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MaxWell Monthly Must-Reads | Retinal Organoids

January 27, 2022

Welcome to our MaxWell Monthly Must-Reads blog for 2022. A new year also means new publications to highlight and new topics to discover. This year as well, for our monthly must-reads, we will choose a theme per month and select five papers that we think are worth reading. Last year we covered a range of topics and in our first edition of 2022, we have decided to focus on Retinal Organoids. Human brain organoids assemble functionally integrated bilateral optic vesicles.…

Join the Conversation with Prof. Kenneth S. Kosik and Dr. Tal Sharf

December 24, 2021

Marie Obien

Applications, Blog, Featured, MaxOne, Organoids, Publications

Interview and Featured Publication Join the Conversation with Prof. Kenneth Kosik and Dr. Tal Sharf Recently, Dr. Tal Sharf, Prof. Kenneth S. Kosik and colleagues released a pre-print on their novel work entitled, “Human brain organoid networks”, currently under revision. Aiming to explore the physiological behavior of neuronal circuits within organoids, this work demonstrates that human brain organoids have self-organized neuronal assemblies of sufficient size, cellular orientation, and functional connectivity to co-activate and generate field potentials from their collective transmembrane…

MaxWell Monthly Must-Reads | CMOS-Based MEA Technology

August 6, 2021

Patricia Valerio

Blog, MaxWell Monthly Must-Reads

It is time for a new edition of our monthly blog. In the August edition during the summer holidays, we highlight the latest developments on CMOS-based MEA technology. CMOS-based MEAs are used for detailed investigations of neuronal electrical activity at network and single-cell levels and to evaluate the effect of drugs on neuronal physiological activity. Therefore, for this Monthly Must-Reads edition, we decided to highlight the article written by Yuan X et al., in which switch-matrix (SM) and active-pixel-sensors…

Look back: the first In-vitro 2D and 3D Neuronal Networks Summit (MaxWell Biosystems User Meeting)　

June 23, 2021

Patricia Valerio

Blog, Events, News

On April 22nd and 23rd, we hosted the first In-vitro 2D and 3D neuronal Networks Summit (MaxWell Biosystems User Meeting) and were very excited about the tremendously successful outcome, with over 700 registrants from 49 countries! First Day: Scientific Talks and Discussions Open for All The first day of the meeting was open to everybody. We had very interesting talks from seven invited speakers, who spoke about their work involving iPSC-derived neurons, brain organoids, and also high-density microelectrode array (HD-MEA)…

HD-MEAs play a role in the functional characterization of human iPSC-derived dopaminergic neurons

June 22, 2021

Patricia Valerio

Blog, iPSC, MaxOne, News, Publications

Maria Sundberg from the Boston Children’s Hospital, Harvard Medical School, and colleagues, recently reported in Nature Communications a study on the reciprocal copy number variations (CNVs) of 16p11.2 gene region, associated with a wide spectrum of neuropsychiatric and neurodevelopmental disorders. For the functional analysis of the developing iPSC-derived dopaminergic (DA) neuron network, complementary-metal-oxide-semiconductor (CMOS)-based high-density microelectrode arrays (HD-MEAs), MaxOne System by MaxWell Biosystems was extensively used. 16p.11.2 Reciprocal copy number variations (CNVs) in neuropsychiatric disorders 16p.11.2 CNVs have been implicated in…

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