Applications

Join the Conversation with Prof. Kenneth S. Kosik and Dr. Tal Sharf

December 24, 2021
Marie Obien
Applications, Blog, Featured, MaxOne, Organoids, Publications

Interview and Featured Publication Join the Conversation with Prof. Kenneth Kosik and Dr. Tal Sharf Recently, Dr. Tal Sharf, Prof. Kenneth S. Kosik and colleagues released a pre-print on their novel work entitled, “Human brain organoid networks”, currently under revision. Aiming to explore the physiological behavior of neuronal circuits within organoids, this work demonstrates that human brain organoids have self-organized neuronal assemblies of sufficient size, cellular orientation, and functional connectivity to co-activate and generate field potentials from their collective transmembrane…

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HD-MEAs play a role in the functional characterization of human iPSC-derived dopaminergic neurons

June 22, 2021
Diana Freire
Blog, iPSC, MaxOne, News, Publications

Maria Sundberg from the Boston Children’s Hospital, Harvard Medical School, and colleagues, recently reported in Nature Communications a study on the reciprocal copy number variations (CNVs) of 16p11.2 gene region, associated with a wide spectrum of neuropsychiatric and neurodevelopmental disorders. For the functional analysis of the developing iPSC-derived dopaminergic (DA) neuron network, complementary-metal-oxide-semiconductor (CMOS)-based high-density microelectrode arrays (HD-MEAs), MaxOne System by MaxWell Biosystems was extensively used. 16p.11.2 Reciprocal copy number variations (CNVs) in neuropsychiatric disorders 16p.11.2 CNVs have been implicated in…

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Observing the activity of human-derived neurons in health and in disease

April 9, 2021
Marie Obien
Applications, Blog, Featured, iPSC, News, Publications

The combination of two technologies—induced pluripotent stem cells and high-density microelectrode arrays—offers an unprecedented platform to study human brain activity in detail outside the body.    Back in 2006, Prof. Yamanaka and colleagues revealed a technique to reprogram adult skin cells into embryonic-like cells called induced pluripotent stem cells or iPSCs. This Nobel Prize winning technology enables access to human neurons derived from adult blood or skin cells in a high-throughput manner, thus opening up the possibilities to study neurological…

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MaxWell Monthly Must-Reads (March 2020)

March 25, 2020
Michele Fiscella
Applications, Blog, MaxWell Monthly Must-Reads, Organoids

During this extraordinary period of the COVID-19 pandemic and while working from home, it is important to sometimes take a break. One way to make use of these breaks is to read up on the latest scientific publications. In order to help you select which papers to read, we publish a Monthly Must-Reads every four weeks. After the last two editions which highlight the topics of Axons  and Retina, we decided that for this  edition we will highlight five articles related…

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