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81 entries « 2 of 2 »

2022

Functional imaging of brain organoids using high-density microelectrode arrays

Schröter Manuel; Wang, Congwei; Terrigno Marco; Hornauer Philipp; Huang Ziqiang; Jagasia Ravi; Hierlemann Andreas

Functional imaging of brain organoids using high-density microelectrode arrays Journal Article

MRS Bulletin, 2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, MaxTwo, Organoids

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells

Xu, Jax H; Yao, Yao; Yao, Fenyong; Chen, Jiehui; Li, Meishi; Xianfa, ; Yang, ; Li, Sheng; Lu, Fangru; Hu, Ping; He, Shuijin; Peng, Guangdun; Jing, Naihe

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells Journal Article

BioRxiv, 2022.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, CMOS, HD-MEA, IPSC, MaxOne

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons

Sommer Daniel ; Rajkumar, Sandeep; Seidel Mira; Aly Amr; Ludolph Albert; Ho Ritchie; Boeckers Tobias; Catanese Alberto.

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons Journal Article

Frontiers in Molecular Neuroscience, 2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, Neuronal Networks

Automated detection of extracellular action potentials from single neurons

Cheng, Zhuowei; Guzman, Elmer; van der Molen, Tjitse; Sharf, Tal; Hansma, Paul K; Kosik, Kenneth S; Petzold, Linda; Tovar, Kenneth R

Automated detection of extracellular action potentials from single neurons Journal Article

bioRxiv, 2022.

Abstract | Links | BibTeX | Tags: Action Potential, HD-MEA, MaxOne

A Biodegradable Magnetic Microrobot Based on Gelatin Methacrylate for Precise Delivery of Stem Cells with Mass Production Capability

Noh Seungmin ; Jeon, Sungwoong; Kim Eunhee; Oh Untaek; Park Danbi; Park Sun Hwa; Kim Sung Won; Pané Salvador; Nelson Bradley; Kim Jin-young; Choi Hongsoo;

A Biodegradable Magnetic Microrobot Based on Gelatin Methacrylate for Precise Delivery of Stem Cells with Mass Production Capability Journal Article

Small, 2022.

Abstract | Links | BibTeX | Tags: MaxOne

Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks

Sato Yuya; Yamamoto, Hideaki; Kato Hideyuki; Tanii Takashi; Sato Shigeo; Hirano-Iwata Ayumi

Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks Journal Article

2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, Neuronal Networks

Recording Saltatory Conduction Along Sensory Axons Using a High-Density Microelectrode Array

Shimba Kenta; Asahina, Takahiro; Sakai Koji; Kotani Kiyoshi; Jimbo Yasuhiko

Recording Saltatory Conduction Along Sensory Axons Using a High-Density Microelectrode Array Journal Article

Frontiers in Neuroscience, 2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, Neuronal cell culture

Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics 2 electrophysiological phenotype of the A53T mutation

Hornauer Philipp; Prack, Gustavo; Anastasi Nadia; Ronchi Silvia; Kim Taehoon; Donner Christian; Fiscella Michele; Borgwardt Karsten; Taylor Verdon; Jagasia Ravi; Roqueiro Damian; Hierlemann Andreas;

Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics 2 electrophysiological phenotype of the A53T mutation Journal Article

bioRxiv, 2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, Neuronal cell culture

Design strategies for controlling neuron-connected robots using reinforcement learning

Sawada, Haruto; Wake, Naoki; Sasabuchi, Kazuhiro; Takamatsu, Jun; Takahashi, Hirokazu; Ikeuchi, Katsushi

Design strategies for controlling neuron-connected robots using reinforcement learning Journal Article

arXiv, 2022.

Abstract | Links | BibTeX | Tags: Machine Learning, MaxOne, Stimulation

Engineered Biological Neural Networks on High Density CMOS Microelectrode Arrays

Duru Jens; Küchler, Joël; Ihle Stephan Forró Csaba; Bernardi Aeneas; Girardin Sophie; Hengsteler Julian; Wheeler Stephen; János; Ruff Tobias; J ; Vörös

Engineered Biological Neural Networks on High Density CMOS Microelectrode Arrays Journal Article

2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, Neuronal Networks

Loss of Neurodevelopmental Gene CASK Disrupts Neural Connectivity in Human Cortical Excitatory Neurons

McSweeney, Danny; Gabriel, Rafael; Jin, Kang; Pang, Zhiping P; Aronow, Bruce; Pak, ChangHui

Loss of Neurodevelopmental Gene CASK Disrupts Neural Connectivity in Human Cortical Excitatory Neurons Journal Article

BioRxiv, 2022.

Abstract | Links | BibTeX | Tags: IPSC, MaxOne, Neuronal Networks

Autism genes converge on asynchronous development of shared neuron classes

Paulsen, Bruna; Velasco, Silvia; Kedaigle, Amanda J; Pigoni, Martina; Quadrato, Giorgia; Deo, Anthony J; Adiconis, Xian; Uzquiano, Ana; Sartore, Rafaela; Yang, Sung Min; Simmons, Sean K; Symvoulidis, Panagiotis; Kim, Kwanho; Tsafou, Kalliopi; Podury, Archana; Abbate, Catherine; Tucewicz, Ashley; Smith, Samantha N; Albanese, Alexandre; Barrett, Lindy; Sanjana, Neville E; Shi, Xi; Chung, Kwanghun; Lage, Kasper; Boyden, Edward S; andJoshua Levin, Aviv Regev Z; Arlotta, Paola

Autism genes converge on asynchronous development of shared neuron classes Journal Article

Nature, 602 , pp. 268–273, 2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, Organoids

Multielectrode Arrays for Functional Phenotyping of Neurons from Induced Pluripotent Stem Cell Models of Neurodevelopmental Disorders

McCready, Fraser P; Gordillo-Sampedro, Sara; Pradeepan, Kartik; Martinez-Trujillo, Julio; Ellis, James

Multielectrode Arrays for Functional Phenotyping of Neurons from Induced Pluripotent Stem Cell Models of Neurodevelopmental Disorders Journal Article

Biology, 2022.

Abstract | Links | BibTeX | Tags: HD-MEA, IPSC, MaxOne, MEA Technology

2021

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

Kagan, Brett J; Kitchen, Andy C; Tran, Nhi T; Parker, Bradyn J; Bhat, Anjali; Rollo, Ben; Razi, Adeel; Friston, Karl J

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world Journal Article

bioRxiv, 2021.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, Activity Scan Assay, closed loop stimulation, HD-MEA, In-Vitro, IPSC, MaxOne, MEA Technology, Network Assay, Neuronal Networks, Primary Neuronal Cell Culture, Stimulation

Unifying framework for information processing in stochastically driven dynamical systems

Kubota, Tomoyuki; Takahashi, Hirokazu; and Nakajima, Kohei

Unifying framework for information processing in stochastically driven dynamical systems Journal Article

Physical Review Research, 2021.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, HD-MEA, MaxOne, Primary Neuronal Cell Culture, Stimulation

Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1

Schenke, Maren; Prause, Hélène-Christine; Bergforth, Wiebke; Przykopanski, Adina

Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1 Journal Article

toxins, 2021.

Abstract | Links | BibTeX | Tags: MaxOne

16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro

Sundberg, Maria; Pinson, Hannah; Smith, Richard S; Winden, Kellen D; Venugopal, Pooja; Tai, Derek J C; Gusella, James F; Talkowski, Michael E; Walsh, Christopher A; Tegmark, Max; Sahin, Mustafa

16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro Journal Article

Nature Communications, 12 (2897 ), 2021.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, IPSC, MaxOne

Inhibitory neurons exhibit high controlling ability in the cortical microconnectome

Kajiwara Motoki; Nomura, Ritsuki; Goetze Felix; Kawabata Masanori; Isomura Yoshikazu; Akutsu Tatsuya; Shimono Masanori;

Inhibitory neurons exhibit high controlling ability in the cortical microconnectome Journal Article

PLOS Computational Biology, 2021.

Abstract | Links | BibTeX | Tags: Brain Slice, MaxOne

2020

Different contrast encoding in ON and OFF visual pathways

Idrees, Saad; Münch, Thomas A

Different contrast encoding in ON and OFF visual pathways Journal Article

BioRxiv, 2020.

Abstract | Links | BibTeX | Tags: MaxOne, Retina

MAPSYNE: Miniaturized micropipette system combined with high-density microelectrode arrays for automated manipulation of neuronal networks in-vitro

Ricci, Chiara; Frey, Urs; Obien, Marie Engelene J

MAPSYNE: Miniaturized micropipette system combined with high-density microelectrode arrays for automated manipulation of neuronal networks in-vitro Journal Article

IEEE, 2020.

Abstract | Links | BibTeX | Tags: Activity Scan Assay, HD-MEA, MaxOne, MEA Technology

Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability

Al-Absi, Abdel-Rahman; Qvist, Per; Okujeni, Samora; Khan, Ahmad Raza; Glerup, Simon; Sanchez, Connie; Nyengaard, Jens R

Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability Journal Article

Molecular Neurobiology, 2020.

Abstract | Links | BibTeX | Tags: MaxOne, Slices

Perceptual saccadic suppression starts in the retina

Idrees, Saad; Baumann, Matthias P; Franke, Felix; Münch, Thomas A; Hafed, Ziad M

Perceptual saccadic suppression starts in the retina Journal Article

Nature Communications, 11 (1977), 2020.

Links | BibTeX | Tags: ETH-CMOS-MEA, MaxOne, Retina

2019

Echo State Property of Neuronal Cell Cultures

Kubota, Tomoyuki; Nakajima, Kohei; Takahashi, Hirokazu

Echo State Property of Neuronal Cell Cultures Book Chapter

11731 , Springer, 2019, ISBN: 978-3-030-30493-5.

Abstract | Links | BibTeX | Tags: Action Potential, MaxOne, Neuronal cell culture

2018

Comparison of axonal-conduction velocity in developing primary cells and human iPSC-derived neurons

Obien, Marie Engelene J; Zorzi, Giulio; Fiscella, Michele; Leary, Noelle; Hierlemann, Andreas

Comparison of axonal-conduction velocity in developing primary cells and human iPSC-derived neurons Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MaxOne

Automatic extraction of axonal arbor morphology applied to h-iPSC-derived neurons

Zorzi, Giulio; Obien, Marie Engelene J; Fiscella, Michele; Leary, Noelle; Hierlemann, Andreas

Automatic extraction of axonal arbor morphology applied to h-iPSC-derived neurons Conference

11th International Meeting on Substrate Integrated Microelectrode Arrays (MEA Meeting) Reutlingen, Germany, 2018.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, MaxOne

2017

Large-scale mapping of cortical synaptic projections with extracellular electrode arrays

Shein-Idelson, Mark; Pammer, Lorenz; Hemberger, Mike; Laurent, Gilles

Large-scale mapping of cortical synaptic projections with extracellular electrode arrays Journal Article

Nature Methods, 14 (9), pp. 882–889, 2017, ISSN: 1548-7091.

Abstract | Links | BibTeX | Tags: Brain Slice, MaxOne, Neuronal Networks

Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex

Hillier, Daniel; Fiscella, Michele; Drinnenberg, Antonia; Trenholm, Stuart; Rompani, Santiago B; Raics, Zoltan; Katona, Gergely; Jüttner, Josephine; Hierlemann, Andreas; Rozsa, Balazs; Roska, Botond

Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex Journal Article

Nature Neuroscience, 20 (7), pp. 960–968, 2017, ISSN: 1097-6256.

Abstract | Links | BibTeX | Tags: MaxOne, Retina

2016

Cortical axons, isolated in channels, display activity-dependent signal modulation as a result of targeted stimulation

Lewandowska, Marta K; Radivojevic, Milos; Jäckel, David; Müller, Jan; Hierlemann, Andreas

Cortical axons, isolated in channels, display activity-dependent signal modulation as a result of targeted stimulation Journal Article

Frontiers in Neuroscience, 10 , pp. 83, 2016, ISSN: 1662453X.

Abstract | Links | BibTeX | Tags: MaxOne, Neuronal Networks, u-Tunnels

2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Müller, Jan; Ballini, Marco; Livi, Paolo; Chen, Yihui; Radivojevic, Milos; Shadmani, Amir; Viswam, Vijay; Jones, Ian L; Fiscella, Michele; Diggelmann, Roland; Stettler, Alexander; Frey, Urs; Bakkum, Douglas J; Hierlemann, Andreas

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels Journal Article

Lab Chip, 15 (13), pp. 2767-2780, 2015, ISSN: 1473-0197.

Abstract | Links | BibTeX | Tags: MaxOne, Neuronal Networks

A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture.

Krol, Jacek; Krol, Ilona; Alvarez, Claudia Patricia Patino; Fiscella, Michele; Hierlemann, Andreas; Roska, Botond; Filipowicz, Witold

A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture. Journal Article

Nature Communications, 6 , pp. 7305, 2015, ISSN: 2041-1723.

Abstract | Links | BibTeX | Tags: MaxOne, Retina

2014

A 1024-channel CMOS microelectrode array with 26,400 electrodes for recording and stimulation of electrogenic cells in vitro

Ballini, Marco; Müller, Jan; Livi, Paolo; Chen, Yihui; Frey, Urs; Stettler, Alexander; Shadmani, Amir; Viswam, Vijay; Jones, Ian L; Jäckel, David; Radivojevic, Milos; Lewandowska, Marta K; Gong, Wei; Fiscella, Michele; Bakkum, Douglas J; Heer, Flavio; Hierlemann, Andreas

A 1024-channel CMOS microelectrode array with 26,400 electrodes for recording and stimulation of electrogenic cells in vitro Journal Article

IEEE Journal of Solid-State Circuits, 49 (11), pp. 2705-2719, 2014, ISSN: 00189200.

Abstract | Links | BibTeX | Tags: MaxOne, MEA Technology

81 entries « 2 of 2 »

Selected Publications

Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.

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