Jansen, Kim Le Cann, Anil Kumar Kalia, Ramya Balaji, Verena Arndt, Andreas Zellner, Yara Mecdad, Thomas Bajaj, Martin Stüger, Martin Karl Schwarz, Anja Nitzsche, Nils Christian Gassen, Natja Haag, Manuel Schröter, Angelika Lampert, Monica M Sousa, Oliver Brüstle
Human iPSC models reveal APOE4-induced microglial remodeling and extracellular vesicle dysregulation in AD pathogenesis
Tsuneya Ikezu, Yang You, Son Nguyen, Sean Mann, Prakruthi Vadakattu, Takahisa Kanekiyo, Zhengrong Zhang, Nibedita Basu Ray, Tony Tuck, Julia Tcw, Alison Goate, Celeste Karch, Seiko Ikezu, Maria Paz Gonzalez-Perez, Wayne Poon, Scott Shaffer, Angela Duong
Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis
Claudia V. Nguyen, Antoni Martija, Daniel C. Jaklic, Rista White, Marty G. Yang, Patricia R. Nano, Jose A. Soto, Jessenya Mil, Dakshesh Rana, Jacqueline M. Martin, Hunter E. Schweiger, Sebastian Hernandez, Elisa Fazzari, Yu Liu, Jack M. Parent, Mohammed A. Mostajo-Radji, Daniel H. Geschwind, Aparna Bhaduri
Sept7 coordinates cytoskeletal dynamics and MAPK/ERK1/2 signaling to orchestrate OPC differentiation and myelination
Jianmei Ma, Cong Du, Xinnan Zhao, Yanna Liu, Xiaohan Yang, Shuang Liu, Kai Fan, Xueru Wang, Gang Liu, Reyisha Tuerhong, Mengyao Ye, Huimin Hao, Xudong Liu, Lei Shi
HydroMEA: A 3D Hydrogel‐Based Microfluidic Device to Study Electrophysiology for Myelinated Nerve‐on‐Chip
Blandine F. Clément, Cédric Pfister, Timothy Kurer, Nicole Baalbaki, Max Paxtian, Jeeho Sim, Céline Labouesse, Dhanajay V. Deshmukh, Julian Hengsteler, Julia Lehmann, Lorenza G. Paganella, Tobias Ruff, Vilius Dranseika, Sean Weaver, Lukas Sommer, Mark W. Tibbitt, János Vörös, Christina M. Tringides
Click chemistry-modified cardiomyocytes enhance cardiac contractility and prevent remodeling in ischemia-reperfusion injured hearts
Donghyun Lee, Woo-Sup Sim, Jae-Hyun Park, Dong-Yeon Han, Soo-Jeong Kim, Jin Ryeol An, Mi Seon Seo, Jin-Ju Kim, Seo Young Cheon, Hyejin Hong, Seong Woo Choi, Kiwon Ban, Heebeom Koo, Hun-Jun Park
Cryptic disease-prone states in human mesocortical assembloids revealed by multimodal profiling
Seongmin Kim, Rian Kang, Taehoon Lee, Yongjun Kim, Chang-Dae Kim, Kyeong-Mo Koo, Jiyu Na, Sumin Lee, Dohoon Kim, Hayoung Oh, Amos Chungwon Lee, Tae-Hyung Kim, Byullee Park, Luke P. Lee, Inki Kim, Jong-Chan Park