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Sensory nerve regrowth is often limited by the inhibitory nature of the extracellular matrix, which restricts axonal regeneration. Although cortical and deep brain stimulation offer potential therapeutic approaches, their effectiveness in sensory restoration is hindered by challenges in spatial resolution, cell specificity, and accessibility. In a recent study published in Advanced Functional Materials, researchers introduced an implantable biohybrid neural interface that integrates neural spheroids with a stretchable stimulation array and a microfluidic axon guidance system…

In a recent study published in Nature Communications, researchers described an experimental setup in which they combined MaxOne Single-Well HD-MEA recordings and optogenetic stimulation using a digital mirror device, achieving parallel stimulation and recording at single-neuron resolution. Applied to rat cortical neuronal cultures, the authors demonstrated that neurons adapt their responses to optical stimulation, while network bursts disrupt this adaptation. Moreover…

In this study, researchers investigated how dopamine-induced changes in network synchrony affect burst patterns in primary hippocampal cultures, using a comprehensive approach with electrophysiological recordings, pharmacological interventions, and computational analyses. The team used the MaxOne Single-Well HD-MEA System to examine the effects of dopamine on the spiking activity of cultured hippocampal neurons from a network-level perspective. Their findings reveal…