Our team will be at ISSCR and would be happy to meet you!
Visit us at booth #301 to learn more about our HD-MEA systems MaxOne and MaxTwo can further your research.
Friday June 16 11:30 – 12:30 | Room 253, Level 2
Title | Advanced Functional Characterization of iPSC-Derived 2D and 3D In Vitro Models at the Frontiers of Molecular Bioscience
Abstract | Two-dimensional (2D) or three-dimensional (3D) cell cultures are currently widely used in stem cell research. They aim to be as close to in vivo conditions to varying degrees, and, when derived from human induced pluripotent stem cells (iPSCs), provide a valuable alternative to animal models. Cell shape, differentiation, and proliferation, drug sensitivity and response to stimuli are among the characteristics guiding researchers to prefer one method to the other based on the scientific question and application. Considering that both 2D and 3D in vitro cellular models can serve as equally valuable tools to overcome the current barriers in stem cell research and further advance the field, we invited three speakers to spotlight on novel applications and methods to functionally characterize iPSC-derived cellular models. Scientific presentations will be followed by Q+A session and panel discussion to shine the light on current opinions about this controversial and highly relevant topic.
Dr. Maria Sundberg Sahin Lab, Boston Children’s Hospital, Harvard Medical School, USA
Functional phenotyping of neurodevelopmental and psychiatric disorders with human iPSC-derived neurons
Dr. Jennifer Erwin Lieber Institute for Brain Development, USA
Integration of 3D human stem cell models derived from post-mortem tissue and statistical genomics to guide schizophrenia therapeutic development
Jay English Pak Lab, University of Massachusetts Amherst, USA
2D Human iPSC Models for Elucidating Synaptopathic Mechanisms of Neurodevelopmental Disorders