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An Implantable Biohybrid Neural Interface Toward Synaptic Deep Brain Stimulation

Sensory nerve regrowth is often limited by the inhibitory nature of the extracellular matrix, which restricts axonal regeneration. Although cortical and deep brain stimulation offer potential therapeutic approaches, their effectiveness in sensory restoration is hindered by challenges in spatial resolution, cell specificity, and accessibility. In a recent study published in Advanced Functional Materials, researchers introduced an implantable biohybrid neural interface that integrates neural spheroids with a stretchable stimulation array and a microfluidic axon guidance system…

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Swift induction of human spinal lower motor neurons and robust ALS cell screening via single-cell imaging

Swift induction of human spinal lower motor neurons and robust ALS cell screening via single-cell imaging Selena Setsu, Satoru Morimoto, Shiho Nakamura, Fumiko Ozawa, Kagistia Hana Utami, Ayumi Nishiyama, Naoki Suzuki, Masashi Aoki, Yukio Takeshita, Yukihide Tomari, Hideyuki Okano. Stem Cell Reports. 2025 Jan 14. https://doi.org/10.1016/j.stemcr.2024.11.007 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by motor neuron degeneration. While induced pluripotent stem cells (iPSCs) have emerged as a powerful tool for drug screening and studying ALS pathology, challenges…

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Revealing single-neuron and network-activity interaction by combining high-density microelectrode array and optogenetics

In a recent study published in Nature Communications, researchers described an experimental setup in which they combined MaxOne Single-Well HD-MEA recordings and optogenetic stimulation using a digital mirror device, achieving parallel stimulation and recording at single-neuron resolution. Applied to rat cortical neuronal cultures, the authors demonstrated that neurons adapt their responses to optical stimulation, while network bursts disrupt this adaptation. Moreover…

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Dopamine-induced relaxation of spike synchrony diversifies burst patterns in cultured hippocampal networks

In this study, researchers investigated how dopamine-induced changes in network synchrony affect burst patterns in primary hippocampal cultures, using a comprehensive approach with electrophysiological recordings, pharmacological interventions, and computational analyses. The team used the MaxOne Single-Well HD-MEA System to examine the effects of dopamine on the spiking activity of cultured hippocampal neurons from a network-level perspective. Their findings reveal…

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Solid-State Nanopores for Spatially Resolved Chemical Neuromodulation

A recent study from the project, published in Nano Letters, describes a planar neural interface that utilizes diffusion-driven neurotransmitter release through a solid-state nanopore array. To test its potential as a spatially resolved neural interface for stimulating neurons with glutamate, the scientists recorded rat retinal tissue on the MaxOne Single-Well HD-MEA. The results showed an increase in glutamate-evoked activity over time, with a clear-cut difference between cellslocated near the nanopores…

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