MaxOne Single-Well HD-MEA System

MaxOne High-Density Microelectrode Array (HD-MEA) System

Key Features

High-Quality Data
High-resolution and high-quality data while tracking dynamic changes at cellular, subcellular and network levels.
Sensitivity
Smallest signals capture (uV) thanks to low-noise recording channels and high electrode density.
Versatility
Compactly built, MaxOne Recording Unit can be flexibly installed in various environments and is compatible with other devices for both cultured samples and acute tissues.
Reproducibility
Optimized recordings strategies to analyze the entire culture at individual neuronal levels, increasing data reproducibility and statistical power.
Long-Term Experiments
Cell development, maturation, or compound effects assess by performing longitudinal experiments over the course of days, weeks, and months.
Integrity
Non-invasive and label-free recordings, eliminating any potential side effects associated with the use of dyes and prolonged exposure to light.

Product Overview

MaxWell Biosystems’ MaxOne is a CMOS-based HD-MEA, an electrical imaging system for neuroscience, drug discovery, and cell assessment applications. MaxOne captures high-quality signals at subcellular resolution from long-term culture experiments and acute tissue experiments (e.g., brain slices, retina).

Cell Activity Footprint
26’400 Pt-Electrodes Per Well
3’625 Electrodes/mm2
Low-Noise Readouts
Flexible Electrical Stimulation
Different readouts
Network level
Cellular level
Subcellular level

MaxOne HD-MEA system can be flexibly installed in diverse environments. For instance, MaxOne Recording Unit can operate long-term inside cell-culture incubators, and can be integrated with perfusion systems, enabling users to perform acute tissue recordings. Additionally, the system is compatible with other devices, such as being placed under an upright microscope for imaging and microscopy purposes, and integrated with tissue holders for acute tissue experiments.

Learn About MaxOne Accessories

All consumable MaxOne Chips share the same core features of our HD-MEA technology but differs in ways that allows them to be more suitable for cultured or acute samples. 

Learn About MaxOne Chips
MaxOne System Features
ComponentsRecording Unit
Hub
System status indicator LED
Dimension (L x W x H)Recording Unit: 150 x 95 x 25 mm3
Hub: 185 x 280 x 90 mm3
Incubator friendlyYes, for the Recording Unit

This might also interest you

MaxTwo Multiwell HD-MEA System is a high-throughput, high-resolution electrophysiology platform for recording and stimulating electrogenic cells in vitro. MaxTwo combines 6 or 24 MaxOne high-density microelectrode arrays in a multiwell format.
MaxLab Live Software is a comprehensive and user-friendly tool designed for visualizing, recording, and analyzing data recorded with MaxOne and MaxTwo. Its assays guide the user through automated workflows to the extraction of key metrics at multiple levels, including network, single-cell, and subcellular details.

Publications Featuring the MaxOne

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CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons

McSweeney, Danny; Gabriel, Rafael; Jin, Kang; Pang, Zhiping P; Aronow, Bruce; and Pak, ChangHui

CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons Journal Article

iScience, 2022.

Abstract | Links | BibTeX

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

Kagan, Brett J; Kitchen, Andy C; Tran, Nhi T; Habibollahi, Forough; Khajehnejad, Moein; Parker, Bradyn J; Bhat, Anjali; Rollo, Ben; Razi, Adeel; Friston, Karl J

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world Journal Article

Neuron, 2022.

Abstract | Links | BibTeX

Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays

Habibey, Rouhollah; Striebel, Johannes; Schmieder, Felix; Czarske, Jürgen; Busskamp, Volker

Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays Journal Article

Frontiers in Neuroscience, 2022.

Abstract | Links | BibTeX

Repeated and On-Demand Intracellular Recordings of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells

Lee, Jihyun; Gänswein, Tobias; Ulusan, Hasan; Emmenegger, Vishalini; Saguner, Ardan M; Duru, Firat; and Hierlemann, Andreas

Repeated and On-Demand Intracellular Recordings of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells Journal Article

ACS Sensors, 2022.

Abstract | Links | BibTeX

Df(h22q11)/+ mouse model exhibits reduced binding levels of GABAA receptors and structural and functional dysregulation in the inhibitory and excitatory networks of hippocampus

Al-Absi, Abdel-Rahman; Thambiappaa, Sakeerthi Kethees; Khanc, Ahmad Raza; Glerup, Simon; Sanchez, Connie; Landau, Anne M; Nyengaard, Jens R

Df(h22q11)/+ mouse model exhibits reduced binding levels of GABAA receptors and structural and functional dysregulation in the inhibitory and excitatory networks of hippocampus Journal Article

Molecular and Cellular Neuroscience, 2022.

Abstract | Links | BibTeX

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays

Buccino Alessio Paolo; Damart, Tanguy; Bartram Julian; Mandge Darshan; Xue Xiaohan; Zbili Mickael; Gänswein Tobias; Jaquier Aurélien; Emmenegger Vishalini; Markram Henry; Hierlemann Andreas; Van Geit Werner.

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays Journal Article

bioRxiv, 2022.

Abstract | Links | BibTeX

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking

Xue, Xiaohan; Buccino, Alessio Paolo; Kumar, Sreedhar Saseendran; Hierlemann, Andreas; Bartram, Julian

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking Journal Article

Journal of Neural Engineering, 2022.

Abstract | Links | BibTeX

Functional neuronal circuitry and oscillatory dynamics in human brain organoids

Sharf Tal; Molen, Tjitse; Glasauer Stella; Guzman Elmer; Buccino Alessio; Luna Gabriel; Cheng Zhuowei; Audouard Morgane; Ranasinghe Kamalini; Kudo Kiwamu; Nagarajan Srikantan; Tovar Kenneth; Petzold Linda; Hierlemann Andreas; Hansma Paul; ; Kosik, Kenneth;

Functional neuronal circuitry and oscillatory dynamics in human brain organoids Journal Article

Nature Communications, 2022.

Abstract | Links | BibTeX

Suppression without inhibition: how retinal computation contributes to saccadic suppression

Idrees, Saad; Baumann, Matthias-Philipp; Korympidou, Maria M; Schubert, Timm; Kling, Alexandra; Franke, Katrin; Hafed, Ziad M; Franke, Felix; Münch, Thomas A

Suppression without inhibition: how retinal computation contributes to saccadic suppression Journal Article

Communications Biology, 2022.

Abstract | Links | BibTeX

Functional imaging of brain organoids using high-density microelectrode arrays

Schröter Manuel; Wang, Congwei; Terrigno Marco; Hornauer Philipp; Huang Ziqiang; Jagasia Ravi; Hierlemann Andreas

Functional imaging of brain organoids using high-density microelectrode arrays Journal Article

MRS Bulletin, 2022.

Abstract | Links | BibTeX

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells

Xu, Jax H; Yao, Yao; Yao, Fenyong; Chen, Jiehui; Li, Meishi; Xianfa, ; Yang, ; Li, Sheng; Lu, Fangru; Hu, Ping; He, Shuijin; Peng, Guangdun; Jing, Naihe

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells Journal Article

BioRxiv, 2022.

Abstract | Links | BibTeX

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons

Sommer Daniel ; Rajkumar, Sandeep; Seidel Mira; Aly Amr; Ludolph Albert; Ho Ritchie; Boeckers Tobias; Catanese Alberto.

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons Journal Article

Frontiers in Molecular Neuroscience, 2022.

Abstract | Links | BibTeX

Automated detection of extracellular action potentials from single neurons

Cheng, Zhuowei; Guzman, Elmer; van der Molen, Tjitse; Sharf, Tal; Hansma, Paul K; Kosik, Kenneth S; Petzold, Linda; Tovar, Kenneth R

Automated detection of extracellular action potentials from single neurons Journal Article

bioRxiv, 2022.

Abstract | Links | BibTeX

A Biodegradable Magnetic Microrobot Based on Gelatin Methacrylate for Precise Delivery of Stem Cells with Mass Production Capability

Noh Seungmin ; Jeon, Sungwoong; Kim Eunhee; Oh Untaek; Park Danbi; Park Sun Hwa; Kim Sung Won; Pané Salvador; Nelson Bradley; Kim Jin-young; Choi Hongsoo;

A Biodegradable Magnetic Microrobot Based on Gelatin Methacrylate for Precise Delivery of Stem Cells with Mass Production Capability Journal Article

Small, 2022.

Abstract | Links | BibTeX

Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks

Sato Yuya; Yamamoto, Hideaki; Kato Hideyuki; Tanii Takashi; Sato Shigeo; Hirano-Iwata Ayumi

Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks Journal Article

2022.

Abstract | Links | BibTeX

Recording Saltatory Conduction Along Sensory Axons Using a High-Density Microelectrode Array

Shimba Kenta; Asahina, Takahiro; Sakai Koji; Kotani Kiyoshi; Jimbo Yasuhiko

Recording Saltatory Conduction Along Sensory Axons Using a High-Density Microelectrode Array Journal Article

Frontiers in Neuroscience, 2022.

Abstract | Links | BibTeX

Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics 2 electrophysiological phenotype of the A53T mutation

Hornauer Philipp; Prack, Gustavo; Anastasi Nadia; Ronchi Silvia; Kim Taehoon; Donner Christian; Fiscella Michele; Borgwardt Karsten; Taylor Verdon; Jagasia Ravi; Roqueiro Damian; Hierlemann Andreas;

Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics 2 electrophysiological phenotype of the A53T mutation Journal Article

bioRxiv, 2022.

Abstract | Links | BibTeX

Design strategies for controlling neuron-connected robots using reinforcement learning

Sawada, Haruto; Wake, Naoki; Sasabuchi, Kazuhiro; Takamatsu, Jun; Takahashi, Hirokazu; Ikeuchi, Katsushi

Design strategies for controlling neuron-connected robots using reinforcement learning Journal Article

arXiv, 2022.

Abstract | Links | BibTeX

Engineered Biological Neural Networks on High Density CMOS Microelectrode Arrays

Duru Jens; Küchler, Joël; Ihle Stephan Forró Csaba; Bernardi Aeneas; Girardin Sophie; Hengsteler Julian; Wheeler Stephen; János; Ruff Tobias; J ; Vörös

Engineered Biological Neural Networks on High Density CMOS Microelectrode Arrays Journal Article

2022.

Abstract | Links | BibTeX

Loss of Neurodevelopmental Gene CASK Disrupts Neural Connectivity in Human Cortical Excitatory Neurons

McSweeney, Danny; Gabriel, Rafael; Jin, Kang; Pang, Zhiping P; Aronow, Bruce; Pak, ChangHui

Loss of Neurodevelopmental Gene CASK Disrupts Neural Connectivity in Human Cortical Excitatory Neurons Journal Article

BioRxiv, 2022.

Abstract | Links | BibTeX

Autism genes converge on asynchronous development of shared neuron classes

Paulsen, Bruna; Velasco, Silvia; Kedaigle, Amanda J; Pigoni, Martina; Quadrato, Giorgia; Deo, Anthony J; Adiconis, Xian; Uzquiano, Ana; Sartore, Rafaela; Yang, Sung Min; Simmons, Sean K; Symvoulidis, Panagiotis; Kim, Kwanho; Tsafou, Kalliopi; Podury, Archana; Abbate, Catherine; Tucewicz, Ashley; Smith, Samantha N; Albanese, Alexandre; Barrett, Lindy; Sanjana, Neville E; Shi, Xi; Chung, Kwanghun; Lage, Kasper; Boyden, Edward S; andJoshua Levin, Aviv Regev Z; Arlotta, Paola

Autism genes converge on asynchronous development of shared neuron classes Journal Article

Nature, 602 , pp. 268–273, 2022.

Abstract | Links | BibTeX

Multielectrode Arrays for Functional Phenotyping of Neurons from Induced Pluripotent Stem Cell Models of Neurodevelopmental Disorders

McCready, Fraser P; Gordillo-Sampedro, Sara; Pradeepan, Kartik; Martinez-Trujillo, Julio; Ellis, James

Multielectrode Arrays for Functional Phenotyping of Neurons from Induced Pluripotent Stem Cell Models of Neurodevelopmental Disorders Journal Article

Biology, 2022.

Abstract | Links | BibTeX

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

Kagan, Brett J; Kitchen, Andy C; Tran, Nhi T; Parker, Bradyn J; Bhat, Anjali; Rollo, Ben; Razi, Adeel; Friston, Karl J

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world Journal Article

bioRxiv, 2021.

Abstract | Links | BibTeX

Unifying framework for information processing in stochastically driven dynamical systems

Kubota, Tomoyuki; Takahashi, Hirokazu; and Nakajima, Kohei

Unifying framework for information processing in stochastically driven dynamical systems Journal Article

Physical Review Research, 2021.

Abstract | Links | BibTeX

Human brain organoid networks

Sharf, Tal; van der Molen, Tjitse; Glasauer, Stella M K; Guzman, Elmer; Buccino, Alessio P; Luna, Gabriel; Cheng, Zhouwei; Audouard, Morgane; Ranasinghe, Kamalini G; Kudo, Kiwamu; Nagarajan, Srikantan S; Tovar, Kenneth R; Petzold, Linda R; Hierlemann, Andreas; Hansma, Paul K; Kosik, Kenneth S

Human brain organoid networks Journal Article

bioRxiv, 2021.

Abstract | Links | BibTeX

Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1

Schenke, Maren; Prause, Hélène-Christine; Bergforth, Wiebke; Przykopanski, Adina

Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1 Journal Article

toxins, 2021.

Abstract | Links | BibTeX

16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro

Sundberg, Maria; Pinson, Hannah; Smith, Richard S; Winden, Kellen D; Venugopal, Pooja; Tai, Derek J C; Gusella, James F; Talkowski, Michael E; Walsh, Christopher A; Tegmark, Max; Sahin, Mustafa

16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro Journal Article

Nature Communications, 12 (2897 ), 2021.

Abstract | Links | BibTeX

Inhibitory neurons exhibit high controlling ability in the cortical microconnectome

Kajiwara Motoki; Nomura, Ritsuki; Goetze Felix; Kawabata Masanori; Isomura Yoshikazu; Akutsu Tatsuya; Shimono Masanori;

Inhibitory neurons exhibit high controlling ability in the cortical microconnectome Journal Article

PLOS Computational Biology, 2021.

Abstract | Links | BibTeX

Different contrast encoding in ON and OFF visual pathways

Idrees, Saad; Münch, Thomas A

Different contrast encoding in ON and OFF visual pathways Journal Article

BioRxiv, 2020.

Abstract | Links | BibTeX

MAPSYNE: Miniaturized micropipette system combined with high-density microelectrode arrays for automated manipulation of neuronal networks in-vitro

Ricci, Chiara; Frey, Urs; Obien, Marie Engelene J

MAPSYNE: Miniaturized micropipette system combined with high-density microelectrode arrays for automated manipulation of neuronal networks in-vitro Journal Article

IEEE, 2020.

Abstract | Links | BibTeX

Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability

Al-Absi, Abdel-Rahman; Qvist, Per; Okujeni, Samora; Khan, Ahmad Raza; Glerup, Simon; Sanchez, Connie; Nyengaard, Jens R

Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability Journal Article

Molecular Neurobiology, 2020.

Abstract | Links | BibTeX

Perceptual saccadic suppression starts in the retina

Idrees, Saad; Baumann, Matthias P; Franke, Felix; Münch, Thomas A; Hafed, Ziad M

Perceptual saccadic suppression starts in the retina Journal Article

Nature Communications, 11 (1977), 2020.

Links | BibTeX

Echo State Property of Neuronal Cell Cultures

Kubota, Tomoyuki; Nakajima, Kohei; Takahashi, Hirokazu

Echo State Property of Neuronal Cell Cultures Book Chapter

11731 , Springer, 2019, ISBN: 978-3-030-30493-5.

Abstract | Links | BibTeX

Comparison of axonal-conduction velocity in developing primary cells and human iPSC-derived neurons

Obien, Marie Engelene J; Zorzi, Giulio; Fiscella, Michele; Leary, Noelle; Hierlemann, Andreas

Comparison of axonal-conduction velocity in developing primary cells and human iPSC-derived neurons Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX

Automatic extraction of axonal arbor morphology applied to h-iPSC-derived neurons

Zorzi, Giulio; Obien, Marie Engelene J; Fiscella, Michele; Leary, Noelle; Hierlemann, Andreas

Automatic extraction of axonal arbor morphology applied to h-iPSC-derived neurons Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX

Large-scale mapping of cortical synaptic projections with extracellular electrode arrays

Shein-Idelson, Mark; Pammer, Lorenz; Hemberger, Mike; Laurent, Gilles

Large-scale mapping of cortical synaptic projections with extracellular electrode arrays Journal Article

Nature Methods, 14 (9), pp. 882–889, 2017, ISSN: 1548-7091.

Abstract | Links | BibTeX

Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex

Hillier, Daniel; Fiscella, Michele; Drinnenberg, Antonia; Trenholm, Stuart; Rompani, Santiago B; Raics, Zoltan; Katona, Gergely; Jüttner, Josephine; Hierlemann, Andreas; Rozsa, Balazs; Roska, Botond

Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex Journal Article

Nature Neuroscience, 20 (7), pp. 960–968, 2017, ISSN: 1097-6256.

Abstract | Links | BibTeX

Cortical axons, isolated in channels, display activity-dependent signal modulation as a result of targeted stimulation

Lewandowska, Marta K; Radivojevic, Milos; Jäckel, David; Müller, Jan; Hierlemann, Andreas

Cortical axons, isolated in channels, display activity-dependent signal modulation as a result of targeted stimulation Journal Article

Frontiers in Neuroscience, 10 , pp. 83, 2016, ISSN: 1662453X.

Abstract | Links | BibTeX

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Müller, Jan; Ballini, Marco; Livi, Paolo; Chen, Yihui; Radivojevic, Milos; Shadmani, Amir; Viswam, Vijay; Jones, Ian L; Fiscella, Michele; Diggelmann, Roland; Stettler, Alexander; Frey, Urs; Bakkum, Douglas J; Hierlemann, Andreas

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels Journal Article

Lab Chip, 15 (13), pp. 2767-2780, 2015, ISSN: 1473-0197.

Abstract | Links | BibTeX

A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture.

Krol, Jacek; Krol, Ilona; Alvarez, Claudia Patricia Patino; Fiscella, Michele; Hierlemann, Andreas; Roska, Botond; Filipowicz, Witold

A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture. Journal Article

Nature Communications, 6 , pp. 7305, 2015, ISSN: 2041-1723.

Abstract | Links | BibTeX

A 1024-channel CMOS microelectrode array with 26,400 electrodes for recording and stimulation of electrogenic cells in vitro

Ballini, Marco; Müller, Jan; Livi, Paolo; Chen, Yihui; Frey, Urs; Stettler, Alexander; Shadmani, Amir; Viswam, Vijay; Jones, Ian L; Jäckel, David; Radivojevic, Milos; Lewandowska, Marta K; Gong, Wei; Fiscella, Michele; Bakkum, Douglas J; Heer, Flavio; Hierlemann, Andreas

A 1024-channel CMOS microelectrode array with 26,400 electrodes for recording and stimulation of electrogenic cells in vitro Journal Article

IEEE Journal of Solid-State Circuits, 49 (11), pp. 2705-2719, 2014, ISSN: 00189200.

Abstract | Links | BibTeX

91 entries « 2 of 2 »

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